Dr. Eric Werner
In silico Multicellular Systems Biology and Minimal Genomes
Author: Eric Werner, Ph.D.
Key Words: in silico multicellular systems, computational systems biology, minimal cell, minimal genomes, genome architecture, genome semantics, minimal multicellular organisms, systems biology hierarchy, multicellular pharmacodynamics, regulatory networks, modeling, simulation, cancer modeling, organ regeneration, tissue engineering, wound healing
The in vivo and in silico understanding of genomes and networks in cellular
and multicellular systems is essential for drug discovery for multicellular
diseases. In silico methodologies when integrated with in vivo engineering
methods, lay the groundwork for understanding of multicellular organisms
and their genomes. The quest to construct a minimal cell will be followed
by designed, minimal multicellular organisms. In silico multicellular
systems biology will be essential in the design and construction of minimal
genomes for minimal multicellular organisms. Advanced methodologies come
to light that can aid drug discovery. These novel approaches include multicellular
pharmacodynamics and networked multicellular pharmacodynamics.
In this section: