Dimitrios Kolokouris

Personal photo - Dimitris Kolokouris

Doctoral Student at the

Doctoral Training Centre

Rex Richards Building, South Parks Road, Oxford OX1 3QU

Background

I am PhD researcher in the Newstead group at the Division of Medical Sciences at Oxford University. I study how cells absorb cationic amino acids. This type of amino acids lead to cancer and other diseases when out of tight control. As a structural biochemist I design experiments to study the mechanisms behind this tight control at the molecular level. Leveraging the burst in computational power available to 21st century scientists, I simulate the phenomena I study to see biochemistry in action. Although exciting on its own, my research aims to uncover new opportunities for drugs, to benefit patient health.

My research is supported by the BBSRC and the Onassis Foundation.

I studied Pharmacy (M.Pharm) specialising in medicinal biochemistry and I am a board certified pharmacist by the Ministry of Health in Greece.


I am very enthusiastic with my work. I come from Greece, where I grew up and lived before moving to the UK. In my free time I enjoy relaxing with friends, exercising and travelling the greek islands.


Publications

Spotting Differences in Moleculer Dynamics Simulations of Influenza A M2 Protein-Ligand Complexes by Varying M2 Construct, Lipid Bilayer and Force Field. Kolokouris D. Kalenderoglou I., Lagarias P. & Kolocouris A. ChemRxiV 2019 (preprint).

Comparative Perturbation Effects Exerted by the Influenza A M2 WT Protein Inhibitors Amantadine and the Spiro[pyrrolidine-2,2'-adamantane] Variant AK13 to Membrane Bilayers Studied Using Biophysical Experiments and Molecular Dynamics Simulations. Konstantinidi, A., Naziris, N., Chountoulesi, M., Kiriakidi, S., Sartori, B., Kolokouris, D., Amentisch, H., Mali, G., Ntountaniotis, D., Demetzos, C., Mavromoustakos, T., & Kolocouris, A.J Phys Chem B. 2018;122(43):9877-9895. doi:10.1021/acs.jpcb.8b07071

Unraveling the Binding, Proton Blockage, and Inhibition of Influenza M2 WT and S31N by Rimantadine Variants. Drakopoulos, A., Tzitzoglaki, C., McGuire, K., Hoffmann, A., Konstantinidi, A., Kolokouris, D., Ma, C., Freudenberger, K., Hutterer, J., Gauglitz, G., Wang, J., Schmidtke, M., Busath, D. D., & Kolocouris, A. (2018). ACS medicinal chemistry letters, 9(3), 198–203. https://doi.org/10.1021/acsmedchemlett.7b00458