Dr. Eric Werner
Net Based Pharmacodynamics May Change the Pharmaceutical Industry
Talk at International Conference Converging Sciences 2006,
Eric Werner, Ph.D.
Traditional drugs act on targets in molecules in chemical pathways. Viewing
targets and pathways in the context of metabolic and genomic networks
that are integrated into a model of cells and multicellular structures,
makes it possible to see the function of targets in a broader dynamic
biological context of developing multicellular systems. We called this
Networked multicellular pharmacodynamics (Net-MCPD)[see Werner, DDT,
vol 8, p 1121, 2003]. It becomes possible, in principle, to view the
effect of a drug at different stages of development. Thus some drugs have
adverse effects on children but not on adults. Also, cancers can be viewed
as caused by pathological developmental networks (see Werner forthcoming).
Furthermore, it may turn out that RNA based "drugs" with their
precise target specificity will become the dominant mode of network control.
Hence, pushing aside traditional drug based approaches to medicine. This
may leave the pharmaceutical industry open to revolutionary competition
from small start ups.
In this section: