Function of CFTR Protein: Developmental Role (2006)

D. R. Gill and J. E. Larson

Cystic fibrosis in the 21st century, 54-60 (3805579608)

Karger   Back to Chapters

In the lung, CFTR is largely expressed in the undifferentiated multipotent stem cells of the first- and second-trimester airway epithelium. As differentiation proceeds, the expression of CFTR dissipates and the adult lung expresses a small fraction of what was expressed in the fetus. There is growing evidence that infants with CF have lungs that are functionally and structurally abnormal prior to the appearance of clinical infection. This chapter examines the expression and role of CFTR in developmental cascades in the lung.

Introductory Videos
Medical Futures Innovation Award 2011
Twitter Feed
About Us
Contact Us
Lab Events
Environemental Policy
About this Site

Google Site Search

Site Feedback Form

All Site Images



How the Consortium works/FAQs

Consortium Website

Centre for Molecular Medicine, Edinburgh
The Roslin Institute
Dep of Gene Therapy, Imperial



The Run-in Study

Single Dose Clinical Trial

Multi Dose Clinical Trial


Our Research

Non-viral Vector Development

Aerosol Mediated Gene Delivery

Viral Vector Development

Taqman Core Facility

Cystic Fibrosis

History of CF

Discovery of the CFTR Gene

CFTR Protein Structure

CFTR Function

CF Links


Gene Therapy

Introduction to Gene Therapy

Other CF Gene Therapy Groups

Why use Gene Therapy for CF

Target Cells for CF Gene Therapy

Barriers for CF Gene Therapy

Clinical Trials

Gene Therapy Successes

Gene Therapy Links




Papers in Journals

Conference Posters & Presentations

Book Chapters

D.Phil Theses



Gene Therapy Seminars


Directions & Venue