G W J Fleet Quick CV, Complete Publication and Patent List

 

Quick CV: Undergraduate at Magdalene College Cambridge UK, Ph D with Ian Fleming at Cambridge on heterocyclic analogues of benzyne. MRC Post doctoral fellow at Oxford with Jeremy Knowles [Dean of Harvard] and Rodney Porter [Nobel prize winner] on the Photoaffinity labeling of antibodies by nitrenes derived from azides. Post doctoral work with E J Corey [Nobel prize winner] at Harvard on prostaglandin synthesis and chromium(VI) oxidation. At Oxford since. Visiting Professor at National Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang. China from 2010. Emeritus research professor St John’s College Oxford 2011. From 2013-2015 Emeritus Leverhulme Research Fellow. Visiting Professor at International Institute of Rare Sugar Research and Education, University of Kagawa, Kagawa, Japan from 2016

 

Research interests: Synthesis and investigations of rare and expensive sugars with only acetone as protecting groups; adding high value cheaply with industrial scale production. Collaborative power of chemistry and biotechnology. Isolation and synthesis of missed bioactive water-soluble low molecular weight nitrogen compounds from plants which are used as sources of food. Pharmacological chaperones: iminosugars as small molecules to assist correction of protein mis-folding diseases including cystic fibrosis and lysosomal storage diseases – Tay-Sachs, Sandhoff, Schindler-Kanzaki, Fabry. Synthesis of iminosugars of all stereoisomers from cheap carbohydrates by convergent syntheses for the systematic investigation of their properties as glycosidase inhibitors; novel anti-cancer strategies. Development of general syntheses of highly functionalized azetidines from sugars. Azetidine carboxylic acids as novel peptidomimetics. Sugar amino acids as scaffolds for the study of foldamers. 

 

Publications and patents: A full list of publications and patents, which runs from the most recent backwards over 7 !! decades, is given below. A reliable assessment of published work for chemists is the Hirsch-index. The group H-index is 72 - H index 24 since 2016; more than 120 papers with >50 citations; total  >21.7K citations [Google scholar].

 

Anyone interested should contact me by e.mail george.fleet@chem.ox.ac.uk

 

607. Kato, A.; Nakagome, I.; Kanekiyo, U.; Lu, T.-T.; Li, Y.-X.; Yshimura, K.; Kishida, M.; Shinzawa, K.; Yoshida, T.; Tanaka, N.; Jia Y.-M.; Nash, R.J.; Fleet, G. W. J.; Yu, C.-Y., 5-C-Branched Deoxynojirimycin: Strategy for Designing DNJ-Based Pharmacological Chaperone with Nanomolar Affinity for Pompe Disease, J. Med. Chem., submitted for publication

 

606. Li, Y.-X.; Wang, J.-Z,; Kato, A.; Shimadate, Y.; Kise, M.; Jia, Y.-M.; Fleet, G. W. J.; Yu, C.-Y., Stereocomplementary synthesis of casuarine and its 6-epi-, 7-epi-, and 6, 7-di-epi-stereoisomers, Org. Biomol. Chem. 2021, 19, 9410-9420.

 

 605. Lu, T.-T.; Shimadate, Y.; Cheng, B.; Kanekiyo, U.; Kato, A.; Wang, J.-Z.; Li, Y.-X.; Jia, Y.-M.; Fleet, G. W. J.; Yu, C.-Y, Synthesis and Glycosidase Inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-L-ido-DNJ Derivatives,  Eur. J. Med. Chem. 2021, 224, 113716.

 

604. Shinzawa, K.; Kageta, D.; Nash, R. J.; Fleet, G. W. J.; Imahori, T.; Kato, A., Azobenzene derivatives show anti-cancer activity against pancreatic cancer cells only under nutrient starvation conditions via G0/G1 cell cycle arrest, Tetrahedron 2021, 85, 132077.

 

603. Yan, X.; Shimadate, Y.; Kato, A.; Li, Y. X.; Jia, Y. M.; Fleet, G. W. J.; Yu, C.-Y., Synthesis of Pyrrolidine Monocyclic Analogues of Pochonicine and Its Stereoisomers: Pursuit of Simplified Structures and Potent β-N-Acetylhexosaminidase Inhibition, Molecules 2020, 25, 1498.

 

602. Liu, Z.; Yoshihara, A.; Jenkinson, S. F.; Wormald, M. R.; Kelly, C.; Heap, J. T.; Marqvorsen, M. H. S.; Estévez, R. J.; Fleet, G. W. J.; Nakagawa, S.; Izumori, K.; Nash, R. J.; Kato, A., Hanessian-Hullar Reaction in the Synthesis of Highly Substituted trans-3,4-Dihydroxypyrrolidines: Rhamnulose Iminosugar Mimics Inhibit a-Glucosidase, Tetrahedron, 2020, 76, 130758.

 

601. Yang; L.-F.; Shimadate, Y.; Kato, A.; Y.-X.; Jia, Y. M.; Fleet, G. W. J.; Yu, C.-Y., Synthesis and glycosidase inhibition of N-substituted derivatives of DIM (1,4-dideoxy-1,4-imino-d-mannitol), Org. Biomol. Chem. 2020, 18,  999-1011.

 

600. Kato, A.; Nakagome, I.; Hata, M.; Nash, R. J.; Fleet, G. W. J.; Natori, Y.; Yoshimura, Y.; Adachi, I.; Hirono, S., Strategy for designing selective lysosomal acid a-glucosidase inhibitors : binding orientation and influence on selectivity, Molecules 2020, 25, 2843.

 

599.  Nash, R. J.; Bartholomew, B.; Penkova, Y. B.; Rotondo, D.; Yamasaka, F.; Stafford, G. P.; Jenkinson, S. F.; Fleet, G. W. J., Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity, ACS Omega  2020, 5, 16263-16271.

 

598. Otero, J. M.; Estévez, A. M.; Estévez, J. C.; Fleet,^, G. W. J.; Estévez,^, R. J., Highly functionalized cyclic and bicyclic b-amino acids from sugar b-nitroesters, Tetrahedron, 2020, 76, 130837.

 

597. Liu, Z.; Jenkinson, S. J.; Yoshihara, A.; Wormald, M. R.; Izumori, K.; Fleet, G. W. J., D-Idose, D-iduronic acid and D-idonic acid from D-glucose via seven carbon sugars, Molecules 2019, 24, 3758.

 

596. Wu, Q.-K.; Kinami, K.; Kato A.; Li. Y.-X.; Jia, Y-M.; Fleet, G. W. J.;Yu, C.-Y., Synthesis and Glycosidase Inhibition of Broussonetine M and Its Analogues, Molecules 2019, 24, 3712.

 

595. Yoshihara, A.; Sakoguchi, H.; Shintani, T.; Fleet, G. W. J.; Izumori. K; Sato. M., Growth inhibition by 1-deoxy-D-allulose, a novel bioactive deoxy sugar, screened using Caenorhabditis elegans assay, Bioorg. Med. Chem. Lett. 2019, 29, 2483-2486.

 

594. Kato, A.; Koyama, J.; Shinzawa, K.; Imaeda, S.; Adachi, I.; Nash, R. J.; Fleet, G. W. J.; Shintani, M.; Takeuchi, C.; Ishikawa, F., Ginnalin B induces differentiation markers and modulates the proliferation/differentiation balance via the upregulation of NOTCH1 in human epidermal keratinocytes, Bioorg. Med. Chem. 2019, 27, 2172-2180.

 

593. Martínez, R. F.; Jenkinson, S. F.; Nakagawa, S.; Kato, A.; Wormald, M. R.; Fleet, G. W. J.; Hollinshead, J.; Nash, R. J., Isolation from Stevia rebaudiana of DMDP acetic acid a novel iminosugar amino acid: protecting group-free synthesis and glycosidase inhibition profile of glycine and b-alanine pyrrolidine amino acids, Amino Acids, 2019, 51, 991-998.

 

592. Wood, A.; Prichard, K.; Clarke, Z.; Houston, T. A.; Kato, A.; Fleet, G. W. J.; Simone, M. I., Synthetic Pathways to 3, 4, 5-Trihydroxypiperidines from the Chiral Pool, Eur. J. Org. Chem. 2018, 6812-6829.

 

591. Prichard, K.; Campkin, D.; O'Brien, N.; Kato, A.; Fleet, G. W. J.; Simone, M. I., Biological Activities of 3, 4, 5-Trihydroxypiperidines and their N and O Derivatives, Chem. Biol. Drug Design, 2018, 92, 1171-1197.

 

590. Kato, A; Nakagome, I.; Nakagawa, S.; Kinami, K.; Adachi, I.; Jenkinson, S. F; Desire, J.; Bleriot, Y.; Nash, R. J.; Fleet, G. W. J.; Hirono, S., in silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease, Org. Biomol. Chem. 2017, 15, 9297-9304.

 

589. Thompson, A. L.; Jenkinson, S. F.; Fleet, G. W. J., Some experimental aspects of absolute configuration determination using single crystal X-ray diffraction, Tetrahedron: Asymmetry 2017, 228, 1330-1336.

 

588. Miyawaki, S.; Hirokami, Y.; Kinami, K.; Hoshino, M.; Minehira, D.; Miyamoto, D.; Nash, R. J.; Fleet, G. W. J.; Adachi, I.; Toyooka, N.; Kato, A., Strategy for designing selective α-L-rhamnosidase inhibitors: Synthesis and biological evaluation of DMDP cyclic isothioureas, Bioorg. Med. Chem. 2017, 25, 107-115.

 

587. Glawar, A. F. G.; Martnez, R. F.; Ayers, B. J.; Hollas, M. A.; Ngo, N.; Nakagawa, S.; Kato, A.; Butters, T. D.; Fleet, G. W. J. ; Jenkinson, S. F., Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids, Org. Biomol. Chem. 2016, 14, 10371–10385.

 

586. Kamori, A.; Kato, A.; Miyawaki, S.; Koyama, J.; Nash, R. J.; Fleet, G. W. J.; Miura, D.; Ishikawa, F.; Adachi, I., Dual action of acertannins as potential regulators of intracellular ceramide levels, Tetrahedron: Asymmetry 2016, 27, 1177-1185.

 

585. Liu, Z.; Yoshihara, A.; Jenkinson, S. F.; Wormald, M. R.; Estevez, R. J.; Fleet, G. W. J.; Izumori, K., Triacetonide of Glucoheptonic Acid in the Scalable Syntheses of D-Gulose, 6-Deoxy-D-gulose, L-Glucose, 6-Deoxy-L-glucose and Related Sugars, Org. Lett. 2016, 18, 4112–4115.

 

584. Liu, Z.; Jenkinson, S. F.; Kato, A.; Nakagawa, S.; Wormald, M. R.; Yu, C.-Y.; Fleet, G. W. J., Azidoazetidines as the first scaffolds for β-amino azetidine carboxylic acid peptidomimetics: azetidine iminosugars containing an acetamido group do not inhibit β-N-acetylhexosaminidases, Tetrahedron: Asymmetry 2016, 27, 872-881.

 

583. Liu, Z.; Yoshihara, A.; Kelly, C. L.; Heap, J. T.; Marqvorsen, M. H. S.; Jenkinson, S. F.; Wormald, M. R.; Otero, J.; Estvez, A.; Kato, A.; Fleet, G. W. J; Estvez, R. J.; Izumori, K.; 6-Deoxyhexoses from L-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology, Chem. Eur. J. 2016, 22, 12557–12565.

 

582. Kelly, C. L.; Liu, Z.; Yoshihara, A.; Jenkinson, S. F.; Wormald, M. R.; Otero, J.; Estvez, A.; Kato, A.; Marqvorsen, M. H. S.; Fleet, G. W. J; Estvez, R. J.; Izumori, K.; Heap, J. T., Synthetic chemical inducers and genetic decoupling enable orthogonal control of the rhaBAD promoter, ACS Synth. Biol. 2016, 5, 1136–1145.

 

581. Song, Y. -Y.; Kinami, K.; Kato, A.; Li, Y.-X.; Fleet, G. W. J.; Yu, C.-Y., First Total Synthesis of (+)-Broussonetine W: Glycosidase Inhibition of Natural Product & Analogs, Org. Biomol. Chem. 2016, 14, 5157-5174.

 

580. Wang, H.-Y.; Kato, A.; Kinami, K.; Li, Y.-X.; Fleet, G. W. J.; Yu, C.-Y., Concise Synthesis of Calystegine B₂ and B₃ via Intramolecular Nozaki–Hiyama–Kishi Reaction, Org. Biomol. Chem. 2016, 14, 4885-4896.

 

579. Qian, B.-C.; Kamori, A.; Kinami, K.; Kato, A.; Li, Y.-X.; Fleet, G. W. J.; Yu, C.-Y., Epimerization of C5 of an N-Hydroxypyrrolidine in the Synthesis of Swainsonine Related Iminosugars, Org. Biomol. Chem. 2016, 14, 4488-4499.

 

578. Li, Y.-X.; Kinami, K.; Hirokami, Y.; Kato, A.; Su, J.-K.; Jia, Y.-M.; Fleet, G. W. J.; Yu, C.-Y., Gem-difluoromethylated and Trifluoromethylated Derivatives of DMDP related Iminosugars: Synthesis and Glycosidase Inhibition, Org. Biomol. Chem. 2016, 14, 2249-2263.

 

577. Li, Y.-X.; Iwaki, R.; Kato, A.; Jia, Y.-M.; Fleet, G. W. J.; Zhao, X.; Xiao, M.; Yu, C.-Y., Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition, Eur. J. Org. Chem. 2016, 1429–1438.

 

576. Kato, A.; Nakagome, I.; Sato, K.; Yamamoto, A.; Adachi, I.; Nash, R. J.; Fleet,  G. W. J.; Natori, Y.; Watanabe, Y.; Imahori, T.; Yoshimura, Y.; Takahata, H.; Hirono, S., Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease, Org. Biomol. Chem. 2016, 14, 1039-1048.

 

575. Li, Y.-X.; Shimada, Y.; Adachi, I.; Kato, A.; Jia, Y.-M.; Fleet, G. W. J.; Xiao, M.; Yu, C.-Y., Fluorinated and Conformationally-fixed Derivatives of L-homoDMDP: Synthesis and Glycosidase Inhibition, J. Org. Chem. 2015, 80, 5151–5158.

 

574. Liu, Z.; Jenkinson, S. F.; Vermaas, T.; Adachi, I.; Wormald, M. R.; Hata, Y.; Kurashima, Y.; Kaji, A.; Yu, C.-Y.; Kato, A.; Fleet, G. W. J., 3-Fluoro-azetidine Carboxylic Acids and trans,trans-3,4-Difluoroproline as Peptide Scaffolds: Inhibition of Pancreatic Cancer Cell Growth by a Fluoroazetidine Iminosugar, J. Org. Chem. 2015, 80, 4244–4258.

 

573. Kato, A.; Zhang, Z.-L.; Wang, H.-Y.; Jia, Y.-M.; Yu, C.-Y.; Kinami, K.; Hirokami, Y.; Tuji, Y.; Adachi, I.; Nash, R. J.; Fleet, G. W. J.; Koseki, J.; Nakagome, I.; Hirono, S., Design and Synthesis of Labystegines, Hybrid Iminosugars from LAB and Calystegine, as Inhibitors of Intestinal a-Glucosidases: Binding Conformation and Interaction for ntSI, J. Org. Chem. 2015, 80, 4501–4515.

 

572. Gonzlez-Castro, M. A.; Poole, D. L.; Estvez, J. C.; Fleet, G. W. J.; Estvez. R. J. A stereoselective transformation of (-)-shikimic acid into (3R,4S,5R,7R)-7-(hydroxymethyl)azepane-3,4,5-triol, a potential glycosidase inhibitor, Tetrahedron: Asymmetry 2015, 26, 320-323.

 

571. Li, Y.-X.: Shimada, Y.; Sato, K.; Kato, A.; Zhang, W.; Jia, Y.-M.; Fleet, G. W. J.; Xiao, M.; Yu, C.-Y., Synthesis and Glycosidase Inhibition of Australine and Its Fluorinated Derivatives, Org. Lett. 2015, 17, 716-719.

 

570. Kato, A.; Hirokami, Y.; Kinami, K.; Tsuji, Y.; Miyawaki, S.; Adachi, I.; Hollinshead, J.; Nash, R. J.; Kiappes, J. L.; Zitzmann, N.; Cha, J. K.; Molyneux, R. J.; Fleet, G. W. J.; Asano, N., Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors, Phytochemistry 2015, 111, 124-131.

 

569. Fleet, G., Raphael, F., Izumori,, K., Manufacture of L-glucose or D-gulose involves extending carbon-1 side of D-glucose using Kiliani reaction, removing hydroxy methyl group, and producing hexose product L-glucose or D-gulose having skeleton of newly enriched carbon, Patent Number: WO2015068724-A1 Patents Published: May 14 2015.

 

568. Zitzmann, N.; Butters, T. D.; Platt, F. M.; Jacob, G. S.; Picker, D. H.; Carrouee, S.; Fleet, G. W. J., Dwek, R. A.; Durantel, D.; Mehta, M.; Block, T. M., Long chain N-alkyl compounds and oxa-derivatives thereof, Patent Number: US 09089515, Official Gazette of the United States Patent and Trademark Office Patents Published: July 28 2015.

 

 567. Butters, T. D.; Dwek, R. A.; Fleet, G. W. J., Deoxynojirimycin and D-arabinitol analogs and methods of using, Patent Number: US 08975280, Official Gazette of the United States Patent and Trademark Office Patents Published: March 10 2015.

 

566. Liu, Z.; Yoshihara, A.; Wormald, M. R.; Jenkinson, S. F.; Gibson, V.; Izumori, K.; Fleet, G. W. J., L-Fucose From Vitamin C With Only Acetonide Protection, Org. Lett. 2014, 16, 5663–5665.

 

565. Dsir, J.; Mondon, M.; Fontelle, N.; Nakagawa, S.; Hirokami, Y.; Adachi, I.; Iwaki, R.; Fleet, G. W. J.; Alonzi, D. S.; Twigg, G.; Butters, T. D.; Bertrand, J.; Cendret, V.; Becq, F.; Norez, C.; Marrot, J.; Bleriot, Y., N- and C-Functionalisation of seven-membered iminosugars with long alkyl chains generate potent glycosidase inhibitors and F508del-CFTR correctors, Org. Biomol. Chem. 2014, 12, 8977-8996.

 

564. Crabtree, E. V.; Martnez, R. F.; Nakagawa, S.; Adachi, I.; Butters, T. D.; Kato, A.; Fleet, G. W. J.; Glawar, A. F. G, Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of b-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols, Org. Biomol. Chem. 2014, 12, 3932-3943.

 

563. Ayers, B. J.; Glawar, A. F. G.; Martnez, R. F.; Ngo, N.; Liu, Z.; Fleet, G. W. J.; Butters, T. D.; Nash, R. J.; Yu, C.-Y.; Wormald, M. R.; Nakagawa, S.; Adachi, I.; Kato, A.; Jenkinson, S. F., 9 of 16 Stereoisomeric Polyhydroxylated Proline Amides are Potent _-N-Acetylhexosaminidase Inhibitors, J. Org. Chem. 2014, 79, 3398-3409.

 

562. Martinez, R. F.; Liu, Z.; Glawar, A. F. G; Yoshihara, A.; Izumori, K.; Fleet, G. W. J.; Jenkinson, S. F., Short and Sweet: D-Glucose to L-Glucose and L-Glucuronic Acid, Angew. Chem. Int. Edit. 2014, 53, 1160-1162; Kurz und Knapp: L-Glucose und L-Gluconsaure von D-Glucose, Angew. Chem. 2014, 126, 1179-1182.

 

561. Ayers, B. J.; Fleet, G. W. J., One-pot tandem Strecker reaction and iminocyclisations – syntheses of trihydroxy piperidine _-iminonitriles, Eur. J. Org. Chem. 2014, 2053–2069.

 

560. Ayers, B. J.; Hollinshead, J.; Saville, A. W.; Nakagawa, S.; Adachi, I.; Kato, A.; Izumori, K.; Bartholomew, B.; Fleet, G. W. J.; Nash. R. J., Iteamine, the first alkaloid isolated from Itea virginica L. inflorescence, Phytochemistry 2014, 100, 126-131. 

 

559. Martnez, R. F.; Fleet, G. W. J., Carbohydrate derived bicyclic azetidin-3-ones as scaffolds for highly functionalized azetidines, Tetrahedron: Asymmetry 2014, 25, 373-380.

 

558. Butters, T. D.; Dwek, R. A.; Fleet, G. W. J.; Orchard, M. G.; Platt, F. M., Pharmaceutically active piperidine derivatives, Patent Number: US 08729099, Official Gazette of the United States Patent and Trademark Office Patents Published: May 20 2014.

 

557. Zhu, J.-S.; Nakagawa, S.; Chen, W.; Adachi, I.; Jia, Y.-M.; Hu, X.-G.; Fleet, G. W. J.; Wilson, F. X.; Nitoda, T.; Horne, G.; van Well, R.; Kato, A.; Yu, C.-Y. Synthesis of Eight Stereoisomers of Pochonicine: Nanomolar Inhibition of b-N-Acetylhexosaminidases, J. Org. Chem. 2013, 78, 10298-10309.

 

556. Glawar, A. F. G.; Jenkinson, S. F.; Newberry, S. J.; Thompson, A. L.; Nakagawa, S.; Yoshihara, A.; Akimitsu, K.; Izumori, K.; Butters, T. D.; Kato, A.; Fleet, G. W. J., An approach to 8 stereoisomers of homonojirimycin from D-glucose via kinetic & thermodynamic azido-g-lactones, Org. Biomol. Chem. 2013, 11, 6886-6899.

