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Title: Body mass index and physical activity in relation to the incidence of hip fracture in postmenopausal women

Authors: M.E.G. Armstrong, E.A. Spencer, B.J. Cairns, E. Banks, K. Pirie, J. Green, F.L. Wright, G.K. Reeves and V. Beral, for the Million Women Study Collaborators

Reference: Journal of Bone and Mineral Research 26(6):1330-1338.

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Hip fracture risk increases with physical inactivity and decreases with obesity but there is little information on their combined effects. We report on the separate and combined effects of body mass index (BMI) and physical activity on hospital admissions for hip fracture among postmenopausal women in a large prospective study of UK women. Self-reported information on body size, physical activity, and other relevant factors was collected in 1996-2001 and participants were followed for incident hip fractures by record linkage to NHS hospital admission data. Cox regression was used to calculate adjusted relative risks of hip fracture. Among 925 345 postmenopausal women followed for an average of 6.2 years, 2582 were admitted to hospital with an incident hip fracture. Hip fracture risk increased with decreasing BMI: compared to obese women (BMI 30+) relative risks were 1.71 (95%CI 1.47-1.97) for BMI 25.0-29.9kg/m2 and 2.55 (95%CI 2.22-2.94) for BMI 20.0-24.9kg/m2. The increase in fracture risk per unit decrease in BMI was significantly greater among lean women than among overweight women (p<0.001). For women in every category of BMI, physical inactivity was associated with increased risk of hip fracture. There was no significant interaction between the relative effects of BMI and physical activity. For women who reported that they took any exercise versus no exercise the adjusted relative risk of hip fracture was 0.68 (95%CI 0.62-0.75), with similar results for strenuous exercise. In this large cohort of postmenopausal women BMI and physical activity had independent effects on hip fracture risk.

Keywords. hip fracture, physical activity, BMI, prospective study, postmenopausal women

Acknowledgement. We thank all the women who participated in the Million Women Study, collaborators from the NHS Breast Screening Centres, members of the study co-ordinating centre, and the study steering committee (listed below). We also thank the General Practitioners for providing height and weight measurements and the Information Centre for Health and Social Care and ISD [Information Services Division] Scotland for providing hospital records. Funding: This work was supported by public funds from Cancer Research UK and the UK Medical Research Council. The funders did not influence the conduct of the study or the preparation of this report.

© 2002-2017 Benjamin J. Cairns: e-mail ; ph +44 1865 289673 ;
Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, U.K.