The Future and Limits of Systems Biology, Sci. STKE 2005, pe16
Systems biology has enjoyed explosive growth in both the number of people
participating in this area of research and in the number of publications
on the topic. And, yet, the paradigms that underlie the field have not
seen a similar expansiveness. Instead, most of these paradigms have been
carried over from other fields like engineering, physics, and mathematics.
As a result, a small set of concepts dominate the field. The traditional
biologist is seen by many as outmoded and tolerated only as a source of
data. In this view, the biologist’s ideas may even be considered
conceptually and theoretically irrelevant. In this perspective, we take
a critical look at some of the paradigms of systems biology and question
whether the biologist’s ideas, methods and theories have really
become outmoded. We see the future of systems biology as tight coupling
of in vivo and in vitro methods for bioengineering with in silico multicellular
modeling and simulation.
Citation: E.Werner, The Future and Limits of Systems
Biology, Sci. STKE 2005, pe16 (2005).