 

555. Bertrand, J; Boinot, C.; Mouzannar, K.; Fleet, G.; Meyer, P.; Becq, F.; Norez, C. Inhibition of HSP90/f508DEL-CFTR interaction by isolab leads to the restoration of the mutated protein to the plasma membrane in cystic fibrosis epithelial cells, Pediatric Pulmonology 2013, 48, 219-220.

 

554. Zhao, H.; Wang, W.-B.; Nakagawa, S.; Jia, Y.-M.; Hu, X.-G.; Fleet, G. W. J.; Wilson, F. X.; Nash, R. J.; Kato, A.; Yu, C.-Y., Novel 2-aryl-3,4,5-trihydroxypiperidines: Synthesis and glycosidase inhibition, Chin. Chem. Lett. 2013, 24, 1059-1063.

 

553. Jenkinson, S. F.; Best, D.; Saville, A. W.; Mui, J.; Martinez, R. F.; Nakagawa, S.; Kunimatsu, T.; Alonzi, D. S.; Butters, T. D.; Norez, C.; Becq, F.; Bleriot, Y.; Wilson, F. X.; Weymouth-Wilson, A. C.; Kato, A.; Fleet, G. W. J., C_Branched Iminosugars: __Glucosidase Inhibition by Enantiomers of isoDMDP, isoDGDP, and isoDAB_L_isoDMDP Compared to Miglitol and Miglustat, J. Org. Chem. 2013, 78, 7380-7397.

 

552. Risseeuw, M. D. P.; Overhand, M.; Fleet, G. W. J.; Simone, M. I., A compendium of cyclic sugar amino acids and their carbocyclic and heterocyclic nitrogen analogues, Amino Acids, 2013, 45, 613-689.

 

551. Zhao, W.-B.; Nakagawa, S.; Kato, A.; Adachi, I.; Jia, Y.-M.; Hu, X.-G.; Fleet, G. W. J.; Wilson, F. X.; Horne, G.; Yoshihara, A.; Izumori, K.; Yu, C.-Y., General Synthesis of Sugar-Derived Azepane Nitrones: Precursors of Azepane Iminosugars, J. Org. Chem. 2013, 78, 3208-3221.

 

550. Martnez, R. F.; Arajoa, N.; Jenkinson, S. F.; Nakagawa, S.; Kato, A.; Fleet, G. W. J., (3R,4S,5R,6R,7S)-3,4,5,7-Tetrahydroxyconidine, an azetidine analogue of 6,7-diepicastanospermine and a conformationally constrained D-deoxyaltronojirimycin, from L-arabinose, Bioorg. Med. Chem. 2013, 21, 4813-4819.

 

549. Glawar, A. F. G.; Jenkinson, S. F.; Thompson, L.; Nakagawa, S.; Kato, A.; Butters, T. D.; Fleet, G. W. J., 3-Hydroxyazetidine Carboxylic Acids: Novel Non-proteinogenic Amino Acids for Medicinal Chemists, ChemMedChem 2013, 8, 658-666.

 

548. Ayers, B. J.; Jenkinson, S. F.; Fleet, G. W. J.; Thompson, A. L., 2-N-Benzyl-2,6-dideoxy-2,6-O-isopropylidene-D-allononitrile, Acta Cryst. 2013, E69, o1772.

 

547. Izumori, K.; Tokuda, M.; Fleet, G. W. .J.; Tsujisaka, Y.; Takeshita, K.; Tsusaki, K.; Okuma, K., Deoxyketohexose isomerase and method for producing deoxyhexose and derivative thereof using same, Official Gazette of the United States Patent and Trademark Office Patents Published: MAR 5 2013

 

546. Clark, N. E.; Metcalf, M. C.; Best, D.; Fleet, G. W. J.; Garman, S. C., Pharmacological Chaperones for Human a-N-Acetylgalactosaminidase, Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 17000-17005.

 

545. Ayers, B. J.; Ngo, N.; Jenkinson, S. F.; Martnez, R. F.; Shimada, Y.; Adachi, I.; Weymouth-Wilson, A. C.; Kato, A.; Fleet, G. W. J., Glycosidase inhibition by all ten stereoisomeric 2,5-dideoxy-2,5-iminohexitols prepared from the enantiomers of glucuronolactone, J. Org. Chem. 2012, 77, 7777-7792.

 

544. Arajo, N.; Jenkinson, S. F.; Martnez, F. R.; Glawar, A. F. G.; Wormald, M. R.; Butters, T. D.; Nakagawa, S.; Adachi, I.; Kato, A.; Yoshihara, A.; Akimitsu, K.; Izumori, K.; Fleet, G. W. J., Synthesis from D-Altrose of (5R,6R,7R,8S)-5,7-Dihydroxy-8-hydroxymethylconidine and 2,4-Dideoxy-2,4-imino-D-glucitol, Azetidine Analogues of Swainsonine and 1,4-Dideoxy-1,4-imino-D-mannitol, Org. Lett. 2012, 14, 4174-4177.

 

543. Glawar, A. F. G.; Best, D.; Ayers, B.; Miyauchi, S.; Nakagawa, S.; Aguilar-Moncayo, M.; Garca Fernndez, J. M.; Mellet, C.O.; Crabtree, E. V.; Butters, T. D.; Wilson, F. X.; Kato, A.; Fleet, G. W. J., Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone; effect of N-alkylation on hexosaminidase inhibition, Chem. Eur. J. 2012, 18, 9341-9359.

 

542. Soengas, R. G.; Fontanella, M.; Santos, J. I.; Fleet, G. W. J.; Jimnez-Barbero, J., Synthesis and Conformational Analysis of Heterogeneous Cyclic Oligomers of 6-Amino-6-deoxygalactonic Acid and Phenylalanine, Eur. J. Org. Chem. 2012, 5701-5711.

 

541. Lenagh-Snow, G. M. J.; Araujo, N.; Jenkinson, S. F.; Martinez, R. F.; Shimada, Y.; Yu, C.-Y.; Kato, A.; Fleet, G. W. J. Azetidine iminosugars from the cyclization of 3,5-di-O-triflates of _-furanosides and of 2,4-di-O-triflates of b-pyranosides derived from glucose, Org. Lett. 2012, 14, 2142-2145.

 

540. Lenagh-Snow, G. M. J.; Jenkinson, S. F.; Newberry, S. J.; Kato, A.; Nakagawa, S.; Adachi, I.; Wormald, M. R.; Yoshihara, A.; Morimoto, K.; Akimitsu, K.; Izumori, K.; Fleet, G. W. J., Eight stereoisomers of homonojirimycin from D-mannose, Org. Lett. 2012, 14, 2050-2053.

 

539. Simone, M. I.; Soengas, R. G.; Jenkinson, S. F.; Evinson, E. L.; Nash; R. J.; Fleet .G. W. J. Synthesis of three branched iminosugars [(3S,4R,5S)-3-(hydroxymethyl)piperidine-3,4,5-triol, (3R,4R,5R)-3-(hydroxymethyl)piperidine-3,4,5-triol and (3S,4R,5R)-3-(hydroxymethyl)piperidine-3,4,5-triol] and a branched trihydroxynipecotic acid [(3R,4R,5R)-3,4,5-trihydroxypiperidine-3-carboxylic acid] from sugar lactones with a carbon substituent at C-2, Tetrahedron: Asymmetry 2012, 23, 401-408.

 

538. Soengas, R. G.; Simone, M. I.; Hunter, S.; Nash; R. J.; Evinson, E. L.; Fleet, G. W. J. Hydroxymethyl-Branched Piperidines from Hydroxymethyl-Branched Lactones: Synthesis and Biological Evaluation of 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-D-mannitol, 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-L-gulitol and 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-D-talitol, Eur. J. Org. Chem. 2012, 2394-2402.

 

537. Edgeley, D. S.; Martinez, R. F.; Jenkinson, S. F.; Nash, R. J.; Fleet G. W. J.; Thompson, A. L. N-(2-Carboxyethyl)-2,5-dideoxy-2,5-imino-D-mannonic acid [(2S,3R,4R,5R)-1-(2-carboxyethyl)-3,4-dihydroxy-5-(hydroxymethyl)proline], Acta Cryst. 2012, E68, o2865- o2866.

 

536. Edgeley, D. S; Jenkinson, S. F.; Lenagh-Snow, G.; Rutherford, C.; Fleet, G. W. J.; Thompson, A. L. N-Benzyl-3,5-dideoxy-3,5-imino-1,2-O-isopropylidene-b-L-lyxofuranose Acta Cryst. 2012, E68, o2410.

 

535. Ayers, B. J.; Jenkinson, S. F.; Fleet, G. W. J.; Thompson, A. L. 2-N-Benzyl-2,6-dideoxy-2,6-imino-3,4-O-isopropylidene-3-C-methyl-D-allononitrile, Acta Cryst. 2012, E68, o1474.

 

534. G. M. J. Lenagh-Snow, N. Araujo, S. F. Jenkinson, C. Rutherford, S. Nakagawa, A. Kato, C.-Y. Yu, A. C. Weymouth-Wilson and G. W. J. Fleet, Inhibition of Nonmammalian Glycosidases by Azetidine Iminosugars Derived from Stable 3,5-Di-O-triflates of Pentoses, Org. Lett. 2011, 13, 5834-5837.

 

533. R. J. Nash, A. Kato, C.-Y. Yu, G. W. J. Fleet, Iminosugars as therapeutic agents: Recent advances and promising trends, Future Med. Chem. 2011, 3, 1513-1521. 

 

532. W. Zhang, K. Sato, A. Kato, Y.-M. Jia, X.-G. Hu, F. X. Wilson, R. van Well, G. Horne, G. W. J. Fleet, R. J. Nash, and C.-Y. Yu, Synthesis of Fully Substituted Polyhydroxylated Pyrrolizidines via Cope–House Cyclization, Org. Lett. 2011, 13, 4414-4417.

 

531. S. F. Jenkinson, G. W. J. Fleet, R. J. Nash, Y. Koike, I. Adachi, A. Yoshihara, K. Morimoto, K. Izumori and A. Kato, Looking-glass synergistic pharmacological chaperones: DGJ and L-DGJ from the enantiomers of tagatose, Org. Lett. 2011, 13, 4064-4067.

 

530. F. P. da Cruz, S. Newberry, S. F. Jenkinson, M. R. Wormald, T. D. Butters, D. S. Alonzi, S. Nakagawa, F. Becq, C. Norez, R. J. Nash, A. Kato and G. W. J. Fleet, 4-C-Methyl-DAB and 4-C-Me-LAB - enantiomeric alkyl branched pyrrolidine iminosugars - are specific and potent a-glucosidase inhibitors; acetone as the sole protecting group, Tetrahedron Lett. 2011, 52, 219-223.

 

529. M. I. Simone, A. A. Edwards, G. E. Tranter, G. W. J. Fleet, C-3 Branched-3,5-cis- and trans-THF sugar amino acids: synthesis of the first generation of branched homooligomers, Amino Acids, 2011, 41, 643-661.

 

528. Y.-X. Li, M.-H. Huang, Y. Yamashita, A. Kato, Y.-M. Jia, W.-B. Wang, G. W. J. Fleet, R. J. Nash and C.-Y. Yu, L-DMDP, L-homoDMDP and Their C-3 Fluorinated Derivatives: Synthesis and Glycosidase-Inhibition, Org. Biomol. Chem. 2011, 9, 3405-3414.

 

527. S. F. Jenkinson, G. W. J. Fleet, Oxetanes from the ring contraction of a-triflates of g-lactones: oxetane nucleosides and oxetane amino acids, Chimia 2011, 65, 71-75.

 

526. J. S. S. Rountree, T. D. Butters, R. A. Dwek and G. W. J. Fleet, Enantiomeric 2-acetamido-1,4-dideoxy-1,4-iminoribitols as potential pyrrolidine N-acetylhexosaminidase inhibitors, Comptes Rendus Chimie 2011, 14, 126-133.

 

525. Jenkinson, S. F., Parry, L. L., Wilson, F. X., Fleet, G. W. J., Watkin, D. J., 6-Deoxy-3,4-O-isopropylidene-2-i-methyl-L-galactono-1,5-lactone, Acta Cryst. 2011, E67, o2531-2532. 

 

524. Jenkinson, S. F., Lenagh-Snow, G. M. J., Fleet, G. W. J., Thompson, A. L., N-Benzyl-1,3-dideoxy-1,3-imino-L-xylitol, Acta Cryst. 2011, E67, o2452. 

 

523. Jenkinson, S. F., O񡬠N., Romero, A., Fleet, G. W. J., Thompson, A. L., Pino-Gonzᬥz, M. S., N,N-Diethyl-6-azido-3-O-benzyl-6-deoxy-1,2-O-isopropylidene-a-D-gluco-heptofuranuronamide, Acta Cryst. 2011, E67, o38-o39.

 

522. G. W. J. Fleet and T. D. Butters, Synthesis of 2-acetamido-1,2-dideoxy-D-galacto-nojirimycin from D-glucuronolactone and its use to inhibit -N-a-acetylgalactosaminidases, PCT Int. Appl. (2011), WO 2011095893 A1 20110811; G. W. J. Fleet and T. D. Butters, Forming 2-acetamido-1,2-dideoxy-D-galacto-nojirimycin/its derivative involves introducing nitrogen at position 5 of D-glucuronolactone, inversion of configuration of hydroxyl at position 3, and introducing nitrogen between position 6 and 2 WO2011095893-A1 CA2788983-A1 EP2531201-A1 KR2013009751-A US2013040990-A1 JP2013518814-W CN102985092-A IN201206974-P1

 

521. G. W. J. Fleet and R. Storer, Novel iminosugar therapeutics, PCT application WO/2011/0095772 A2 published 11/08/11; G. W. J. Fleet and R. Storer, Pyrrolidine Iminosugars used in the treatment of cystic fibrosis PCT application WO/2011/086347 A1 published 21/07/11. New carbon-branched pyrrolidine iminosugar compound used in pharmaceutical composition and in inhalation device such as metered dose inhaler and nebulizer for treating cystic fibrosis Patent Number: WO2011086347-A1

 

520. G. W. J. Fleet and R. Storer, New pyrrolidine or azetidine iminosugars useful for treating or preventing infection selected from viral, bacterial, fungal or protozoal, immune disorder, neoplasia, insulin resistance, obesity, polycystic ovarian syndrome, hemochromatosis WO2011095772-A2 WO2011095772-A3 Patent Assignee: SUMMIT CORP PLC

 

519. D. Best, S. F. Jenkinson, A. W. Saville, D. S. Alonzi, M. R. Wormald, T. D. Butters, C. Norez, F. Becq, Y. Bl鲩ot, I. Adachi, A. Kato and G. W. J. Fleet. Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon branched pyrrolidine iminosugars, Tetrahedron Lett. 2010, 51, 4170-4174.

                            

518. X.-G. Hu, B. Bartholomew, R. J. Nash, F. X. Wilson, G. W. J. Fleet, S. Nakagawa, A. Kato, Y.-M. Jia, R. van Well, and C.-Y. Yu, Synthesis and Glycosidase Inhibition of the Enantiomer of (-)-Steviamine, the First Example of a New Class of Indolizidine Alkaloid, Org. Lett. 2010, 12, 2562-2565.

                            

517. A. Kato, J. Hollinshead, Y. Yamashita, S. Nakagawa, Y. Koike, I. Adachi, C.-Y. Yu, G. W. J. Fleet, R. J. Nash, An a-glucoside of 1,4-dideoxy-1,4-imino-D-lyxitol with an eleven carbon side chain Phytochem. Lett. 2010, 3, 230-233

 

516. A. Michalik, J. Hollinshead, L. Jones, G. W. J. Fleet, C.-Y. Yu, X.-G. Hu, R. van Well, G. Horne, F. X. Wilson, R. J. Nash, Steviamine, a new class of indolizidine alkaloid from Stevia rebaudiana, Phytochem. Lett. 2010, 3, 136-138.

                            

515. L. Jones, J. Hollinshead, G. W. J. Fleet, A. L. Thompson, D. J. Watkin, Z. A. Gal, S. F. Jenkinson, A. Kato, R. J. Nash, Isolation of the pyrrolizidine alkaloid 1-epialexine from Castanospermum australe. Phytochem. Lett. 2010, 3, 133-135.

 

514. D. Best, P. Chairatana, A. F. G. Glawar, E. Crabtree, T. D. Butters, F. X. Wilson, C.-Y. Yu, W.-B. Wang, Y.-M. Jia, I. Adachi, A. Kato and G. W. J. Fleet, Synthesis of DGJNAc [2-acetamido-1,2-dideoxy-D-galacto-nojirimycin] - the first sub-micromolar inhibitor of a-N-acetylgalactosaminidases - from D-glucuronolactone, Tetrahedron Lett. 2010, 51, 2222-2224.

 

513. S. D. Boomkamp, J. S. S. Rountree, D. C. A. Neville, R. A. Dwek, G. W. J. Fleet, T. D. Butters, Lysosomal storage of oligosaccharide and glycosphingolipid in imino sugar treated cells, Glycoconj. J. 2010, 27, 297-308.

 

512. D. Best, C. Wang, A. C. Weymouth-Wilson, R. A. Clarkson, F. X. Wilson, R. J. Nash, S. Miyauchi, A. Kato and G. W. J. Fleet, Looking glass inhibitors: scalable syntheses of DNJ, DMDP and (3R)-3-hydroxy-L-bulgecinine from D-glucuronolactone and of L-DNJ, L-DMDP and (3S)-3-hydroxy-D-bulgecinine from L-glucuronolactone. DMDP inhibits b-glucosidases and b-galactosidases whereas L-DMDP is a potent and specific inhibitor of a-glucosidases Tetrahedron: Asymmetry 2010, 21, 311-319.

 

511. P. Gullapalli, A. Yoshihara, K. Morimoto, D. Rao, S. F. Jenkinson, M. R. Wormald, G. W. J. Fleet and K. Izumori, Conversion of L-rhamnose into ten of the sixteen 1- and 6-deoxyketohexoses in water with 3 reagents: D-tagatose-3-epimerase equilibrates C3 epimers of deoxyketoses, Tetrahedron Lett. 2010, 51, 895-898.

 

510. M. I. Simone, A. A. Edwards, A. R. Cowley, G. W. J. Fleet and D. J. Watkin, (3R,4R,5R)-5-(Acetamidomethyl)-N-benzyl-3,4-dihydroxytetrahydrofuran-3-carboxamide, Acta Cryst. 2010, E66, 2750-o2751. 

 

509. M. I. Simone, A. A. Edwards, S. G. Parker, G. E. Tranter, G. W. J. Fleet and D. J. Watkin, Pentafluorophenyl (3R,4R,5S)-5-{[(3R,4R,5S)-5-azidomethyl-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxamido]methyl}-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxylate, Acta Cryst. 2010, E66, o2699-o2700. 

 

508. S. F. Jenkinson, D. Best, K. Izumori, F. X. Wilson, A. C. Weymouth-Wilson, G. W. J. Fleet and A. L. Thompson, 1-Deoxy-1-fluoro-L-galactitol, Acta Cryst. 2010, E66, o1330.

 

507. S. F. Jenkinson, D. Best, K. Izumori, F. X. Wilson, A. C. Weymouth-Wilson, G. W. J. Fleet and A. L. Thompson, 6-Deoxy-6-fluoro-D-galactose, Acta Cryst. 2010, E66, o1315.

 

506. S. F. Jenkinson, N. Dai, G. W. J. Fleet, D. J. Watkin, 2-Azido-2-deoxy-3,4-O-isopropylidene-2-C-methyl-D-talono-1,5-lactone, Acta Cryst. 2010, E66, o1221-o1222.

 

505. S. F. Jenkinson, E. V. Crabtree, A. F. G. Glawar, T. D. Butters, G. W. J. Fleet, D. J. Watkin, 2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-xylitol (N-Benzyl-XYLNAc), Acta Cryst. 2010, E66, o1147-o1148.

 

504. S. F. Jenkinson, D. Best, F. X. Wilson, G. W. J. Fleet, D. J. Watkin, (1R,2R,3S,6aS,7R,8R,9S,12aS)-1,2,3,7,8,9-Hexahydroxyperhydrodipyrido[1,2-a:1',2'-d]pyrazine-6,12-dione, Acta Cryst. 2010, E66, o853-o853.

 

503. S. F. Jenkinson, G. M. J. Lenagh-Snow, K. Izumori, G. W. J. Fleet, D. J. Watkin and A. L. Thompson, 2-Azido-3,4;6,7-di-O-isopropylidene-a-D-glycero-D-talo-heptopyranose, Acta Cryst. 2010, E66, o525-o526.

 

502. N. Dai, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin 3 4-O-Isopropylidene-2-C-methyl-D-galactonolactone Acta Cryst. 2010, E66, o406-o407.

 

501. G. M. J. Lenagh-Snow, S. F. Jenkinson, A. J. Stewart, G. W. J. Fleet and D. J. Watkin 1-(1-Carboxymethyl-1,4-anhydro-2,3-O-isopropylidene-a-D-erythrofuranosyl)thymine, Acta Cryst. 2010, E66, o404.

 

500. A C Weymouth-Wilson and G W J Fleet, Stereospecific Synthesis Of Iduronic Acid Derivatives, Deoxynojirimycin and Deoxyidonojirimycin PCT application WO/2010/004269 14 January 2010; G W J Fleet and A C Weymouth-Wilson Synthesizing substituted hydroxy-tetrahydro-furo-dioxolone compounds, useful as intermediates in the synthesis of e.g. 1-deoxynojirimycin, comprises reacting glucuronolactone with ketone compounds and introducing leaving group WO2010004269-A2 WO2010004269-A3

 

499. T. B. Mercer, S. F. Jenkinson, R. J. Nash, S. Miyauchi, A. Kato and G. W. J. Fleet, Looking glass inhibitors: both enantiomeric N-benzyl derivatives of 1,4-dideoxy-1,4-imino-D-lyxitol [a potent competitive inhibitor of a-D-galactosidase] and of 1,4-dideoxy-1,4-imino-L-lyxitol [a weak competitive inhibitor of a-D-galactosidase] inhibit naringinase, an a-L-rhamnosidase, competitively, Tetrahedron: Asymmetry 2009, 20, 2368-2373.

 

498. S. F. Jenkinson, K. V. Booth, A. M. Estevez Reino, G. Horne, R. J. Estevez and G. W. J. Fleet, Carbon-branched carbohydrate chirons: synthesis of C-3 and C-4 branched sugar lactones derived from D-erythronolactone, Tetrahedron: Asymmetry 2009, 20, 2357-2367.

 

497. A. C. Weymouth-Wilson, R. Clarkson, D. Best, M.-S. Pino-Gonzalez, F. X. Wilson and G. W. J. Fleet, Large scale synthesis of the acetonides of L-glucuronolactone and of L-glucose: easy access to L-sugar chirons, Tetrahedron Lett. 2009, 50, 6307-6310.

 

496. K. V. Booth, S. F. Jenkinson, D. Best, F. Fernandez Nieto, R. J. Estevez, M. R. Wormald, A. C. Weymouth-Wilson and G. W. J. Fleet, Doubly carbon-branched pentoses: synthesis of both enantiomers of 2,4-di-C-methyl arabinose and 2-deoxy-2,4-di-C-methyl arabinose using only acetonide protection, Tetrahedron Lett. 2009, 50, 5088-5093.

 

495. D. Rao, D. Best, A. Yoshihara, P. Gullapalli, K. Morimoto, M. R. Wormald, F. X. Wilson, K. Izumori and G. W. J. Fleet, A concise approach to the synthesis of all twelve 5-deoxyhexoses: D-Tagatose-3-epimerase - a reagent that is both specific and general, Tetrahedron Lett. 2009, 50, 3559-3563.

 

494. A. J. Rawlings, H. Lomas, A. W. Pilling, M. J-R Lee, D. S. Alonzi, J. S. S. Rountree, S. F. Jenkinson, G. W. J. Fleet, R. A. Dwek, J. H. Jones and T. D. Butters, Synthesis and Biological Characterisation of Novel N-Alkyl-DNJ [Deoxynojirimycin] a-Glucosidase Inhibitors, ChemBioChem 2009, 10, 1101-1105.

 

493. J. S. S. Rountree, T. D. Butters, M. R. Wormald, R. A. Dwek, N. Asano, K. Ikeda, E. L. Evinson, R. J. Nash and G. W. J. Fleet, Design, synthesis and biological evaluation of enantiomeric b-N-acetylhexosaminidase inhibitors; LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff diseases, ChemMedChem 2009, 4, 378-392.

 

492. A. L. Thompson, A. Michalik, R. J. Nash, F. X. Wilson, R. van Well, P. Johnson, G. W. J. Fleet, C.-Y. Yu, X.-G. Hu, R. I. Cooper and D. J. Watkin, Steviamine, a new class of indolizidine alkaloid [(1R,2S,3R,5R,8aR)-3-(Hydroxymethyl)-5- methyloctahydroindolizine-1,2-diol hydrobromide], Acta Cryst. 2009, E65, o2904.

 

491. D. Best, S. F. Jenkinson, D. J. Watkin, F. X. Wilson, R. J. Nash and G. W. J. Fleet, (2S,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidine-2-carboxylic acid [(2S,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-L-proline], Acta Cryst. 2009, E65, o2418-o2419.

 

490. K. V. Booth, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet, 2,3-O-(S)-Benzylidene-2-C-methyl-D-ribono-1,4-lactone, Acta Cryst. 2009, E65, o2199.

 

489. S. F. Jenkinson, K. V. Booth, S. Newberry, G. W. J. Fleet, K. Izumori, K. Morimoto, R. J. Nash, L. Jones, D. J. Watkin and A. L. Thompson, 2,6-Dideoxy-2,6-imino-L-glycero-D-ido-heptitol, Acta Cryst. 2009, E65, o1755-o1756

 

488. F. Punzo, D. J. Watkin and G W. J. Fleet, a-D-Tagatopyranose, Acta Cryst. 2009, E65, o1393-1394.  

 

487. K. V. Booth, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin, 2-Deoxy-2,3-O-isopropylidene-2,4-di-C-methyl-b-L-arabinose, Acta Cryst. 2009, E65, o570.

 

486. S. F. Jenkinson, J. R. Fenton, K. V. Booth, G. W. J. Fleet and D. J. Watkin, (4S,5R,6R)-Methyl 4-hydroxy-4,5-isopropylidenedioxy-4,5,6,7-tetrahydro-1,2,3-triazolo[1,5-a]pyridine-3-carboxylate, Acta Cryst. 2009, E65, o610-o611

 

485. S. F. Jenkinson, D. Best, A. C. Weymouth-Wilson, R. A. Clarkson, G. W. J. Fleet and D. J. Watkin, (1S)-1,2-O-Benzylidene-a-D-glucurono-6,3-lactone, Acta Cryst. 2009, E65, o414-o415.

 

484.S. F. Jenkinson, C. Wang, M.-S. Pino-Gonzlez, G. W. J. Fleet and D. J. Watkin, 7-Azido-N,N-diethyl-4,5-O-isopropylidene-4-C-methyl-3,6-anhydro-7-deoxy-D-glycero-D-manno-heptonamide, Acta Cryst. 2009, E65, o263.

 

483. Izumori, K.; Tokuda, M.; Fleet, G.; Tsujisaka, Y.; Takeshita, K.; Tsusaki, K.; Okuma, K., Preparation of deoxyketohexose isomerase of Pseudomonas cichorii for deoxyhexose epimerization and enzymic production of rare deoxy-sugars by the Izumoring strategy, PCT Int. Appl. 2008, WO 2008062780 A1 20080529.

 

482. D. Rao, P. Gullapalli, A. Yoshihara, K. Morimoto, G. Takata, S. F. Jenkinson, G. W. J. Fleet and K. Izumori, Direct production of L-tagatose from L-psicose by Enterobacter aerogenes 230S, J. Biosci. Bioengineer. 2008, 106, 473-480.

 

481. M. I. Simone; A. A. Edwards; G. E. Tranter; G. W. J. Fleet, Carbon-branched d-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds, Tetrahedron: Asymmetry 2008, 19, 2887-2894.

 

480. J. M Otero, A. M Estevez, R. M Soengas, R. J Nash, J C Estevez, G. W. J. Fleet, R. J Estevez, Studies on the transformation of nitrosugars into branched chain iminosugars. II: Synthesis of (3R,4R,5R,6S)-2,2-bis(hydroxymethyl)azepane-3,4,5,6-tetraol, Tetrahedron: Asymmetry 2008, 19, 2443-2446.

 

479. K. V. Booth, F. P. da Cruz, D. J. Hotchkiss, S. F. Jenkinson, N. A. Jones, A. C. Weymouth-Wilson, R. Clarkson, T. Heinz and G. W. J. Fleet, Carbon-branched carbohydrate chirons: practical access to both enantiomers of 2-C-methyl-ribono-1,4-lactone and 2-C-methyl-arabinonolactone Tetrahedron: Asymmetry 2008, 19, 2417-2424

 

478. F. P. da Cruz, G. Horne and G. W. J. Fleet, Hydroxylated C-branched pyrrolidines, C-branched prolines and C-branched piperidines from a 2-C-methyl sugar lactone; efficient azide displacement of a tertiary triflate with inversion of configuration, Tetrahedron Lett. 2008, 49, 6812-6815.

 

477. A. L. Thompson, D. J. Watkin, Z. A. Gal, L. Jones, J. Hollinshead, S. F. Jenkinson, G. W. J. Fleet and R. J. Nash, The absolute configuration of 1-epialexine hemihydrate, Acta Cryst. 2008, C64, o649-o652.

 

476. N. A. Jones, D. Rao, A. Yoshihara, P. Gullapalli, K. Morimoto, G. Takata, S. J. Hunter, M. R. Wormald, R. A. Dwek, K. Izumori and G. W. J. Fleet, Green syntheses of new 2-C-methyl aldohexoses and 5-C-methyl ketohexoses: D-Tagatose-3-epimerase (DTE) - a promiscuous enzyme, Tetrahedron: Asymmetry 2008, 19, 1904-1918.

 

475. A. A. Edwards, B. D. Alexander, G. W. J. Fleet, G. E. Tranter, Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids, Chirality 2008, 20, 969-972.

 

474. Y. Minami, C. Kuriyama, K. Ikeda, A. Kato, K. Takebayashi, I. Adachi, G. W. J. Fleet, A. Kettawan, T. Okamoto and N. Asano, Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases, Bioorg. Med. Chem. 2008, 16, 2734-2740.

 

473. T. D. W. Claridge, B. Lopez-Ortega, S. F. Jenkinson and G. W. J. Fleet, Secondary structural investigations into homooligomers of delta-2,4-cis oxetane amino acids, Tetrahedron: Asymmetry 2008, 19, 984-988.

 

472. B. Lopez-Ortega, S. F. Jenkinson, T. D. W. Claridge and G. W. J. Fleet, Oxetane amino acids: synthesis of tetrameric and hexameric carbopeptoids derived from L-ribo 4-(aminomethyl)-oxetan-2-carboxylic acid, Tetrahedron: Asymmetry 2008, 19, 976-983.

 

471. D. Rao, A. Yoshihara, P. Gullapalli, K. Morimoto, G. Takata, F P. da Cruz, S. F. Jenkinson, M. R. Wormald, R. A. Dwek, G. W. J. Fleet and K. Izumori, Towards the biotechnological isomerization of branched sugars: D-Tagatose-3-epimerase equilibrates both enantiomers of 4-C-methyl-ribulose with both enantiomers of 4-C-methyl-xylulose, Tetrahedron Lett. 2008, 49, 3316-3121.

 

470. A. Yoshihara, S. Haraguchi, P. Gullapalli, D. Rao, K. Morimoto, G. Takata, N. A. Jones, S. F. Jenkinson, M. R. Wormald, R. A. Dwek, G. W. J. Fleet and K. Izumori, Isomerization of deoxyhexoses: bioproduction of 1-deoxy-D-tagatose from L-fucose and of 6-deoxy-D-tagatose from D-fucose using Enterobacter agglomerans strain 221e, Tetrahedron: Asymmetry 2008, 19, 739-745.

 

469. D. Best, S. F. Jenkinson, S. D. Rule, R. Higham, T. B. Mercer, R. J. Newell, A. C. Weymouth-Wilson, G. W. J. Fleet, and S. Petursson, High yield protection of alcohols, including tertiary and base sensitive alcohols, as benzhydryl ethers by heating with diphenyldiazomethane in the absence of any other reagent, Tetrahedron Lett. 2008, 49, 2196-2199.

 

468. A. E. Hakansson, J. van Ameijde, G. Horne, R. J. Nash, M. R. Wormald, A. Kato, G. S. Besra, S. Gurcha and G. W. J. Fleet, Synthesis of the naringinase inhibitors L-swainsonine and related 6-C-methyl-L-swainsonine analogues: (6R)-C-methyl-L-swainsonine is a more potent inhibitor of L-rhamnosidase by an order of magnitude than L-swainsonine, Tetrahedron Lett. 2008, 49, 179-184.

 

467. S. F. Jenkinson, D. Best, F. X. Wilson, G. W. J. Fleet and D. J. Watkin, (4R)-4-(2-Allyl-2H-1,2,3-triazol-4-yl)-1,2-O-isopropylidene-L-threose, Acta Cryst. 2008, E64, o2361-2362.

 

466. S. F. Jenkinson, K. V. Booth, D. Best, G. W. J. Fleet and D. J. Watkin, tert-Butyl 2-deoxy-4,5-O-isopropylidene-D-gluconate, Acta Cryst. 2008, E64, o2011-o2012.

              

465. F. P. da Cruz, K. V. Booth, G. W. J. Fleet and D. J. Watkin 3-O-Benzhydryl-2,5-dideoxy-2,5-imino-2-C-methyl-L-lyxono-1,4-lactone, Acta Cryst. 2008, E64, o1902-o1903.

 

464. S. F. Jenkinson, K. V. Booth, P. Gullapalli, K. Morimoto, K. Izumori, G. W. J. Fleet and D. J. Watkin 1-Deoxy-L-mannitol (6-deoxy-L-mannitol or L-rhamnitol), Acta Cryst. 2008, E64, o1705-o1706.

 

463. K. V. Booth, S. F. Jenkinson, D. Rao, T. Simonisi, G. W. J. Fleet, K. Izumori and D. J. Watkin 6-Azido-6-deoxy-a-L-galactose (6-Azidofucose), Acta Cryst. 2008, E64, o1568-o1569.

 

462. S. F. Jenkinson, K. V. Booth, A. Yoshihara, K. Morimoto, G. W. J. Fleet, K. Izumori and D. J. Watkin, 1-Deoxy-D-galactitol (L-fucitol), Acta Cryst. 2008, E64, o1429.

 

461. K. V. Booth, S. F. Jenkinson, G. W. J. Fleet, P. Gullapalli, A. Yoshihara, K. Izumori and D. J. Watkin 6-Deoxy-a-L-talopyranose, Acta Cryst. 2008, E64, o1385.

 

460. S. F. Jenkinson, S. D. Rule, K. V. Booth, G. W. J. Fleet, D. J. Watkin and S. Petursson, 2-O-Benzhydryl-3,4-(S)-O-benzylidene-D-xylono-1,4-lactone, Acta Cryst. 2008, E64, o1012 .

 

459. S. F. Jenkinson, F. P. Cruz, K. V. Booth, G. W. J. Fleet, K. Izumori, C.-Y. Yu and D. J. Watkin, 1-Deoxy-D-arabinitol, Acta Cryst. 2008, E64, o1010-o1011.

 

458. S. F. Jenkinson, D. J. Hotchkiss, A. R. Cowley, G. W. J. Fleet and D. J. Watkin, (S)-3-Dimethylamino-2-{(4S,5R)-5-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hydroxypropanoic acid Acta Cryst. 2008, E64, o294-o295.

 

457. S. F. Jenkinson, S. D. Rule, K. V. Booth, G. W. J. Fleet, D. J. Watkin and S. Petursson, 2-O-Benzhydryl-3,4-(S)-O-benzylidene-D-lyxono-1,4-lactone, Acta Cryst. 2008, E64, o26-o26.

 

456. S. F. Jenkinson, N. A. Jones, A. Moussa, A. J. Stewart, T. Heinz and G. W. J. Fleet Anomeric stereospecific synthesis of 2-C-methyl-b-nucleosides; the Holy reaction of cyanamide with 2-C-methyl-D-arabinose, Tetrahedron Lett. 2007, 48, 4441-4445.

 

455. J. S. S. Rountree, T. D. Butters, M. R. Wormald, R. A. Dwek, N. Asano, K. Ikeda, E. L. Evinson, R. J. Nash and G. W. J. Fleet, Efficient Synthesis from D-lyxonolactone of 2-acetamido-1,4-imino-1,2,4-trideoxy-L-arabinitol LABNAc, a potent pyrrolidine inhibitor of hexosaminidases, Tetrahedron Lett. 2007, 48, 4287-4291.

 

454. P. Gullapalli, T. Shiji, D. Rao, A. Yoshihara, K. Morimoto, G. Takata , G. W. J. Fleet and K. Izumori, Bioproduction of a novel sugar 1-deoxy-L-fructose by Enterobacter aerogenes IK7; isomerization of a 6-deoxyhexose to a 1-deoxyhexose, Tetrahedron: Asymmetry 2007, 18, 1995-2000.

 

453. M. D. P. Risseeuw, M. Overhand, G. W. J. Fleet, M. I. Simone, A compendium of sugar amino acids (SAA): scaffolds, peptide- and glyco-mimetics, Tetrahedron: Asymmetry 2007, 18, 2001-2010.

 

452. D. A. Mitchell, N. A. Jones, S. J. Hunter, J. M. D. Cook, S. F. Jenkinson, M. R. Wormald, R. A. Dwek and G. W. J. Fleet, Synthesis 2-C-branched derivatives of D-mannose: 2-C-aminomethyl-D-mannose binds to the human C-type lectin DC-SIGN with affinity greater than an order of magnitude compared to that of D-mannose, Tetrahedron: Asymmetry 2007, 18, 1502-1510.

 

451. D. J. Hotchkiss, R. Soengas, K. V. Booth, A. C. Weymouth-Wilson, V. Eastwick-Field and G. W. J. Fleet, Green aldose isomerisation: 2-C-Methyl-1,4-lactones from the reaction of Amadori ketoses with calcium hydroxide, Tetrahedron Lett. 2007, 48, 517-520. 

 

450. N. A. Jones, S. F. Jenkinson, R. Soengas, M. Fanefjord, M. R. Wormald, R. A. Dwek, G. P. Kiran, R. Devendar, G. Takata, K. Morimoto, K. Izumori and G. W. J. Fleet, Synthesis of and NMR studies on the four diastereomeric 1-deoxy-ketohexoses, Tetrahedron: Asymmetry 2007, 18, 774-786.

 

449. D. J. Hotchkiss, A. Kato, B. Odell, T. D. W. Claridge and G. W. J. Fleet, Homochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer - removal of glycosidase inhibition, Tetrahedron: Asymmetry 2007, 18, 500-512.

 

448. A. E. H嫡nsson, J. van Ameijde, L. Guglielmini, G. Horne, R. J. Nash, E. L. Evinson, A. Kato and G. W. J. Fleet^, Looking glass inhibitors: Synthesis of a potent naringinase inhibitor L-DIM [1,4-dideoxy-1,4-imino-L-mannitol], the enantiomer of DIM [1,4-dideoxy-1,4-imino-D-mannitol] a potent _-D-mannosidase inhibitor, Tetrahedron: Asymmetry 2007, 18, 282-289.

 

447. Kato, A.; Kato, N.; Adachi. I.; Hollinshead, J.; Fleet, G. W. J.; Kuriyama, C.; Ikeda, K.; Asano, N.; Nash, R. J. Isolation of glycosidase-inhibiting hyacanthines and related alkaloids from Scilla socialis, J. Nat. Prod. 2007, 70, 993-997.

 

446. J. M. Otero, R. G. Soengas, J. C. Est鶥z, R. J. Est鶥z, D. J. Watkin, E. L. Evinson, R. J. Nash, G. W. J. Fleet, Preliminary studies on the transformation of nitrosugars into branched aza-sugars: Synthesis of 1,4-dideoxy-4-C-hydroxymethyl-1,4-imino-pentanols, Org. Lett., 2007, 9, 623-626.

 

445. I. Streeter; S. F. Jenkinson; G. W. J. Fleet; R. G. Compton, Chemical instability promotes apparent electrochemical irreversibility: Studies on the electrode kinetics of the one electron reduction of the 2,6-diphenylpyrylium cation in acetonitrile solution, J. Electroanalytical Chem. 2007, 600, 285-293.

 

444. D. D. Le Pevelen, A. A. Edwards, G. E. Tranter, D. J. Watkin and G. W.J. Fleet, Isopropyl 6-amino-2,5-anhydro-3,6-dideoxy-6- N-(2,5-anhydro-6-azido-3,6-dideoxy-L-lyxo-hexonyl)–L-lyxo-hexonate, Acta Cryst. 2007, E63, o4719-o4720.

 

443. S. Petursson, S. F. Jenkinson, K. V. Booth, A. C. Weymouth-Wilson, D. J. Watkin, G. W. J. Fleet and D. Best, 2-O-(4,4'-Dimethylbenzhydryl)-L-erythronolactone, Acta Cryst. 2007, E63, o4121-o4121.

 

442. K. V. Booth, S. F. Jenkinson, D. J. Watkin, H. Sharp, P. W. Jones, R. J. Nash and G. W. J. Fleet, (2S,3R,4R,5S)-3,4,5-Trihydroxypipecolic acid dihydrate [(2S,3R,4R,5S)-3,4,5-Trihydroxypiperidine-2-carboxylic acid dihydrate], Acta Cryst. 2007, E63, o3783-o3784.

 

441. K. V. Booth, S. F. Jenkinson A. Cowley, A. Kato, N. Kato, J. Hollinshead, R. J. Nash and G. W. J. Fleet, (2R,3S)3-Hydroxy-N,N-dimethylproline hydrate, Acta Cryst. 2007, E63, o3717-o3717.

 

440. K. V. Booth, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet, 2,4-Di-C-methyl-a-L-arabinose monohydrate, Acta Cryst. 2007, E63, o3592-o3593.

 

439. L. A. Curran, N. A. Jones, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet, 5,6-O-Isopropylidene-3-C-methyl-D-mannono-1,4-lactone, Acta Cryst. 2007, E63, o3416-o3416.

 

438. N. A. Jones, S. F. Jenkinson, L. A. Curran, D. J. Watkin and G. W. J. Fleet, 2,3-Di-C-methyl-D-allono-1,4-lactone, Acta Cryst. 2007, E63, o3415-o3415.

