Publications in Peer Reviewed Journals

2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 Older

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2012

Rapid identification of novel functional promoters for gene therapy (2012). Pringle, I.A. et al., Journal of Molecular Medicine, June 5, [Epub ahead of print].

CpG-free plasmid expression cassettes for cystic fibrosis gene therapy (2012). Pringle, I.A. et al., Biomaterials, May 8, [Epub ahead of print].

The use of CpG-free plasmids to mediate persistent gene expression following repeated aerosol delivery of pDNA/PEI complexes (2012). Davies, L. A. et al., Biomaterials, 33, 5618-27.

2011

The significance of plasmid DNA preparations contaminated with bacterial genomic DNA on inflammatory responses following delivery of lipoplexes to the murine lung (2011). Bazzani, R. P. et al., Biomaterials, 32, 9854-9865.

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung (2011). McLachlan, G. et al., Gene Therapy, Advanced online publication.

Secreted Gaussia luciferase as a sensitive reporter gene for in vivo and ex vivo studies of airway gene transfer (2011). Griesenbach, U. et al., Biomaterials, 32, 2614-2624.

2010

A novel mixing device for the reproducible generation of nonviral gene therapy formulations (2010). Davies, L. A. et al., Biotechniques 49, 666-668.  Download

Strategies for long-term expression of transgenes in the respiratory epithelium (2010). Gill, D. R. et al., Curr Opin Mol Ther 12, 386-393.

The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways (2010). Griesenbach, U. et al., Biomaterials 31, 2665-2672.

Limitations of the murine nose in the development of nonviral airway gene transfer (2010). Griesenbach, U. et al., Am J Respir Cell Mol Biol 43, 46-54.

Detection of CFTR transgene mRNA expression in respiratory epithelium isolated from the murine nasal cavity (2010). Holder, E. et al., J Gene Med 12, 55-63.  Download

2009 ^Top

An immunocytochemical assay to detect human CFTR expression following gene transfer (2009). Davidson, H. et al., Mol Cell Probes 23, 272-280.

Progress and prospects: the design and production of plasmid vectors (2009). Gill, D. R. et al., Gene Ther 16, 165-171.

Identification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import (2009). Munkonge, F. M. et al., J Biol Chem 284, 26978-26987.  Download

Non-viral vectors in cystic fibrosis gene therapy: recent developments and future prospects (2009). Pringle, I. A. et al., Expert Opin Biol Ther 9, 991-1003.

2008 ^Top

Enhanced lung gene expression after aerosol delivery of concentrated pDNA/PEI complexes (2008). Davies, L. A. et al., Mol Ther 16, 1283-1290.  Download

Adenovirus-mediated in utero expression of CFTR does not improve survival of CFTR knockout mice (2008). Davies, L. A. et al., Mol Ther 16, 812-818.  Download

Assessment of CFTR function after gene transfer in vitro and in vivo (2008). Griesenbach, U. et al., Methods Mol Biol 433, 229-242.

Ignoring the nonsense: a phase II trial in cystic fibrosis (2008). Hyde, S. C. & Gill, D. R., Lancet 372, 691-692.

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression (2008). Hyde, S. C. et al., Nat Biotechnol 26, 549-551.

2007^Top

Identification of transfected cell types following non-viral gene transfer to the murine lung (2007). Davies, L. A. et al., J Gene Med 9, 184-196.

Optimizing aerosol gene delivery and expression in the ovine lung (2007). McLachlan, G. et al., Mol Ther 15, 348-354.  Download

Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung (2007). Pringle, I. A. et al., J Gene Med 9, 369-380.  Download

Lack of repeat transduction by recombinant adeno-associated virus type 5/5 vectors in the mouse airway (2007). Sumner-Jones, S. G. et al., J Virol 81, 12360-12367.  Download

2006^Top

Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways (2006). Davidson, H. et al., Am J Respir Cell Mol Biol 35, 72-83.  Download

Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo (2006). Griesenbach, U. et al., Respir Res 7, 26.  Download

Optimising non-viral gene delivery in a tumour spheroid model (2006). Mellor, H. R. et al., J Gene Med 8, 1160-1170.

Long-term persistence of gene expression from adeno-associated virus serotype 5 in the mouse airways (2006). Sumner-Jones, S. G. et al., Gene Ther 13, 1703-1713. Download

Electroporation-mediated interleukin-10 overexpression in skeletal muscle reduces acute rejection in rat cardiac allografts (2006). Tavakoli, R. et al., J Gene Med 8, 242-248.

2005^Top

Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA (2005). Davies, L. A. et al., Pharm Res 22, 1294-1304.

Detection of plasmid DNA vectors following gene transfer to the murine airways (2005). Pringle, I. A. et al., Gene Ther 12, 1206-1214.  Download

Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury (2005). Ulrich, K. et al., Am J Physiol Lung Cell Mol Physiol 288, L1179-1192.  Download

2004^Top

The development of gene therapy for diseases of the lung (2004). Gill, D. R. et al., Cell Mol Life Sci 61, 355-368.

2003^Top

Transfection efficiency and toxicity following delivery of naked plasmid DNA and cationic lipid-DNA complexes to ovine lung segments (2003). Emerson, M. et al., Mol Ther 8, 646-653.  Download

2002^Top

Optimisation of real-time quantitative RT-PCR for the evaluation of non-viral mediated gene transfer to the airways (2002). Rose, A. C. et al., Gene Ther 9, 1312-1320.  Download

2001^Top^Top

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter (2001). Gill, D. R. et al., Gene Ther 8, 1539-1546.  Download

Older^Top

Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis (2000). Hyde, S. C. et al., Gene Ther 7, 1156-1165.  Download

Towards gene therapy for cystic fibrosis: a clinical progress report (1998). Alton, E. W. et al., Gene Ther 5, 291-292.  Download

A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis (1997). Gill, D. R. et al., Gene Ther 4, 199-209.  Download

A second dose of a CFTR cDNA-liposome complex is as effective as the first dose in restoring cAMP-dependent chloride secretion to null CF mice trachea (1997). Goddard, C. A. et al., Gene Ther 4, 1231-1236.  Download

Chloride secretion in the trachea of null cystic fibrosis mice: the effects of transfection with pTrial10-CFTR2 (1997). MacVinish, L. J. et al., J Physiol 499 ( Pt 3), 677-687.  Download

Drug efflux mediated by the human multidrug resistance P-glycoprotein is inhibited by cell swelling (1994). Sardini, A. et al., J Cell Sci 107 ( Pt 12), 3281-3290.

Tamoxifen blocks chloride channels. A possible mechanism for cataract formation (1994). Zhang, J. J. et al., J Clin Invest 94, 1690-1697.  Download

Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy (1993). Hyde, S. C. et al., Nature 362, 250-255.

Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the human multidrug resistance P-glycoprotein (1993). Mintenig, G. M. et al., Receptors Channels 1, 305-313.

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein (1992). Gill, D. R. et al., Cell 71, 23-32.

The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression (1992). Trezise, A. E. et al., EMBO J 11, 4291-4303.  Download

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein (1992). Valverde, M. A. et al., Nature 355, 830-833.

Binding protein-dependent transport systems (1990). Higgins, C. F. et al., J Bioenerg Biomembr 22, 571-592.

Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport (1990). Hyde, S. C. et al., Nature 346, 362-365.

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