 

437. L. A. Curran, S. F. Jenkinson, N. A. Jones, D. J. Watkin and G. W. J. Fleet, 2,6-Anhydro-1-deoxy-3,4-O-isopropylidene-3-C-methyl-b-D-ribo-hex-2-ulofuranose, Acta Cryst. 2007, E63, o3388- o3388.

 

436. L. A. Curran, S. F. Jenkinson, N. A. Jones, D. J. Watkin and G. W. J. Fleet, 2,3-C-Dimethyl-3,4-O-isopropylidene-D-allono-1,5-lactone, Acta Cryst. 2007, E63, o3387- o3387. 

 

435. K. V. Booth, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet, 2-C-Hydroxymethyl-2,3-O-isopropylidene-3-C-methyl- b-L-erythrose, Acta Cryst. 2007, E63, o3386- o3386.

 

434. K. V. Booth, S. F. Jenkinson, G. J. W. Fleet and D. J. Watkin, 3,5-Di-C-methyl-5,6-O-isopropylidene-L-mannono-1,4-lactone, Acta Cryst. 2007, E63, o2427-o2429.

 

433. K. V. Booth, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin, 3,5-Di-C-methyl-5,6-O-isopropylidene-L-glucono-1,4-lactone, Acta Cryst. 2007, E63, o2424-o2426.

 

432. K. V. Booth, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin, 2,3:5,6-Di-O-isopropylidene-3,5-di-C-methyl-L-mannono-1,4-lactone, Acta Cryst. 2007, E63, o2204-o2206.

 

431. S. F. Jenkinson, N. A. Jones, A. Moussa, A. J. Stewart, T. Heinz, G. W. J. Fleet and D. J. Watkin, 2,2'-Anhydro-2'-C-methyl-1-(D-arabinofuranosyl)uracil (2,2'-anhydro-2'-C-methyluridine), Acta Cryst. 2007, E63, o2171-o2173.

 

430. D. J. Hotchkiss, S. F. Jenkinson, K. V. Booth, G. W. J. Fleet and D. J. Watkin, 2-Azido-(R)-3,5-O-benzylidene-2-deoxy-2-C-methyl-D-xylono-1,4-lactone [(2S,4aR,7R,7aR)-7-azido-7-methyl-2-phenyldihydro-4H-furo[3,2-d][1,3]dioxin-6(4aH)-one], Acta Cryst. 2007, E63, o2168-o2170.

 

429. D. Best, S. F. Jenkinson, K. V. Booth, G. W. J. Fleet and D. J. Watkin, 1-Deoxy-4-C-hydroxymethyl-3,4-O-isopropylidene-L-ribulofuranose [(2R,3S,4S)-4-(hydroxymethyl)-3,4-O-isopropylidene-2-methyltetrahydrofuran-2,3,4-triol], Acta Cryst. 2007, E63, o2165-o2167.

 

428. K. Izumori, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet 1-Deoxy-b-fructopyranose monohydrate, Acta Cryst. 2007, E63, o1882-o1884.

 

427. K. V. Booth, D. J. Watkin, S. F. Jenkinson and G. W. J. Fleet, 2-Azido-2-deoxy-2,4-C-dimethyl-3,4-O-isopropylidene-L-ribono-1,5-lactone, Acta Cryst. 2007, E63, o1759-o1760.

 

426. M. Simone, G W. J. Fleet, R. Bream and D. J. Watkin, 5-Amino-5-deoxy-2-C-hydroxymethyl-2,3-O-isopropylidene-L-lyxono-1,5-lactam, Acta Cryst. 2007, E63, o1409-o1411.

 

 

425. K. V. Booth, D. J. Watkin, S. F. Jenkinson and G. W. J. Fleet, 2,4-Dimethyl-3,4-O-isopropylidene-L-arabinono-1,5-lactone, Acta Cryst. 2007, E63, o1128-o1130

 

424. M. Simone, G. W. J. Fleet and D. J. Watkin, 5-O-tert-Butyldiphenylsilyl-2-C-hydroxymethyl-2,3-O-isopropylidene-2'-O-trifluoromethanesulfonyl-D-ribono-1,4-lactone, Acta Cryst. 2007, E63, o1088-o1090.

 

423. D. Best, S. F. Jenkinson, D. J. Watkin, K. V. Booth and G. W. J. Fleet, 2,3-O-Isopropylidene-L-apiono-1,4-lactone [(3S,4S)-3,4-dihydroxy-4-(hydroxymethyl)-3,4-di-O-isopropylidene-dihydrofuran-2(3H)-one], Acta Cryst. 2007, E63, o1056-o1057.

 

422. N. A. Jones, D. J. Watkin, L. A. Curran, S. F. Jenkinson and G. W. J. Fleet, 3-C-Methyl-D-allono-1,5-lactone, Acta Cryst. 2007, E63, o992-o994.

 

421. M. Simone, G. W. J. Fleet and D. J. Watkin, 1,5-Anhydro-2,3-O-isopropylidene-L-lyxofuranose [(1S,4S,5S,6R)-5,6-O-isopropylidene-2,7-dioxabicyclo[2.2.1]heptane-5,6-diol], Acta Cryst. 2007, E63, o896-o897.

 

420. R. Bream, D. J. Watkin, A. R. Cowley, M. I Simone and G. W. J. Fleet, 3,3:5,6-Di-O-isopropylidene-3-C-hydroxymethyl-D-allono-1,4-lactone: An organic lattice structure containing a large unoccupied void, Acta Cryst. 2007, E63, o799-o801.

 

419. R. Bream, S. J. Hunter, G. W. J. Fleet and D. J. Watkin, 2-C-Hydroxymethyl-2,3-O-isopropylidene-D-mannono-1,5-lactam, Acta Cryst. 2007, E63, o621-o623.

 

418. Cox, D. J.; Hakansson, A.E.; Fleet, G. W. J.; Watkin, D. J., 2,5-Anhydro-N-benzyl-2-C-methyl-D-arabinonamide [(2S,3R,4R)-N-benzyl-3,4-dihydroxy-2-methyltetrahydrofuran-2-carboxamide], Acta Cryst. 2007, E63, o574-o576.

 

417. Jones, N. A., Jenkinson, S. F., Soengas, R., Izumori, K., Fleet, G. W. J., Watkin, D. J., The concomitant crystallization of two polymorphs of 1-deoxy-a-D-tagatose, Acta Cryst. 2007, C63, o7-o10.

 

416. Hakansson, A.E., Horne, G., Fleet, G.W.J. Watkin, D.J., (6S)-Methyl-L-swainsonine [(1R,2S,6S,8S,8aS)-6-methyloctahydroindolizine-1,2,8-triol] Acta Cryst. 2007, E63, o210-o212.

 

415. R. H. Furneaux; P. C. Tyler;S. P. H.; Mee; G. B. Evans; V. L. Schramm,.; G. Fleet,. Preparation of deazapurine analogs of 4'-aza-l-nucleosides as prodrugs treating cancer, bacterial and parasitic infection, and T-cell mediated diseases. PCT Int. Appl. (2007), 59pp. CODEN: PIXXD2 WO 2007069924

 

414. R. J. Nash; M. W. Carroll; A. A. Watson; G. W. J. Fleet; G. Horne Pyrrolidine derivatives as immunomodulators and antiviral agents. PCT Int. Appl. (2007), 72pp. CODEN: PIXXD2 WO 2007010266

 

413. D. Hotchkiss; G. Fleet; T. Heinz; R. Storer Process for preparing saccharinic acids and lactones. PCT Int. Appl. (2007), 53pp. CODEN: PIXXD2 WO 2007025304.

 

412. R. A. Jockusch, F. O. Talbot, M. I. Simone, P. S. Rogers, G. W. J. Fleet and J. P. Simons, Carbohydrate amino acids: the intrinsic conformational preference for a b-turn type structure in a carbopeptoid building block, J. Am. Chem. Soc., 2006, 128, 16771-16777.

 

411. J. Van Ameijde, G. Horne, M. R. Wormald, R. A. Dwek, R. J. Nash, P. W. Jones, E. L. Evinson and G. W. J. Fleet, Isolation synthesis and glycosidase inhibition profile of 3-epi-casuarine, Tetrahedron: Asymmetry 2006, 17, 2702-2713.

 

410. N. A. Jones, M. Fanefjord, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin, 1-Deoxy-a-D-sorbopyranose, Acta Cryst. 2006, E62, o4663-o4665.

 

409. R. Bream, D. J. Watkin, N. A. Jones, S. F. Jenkinson and G. W. J. Fleet, 2-C-Methyl-3,4-O-methylidene-D-arabinono-1,5-lactone, Acta Cryst. 2006, E62, o4356-o4358.

 

408. S. Parker, D. J. Watkin, M. I Simone and G. W. J. Fleet, 3,4:5,6-Di-O-isopropylidene-3-C-hydroxymethyl-D-altrono-1,3-lactone, Acta Cryst. 2006, E62, o3961-o3963.

 

407. Y. Bleriot, M. I. Simone, M. R. Wormald, R. A. Dwek, D. J. Watkin and G. W. J. Fleet, Sugar amino acids at the anomeric position of carbohydrates: synthesis of spirocyclic amino acids of 6-deoxy-L-lyxofuranose, Tetrahedron: Asymmetry 2006, 17, 2276-2286.

 

406. Hakansson, A.E., van Ameijde, J., Horne, G., Guglielmini, L., Nash, R.J., Fleet, G.W.J. Watkin, D.J., 2,3:6,7-Di-O-diethylidene-D-glycero-L-talo-heptono-1,4-lactone, Acta Cryst. 2006, E62, o3890-o3892.

 

405. A. A. Edwards, G. J. Sanjayan, S. Hachisu, G. E. Tranter and G. W. J. Fleet, A novel series of oligomers from 4-aminomethyl-tetrahydrofuran-2-carboxylates with 2,4-cis and 2,4-trans stereochemistry, Tetrahedron 2006, 62, 7718-7725.

 

404. S. W. Johnson, G. W. J. Fleet and J. H. Jones, Cyclic oligomers of oxetane-based dipeptide isosteres derived from L-Rhamnose, J. Peptide Sci., 2006, 12, 559-561.

 

403. Nash, R. J., Fleet, G. W. J., Van Ameijde, J., and Horne, G., Synthesis of Polyhydroxylated Alkaloids PCT Int. Appl. Publication date 26 Jan 2006, publication no WO 2006/008493 A1

 

402. A. A. Edwards, G. J. Sanjayan, S. Haschisu, R. Soengas, A. Stewart, G. E. Tranter and G. W. J. Fleet, Synthesis of 4-aminomethyl-tetrahydrofuran-2-carboxylates with 2,4-cis and 2,4-trans relationships, Tetrahedron 2006, 62, 4110-4119.

 

401. K. Clinch, G. B. Evans, G. W. J. Fleet, R. H. Furneaux, S. W. Johnson, D. Lenz, S. Mee, P. R. Rands, V. L. Schramm, E. A. T. Ringia and P. C. Tyler, Syntheses and activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases, Org. Biomol. Chem., 2006, 4, 1131-1139.

 

400. Edwards, A.A.; Fleet, G.W.J.; Tranter, G.E., Classification of Conformation for Sugar Amino Acid Systems using Chiroptical Spectroscopy, Chirality 2006, 18, 265-272.

 

399. D. J. Hotchkiss, S. F. Jenkinson, R. Storer, T. Heinz and G. W. J. Fleet, Amadori ketoses with calcium hydroxide and the Kiliani reaction on 1-deoxy ketoses: two approaches to the synthesis of saccharinic acids, Tetrahedron Lett. 2006, 47, 315-318.

 

398. Chesterton A.K.S., Jenkinson S.F., Jones N.A., Fleet G.W.J., Watkin D.J., (2S,4S)-4-Azido-1-benzyl-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl] pyrrolidine Acta Cryst. 2006, E62, o2983-o2985.

 

397. R. Bream, D. Watkin, R. Soengas, G. W. J. Fleet, Alison A. Edwards, S. J. Hunter and G. E. Tranter, cyclo[(6-Amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonic acid)-(D-Phe)]₂), Acta Cryst. 2006, E62, o1851-o1853.

 

396. F. Punzo, D. J. Watkin, D. Hotchkiss and G. W. J. Fleet, 3-Deoxy-D-galactono-1,4-lactone (3-deoxy-D-xylo-hexono-1,4-lactone), Acta Cryst. 2006, E62, o1344-o1346

 

395. S. Parker, D. J. Watkin, B. Mayes, R. Storer, S. Jenkinson and G. Fleet, 2-Deoxy-2-fluoro-2-C-methyl-D-ribono-1,4-lactone (fluoromethylrib), Acta Cryst. 2006, E62, o1208-o1210.

 

394. R. Bream, D. J. Watkin, R. Soengas, V. Eastwick-Field and G. W. J. Fleet, 2,5-Di-O-acetyl-3-C-methyl-D-lyxono-1,4-lactone, Acta Cryst. 2006, E62, o977-o979.

 

393. F. Punzo, D. J. Watkin, J. van Ameijde, G. Horne and G. W. J. Fleet, 3,7,7a-Tri-epi-casuarine pentaacetate, Acta Cryst. 2006, E62, o928-o930.

 

392. F. Punzo, A. R. Cowley, D. J. Watkin, M. I. Simone, A. A. Edwards, G. E. Tranter and G. W. J. Fleet, Pentafluorophenyl (3R,4R,5R)-5-{[(3R,4R,5R)-5-Azidomethyl-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carbonylamino]methyl}-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxylate, Acta Cryst. 2006, E62, o473-o475.

 

391. D. J. Watkin, M. Watterson, G. E. Tranter, A. A. Edwards and G. W. J. Fleet Isopropyl 2,5-anhydro-6-azido-3,6-dideoxy-D-xylo-hexonate, Acta Cryst. 2006, E62, o363-o365.

 

390. F. Punzo, D. J. Watkin, S. F. Jenkinson, F. P. da Cruz and G. W. J. Fleet, 2-C-Azidomethyl-2-deoxy-3,4-O-isopropylidene-D-ribono-1,5-lactone, Acta Cryst. 2006, E62, o321-o323.

 

389. F. Punzo, D. J. Watkin, D. Hotchkiss and G. W. J. Fleet, 2-C-Methyl-D-lyxono-1,4-lactone, Acta Cryst. 2006, E62, o98-o100.

 

388. Nash, R. J., Wolferstan, P., Fleet, G. W. J., Van Ameijde, J., and Horne, G., Antibacterial Compounds PCT Int. Appl. Publication date 26 May 2005, publication no WO 2005/046674 A2

 

387. K. A. Watson, E. D. Chrysina, K. E. Tsitsanou, S. E. Zographos, G. Archontis, D. D. Leonidas, N. G. Oikonomakos, G. W. J. Fleet, Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogues inhibitors of glycogen phosphorylase. Proteins: Structure, Function, and Bioinformatics, 2005, 61, 966-983.

 

386. Y. Bl鲩ot, D. Gretzke, T. M. Krlle, T. D. Butters, R. A. Dwek, R. J. Nash, N. Asano, G. W. J. Fleet, Looking glass inhibitors: efficient synthesis and biological evaluation of D-deoxyfuconojirimycin, Carbohydr. Res., 2005, 340, 2713-2718.

 

385. D. J. Watkin, L. L. Parry, D. J. Hotchkiss, V. Eastwick-Field and G. W. J. Fleet, 3,5-O-Isopropylidene-2-C-methyl-D-xylonolactone, Acta Cryst. 2005, E61, o3302-o3303.

 

384. D. J. Watkin, A. F. G. Glawar, R. Soengas, K. Izumori, M. R. Wormald, R. A. Dwek and G. W. J. Fleet, 1,2:3,4-Di-O-isopropylidene-b-D-psicofuranose, Acta Cryst. 2005, E61, o2949-o2951.

 

383. D. J. Watkin, L. L. Parry, R. Soengas, K. Izumori and G. W. J. Fleet, 2-C-Benzyloxymethyl-2,3:5,6-di-O-isopropylidene-D-allono-1,4-lactone, Acta Cryst. 2005, E61, o2955-o2957.

 

382. S. W. Johnson, S. F. Jenkinson (n饠Barker), D. Angus, I. Perez-Victoria, A. A. Edwards, T. D. W. Claridge, G. E. Tranter, G. W. J. Fleet, J. H. Jones. Conformational Studies of Oligomeric Oxetane-Based Dipeptide Isosteres derived from L-Rhamnose or D-Xylose, J. Peptide Sci., 2005, 11, 517-524.

 

381. M. I. Simone, R. Soengas, C. R. Newton, D. J. Watkin and G. W. J. Fleet, Branched tetrahydrofuran a,a-disubstituted d-sugar amino acid scaffolds from branched sugar lactones: a new family of foldamers?, Tetrahedron Lett. 2005, 46, 5761-5765.

 

380. R. Soengas, K, Izumori, M. I. Simone, D. J. Watkin, U. P. Skytte, W. Soetaert and G. W. J. Fleet^, Kiliani reaction on ketoses: branched carbohydrate building blocks from D-tagatose and D-psicose, Tetrahedron Lett. 2005, 46, 5755-5759.

 

379. S. W. Johnson, S. F. Jenkinson (n饠Barker), D. Angus, I. Perez-Victoria, T. D. W. Claridge, G. W. J. Fleet, J. H. Jones. The Synthesis of Oligomers of Oxetane-Based Dipeptide Isosteres derived from L-Rhamnose or D-Xylose, J. Peptide Sci., 2005, 11, 303-318.

 

378. Edwards, A.A.; Fleet, G.W.J.; Mayes, B.A.; Hunter, S.J.; Tranter, G.E., Spectroscopic studies of carbopeptoid-cyclodextrins, Chirality 2005, 17, S114-S117.

 

377. T. D. W. Claridge, D. D. Long, C. M. Baker, B. Odell, G. H. Grant, A. A. Edwards, G. E. Tranter, G. W. J. Fleet and M. D. Smith, Helix-forming carbohydrate amino acids, J. Org. Chem., 2005, 70, 2082-2090.

 

376. D. J. Watkin, A. F. G. Glawar, R. Soengas, U. P. Skytte, M. R. Wormald, R. A. Dwek and G. W. J. Fleet, 1,2:3,4-Di-O-isopropylidene-a-D-tagatofuranose, Acta Cryst. 2005, E61, o2891-o2893.

 

375. D. J. Watkin, L. L. Parry, R. Soengas and G. W. J. Fleet, 1,4-Anhydro-2-C-benzyloxymethyl-2,3:5,6-di-O-isopropylidene-D-tallitol, Acta Cryst. 2005, E61, o2865-o2867.

 

374. A. Glawar, B. A. Mayes, D. J. Watkin and G. W. J. Fleet, (2R,3S,4S,5R)-Methyl 5-cyano-2,3:4,5-di-O-isopropylidene-2,3,4,5-tetrahydroxypentanoate, Acta Cryst. 2005, E61, o2727-o2729.

 

373. A. F. G. Glawar, D. J. Watkin, G. J. Sanjayan, G. E. Tranter, A. A. Edwards and G. W. J. Fleet, Isopropyl 2,5-anhydro-3,4-di-O-tert-butyldiphenylsilyl-L-ribonate, Acta Cryst. 2005, E61, o2724-o2726.

 

372. F. Punzo, D. J. Watkin, J.M.D. Cook, D. Hotchkiss and G. W. J. Fleet, N-(p-Tolyl)-b-L-rhamnopyranosylamine 1.5 hydrate, Acta Cryst. 2005, E61, o2155-o2157.

 

371. M. R. Probert, D. J. Watkin, A. J. Stewart, R. Storer and G. W. J. Fleet, The crystal and molecular structure of (2R,3R,4R)-Methyl 2-bromo-3,4-dihydroxy-3,4-di-O-isopropylidene-tetrahydrofuran-2-carboxylate, Acta Cryst. 2005, E61, o1718-o1720.

 

370. C. C. Harding, J. S. S. Rountree, D. J. Watkin, A. R. Cowley, T. D. Butters, M. R. Wormald, R. A. Dwek and G W. J. Fleet, 2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-arabinitol hydrate, Acta Cryst., 2005, E61, o1683-o1685.

 

369. C. C. Harding, A. R. Cowley, D. J. Watkin, F. Punzo, D. J. Hotchkiss and G. W. J. Fleet, 1-Amino-1-deoxy-N,N-dibenzyl-a-D-tagatopyranose methanol solvate, Acta Cryst. 2005, E61, o1475-o1477.

 

368. C. C. Harding, D. J. Watkin, N. K. Sawyer, S. F. Jenkinson and G. W. J. Fleet, 2-C-Methyl-D-allono-1,4-lactone, Acta Cryst. 2005, E61, o1472-o1474.

 

367.C. C. Harding, D. J. Watkin, D. J. Hotchkiss, J. M. D. Cook and G. W. J. Fleet,1-Amino-N,N-dibenzyl-1,6-dideoxy-b-L-fructofuranose, Acta Cryst. 2005, E61, o995-o997

 

366. C. C. Harding, D. J. Watkin, J. S. S. Rountree, T. D. Butters, M. R. Wormald, R. A. Dwek and G W. J. Fleet, 2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-ribitol, Acta Cryst., 2005, E61, o930-932

 

365. S. Humphreys, D. J. Watkin, G. J. Sanjayan, G. E. Tranter, A. A. Edwards and G. W. J. Fleet, Isopropyl 2,5-anhydro-4-(2,5-anhydro-4-azido-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonylamino)-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonate, Acta Cryst., 2005, E61, o918-o919.

 

364. N. Asano, K. Ikeda, L. Yu, A. Kato, K. Takebayashi, I. Adachi, I. Kato, H. Ouchi, H. Takahata and G. W. J. Fleet, The L-enantiomers of D-sugar-mimicking iminosugars are non-competitive inhibitors of D-glycohydrolase?, Tetrahedron: Asymmetry, 2005, 16, 223-229.

 

363. G. W. J. Fleet Carbohydrate Science Tetrahedron: Asymmetry, 2005, 16, 1-2.

 

362. F. Punzo, D. J. Watkin, M. Iezzi Simone and G. W. J. Fleet, (3R,4R,5S)-5-(Acetamidomethyl)-N-benzyl-3,4-dihydroxytetrahydrofuran-3-carboxamide, Acta Cryst., 2005, E61, o513-o515.

 

361. F. Punzo, D. J. Watkin, S. F. Jenkinson, F. P. Cruz and G. W. J. Fleet, 2-Azido-2-deoxy-3,4-O-isopropylidene-2-C-methyl-D-ribono-1,5-lactone, Acta Cryst., 2005, E61, o511-o512.

 

360. F. Punzo, D. J. Watkin, S. F. Jenkinson and G. W. J. Fleet, 2C-Methyl-D-arabinono-1,4-lactone monohydrate, Acta Cryst., 2005, E61, o326-o327.

 

359. C. C. Harding, D. J. Watkin, A. R. Cowley, R. Soengas, U. P. Skytte and G. W. J. Fleet, 2,2:5,6-Di-O-isopropylidene-2-C-hydroxymethyl-D-talono-1,4-lactone, Acta Cryst., 2005, E61, o250-o252.

 

358. F. Punzo, D. J. Watkin, S. F. Jenkinson and G. W. J. Fleet, 3,4-O-Isopropylidene-2C-methyl-D-arabinono-1,5-lactone, Acta Cryst., 2005, E61, o127-129.

 

357. R.A. Jockusch, F.O. Talbot, N. Asano, G.W.J. Fleet and J.P. Simons, Gas phase structure and conformation of the glycosidase and ceramide glucosyltransferase inhibitor N-benzyl-deoxynojirimycin, Phys. Chem. Chem. Phys. 2004, 6, 5283-5287.

 

356. D. Hotchkiss, R. Soengas, M. I. Simone, J. van Ameijde, S. Hunter, A. R. Cowley and G. W. J. Fleet, Kiliani on ketoses: branched carbohydrate building blocks from D-fructose and L-sorbose, Tetrahedron Lett. 2004, 45, 9461-9464.

 

355. C. C. Harding, H. Shallard-Brown, D. J. Watkin, R. Soengas and George W. J. Fleet, 3-Azido-3-deoxy-2,2':5,6-di-O-isopropylidene-2-C-hydroxmethyl-D-gulono-1,4-lactone, Acta Cryst., 2004, E60, o2334-o2336.

 

354. F. Punzo, D. J. Watkin, M. I. Simone and G. W. J. Fleet , (1R,5S,8R)-1,8-Dihydroxy-6-oxa-3-azabicyclo[3.2.1]octan-2-one, Acta Cryst., 2004, E60, o2315-2317.

 

353. H. A. Shallard-Brown, C. C. Harding, D. J. Watkin, R. Soengas, U. P. Skytte and G. W. J. Fleet, 2,3:5,6-Di-O-isopropylidene-2-C-hydroxymethyl-D-talono-1,4-lactone, Acta Cryst. 2004 E60, o2163-o2164.

 

352. A. R. Cowley, G. W. J. Fleet, M. I. Simone and R. Soengas, 3-O-tert-Butyldimethylsilyl-2,2':5,6-di-O-isopropylidene-2-C-hydroxymethyl-D-1,4-gluconolactone, Acta Cryst. 2004 E60, o2142-o2143.

 

351. J. van Ameijde, A. R. Cowley, G. W. J. Fleet, R. J. Nash, M. I. Simone and R. Soengas, 5-Amino-5-deoxy-2-C-hydroxymethyl-2,3-O-isopropylidene-D-talono-1,5-lactam, Acta Cryst. 2004 E60, o2140-o2141.

   

350. D. J. Watkin, M. Muller, Y. Bleriot, M.I. Simone and G. W. J. Fleet, (2S,3R,4R,5S)-3,4-O-isopropylidene-2-methyl-6,9-diazo-1-oxaspiro-[4.5]-decane-7,10-dione, Acta Cryst. 2004 E60, o1820-o1822.

 

349. S. W. Johnson, S. F. Jenkinson (nȥ Barker), J. H. Jones, D. J. Watkin and G. W. J. Fleet, Pseudoenantiomeric oxetane d-amino acid scaffolds derived from L-rhamnose and D-xylose; D/L-Alanine-D-Serine and Glycine-L-Serine dipeptide isosteres, Tetrahedron: Asymmetry 2004, 15, 3263-3273.

 

348. D. J. Watkin, S. W. Johnson, J. H. Jones, G. W. J. Fleet, Methyl 2,4-anhydro-5-azido-5,6-dideoxy-L-altronate, Acta Cryst. 2004 E60, o1609-o1610.

 

347. S. W. Johnson, S. F. Jenkinson (nȥ Barker), D. Angus, C. Taillefumier, J. H. Jones and G. W. J. Fleet Oxetane cis- and trans b-amino-acid scaffolds from L-rhamnose by efficient S_N2 reactions in oxetane rings; pseudoenantiomeric analogues of the antibiotic oxetin, Tetrahedron: Asymmetry, 2004, 15, 2681-2686.

 

346. S. F. Jenkinson (nȥ Barker), T. Harris and G. W. J. Fleet Oxetane cis- and trans b-amino-acid scaffolds from D-xylose by efficient S_N2 reactions in oxetane rings: methyl and hydroxymethyl analogues of the antibiotic oxetin, an oxetane b-amino-acid, Tetrahedron: Asymmetry, 2004, 15, 2667-2679.

 

345. Chu-Yi Yu, Naoki Asano, Kyoko Ikeda, Mei-Xiang Wang, Terry D. Butters, Mark R. Wormald, Raymond A. Dwek, Ana L. Winters, Robert J. Nash and George W. J. Fleet, L-DMDP, a More Potent and Specific Inhibitor of a-Glucosidases than the Enantiomeric Natural Product DMDP, Chem. Commun., 2004, 1936-1937.

 

344. Newton, C.R.; van Ameijde, J.; Fleet, G.W.J.; Nash, R.J.; Watkin, D.J. 3-epi-Casuarine monohydrate, Acta Cryst. 2004 E60, o1463-o1464.

 

343. Newton, C.R.; Simone, M.I.; Fleet, G.W.J.; Bleriot, Y.; Watkin, D.J. 2-C-Hydroxymethyl-2,3-O-isopropylidene-D-ribono-1,5-lactam, Acta Cryst. 2004 E60, o909-o910.

 

342. Newton, C. R.; Horne, G.; Fleet, G. W. J.; Nash, R. J.; Watkin, D.J. Methyl 3,6-anhydro-4-azido-5,7-O-(S)-benzylidene-2,4-dideoxy-D-talo-heptonate, Acta Cryst. 2004 E60, o839-o840

 

341. Zhao, M.X., Wang M.X., Yu, C.Y., Huang, Z.T., Fleet, G.W.J., Ring-chain tautomerism in organic synthesis: Synthesis of heterocyclic enamines from a novel and practical formal ring transformation reaction of lactones, J. Org. Chem., 2004, 69, 997-1000

 

340. B. A. Mayes, R.J.E. Stetz, M. P. Watterson, A. A. Edwards, C. W.G. Ansell, G. E. Tranter and G. W.J. Fleet, Towards hydroxylated nylon 6: linear and cyclic oligomers from a protected 6-amino-6-deoxy-D-galactonate – a novel class of carbopeptoid-cyclodextrin (CPCD), Tetrahedron: Asymmetry, 2004, 15, 627-638.

 

339. Y.-K. Chung, T.D.W. Claridge, G.W.J. Fleet, S.W. Johnson, J.H. Jones, K.W. Lumbard, A.V. Stachulski, An Unsaturated peptidomimetic assembly derived from a carbohydrate, J. Peptide. Sci., 2004, 10, 1-7.

 

338. A. A. Edwards,^, O. Ichihara, S. Murfin, R. Wilkes, D. J. Watkin, and G. W. J. Fleet, Tetrahydrofuran based amino acids as novel library scaffolds, J. Combinatorial Chem., 2004, 6, 230-238.

 

337. B. A. Mayes, A.R. Cowley, C.W.G. Ansell and G. W.J. Fleet, Mixed sugar-nylon 14-, 28- and 42-membered ring macrocyclic lactams, Tetrahedron Lett., 2004, 45, 163-166.

 

336. B. A. Mayes, L. Simon, D. J. Watkin, C.W.G. Ansell and G. W.J. Fleet, Huge (14-, 21-, 28-, 35-, 56- and 70-membered ring) macrocyclic lactams – a novel family of carbopeptoid-cyclodextrins Tetrahedron Lett., 2004, 45, 157-162.

 

335. B. A. Mayes, R.J.E. Stetz, C.W.G. Ansell and G. W.J. Fleet, Cyclo[(6-amino-6-deoxy-D-galactonic acid)₄]: a new class of carbopeptoid-cyclodextrin (CPCD), Tetrahedron Lett., 2004, 45, 153-156.

 

334. S. Mons and G. W.J. Fleet, An approach to the generation of simple analogues of the antitumor agent spicamycin, Org. Biomol. Chem., 2003, 1, 3685-3691.

 

333. M. D. Smith, T. D. W. Claridge, M. P. Sansom and G. W. J. Fleet, Bend ribbon-forming Tetrahydrofuran amino acids, Org. Biomol. Chem., 2003, 1, 3647-3655.

 

332. D.F.W. Hunter and G.W. J. Fleet, Towards hydroxylated nylon 6: oligomers from a protected 6-amino-6-deoxy-D-allonate, Tetrahedron: Asymmetry, 2003, 14, 3831-3839.

 

331. R. I. Cooper, A. Edwards, G. W. J. Fleet and D. J.Watkin, Isopropyl 6-amino-2,5-anhydro-3,6-dideoxy-6-N-(2,5-anhydro-6-azido-3,6-dideoxy-L- arabino-hexonyl)-L-arabino-hexonate,

Acta Cryst. 2003 E59, 1712-1714

 

330. M.P. Watterson, A.A. Edwards, J.A. Leach, M.D. Smith, O. Ichihara, G. W. J. Fleet, Synthesis of all diastereomeric methyl 2,5-anhydro-3-deoxy-hexonates: precursors to C-2- deoxynucleosides and THF-templated g- and d-amino acids, Tetrahedron Lett., 2003, 44, 5853-5857.

 

329. G. J. Sanjayan, A.J. Stewart, S. Hachisu, R. Gonzalez, M. P. Watterson and G. W. J. Fleet, Templated scaffolds of cis- and trans-tetrahydrofuran g-amino acids: g-azido-b-hydroxy-tetrahydrofuran-2-carboxylates from pentono-d-lactones, Tetrahedron Lett., 2003, 44, 5847-5852.

 

328. Wang M.X., Liu Y,, Gao, H.Y., Zhang, Y., Yu, C.Y., Huang, Z.T., Fleet, G.W.J., Ring-chain tautomerism in organic synthesis: Synthesis of heterocyclic enamines from a novel and practical formal ring transformation reaction of lactones, J. Org. Chem., 2003, 68, 3281-3286.

 

327. Kato A, Kano E, Adachi I, Molyneux RJ, Watson AA, Nash RJ, Fleet GWJ, Wormald MR, Kizu H, Ikeda K, Asano N Australine and related alkaloids: easy structural confirmation by C-13 NMR spectral data and biological activities,, Tetrahedron: Asymmetry, 2003 14, 325-331.

 

326. Butters, Terence D.; Dwek, Raymond A.; Fleet, George; Orchard, Michael Glen; Platt, Frances Mary. Preparation of pharmaceutically active aza-sugar piperidine derivatives as inhibitors of galactosidase and glucosylceramide synthase. PCT Int. Appl. (2002), 38 pp. CODEN: PIXXD2 WO 2002055498 A1 20020718 CAN 137:93950 AN 2002:539660 CAPLUS

 

325 Yamashita T, Yasuda K, Kizu H, Kameda Y, Watson AA, Nash RJ, Fleet GWJ , Asano N, New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica, J. Nat. Prod., 2002, 65, 1875-1881.

 

324. A.J. Stewart, R.M. Evans, A.C. Weymouth-Wilson, A.R. Cowley, D.J. Watkin, and G.W.J. Fleet, 2-Deoxy-L-ribose from an L-arabinono-1,5-lactone, Tetrahedron: Asymmetry, 2002, 13, 2667-2672.

 

323. Long DD, Smith MD, Martin A, Wheatley JR, Watkin DG, Muller M, Fleet GWJ Complex tetrahydrofurans from carbohydrate lactones: THF amino acids as building blocks for unnatural biopolymers, J. Chem. Soc., Perkin Trans. 1, 2002, 1982-1998.

 

322. Mellor HR, Nolan J, Pickering L, Wormald MR, Platt FM, Dwek RA, Fleet GWJ, Butters TD Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins, Biochem. J., 2002, 366, 225-233.

 

321. K. Yasuda, H. Kizu, T. Yamashita, Y. Kameda, A. Kato, R.J. Nash, G.W.J.Fleet N. Asano, New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii, J. Nat. Prod., 2002, 65, 198-202

 

320. T. D. W. Claridge, J. M. Goodman, A. Moreno, D. Angus, S. F. Barker, C. Taillefumier, M. P. Watterson, and G. W. J. Fleet, 10-Helical conformations in oxetane b-amino acid hexamers, Tetrahedron Lett., 2001, 42, 4251-4255.

 

318. S. F. Barker, D. Angus, C. Taillefumier, M.R. Probert, D.J. Watkin, M. P. Watterson, T.D.W. Claridge and G. W. J. Fleet, cis- and trans-3-Azido-oxetane-2-carboylate scaffolds: Hexamers of oxetane cis-b-amino acids, Tetrahedron Lett., 2001, 42, 4247-4250.

 

317. Watson, A.A., Fleet, G.W.J., Asano, N., Molyneux, R.J., Nash, R.J., Polyhydroxylated alkaloids – natural occurrence and therapeutic applications, Phytochemistry, 2001, 56, 265-295

 

316. Long, D.D.; Tennant-Eyles, R.J; Estevez, J.C.; Wormald, M.R.; Dwek, R.A.; Smith, M.D.; Fleet, G.W.J. Carbopeptoids: Peptides and diketopiperazines incorporating the anomeric centre of mannopyranose, J. Chem. Soc., Perkin Trans. 1, 2001, 807-813.

 

315. Asano N, Yasuda K, Kizu H, Kato A, Fan JQ, Nash RJ, Fleet GWJ, Molyneux RJ, Novel alpha-L-fucosidase inhibitors from the bark of Angylocalyx pynaertii (Leguminosae), Eur. J. Biochem., 2001, 268, 35-41.

 

314. Zitzmann, Nicole; Butters, Terry D.; Platt, Frances M.; Carrouee, Sandra; Jacob, Gary S.; Picker, Donald H.; Fleet, George W. J.; Dwek, Raymond A. Preparation of long chain N-alkyl amino and imino alditols and oxa-derivatives as antiviral agents. PCT Int. Appl. (2001), 47 pp. CODEN: PIXXD2 WO 2001010429 A2 20010215 CAN 134:163282 AN 2001:114972 CAPLUS

 

313. Fleet, George; Scott, David; Finn, Malcolm; Krulle, Thomas. Bis(1,3-dihydroxy-prop-2-yl)amine and derivatives thereof in manufacture of polymers. PCT Int. Appl. (2000), 77 pp. CODEN: PIXXD2 WO 2000055111 A2 20000921 CAN 133:252855 AN 2000:666687 CAPLUS

 

312. S. W. Johnson, D. Angus, C. Taillefumier, J. H. Jones, D. J. Watkin, E. Floyd, J. G. Buchanan and G. W. J. Fleet, Two Epimerisations in the formation of oxetanes from L-rhamnose: towards oxetane-containing peptidomimetics, Tetrahedron Asymm., 2000, 11, 4113-4125.

 

311. N. L. Hungerford and G. W. J. Fleet, Tetrahydrofuran Amino Acids: b- and g-Azido-tetrahydrofuran carboxylic acid monomers derived from D-glucoheptonolactone as building blocks for b- and g-oligopeptides, J. Chem. Soc., Perkin Trans. 1, 2000, 3680-3685.

 

310. N. L. Hungerford, T. D. W. Claridge, M. P. Watterson, R. T. Aplin, A. Moreno and G. W. J. Fleet, Tetrahydrofuran Amino Acids: Secondary Structure in Tetrameric and Octameric Carbopeptoids Derived from a D-allo 5-Aminomethyl Tetrahydrofuran-2-Carboxylic Acid, J. Chem. Soc., Perkin Trans. 1, 2000, 3666-3679.

 

309. D. E. A. Brittain, M. P. Watterson, T. D. W. Claridge, M. D. Smith and G. W. J. Fleet, Tetrahydrofuran Amino Acids - Versatile Building blocks for Unnatural Biopolymers: Lack of Secondary Structure in Oligomeric Carbopeptoids Derived from a D-galacto-5-Aminomethyl Tetrahydrofuran-2-Carboxylic Acid, J. Chem. Soc., Perkin Trans. 1, 2000, 3655-3665.

 

308. D. A. Scott, T. M. Krulle, M. Finn and G. W.J. Fleet, Bis(1,3-dihydroxy-isopropyl)amine (BDI) as an AB₄ Dendritic Building Block: Rapid Synthesis of a Second Generation Dendrimer, Tetrahedron Lett., 2000, 41, 3955-3958.

 

307. N. Asano, R. J. Nash, R. J. Molyneux and G. W.J. Fleet, Nitrogen-in-the-Ring Sugar Mimetics: Natural Occurrence, Biological Activity and Prospects for Therapeutic Application, in Tetrahedron Asymm., 2000, 11, 1645-1680.

 

306. N. Asano, M. Nishida, M. Miyauchi, K. Ikeda, M. Yamamoto, H. Kizu, Y. Kameda, A. A. Watson, R. J. Nash, G. W. J. Fleet, Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae), Phytochemistry, 2000, 53, 379-382.

 

305. N. Asano, H. Kuroi, K. Ikeda, H. Kizu, Y. Kameda, A. Kato, I. Adachi, A. A Watson, R. J. Nash, and G. W.J. Fleet, New polyhydroxylated pyrrolizidine alkaloids from Muscari armeniacum: structural determination and biological activity, Tetrahedron Asymm., 2000, 11, 1-8.

 

304. T.D. Butters, L.A.G.M. van den Broek, G.W.J.Fleet, T. M. Krulle, M. R. Wormald, R. A. Dwek, and F. M. Platt, Molecular Requirements of Imino Sugars for the Selective Control of N-linked Glycosylation and Glycosphingolipid Biosynthesis, Tetrahedron Asymm., 2000, 11, 113-125.

 

303. B. Winchester, G. W. J. Fleet, Modification Of Glycosylation As A Therapeutic Strategy, J. Carbohydr. Chem., 2000, 19, 471-483.

 

302. K. Ikeda, M. Takahashi , M. Nishida, M. Miyauchi, H. Kizu, Y. Kameda, M. Arisawa, A. A Watson, R. J. Nash, G. W.J. Fleet, N. Asano, Homonojirimycin analogues and their glucosides from Lobelia sessilifolia and Adenophora spp. (Campanulaceae), Carbohydr. Res., 2000, 323, 73-80.

 

301. D. A. Scott, T. M. Krlle, M. Finn, R. J. Nash, A. L. Winters, N. Asano, T. D. Butters and G. W. J. Fleet Synthesis of bis(1,3-Dihydroxy-isopropyl)amine by Reductive Amination of Dihydroxyacetone: Open Chain Equivalent of DMDP and a Potential AB₄ Dendritic Monomer, Tetrahedron Lett., 1999, 40, 7581-7584.

 

300. M. D. Smith and G. W. J. Fleet, Carbohydrate-Derived Dipeptide Isosteres, J. Peptide Sci., 1999, 5 , 425-441.

 

299. R. E. Lee, M. D. Smith, L. Pickering and G. W. J. Fleet, An Approach to Combinatorial Library Generation of Galactofuranose Mimics in the Search for Inhibition of Mycobacterial Cell Wall Biosynthesis: Synthesis of a Peptidomimetic of Uridine 5-Diphosphogalactofuranose (UDP-Galf), Tetrahedron Lett., 1999, 40, 8689-8692.

 

298. Kato, A, Adachi_I, Miyauchi, M, Ikeda, K, Komae, T, Kizu, H, Kameda, Y, Watson, AA, Nash, R. J., Wormald, M. R., Fleet, G. W. J., Asano, N Polyhydroxylated pyrrolidine and pyrrolizidine alkaloids from Hyacinthoides non-scripta and Scilla campanulata, Carbohydr. Res.,1999, 316, 95-103.

 

297. J. P. Shilvock, R. J. Nash, A. A. Watson, A. L. Winters, T. D. Butters, R. A. Dwek, D. A. Winkler, and G. W.J. Fleet, Piperidine analogues of D-galactose as potent inhibitors of a-galactosidase: Synthesis by stannane mediated hydroxymethylation of 5-azido-1,4-lactones. Structural relationships between D-galactosidase and L-rhamnosidase inhibitors, J. Chem. Soc., Perkin Trans. 1, 1999, 2747-2754.

 

296. J. P. Shilvock, J. R. Wheatley, R. J. Nash, A. A. Watson, R. C. Griffiths, T. D. Butters, M. Mller, D. J. Watkin, D. A. Winkler, and G. W.J. Fleet, Synthesisis of Homorhamnojirimycins and Related Trihydroxypipecolic Acid Derivatives via Divergent Bicyclic Aminolactone Intermediates: Inhibition of Naringinase (L-Rhamnosidase) and dTDP-rhamnose Biosynthesis, J. Chem. Soc., Perkin Trans. 1, 1999, 2735-2745.

 

295. A. Mart̮, T. D. Butters and G. W.J. Fleet, Synthesis and Biological Evaluation of Enantiomeric Rhamnose Analogues of the Antitumour Agent Spicamycin - Is the Mode of Action by Modification of N-linked Glycoproteins?, Tetrahedron Asymm., 1999, 10, 2343-2360.

 

294. M. P Watterson, L. Pickering, M. D. Smith, S. H. Hudson, P. R. Marsh, J. E. Mordaunt, D. J. Watkin, C. J. Newman and G. W. J. Fleet, 3-Azidotetrahydrofuran-2-Carboxylates: A Family of Five-ring Templated b-Aminoacid Foldamers?, Tetrahedron Asymm., 1999, 10, 1855-1859.

 

293. M. D. Smith, D. D. Long, A. Mart̮, N. Campbell, Y. BlȲiot, G. W. J. Fleet, Tetrahydrofuran a-Azido Esters: Precursors of Anomeric a-Amino Acid Monomers via Radical Bromination, Synlett, 1999, 1151-1153.

 

292. Tsitsanou, K.E., Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Gregoriou, M., Watson, K.A., Johnson, L.N., Fleet, G.W.J. Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure, Protein Sci., 1999, 8, 741-749.

 

291. K. H. Smelt, A. J. Harrison, K. Biggadike, M. Muller, C. K. Prout, D. J. Watkin, G. W. J. Fleet, Components for a Combinatorial Library of Rigid Azabicyclic a-L-Fucose Mimics: First X-Ray Crystal Structure of a Stable Monoalkylated Triazene formed by Hydrogenation of an Azide, Tetrahedron Lett., 1999, 40, 3259-3262.

 

290. K. H. Smelt, Y. BlȲiot, K. Biggadike, S. Lynn, A. L. Lane, D. J. Watkin, G. W. J. Fleet, Photobromination of a Bicyclic Mimic of a-L-Fucose; Components for a Combinatorial Library of Rigid Fucose Analogues, Tetrahedron Lett., 1999, 40, 3255-3258.

 

289. D. D. Long, R. J. E. Stetz, R. J. Nash, D. G. Marquess, J. D. Lloyd, A. L. Winters, N. Asano, G. W.J. Fleet, Open Chain Acetonides of 1,4-D-Galactonolactone as Starting Materials for Pyrrolidines, Azepines and 5-Azidomethyltetrahydrofuran-2-carboxylates: Monomers for Polyhydroxylated Nylon and for Tetrahydrofuran Carbopeptoids, J. Chem. Soc., Perkin Trans. 1, 1999, 901-908.

 

288. T.D.W. Claridge, D.D. Long, N.L. Hungerford, M.D. Smith, R.T. Aplin, D.G. Marquess, G.W.J. Fleet, An Octameric Carbopeptoid; Secondary Structure in Octameric and Tetrameric 5-Aminomethyl-Tetrahydrofuran-2-carboxylates, Tetrahedron Lett., 1999, 40, 2199-2203.

 

287. D.D. Long, N.L. Hungerford, M.D. Smith, D.E.A. Brittain, D.G. Marquess, T.D.W. Claridge, G.W.J Fleet, From Sequencamers to foldamers? Tetrameric Furanose Carbopeptoids from cis- and trans-5-Aminomethyl-Tetrahydrofuran-2-carboxylates, Tetrahedron Lett., 1999, 40, 2195-2198.

 

286. M. D. Smith, D. D. Long, A. Mart̮, D. G. Marquess, T. D. W. Claridge, G. W. J. Fleet, Absence of Secondary Structure in a Carbopeptoid Tetramer of a trans-5-Aminomethyl-Tetrahydrofuran-2-carboxylate, Tetrahedron Lett., 1999, 40, 2191-2194.

 

285. B. G. Davis, R. J. Nash, A. A. Watson, C. Smith, G. W. J. Fleet, Tetrazoles of Manno- and Rhamno- Furanoses, Tetrahedron, 1999, 55, 4489-4500

 

284. B. G. Davis, T. W. Brandstetter, L. Hackett, B. G. Winchester, R. J. Nash, A. A. Watson, R. C. Griffiths, C. Smith, G. W. J. Fleet, Tetrazoles of Manno- and Rhamno-Pyranoses: Contrasting Inhibition of Mannosidases by [4.3.0] but of Rhamnosidase by [3.3.0] Bicyclic Tetrazoles, Tetrahedron, 1999, 55, 4501-4520.

 

283. A. Mart̮, M. P. Watterson, A. R. Brown, F. Imtiaz, B.G. Winchester, D J. Watkin, G. W. J. Fleet 6R-, and 6S, -6C-Methylmannose from D-Mannuronolactone: Inhibition of Phosphoglucomutase and Phosphomannomutase: Agents for the Study of the Primary Metabolism of Mannose, Tetrahedron Asymm., 1999, 10, 355-366.

 

282. J. P. Shilvock, K. Y. Hsia, R. J. Nash, J. D. Lloyd, A. L. Winters, N. Asano, G. W. J. Fleet, Synthesis of an Eight carbon Homologue of a-Homomannojirimycin via a Bicyclic Aminolactone, Tetrahedron Asymm., 1998, 9, 4157-4164.

 

281. J. P. Shilvock, R. J. Nash, J. D. Lloyd, A. L. Winters, N. Asano, G. W. J. Fleet, Intermediates for incorporation of tetrahydroxypipecolic acid analogues of a- and b-D-mannopyranose into combinatorial Libraries: Unexpected Nanomolar-range Hexosaminidase Inhibitors. Synthesis of a- and b-Homomannojirimycin, Tetrahedron Asymm., 1998, 9, 3505-3516.

 

280. D. D. Long, M. D. Smith, D. G. Marquess, T. D. W. Claridge, G. W. J. Fleet, A Solid Phase Approach to Oligomers of Carbohydrate Amino-Acids: Secondary Structure in a Trimeric Furanose Carbopeptoid, Tetrahedron Lett., 1998, 39, 9293-9296.

 

279. B. G. Davis, A. Hull, C. Smith, R. J. Nash, A. A. Watson, D. A. Winkler, R. C. Griffiths, G. W. J. Fleet, 5-epi-Deoxyrhamnojirimycin is a Potent Inhibitor of an a-L-Rhamnosidase: 5-epi-Deoxymannojirimycin is not a Potent Inhibitor of an a-D-Mannosidase, Tetrahedron Asymm., 1998, 9, 2947-2960.

 

278. A. Mart̮, T. D. Butters, G. W. J. Fleet, A Highly Cytotoxic L-Rhamnose Analogue of the Antitumour Agent Spicamycin, J. Chem. Soc., Chem. Commun., 1998, 2119-2220.

 

277. M. D. Smith, D. D. Long, T. D. W. Claridge, D. G. Marquess, G. W. J. Fleet, Synthesis of Oligomers of Tetrahydrofuran Amino-Acids: Furanose Carbopeptoids, J. Chem. Soc., Chem. Commun., 1998, 2039-2040.

 

276. M. D. Smith, T. D. W. Claridge, G. E. Tranter, M. S. P. Sansom, G. W. J. Fleet, Secondary Structure in Oligomers of Carbohydrate Amino-Acids, J. Chem. Soc., Chem. Commun., 1998, 2041-2042.

 

275. J. C. Estevez, A. J. Fairbanks, G. W. J. Fleet, Synthesis of Tetrahydropyrans from Sugar Lactones, Tetrahedron, 1998, 54, 13591-13620.

 

274. M. R. Wormald, R. J. Nash, P. Hrnicar, J. D. White, R. J. Molyneux and G. W. J. Fleet, Configurational and Conformational Analysis of Highly Oxygenated Pyrrolizidines: Definitive Identification of Some Naturally Occurring 7a-epi-Alexines, Tetrahedron Asymm., 1998, 9, 2549-2558.

 

273. D. D. Long, S. M. Frederiksen, D. G. Marquess, A. L. Lane, D. J. Watkin, D. A. Winkler, G. W. J. Fleet, Potential intermediates for incorporation of polyhydroxylated prolines into combinatorial libraries, Tetrahedron Lett., 1998, 39, 6091-6094.

 

272. N Asano, A. Kato, M. Miyauchi, H. Kizu, A. A. Watson, R. J. Nash, G. W. J. Fleet, Nitrogen-in-the-Ring Furanose and Pyranose Analogues form Hyacinthus orientalis, J. Nat. Prod., 1998, 61, 625-628.

 

271. N. Asano, M. Nishida, A. Kato, H. Kizu, K. Matsui, Y. Shimada, T. Itoh, M. Baba, A. A. Watson, R. J. Nash, P. M. de Q. Lilley, D. J. Watkin, G. W. J. Fleet, Homonojirimycin Isomers and N-Alkylated Homonojirimycins: Structural and Conformational Basis of Inhibition of Glycosidases, J. Med. Chem., 1998, 41, 2565-2571.

 

270. J. C. Estevez, J. W. Burton, R. J. Estevez, H. Ardron, M. R. Wormald, R. A. Dwek, D. Brown, G. W. J Fleet, Spirodiketopiperazines of Mannofuranose: Carbopeptoid a-Amino Acid esters at the anomeric position of mannofuranose, Tetrahedron Asymm., 1998, 9, 2137-2154.

 

269. M. Gregoriou, M. E. M. Noble, K. A. Watson, E. F. Garman, T. M. Krlle, C. de la Fuente, G. W. J. Fleet, N. G. Oikonomakos, L. N. Johnson, The Structure of a Glycogen Phosphorylase Glucopyranose Spirohydantoin Complex at 1.8A resolution and 100 K: the Role of the Water Structure and its Contribution to Binding, Protein Sci., 1998, 7, 915-927.

 

268. J. P. Shilvock and G. W. J. Fleet, The Synthesis of Deoxygalactostatin and 2,6-Imino-heptitol Derivatives via Stannane Mediated Hydroxymethylation of 5-Azido-1,4-lactones Synlett, 1998, 554-556.

 

267. G. W. J. Fleet, J. C. Estevez, M. D. Smith, Y. BlȲiot, C. de la Fuente, T. M. Krlle, G. S. Besra, P. J. Brennan, R.J. Nash, L. N. Johnson, N. G. Oikonomakos and W. Stalmans, Sugar Mimics from Sugar Lactones, Pure Appl. Chem., 1998, 70, 279-284.

 

266. Y. Wang, G. W J Fleet, L. Zhao, 1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl (TIPS) Migration Facilitates One-pot formation of Enantiomerically Pure Methyl 2,3-Epoxy-D-xylonate, Carbohydr. Res., 1998, 307, 159-162

 

265. Nash, R.J., Watson, A.A., Winters, A.L., Fleet, G.W.J., Wormald, M.R., Dealler, S., Lees, E., Asano, N., and Molyneux, R.J.Glycosidase Inhibitors in British Plants as Causes of Livestock Disorders. Chapter 56, pp. 276-284 In: Toxic Plants and Other Natural Toxicants. (Ed. Garland, T., Barr, A. C.), , CAB International, Wallingford, U, K, 1998

 

264. A. R. Beacham, K. H. Smelt, K. Biggadike, C. J. Britten, L. Hackett, B. G. Winchester, R. J. Nash, R. C. Griffiths, and G. W. J. Fleet, Inhibition of Fucosyl Transferase and Fucosidase by a Rigid Bicyclic Mimic of a-L-Fucose, Tetrahedron Lett., 1998, 39, 151-154.

 

263. M. P. Watterson, A. Martin, T. M. Krlle J. C. Estevez and G. W. J. Fleet, Mannuronolactone Acetonide: Easy Access to C-3 OH and C-5 OH of Mannose, Tetrahedron Asymm., 1997, 8, 4111-4120.

 

262. T. M. Krlle, C. de la Fuente, L. Pickering, R. T. Aplin, K. E. Tsitsanou, S. E. Zographos, N. G. Oikonomakos, R. J. Nash, R. C. Griffiths and G. W. J. Fleet, Triazole Carboxylic Acids as Anionic Sugars Mimics? Inhibition of Glycogen Phosphorylase by a Glucotriazole Carboxylate, Tetrahedron Asymm., 1997, 8, 3807-3820.

 

261. C. F. Masaguer, Y. BlȲiot, J. Charlwood, B. G. Winchester and G. W. J. Fleet, 6C-Butylglucoses from Glucuronolactone: Suppression of Silyl Migration during Borohydride Reduction of Lactols by Cerium(III) Chloride: Inhibition of Phosphoglucomutase, Tetrahedron, 1997, 53, 15147-15156.

 

260. Y. BlȲiot, C. F. Masaguer, J. Charlwood, B. G, Winchester, A. L. Lane, S. Crook, D. J. Watkin, G. W. J. Fleet, 6R-, and 6S, -6C-Methylglucose from D-Glucuronolactone: Efficient Synthesis of a Seven Carbon Fucose Analogue: Inhibition of Some Enzymes of Primary Metabolism, Tetrahedron, 1997, 53, 15135-15146.

 

259. A. A. Bell, L. Pickering, M. Finn, C. de la Fuente, T. M. Krlle, B. G. Davis, and G. W. J. Fleet, Caesium Trifluoroacetate Displacement of Triflates in the Inversion of Alcohols, Synlett, 1997, 1077-1080.

 

258. R. E Lee, M. D. Smith, R. J. Nash, R. C. Griffiths, M. McNeil, R. K. Grewal, W.Yan, G. S. Besra, P. J. Brennan and G. W. J. Fleet, Inhibition of UDP-Gal Mutase and Mycobacterial Galactan Biosynthesis by Pyrrolidine Analogues of Galactofuranose, Tetrahedron Lett., 1997, 38, 6733-6736.

 

257. A. A. Bell, L. Pickering, A. A. Watson, Robert J. Nash, Y. T. Pan, A. D. Elbein and G. W. J. Fleet, Synthesis of Casuarines [Pentahydroxylated Pyrrolizidines] by Sodium Hydrogen Telluride-Induced Cyclisations of Azidodimesylates, Tetrahedron Lett., 1997, 38, 5869-5872.

 

256. A. A. Watson, R. J. Nash, M. R. Wormald, D. J. Harvey, S. Dealler, E. Lees, N. Asano, H. Kizu, A. Kato, R. C. Griffiths, A. J. Cairns and G. W.J. Fleet, Glycosidase-Inhibiting Pyrrolidine Alkaloids from Hyanithoides non-scripta, Phytochemistry, 1997, 46, 255-259.

 

255. R. J. Nash, A. A. Watson, A. L. Winters, G. W. J. Fleet, M. R. Wormald, S. Dealler, E. Lees, N. Asano and H. Kizu, Novel Biologically-Active Alkaloids from British Plants, in Phytochemical Diversity: A Source of New Industrial Products, (Ed: S Wrigley, M. Hayes, R. Thomas, E. Chrystal), pp. 106-114, Royal Soc. Chem., Spec. Public. 200, Royal Soc. Chem., Cambridge, 1997.

 

254. G. W. J. Fleet, Oxidation and Reduction, Chap. 5 in Organic Reaction Mechanisms, 1995, Ed. A. C. Knipe and W. E. Watts, John Wiley, 1997.

 

253. C. de la Fuente, T. M. Krlle, K. A. Watson, M. Gregoriou, L. N. Johnson, K. E. Tsitsanou, S. E. Zographos, N. G. Oikonomakos and G. W. J. Fleet, Glucopyranose Spirohydantoins: Specific Inhibitors of Glycogen Phosphorylase, Synlett, 1997, 485-487.

 

252. T. M. Krlle, C. de la Fuente, K. A. Watson, M. Gregoriou, L. N. Johnson, K. E. Tsitsanou, S. E. Zographos, N. G. Oikonomakos and G. W. J. Fleet, Stereospecific Synthesis of Spirohydantoins of b-Glucopyranose: Inhibitors of Glycogen Phosphorylase, Synlett, 1997, 211-213.

 

251. M. R. Wormald, R. J. Nash, A. A. Watson, B. K. Bhadoria, R. Langford, M. Sims and G. W. J. Fleet, Casuarine-6-a-D-Glucoside from Casuarina equisetifolia and Eugenia jambolana, Carbohydr. Lett., 1996, 2, 169-174.

 

250. J. P. Shilvock, J. R. Wheatley, B. Davis, R. J. Nash, R. C. Griffiths, M. G. Jones, M. Muller, S. Crook, D. J. Watkin, C. Smith, G. S. Besra, P. J. Brennan and G. W. J. Fleet, Inhibition of Naringinase (L-Rhamnosidase) by Piperidine Analogues of L-Rhamnose: Scaffolds for Libraries Incorporating Trihydroxypipecolic Acids, Tetrahedron Lett., 1996, 37, 8569-8572.

 

249. B. Davis, A. A. Bell, R. J. Nash, A. A. Watson, R. C. Griffiths, M. G. Jones, C. Smith and G. W. J. Fleet, L-(+)-Swainsonine and Other Pyrrolidine Inhibitors of Naringinase: Through an Enzymic Looking Glass from D-Mannosidase to L-Rhamnosidase?, Tetrahedron Lett., 1996, 37, 8565-8568.

 

248. A. A. Bell, L. Pickering, A. A. Watson, R. J. Nash, R. C. Griffiths, M. G. Jones and G. W. J. Fleet, 2-HydroxyCastanospermines (Dihydroxy-L-swainsonines) from Octonolactones: Inhibition of Naringinase (L-Rhamnosidase), Tetrahedron Lett., 1996, 37, 8561-8564.

 

247. Y. BlȲiot, C. Veighey, K. H. Smelt, J. Cadefau, W. Stalmans, K. Biggadike, A. L. Lane, M. Muller, D. J. Watkin and G. W. J. Fleet, The First Example of a 6C-Arylglucose: Inhibition of Glucokinase, Tetrahedron Asymm., 1996, 7, 2761-2772.

 

246. Y. BlȲiot, K. H. Smelt, J. Cadefau, M. Bollen, W. Stalmans, K. Biggadike, L. N. Johnson, N. G. Oikonomakos, A. L. Lane, S. Crook, D. J. Watkin and G. W. J. Fleet, 7-Carbon Mimics of D-Glucose and L-Fucose: Activation by 6R-, and Inactivation by 6S, -6C-Methylglucose of Glycogen Synthase: Inhibition of Glucokinase and/or Glucose-6-Phosphatase, Tetrahedron Lett., 1996, 37, 7155-7158.

 

245. C. J. F. Bichard, T. W. Brandstetter, J. C. Estevez, G. W. J. Fleet, D. J. Hughes and J. R. Wheatley, Complex Tetrahydrofurans from Carbohydrate Lactones: Easy Access to Epimeric C-Glycosides of Gluco-furanose from D-glycero-D-gulo-Heptono-1,4-lactone, J. Chem. Soc., Perkin Trans. 1, 1996, 2151-2156.

 

244. G. W. J. Fleet, Oxidation and Reduction, Chap. 5 in Organic Reaction Mechanisms, 1994, Ed. A. C. Knipe and W. E. Watts, John Wiley, 1996.

 

243. T. W. Brandstetter, C. de la Fuente, Y. Kim, L. N. Johnson, S. Crook, P. M. De Q. Lilley, D. J. Watkin, K. E. Tsitsanou, S. E. Zographos, E. D. Chrysina, N. G. Oikonomakos and G. W. J. Fleet Glucofuranose Analogues of Hydantocidin, Tetrahedron, 1996, 52, 10721-10736.

 

242. T. W. Brandstetter, C. de la Fuente, Y. Kim, R. I. Cooper, D. J. Watkin, N. G. Oikonomakos, L. N. Johnson and G. W. J. Fleet, a-Azidoesters as Divergent Intermediates for Combinatorial Generation of Glucofuranose Libraries, Tetrahedron, 1996, 52, 10711-10720.

 

241. T. M. Krlle, B. Davis, H. Ardron, D. D. Long, N. A. Hindle, C. Smith, D. Brown, A. L. Lane, D. J. Watkin, D. G. Marquess and G. W. J. Fleet, Kinetic and Thermodynamic Azides from a-O-Triflates of g-Lactones: Intermediates for the Incorporation of Polyhydroxylated D- and L-a-Aminoacids into Combinatorial Libraries, J. Chem. Soc., Chem. Commun., 1996, 1271-1272.

 

240. R. C. Griffiths, A. A. Watson, H. Kizu, N. Asano, H. J. Sharp, M. G. Jones, M. R. Wormald, G. W. J. Fleet and R. J. Nash, The Isolation from Nicandra physalodes and Identification of 3-O-b-D-Glucopyranoside of 1a,2b,3a,6a-Tetrahydroxy-nor-tropane (Calystegine B₁), Tetrahedron Lett., 1996, 37, 3207-3208.

 

239. A. A. Bell, R. J. Nash and G. W. J. Fleet, Acetonides of Octonolactones, Tetrahedron Asymm., 1996, 7, 593-604.

 

238. J. C. Estevez, M. D. Smith, M. R. Wormald, G. S. Besra, P. J. Brennan, R. J. Nash and G. W. J. Fleet, Mimics of l-Rhamnose: Analogues of Rhamnopyranose Containing a Constituent a-Amino Acid at the Anomeric Position. A Pyranose Analogue of Hydantocidin, Tetrahedron Asymm., 1996, 7, 391-394.

 

237. J. C. Estevez, M. D. Smith, A. L. Lane, S. Crook, D. J. Watkin, G. S. Besra, P. J. Brennan, R. J. Nash and G. W. J. Fleet, Mimics of l-Rhamnose: Anomeric Spirohydantoins and Diketopiperazines -Approaches to Novel N-Linked Glycopeptides of Rhamnofuranose, Tetrahedron Asymm., 1996, 7, 387-390.

 

236. J. C. Estevez, J. Saunders, G. S. Besra, P. J. Brennan, R. J. Nash and G. W. J. Fleet, Mimics of l-Rhamnose: Synthess of C-Glycosides of L-Rhamnofuranose and an a-Azidoester as Divergent Intermediates for Combinatorial Generation of Rhamnofuranose Libraries, Tetrahedron Asymm., 1996, 7, 383-386.

 

235. T. W. Brandstetter, M. R. Wormald, R. A. Dwek, T. D. Butters, F. M. Platt, K. E. Tsitsanou, S. E. Zographos, N. G. Oikonomakos and G. W. J. Fleet, A Galactopyranose Analogue of Hydantocidin, Tetrahedron Asymm., 1996, 7, 157-170.

 

234. Oikonomakos, N. G., Kontou, M., Zographos, S. E., Watson, K. A., Johnson, L. N., Bichard, C. J. F., Fleet, G. W. J., Acharya, K. R., N-Acetyl-b-glucopyranosylamine: a Potent T State Inhibitor of Glycogen Phosphorylase, Protein Sci., 1995, 4, 2469-2477.

 

233. Board, M., Bollen, M., Stalmans, W., Kim, Y., Fleet, G. W. J., Johnson, L. N., Effects of a C1 Substituted Glucose Analogue on the Activation States of Glycogen Synthase and Glycogen Phosphorylase in Rat Hepatocytes, Biochem. J., 1995, 311, 845-852.

 

232. Krlle, T. M., Watson, K. A., Gregoriou, M., Johnson, L. N., Crook, S., Watkin, D. J., Griffiths, R. C., Nash, R. J., Tsitsanou, K. E., Zographos, S. E., Oikonomakos, N. G., Fleet, G. W. J., Specific Inhibition of Glycogen Phosphorylase by a Spirodiketopiperazine at the Anomeric position of Glucopyranose, Tetrahedron Lett., 1995, 36, 8291-8294.

 

231. Estevez, J. C., Long, D. D., Wormald, M. R., Dwek, R. A., Fleet, G. W. J., Spirodiketopiperazines at the Anomeric position of Mannopyranose: Novel N-Linked Glycopeptides Incorporating an a-Amino acid at the Anomeric position of Mannopyranose, Tetrahedron Lett., 1995, 36, 8287-8290.

 

230. Brandstetter, T. W., Davis, B., Hyett, D., Smith, C., Hackett, L., Winchester, B. G., Fleet, G. W. J., Tetrazoles of Manno- and Rhamno-Pyranoses: Inhibition of Glycosidases by Tetrazoles and Other Mannose Mimics, Tetrahedron Lett., 1995, 36, 7511-7514.

 

229. Davis, B., Brandstetter, T. W., Smith, C., Hackett, L., Winchester, B. G., Fleet, G. W. J., Tetrazoles of Manno- and Rhamno-furanoses, Tetrahedron Lett., 1995, 36, 7507-7510.

 

 

228. R. G. Compton, R. A. W. Dryfe, J. C. Eklund, S. D. Page, J. Hirst, L. Nei, G. W. J. Fleet, K. Y. Hsia, D. Bethell, and L. Y. Martingale, Photoelectrochemical reduction of meta-Halonitrobenzenes and Related Species, J. Chem. Soc., Perkin Trans. 2, 1995, 1673-1679.

 

227. G. W. J. Fleet, United States Patent 5,384,417, 24 January 1995, Novel Heptitols.

 

226. A. J. Fairbanks, G. W. J. Fleet, Synthesis of 5-epiHydantocidin, Tetrahedron, 1995, 51, 3881-3894.

 

225. T. W. Brandstetter, Y.-H. Kim, J. C. Son, H. M. Taylor, Paul M. de Q. Lilley, D. J. Watkin, L. N. Johnson, N. G. Oikonomakos and G. W. J. Fleet, Spirohydantoins of Glucofuranose: Analogues of Hydantocidin, Tetrahedron Lett., 1995, 36, 2149-2153.

 

224. C. J. F. Bichard, E. P. Mitchell, M. R. Wormald, K. A. Watson, L. N. Johnson, S. E. Zographos, D. D. Koutra, N. G. Oikonomakos and G. W. J. Fleet, Potent Inhibition of Glycogen Phosphorylase by a Spirohydantoin of Glucopyranose: First Pyranose Analogues of Hydantocidin, Tetrahedron Lett., 1995, 36, 2145-2148.

 

223. K. A. Watson, E. P. Mitchell, L. N. Johnson, J. C. Son, C. J. F. Bichard, G. W. J. Fleet, N. G. Oikonomakos, M. Kontou and S. E. Zographos, Glucose Analogue Inhibitors of Glycogen Phosphorylase: From Crystallographic Analysis to Drug Prediction Using Grid and Golpe Variable Selection, Acta Cryst. Sect. D, 1995, 51, 458.

 

222. M. P. Vazquez-Tato, J. A. Seijas, G. W. J. Fleet, C. J. Mathews, P. R. Hemmings and D. Brown, Synthesis of (3S,5S)-Quinuclidine-3,5-diol and of [3S-(3a,3aa,7aa)]-Octahydro-2-furo[2,3-c]pyridinol from D-Arabinose, Tetrahedron, 1995, 51, 959-974.

 

221. G. W. J. Fleet, Oxidation and Reduction, Chap. 5 in Organic Reaction Mechanisms, 1993, Ed. A. C. Knipe and W. E. Watts, John Wiley, 1995.

 

220. J. R. Wheatley, A. R. Beacham, P. M. de Q. Lilley, D. J. Watkin and G. W. J. Fleet, Ketals of L-Rhamnoheptonolactones: Potential Mimics of L-Rhamnose, Tetrahedron Asymm., 1994, 5, 2523-2534.

 

219. A. Hui, A. J. Fairbanks, R. J. Nash, P. M. de Q. Lilley, R. Storer, D. J. Watkin and G. W. J. Fleet^, Aldol Equilibrations of Unprotected Trihydroxybicyclic Lactones: Synthesis of Enantiomeric Tetrahydroxy-a-Aminocyclopentane Carboxylic Acids from Epimeric Bicyclic Lactones, Tetrahedron Lett., 1994, 35, 8895-8898.

 

218. A. J. Fairbanks, A. Hui, B. M. Skead, P. M. de Q. Lilley, R. B. Lamont, R. Storer, J. Saunders, D. J. Watkin and G. W. J. Fleet, Polyhydroxylated Cyclohexane and Cyclopentane a-Amino Acids from Cyclisations of an Azidolactone, Tetrahedron Lett., 1994, 35, 8891-8894.

 

217. J. C. Estevez, H. Ardron, M. R. Wormald, D. Brown and G. W. J. Fleet, Spirocyclic Peptides at the Anomeric Position of Mannofuranose, Tetrahedron Lett., 1994, 35, 8889-8890.

 

216. J. C. Estevez, R. J. Estevez, H. Ardron, M. R. Wormald, D. Brown and G. W. J. Fleet, Tri- and Tetra-Peptides Incorporating an a-Amino acid at the Anomeric position of Mannofuranose, Tetrahedron Lett., 1994, 35, 8885-8888.

 

215. N. G. Oikonomakos, M. Kontou, S. E. Zographos, H. S. Tsitoura, L. N. Johnson, K. A. Watson, E. P. Mitchell, G. W. J. Fleet, J. C. Son, C. J. F. Bichard, D. D. Leonidas and K. R. Acharya, The Design of Potential Antidiabetic Drugs - Experimental Investigation of a Number of b-D-Glucose Analog Inhibitors of Glycogen Phosphorylase, Eur. J. Drug Metabolism Pharmacokinet., 1994, 19, 185-192.

 

214. R. J. Nash, P. I. Thomas, R. D. Waigh, G. W. J. Fleet, M. R. Wormald, P. M. de Q. Lilley and D. J. Watkin, Casuarine: A Very Highly Oxygenated Pyrrolizidine Alkaloid, Tetrahedron Lett., 1994, 35, 7849-7852.

 

213. A. R. Beacham, K. Biggadike, H. E. Taylor, L. Hackett, B. G. Winchester, D. J. Watkin and G. W. J. Fleet, Short Synthesis of a Bicyclic Mimic of a-L-Fucose, J. Chem. Soc., Chem. Commun., 1994, 2001-2002.

 

212. K. Y. Hsia, P. Ward, R. B. Lamont, P. M. de Q. Lilley, D. J. Watkin and G. W. J. Fleet, Formation of Highly Substituted Cyclopentanes from Radical and Anionic Michael Cyclisations of a-Iodo-g- and -d-lactones, Tetrahedron Lett., 1994, 35, 4823-4826.

 

211. L. N. Johnson, K. A. Watson, E. P. Mitchell, G. W. J. Fleet, J. C. Son, C. J. F. Bichard, N. G. Oikonomakos, A. Papageoriou and D. D. Leonidas, Glucose Analogue Inhibitors of Glycogen Phosphorylase, Complex Carbohydrates in Drug Research, (Ed. K. Bock and H. Clausen), pp. 214-228, Munksgaard, Copenhagen, 1994.

 

210. G. W. J. Fleet and B. G. Winchester, United States Patent 5,300,659, 5 Apr 1994, Heptitols.

 

209. K. A. Watson, E. P. Mitchell, L. N. Johnson, J. C. Son, C. J. F. Bichard, M. G. Orchard, G. W. J. Fleet, N. G. Oikonomakos, D. D. Leonidas, M. Kontou and A. Papageoriouo, The Design of Inhibitors of Glycogen Phosphorylase: A study of a- and b-C-Glucosides and 1-Thio-b-D-glucose Compounds, Biochemistry, 1994, 33, 5745-5758.

 

208. J. R. Behling, J. R. Medich, K. A. Babiak and G. W. J. Fleet, United States Patent 5,286,877, 15 February 1994, Synthesis 1,4-Dideoxy-1,4-Imino-L-Arabinitol

 

207. J. C. Estevez, A. J. Fairbanks, K. Y. Hsia, P. Ward and G. W. J. Fleet, Tetrahydropyran Derivatives from g- and d-Hexonolactones, Tetrahedron Lett., 1994, 35, 3361-3364.

 

206. C. J. F. Bichard, J. R. Wheatley and G. W. J. Fleet, Acetonides of Heptonolactones: Kiliani Ascension of 3-O-Benzyl-D-Glucose and 3-O-Benzyl-D-Allose, Tetrahedron Asymm., 1994, 5, 431-440.

 

205. G. W. J. Fleet, Oxidation and Reduction, Chap. 5 in Organic Reaction Mechanisms, 1992, Ed. A. C. Knipe and W. E. Watts, pp. 161-204, John Wiley, 1994.

 

204. D. Brown, D. Liston, S. J. Mantell, S. Howard and G. W. J. Fleet, Synthesis and SAR of 3-Substituted Muscarines, Carbohydr. Lett., 1994, 1, 31-36.

 

203. G. W. J. Fleet and B. G. Winchester, United States Patent 5,250,703, 5 Oct 1993, Pyrrolidin-3,4-diol Derivatives of Heptitols and Preparation Thereof.

 

202. G. W. J. Fleet, United States Patent 5,248,779, 28 September 1993, Synthesis of Nojirimycin Derivatives.

 

201. A. J. Fairbanks, R. P. Elliott, C. Smith, A. Hui, G. Way, R. Storer, H. Taylor, D. J. Watkin, B. G. Winchester and G. W. J. Fleet, Aldol Condensations in the Synthesis of Cyclopentane Spirohydantoins: an Approach to Highly Substituted a-Cyclopentane Amino Acids, Tetrahedron Lett., 1993, 34, 7953-7956.

 

200. R. P. Elliott, A. Hui, A. J. Fairbanks, R. J. Nash, B. G. Winchester, G. Way, C. Smith, R. B. Lamont, R. Storer and G. W. J. Fleet, Highly Substituted cis-b-Cyclopentane Amino Acids; an Approach to the Synthesis of Trehazolin Analogues, Tetrahedron Lett., 1993, 34, 7949-7952.

 

199. R J. Molyneux, Y. T. Pan, J. E. Tropea, A. D. Elbein, C. H. Lawyer, D. J. Hughes and G. W. J. Fleet, 2-Hydroxymethyl-3,4-dihydroxy-6-methylpyrrolidine (6-Deoxy-DMDP), an Alkaloid b-Mannosidase Inhibitor from Seed of Anglyocalyx Pynaerth, J. Nat. Prod., 1993, 56, 1356-1364.

 

198. M. Horsch, L. Hoesch, G. W. J. Fleet and D. M. Rast, Inhibition of b-N-Acetylglucosaminidase by Glycon-related Analogues of the Substrate, J. Enzyme Inhibition, 1993, 7, 47-53.

 

197. H. Ardron, T. D. Butters, F. M. Platt, M. R. Wormald, R. A Dwek, G. W. J. Fleet and G. S. Jacob, Synthesis of 1,5-Dideoxy-3-O-(a-D-mannopyranosyl)-1,5-imino-D-mannitol and 1,5-Dideoxy-3-O-(a-D-glucopyranosyl)-1,5-imino-D-mannitol: Powerful Inhibitors of Endomannosidase, Tetrahedron Asymm., 1993, 4, 2011-2024.

 

196. J. W. Burton, J. C. Son, A. J. Fairbanks, S. S. Choi, H. Taylor, D. J. Watkin, B. Winchester and G. W. J. Fleet, Anomeric Spirohydantoins of Mannofuranose: Approaches to Novel Anomeric Amino Acids by an Oxidative Ring Contraction of a-Amino-d-lactones, Tetrahedron Lett., 1993, 34, 6119-6122.

 

195. B. M. Skead, G. W. J. Fleet, J. Saunders and R. B. Lamont, Cyclic Sulphates of d-Lactones in the Synthesis of Tetrahydrofurans Tetrahydropyrans and Cyclohexanes, Tetrahedron Lett., 1993, 34, 6115-6118.

 

194. G. W. J. Fleet and B. G. Winchester, United States Patent 5,210,089, 11 May 1993, D-Rhamnono-1,5-lactam.

 

193. G. W. J. Fleet, United States Patent 5,200,523, 6 Apr 1993, Synthesis of Nojirimycin Derivatives.

 

192. J. R. Wheatley, C. J. F. Bichard, S. J. Mantell, J. C. Son, D. J. Hughes, G. W. J. Fleet and D. Brown, Acid Catalysed Transformation of a-Triflates of g- and d-Lactones into 2,5-Disubstituted Homochiral tetrahydrofurans, J .Chem. Soc., Chem. Commun., 1993, 1065-1067.

 

191. C. J. F. Bichard, I. Bruce, D. J. Hughes, A. Girdhar, G. W. J. Fleet and D. J. Watkin, Benzylidene Acetals of Heptonolactones, Tetrahedron Asymm., 1993, 4, 1579-1589.

 

190. A. J. Fairbanks, P. S. Ford, D. J. Watkin and G. W. J. Fleet, Synthesis of 1-epiHydantocidin from D-Ribose, Tetrahedron Lett., 1993, 34, 3327-3330.

 

189. G. W. J. Fleet, Sugar Lactones as Useful Starting Materials in Antibiotics and Antiviral Compounds: Chemical Synthesis and Modification, (Ed. E. Krohn, H. Kirst and H. Maas), pp. 333-342, VCH Verlagsgesechhschaft, Wienheim, 1993.

 

188.J. R. Behling, A. L. Campbell, K. A. Babiak, J. S. Ng, J. Medich, P. Farid and G. W. J. Fleet, Synthesis from D-Lyxonolactone of 1,4-Dideoxy-1,4-imino-L-arabinitol, a Glucosidase Inhibitor with in vitro Anti-viral Activity, Tetrahedron, 1993, 49, 3359-3368.

 

187.S. J. Mantell, P. S. Ford, D. J. Watkin, G. W. J. Fleet and D. Brown, 3-Hydroxymuscarines from L-Rhamnose, Tetrahedron, 1993, 49, 3343-3358.

 

186. G. W. J. Fleet, Oxidation and Reduction, Chap. 5 in Organic Reaction Mechanisms, 1991, Ed. A. C. Knipe and W. E. Watts, pp. 161-206, John Wiley, 1993.

 

185. K. A. Watson, E. P. Mitchell, L. N. Johnson, J. C. Son, C. J. F. Bichard, G W J. Fleet, P. Ford, D. J. Watkin and N. G. Oikonomakos, X-Ray Crystallographic Analysis of 2,6-Anhydro-N-methyl-D-glycero-D-ido-heptonamide; the First Example of a Simple Glucose Analogue with a Skew Boat Structure, J .Chem. Soc., Chem. Commun., 1993, 654-656.

 

184. B. Winchester, S. Al-Daher, N. C. Carpenter, I. Cenci di Bello, S. S. Choi, A. J. Fairbanks and G. W. J. Fleet, The Structural Basis of the Inhibition of Human a-Mannosidases by Azafuranose Analogues of Mannose, Biochem. J., 1993, 290, 743-749.

 

183. E. M. H. Duke, A. Hadfield. J. L. Martin, I. J. Clifton, J. Hajdu, L. N. Johnson, G. P. Reid, D. R. Trentham, I. Bruce, and G. W. J. Fleet Towards Time-Resolved Diffraction Studies with Glycogen Phosphorylase, CIBA Foundation Symposia, 1991, 161 75-90.

 

182. G. W. J. Fleet, and S. K. Namgoong, United States Patent 5,153,325, 6 October 1992, Fucosidase Inhibitor

 

181. G. W. J. Fleet, and I. Bruce, United States Patent 5,136,036, 4 August 1992, Synthesis of Mannojirimycin Derivatives.

 

180. G. W. J. Fleet, and I. Bruce, United States Patent 5,101,027, 31 March 1992, Synthesis of Mannojirimycin Derivatives.

 

179. G. W. J. Fleet, and S. K. Namgoong, United States Patent 5,100,797, 31 March 1992, Novel Fucosidase Inhibitors.

 

178. G. W. J. Fleet, and S. K. Namgoong, United States Patent 5,096,909 , 17 March 1992, Fucosidase Inhibitor.

 

177. G. W. J. Fleet, T. W. Rademacher, and R A Dwek, United States Patent 5,089,520, 18 February 1992, Method of Inhibiting Virus.

 

176. C. A. Collyer, J. D. Goldberg, H. Viehmann, D. M. Blow, N. G. Ramsden, G. W. J. Fleet, F. J. Montgomery and P. Grice, Anomeric Specificity of D-Xylose Isomerase, Biochemistry, 1992, 31, 12211-12218.

 

175. I. Bruce, G. W. J. Fleet, I. Cenci di Bello and B. Winchester,, Iminoheptitols as Glycosidase Inhibitors: Synthesis of a-Homomannojirimycin, 6-epi-a-Homomannojirimycin and of a Highly Substituted Pipecolic Acid, Tetrahedron, 1992, 48, 10191-10200.

 

174. P. M. Myerscough, A. J. Fairbanks, A. H. Jones, S.-S. Choi, G. W. J. Fleet, S. S. Al-Daher, I. Cenci di Bello and B. Winchester, Inhibition of some a-Mannosidases by Seven Carbon Sugars: Synthesis of Some Seven Carbon Analogues of Mannofuranose, Tetrahedron, 1992, 48, 10177-10190.

 

173. S. J. Mantell, G. W. J. Fleet, and D. Brown, A Practical Synthesis of (+)-Muscarine from L-Rhamnose, J. Chem. Soc., Perkin Trans. 1, 1992, 3023-3028

 

172. S. S. Choi, P. M. Myerscough, A. J. Fairbanks, B. M. Skead, C. J. F. Bichard, S. J. Mantell, G. W. J. Fleet, J. Saunders and D. Brown, The Ring Contraction of d-Lactones with Leaving Group a-Substituents: a Strategy for the Synthesis of 2,5-Disubstituted Highly Substituted Homochiral Tetrahydrofurans, J. Chem. Soc., Chem. Commun., 1992, 1605-1607.

 

171. B. Winchester and G. W. J. Fleet, Amino-sugar Inhibitors: Versatile Tools for Glycobiologists, Glycobiology, 1992, 2, 199-210.

 

170. S. J. Mantell, G. W. J. Fleet, and D. Brown, 3R-Hydroxymuscarine from L-Rhamnose without Protection, Tetrahedron Lett., 1992, 33, 4503-4506

 

169. A. J. Fairbanks, N. C. Carpenter, G. W. J. Fleet, N. G. Ramsden, I. Cenci de Bello, B. G. Winchester, S. S. Al-Daher, and G. Nagahashi, Synthesis of, and Lack of Inhibition of a Rhamnosidase by, Both Enantiomers of Deoxyrhamnojirimycin and Rhamnonolactam: b-Mannosidase Inhibition by d-Lactams, Tetrahedron, 1992, 48, 3365-3376.

 

168. G. W. J. Fleet, Oxidation and Reduction, Chap. 5 in Organic Reaction Mechanisms, 1990, Ed. A. C. Knipe and W. E. Watts, John Wiley, 1992, 179-237.

 

167. B. Woynarowska, H. Wilkiel, M. Sharma, N. Carpenter, G. W. J. Fleet and R. J. Bernacki, Inhibition of Human Ovarian Carcinoma Cell- and Hexoseaminidase- Mediated Degradation of Extra Cellular Matrix by Sugar Analogues, Anticancer Res., 1992, 12, 161-166.

 

166. G. W. J. Fleet, European Patent 417,060, 13 March 1991, Bicyclic Tetrahydroxypyrrolizidine.

 

165. G. W. J. Fleet and S. K. Namgoong, European Patent 406,812, 23 January 1991, Novel Fucosidase Inhibitor 2,6-Imino-2,6,7-Trideoxy-D-glycero-D-glucoheptitol.

 

164. G. W. J. Fleet and S. K. Namgoong, European Patent 406,211, 2 January 1991, C-Alkyldeoxymannojirimycins as Fucosidase Inhibitors

 

163. G. W. J. Fleet, United States Patent 5,075,457, December 24 1991, Synthesis of Swainsonine and Analogs Thereof.

 

162. G. W. J. Fleet , United States Patent 5,075,448, December 24 1991, Synthesis of Swainsonine and Analogs Thereof.

 

161. G. W. J. Fleet , United States Patent 5,058,423, November 26 1991, Bicylic Tetrahydroxyyrrolizidine.

 

160. G. W. J. Fleet, T. W. Rademacher, and R A Dwek, United States Patent 5,043,416, August 27 1991, Method of Inhibiting Virus.

 

157. G. W. J. Fleet, B. Winchester and N. M. Carpenter, United States Patent 5,041,555, August 20 1991, Derivatives of 1,4-Dideoxy-1,4-imino-D-mannitol and Preparation Thereof.

 

156. G. W. J. Fleet , United States Patent 5,026,870, June 25 1991, Method of Preparing Bicylic Tetrahydroxylated Pyrrolizidines.

 

155. G. W. J. Fleet , United States Patent 5,025,098, June 18 1991, Method of Preparing Bicyclic Tetrahydroxylated Pyrrolizidines.

 

154. G. W. J. Fleet, United States Patent 5,023,340, June 11 1991, Preparation of Swainsonine and Ring Contracted Analogues Thereof from 4,5-Anhydro-1-azido-1-deoxy-2,3-O-isopropylidene-D-talitol.

 

153. G. W. J. Fleet and I. Bruce, United States Patent 5,021,562, June 4 1991, Method for Azide Displacement of a-Triflates of 1,5-Lactones.

 

152. G. W. J. Fleet and S. K. Namgoong, United States Patent 5,017, 704 , May 21 1991, Fucosidase Inhibitor

 

151. G. W. J. Fleet and D. R. Witty, United States Patent 5,013,842, May 7 1991, Synthesis of Chiral Pyrrolidine and Piperidine Glycosidase Inhibitors.

 

150. G. W. J. Fleet and I. Bruce, United States Patent 5,011,929, April 30 1991, Synthesis of Mannojirimycin Derivatives.

 

149. G. W. J. Fleet, T. W. Rademacher, and R A Dwek, United States Patent 4,999,360, March 12 1991, Method of Inhibiting Virus.

 

148. G. W. J. Fleet, B. Winchester and N. M. Carpenter, United States Patent 4,996,329, February 26 1991, Derivatives of 1,4-Dideoxy-1,4-imino-D-mannitol and a Process for their Preparation.

 

147. G. W. J. Fleet, United States Patent 4,994,572, February 19 1991, Synthesis of Nojirimycin Derivatives.

 

146. G. W. J. Fleet, United States Patent 4,992,460, February 12 1991, Preparation of Bicyclic Tetrahydroxylated Pyrrolizidines as Glycosidase Inhibitors.

 

145. N. G. Ramsden, G. W. J. Fleet and S. K. Namgoong, Interception of an Iminium Ion Equivalent by Intramolecular Nucleophilic Attack By a Silyl Ether During Lithium Aluminum Hydride Reduction of a Tertiary Lactam, J. Chem. Soc., Perkin Trans. 2, 1991, 1991.

 

144. S. J. Mantell, G. W. J. Fleet, and D. Brown, (+)-Muscarine from L-Rhamnose, J. Chem. Soc., Chem. Commun., 1991, 1563.

 

143. S. Choi, I. Bruce, A. J. Fairbanks, G. W. J. Fleet, A. H. Jones, R. J. Nash and L. E. Fellows, Synthesis of Alexines from Heptonolactones, Tetrahedron Lett., 1991, 32, 5517.

 

142. R. P. Elliott, G. W. J. Fleet, L. Pearce, C. Smith and D. J Watkin, A Reductive Aldol Strategy for the Synthesis of Very Highly Substituted Cyclopentanes from Sugar Lactones, Tetrahedron Lett., 1991, 32, 6227.

 

141. Martin, J. L., Veluraja, K., Johnson, L. N., Fleet, G. W. J., Ramsden, N. G., Bruce, I., Orchard, M. G., Oikonomakos, N. G., Papgeorgiou, A. C., Leonodas, D. D., and Tsitoura, H. S., Glucose Analogue Inhibitors of Glycogen Phosphorylase: The Design of Potential Drugs for Diabetes, Biochemistry, 1991, 30, 10101-10116.

 

140. Bichard, C. J. F., Fairbanks, A. J., Fleet, G. W. J., Ramsden, N. G., Vogt, K., Doherty, O., Pearce, L., and Watkin, D. J., Acetonides of a-Hydroxy-d-lactones, Tetrahedron: Asymm., 1991, 2, 901-912.

 

139. Beacham, A. R., Bruce, I., Choi, S., Doherty, O., Fairbanks, A. J., Fleet, G. W. J., Skead, B. M., Peach, J. M., Saunders, J., and Watkin, D. J., Acetonides of Heptonolactones: Powerful Chirons, Tetrahedron: Asymm., 1991, 2, 883-900.

 

138. T. D. Butters, P. Scudder, S. Petursson, G. W. J. Fleet, F. W. Willenbrock, J. Rotsaert and G. S. Jacob, Purification to Homogeneity of Charonia lampas a-Fucosidase Using Sequential Ligand Affinity Chromatography, Biochem. J., 1991, 279, 189-195.

 

137. R. J. Nash, L. E. Fellows, A. M. Scofield, G. W. J. Fleet, Alexine and Related Polyhydroxylated Alkaloids, pp 169-174 in "Poisonous Plants - Proc 3rd Int. Symp.," Ed L. F. James, R. F. Keeler, E. M. Bailey, P. R. Cheeke, and M. P. Hegarty, Iowa State University Press, Ames, Iowa, 1991.

 

136. G. W. J. Fleet, Sugar Lactones as Surprisingly Versatile Chirons, pp. 73-88, Plenarias 23 Reunion Bienal de la Socieded Espanola de Quimica, Ed. San Feliciano, A., Grande, M., and Casado, J., Universidad de Salamanca, 1991.

 

135. S. Choi, D.R. Witty, G. W. J. Fleet, P. L. Myers, R Storer, C. J. Wallis, D. Watkin and L. Pearce, Approach to Oxetane and Furan Nucleosides with an Anomeric Carbon Substituent: Nucleophilic Substitution at Highly Hindered a-Bromo-oxetane- and -Tetrahydrofuran-Carboxylates, Tetrahedron Lett., 1991, 32, 3569.

 

134. A. C. de S. Pereira, M. A. C. Kaplan, J. G. S. Maia, O. R. Gottlieb, R. J. Nash, G. Fleet, L. Pearce, D. J Watkin and A. M. Scofield, Isolation of 7a-Epialexaflorine from leaves of Alexa grandiflora; a unique pyrrolizidine amino acid with a carboxylic acid substituent at C-3, Tetrahedron, 1991, 47, 5637.

 

133. Y. Wang, G. W. J. Fleet, F. X. Wilson, R. Storer, P. L. Myers, C. J. Wallis, O. Doherty, D. J. Watkin, K. Vogt, D. R. Witty and J. M. Peach, Oxetane Nucleosides with Fluorine and Azide Substituents: Nucleophilic Displacements on an Oxetane Ring, Tetrahedron Lett., 1991, 32, 1675-1679.

 

132. G. W. J. Fleet, Oxidation and Reduction, Chap. 5 in Organic Reaction Mechanisms, 1989, Ed. A. C. Knipe and W. E. Watts, John Wiley, 1991.

 

131. G. W. J. Fleet, J. A. Seijas and M. P. Vzquez-Tato, Synthesis of the Necine Base Platynecine from Glucose, Tetrahedron, 1991, 47, 525-529..

 

130.A. J. Fairbanks, G. W. J. Fleet, A. H. Jones, I. Bruce, S. Al Daher, I. Cenci di Bello, B. Winchester, Synthesis from a Heptonolactone and Effect on Glycosidases of (1S,2R,6R,7S)-1,2,6,7-Tetrahydroxypyrrolizidine, Tetrahedron, 1991, 47, 131-138.

 

129. G. W. J. Fleet and I. Bruce, European Patent 398,857, 22 November 1990, Method of Displacement of alpha triflates of 1,5-lactones.

 

128. A. L. Campbell, J. R. Behling, K. A. Babiak, J. S. Ng, R. A. Mueller and G. W. J. Fleet, United States Patent 4,910,310, March 20 1990, Synthesis of N-Substituted 1,5-Imino-L-fucitol Derivatives as HIV Inhibitors.

 

127. G. W. J. Fleet, United States Patent 4,894,388, January 16, 1990, Dideoxyiminoallitols as Liver Glycosidase Inhibitors and Use Thereof.

 

126. F. X. Wilson, G. W. J. Fleet, K. Vogt, Y. Wang, D. R. Witty, R. Storer, P. L. Myers, C. J. Wallis, Synthesis of oxetanocin, Tetrahedron Lett., 1990, 31, 6931-6934.

 

125. D. R. Witty, G. W. J. Fleet, S. Choi, K. Vogt, F. X. Wilson, Y. Wang, R. Storer, P. L. Myers, C. J. Wallis, Ring Contraction of 3-Deoxy-2-O-trifluoromethanesulphonates of a-Hydroxy-g-lactones to oxetanes, Tetrahedron Lett., 1990, 31, 6927-6930.

 

124. R. P. Elliott, G. W. J. Fleet, K. Vogt, F. X. Wilson, Y. Wang, D. R. Witty, R. Storer, P. L. Myers, C. J. Wallis, Attempted Ring Contraction of a-Triflates of 3-Azido- and 3-Fluoro-g-Lactones to Oxetanes, Tetrahedron: Asymm., 1990, 1, 715-718.

 

123. Y. Wang, G. W. J. Fleet, R. Storer, P. L. Myers, C. J. Wallis, O. Doherty, D. J. Watkin, K. Vogt, D. R. Witty, F. X. Wilson, J. M. Peach, Synthesis of the Potent Antiviral Oxetane Nucleoside Epinoroxetanocin from D-Lyxonolactone, Tetrahedron: Asymm., 1990, 1, 527-530.

 

122. F. X. Wilson, G. W. J. Fleet, D. R. Witty, K. Vogt, Y. Wang, R. Storer, P. L. Myers, C. J. Wallis, Synthesis of the Oxetane Nucleosides a- and b-Noroxetanocin, Tetrahedron: Asymm., 1990, 1, 525-526.

 

121. D. R. Witty, G. W. J. Fleet, K. Vogt, F. X. Wilson, Y Wang, R. Storer, P. L. Myers, C. J. Wallis, Ring Contraction of 2-O-Trifluoromethanesulphonates of a-Hydroxy-g-lactones to Oxetane Carboxylic Esters, Tetrahedron Lett., 1990, 31, 4787-4790.

 

120. P. Scudder, D. C. A. Neville, T. D. Butters, G. W. J. Fleet, R. A. Dwek, T. W. Rademacher, G. S. Jacob, The Isolation by Ligand-Affinity Chromatography of a Novel Form of a-L-Fucosidase from Almond, J. Biol. Chem., 1990, 265, 16472-16477.

 

119. G. W. J. Fleet, L. E. Fellows, and B. Winchester, Plagiarizing Plants: Aminosugars as a Class of Glycosidase Inhibitors, In: Bioactive Compounds from Plants, p 112-125, Wiley, Chichester (Ciba Found. Symp 154), 1990.

 

118. G. W. J. Fleet, N. G. Ramsden, R. J. Nash, L. E. Fellows, G. S. Jacob, I. Cenci di Bello, and B. Winchester, Synthesis of the Enantiomers of 6-Epicastanospermine and 1,6-Diepicastanospermine from D- and L-Gulonolactone, Carbohydr. Res , 1990, 205, 269-282.

 

 

117. R. P. Elliott, G. W. J. Fleet, Y. S. Gyoung, N. G. Ramsden and C. Smith, High Yield Reduction of 2-O-Trifluoromethanesulphonate Esters of a-Hydroxylactones to the Corresponding 2-Deoxylactones by Lithium Iodide Trihydrate, Tetrahedron Lett., 1990, 31, 3785-3788.

 

116. G. Nagahashi, S.-I. Tu, G. W. J. Fleet, S. K. Namgoong, Inhibition of Cell-wall Associated Enzymes in vitro and in vivo with Sugar Analogues, Plant Physiology, 1990, 92, 413-418.

 

115. B. G. Winchester, I. Cenci di Bello, A. C. Richardson, R. J. Nash, L. E. Fellows, N. G. Ramsden, and G. Fleet, The Structural Basis of the Inhibition of Human Glycosidases by Castanospermine Analogues, Biochem. J., 1990, 269, 227-231.

 

114. Fleet, G. W. J., Collin, W. F., Haraldsson, M., Cenci di Bello, I., and Winchester, B., Effect on Human Liver Glycosidases and Short Syntheses of 1a,2a,6a,7a,7a-1,2,6,7-Tetrahydroxypyrrolizidine from D-glycero-D-gulo-Heptono-1,4-lactone, Carbohydr. Res., 1990, 202, 105-116.

 

113. Nash, R. J., Fellows, L. E., Girdhar, A., Fleet, G. W. J., Peach, J. M., Ramsden N. G., Hegarty, M. P., Scofield, A. M., Two Alexines [3-Hydroxymethyl-1,2,7-trihydroxypyrrolizidines] from Castanospermum Australe, Phytochemistry, 1990, 29, 111-114.

 

112. Nash, R. J., Fellows, L. E., Girdhar, A., Fleet, G. W. J., Peach, J. M., Watkin, D. J., Hegarty, M. P., X-Ray Crystal Structure of the Hydrochloride of 6-Epicastanospermine [(1S,6R,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizine], Phytochemistry, 1990, 29, 1356-1358.

 

111. Axamawaty, M. T. H., Fleet, G. W. J., Hannah, K. A., Namgoong, S. K., Sinnott, M. L., Inhibition of the a-L-arabinofuranosidase III of Monilinia fructigena by 1,4-dideoxy-1,4-imino-L-threitol and 1,4-dideoxy-1,4-imino-L-arabinitol, Biochem. J., 1990, 266, 245-249.

 

110. G. W. J. Fleet, D. Witty, Synthesis of Homochiral b-Hydroxy-a-amino Acids [(2S,3R.4R)-3,4-Dihydroxyproline and (2S,3R.4R)-3,4-Dihydroxypipecolic acid] and of 1,4-Dideoxy-1,4-imino-D-arabinitol [DAB1] and Fagomine [1,5-Imino-1,2,5-trideoxy-D-arabino-hexitol], Tetrahedron: Asymm., 1990, 1, 19.

 

109. G. W. J. Fleet, N. G. Ramsden, N. M. Carpenter, S. Petursson and R. T. Aplin, Some Comments on an Allegedly "Facile Synthesis of Nojirimycin," Tetrahedron Lett., 1990, 31, 405.

 

108. G. W. J. Fleet, N. M. Carpenter, S. Petursson, and N. G. Ramsden, Synthesis of Deoxynojirimycin and of Nojirimycin d-Lactam, Tetrahedron Lett., 1990, 31, 409.

 

107. G. W. J. Fleet, Oxidation and Reduction, Chap. 5 in Organic Reaction Mechanisms, 1988, Ed. A. C. Knipe and W. E. Watts, John Wiley, 1990.

 

106. Fleet, G. W. J., Bruce, I., Girdhar, A., Haraldsson, M., Peach, J. M., Watkin, D. J., Retention and Apparent Inversion during Azide Displacement of a-Triflates of 1,5-Lactones, Tetrahedron, 1990, 46, 19.

 

105. Winchester, B., Barker, C., Baines, S., Jacob, G., Namgoong, S. K., Fleet, G. W. J., Inhibition of a-L-fucosidase by Derivatives of Deoxyfuconojirimycin and Deoxymannojirimycin, Biochem. J., 1990, 265, 277-282.

 

104. G. W. J. Fleet, United States Patent 4,861,892, August 29, 1989, Method for Synthesis of Deoxymannojirimycin

 

103. G. W. J. Fleet, T. W. Rademacher, and R A Dwek, United States Patent 4,849,430, July 18 1989, Method of Inhibiting Virus.

 

102. N. M. Carpenter, G. W. J. Fleet, I. Cenci di Bello, B. Winchester, L. E. Fellows, R. J. Nash, Synthesis of the Mannosidase Inhibitors, Swainsonine and 1,4-Dideoxy-1,4-imino-D-mannitol and of the ring contracted swainsonines, (1S, 2R, 7R, 7aR)-1,2,7-trihydroxypyrrolizidine and (1S, 2R, 7S, 7aR)-1,2,7-trihydroxypyrrolizidine, Tetrahedron Lett., 1989, 30, 7261.

 

101. I. Bruce, G. W. J. Fleet, I. Cenci di Bello, and B. Winchester, Iminoheptitols as Glycosidase Inhibitors: Synthesis of, and Mannosidase and Fucosidase Inhibition by, a-homomannojirimycin and 6-epi-homomannojirimycin, Tetrahedron Lett., 1989, 30, 7257.

 

100. G. W. J. Fleet, P. F. Daniel, D. S. Newburg, N. E. O'Neil and P. W. Smith, Comparison of the Effects of the Mannosidase Inhibitors Swainsonine and 1,4-Dideoxy-1,4-imino-D-mannitol on Glycoprotein Turnover in Cultured Macrophages, Glycoconjugate J., 1989, 6, 229.

 

99. Fleet, G. W. J., Namgoong, S. K., Barker, C., Baines, S., Jacob, G. S., Winchester, B., Iminoheptitols as Glycosidase Inhibitors: Synthesis of and Specific a-L-fucosidase Inhibition by -L-Homofuconojirimycin and 1--C-Substituted Deoxymannojirimycins, Tetrahedron Lett., 1989, 30, 4439.

 

98. G. W. J. Fleet, Synthesis of Polyhydroxylated Pyrrolidines, Piperidines and Octahydroindolizidines as Glycosidase Inhibitors, Swainsonine and Related Glycosidase Inhibitors, Chapter 28, p 382- 395, Ed. L. F. James, A. D. Elbein, R. J. Molyneux and C. D. Warren, University of Iowa Press, 1989.

 

97. I. C. di Bello, G. W. J. Fleet, J. C. Son, K. Tadano, and B. Winchester, Inhibition of Mammalian a-D-Mannosidases in vitro and in vivo by Swainsonine Analogues, Swainsonine and Related Glycosidase Inhibitors, Chapter 27, p 367-381, Ed. L. F. James, A. D. Elbein, R. J. Molyneux and C. D. Warren, University of Iowa Press, 1989.

 

96. W. McDowell, G. W. J. Fleet, L. E. Fellows and R. T. Schwarz, Manipulation of the Oligosaccharide Composition of Influenza Virus and Sindbis Virus Glycoproteins with Glycosidase Inhibitors, Swainsonine and Related Glycosidase Inhibitors, Chapter 17, p 220-230, Ed. L. F. James, A. D. Elbein, R. J. Molyneux and C. D. Warren, University of Iowa Press, 1989.

 

95. G. W. J. Fleet, I. C. di Bello, S. A. Daher, S. K. Namgoong, J. C. Son, K. Tadano and B. Winchester, Inhibition of Human a-Mannosidases in vitro and in vivo by Swainsonine Analogues, Biochem. J., 1989, 259, 855.

 

94. Woynarowska, B., Wikiel, H., Sharma, M., Fleet, G. W. J., Bernacki, R. J., Inhibition of Tumour Cell-mediated Degradation of Extracellular Matrix, Proc. Amer. Assoc. Cancer Res., 1989, 30, 91.

 

93. G. W. J. Fleet, Oxidation and Reduction, Chap. 5 in Organic Reaction Mechanisms, 1987, ed. A. C. Knipe and W. E. Watts, John Wiley, 1989.

 

92. G. W. J. Fleet, C. J. Mathews, J. A. Seijas, M. P. V. Tato, P. D. Baird and D. Brown, Complex Quinuclidines from Sugars: Synthesis of (1a,3a,4a,5a)-quinuclidin-3,5-diol from D-Glucose, J. Chem. Soc., Perkin Trans. 1, 1989, 1067.

 

91. G. W. J. Fleet, C. J. Mathews, J. A. Seijas, M. P. V. Tato and D. Brown, Chiral Quinuclidines from Sugars: Synthesis of (3S,5S)-Quinuclidin-3,5-diol from D-Arabinose, J. Chem. Soc., Perkin Trans. 1, 1989, 1065.

 

90. G. W. J. Fleet, Synthesis of Highly Functionalised Homochiral Compounds from Sugars, Chem. in Brit., 1989, 25, 287.

 

89. G. W. J. Fleet, J. M. Brown, S. G. Davies and A. J. Pratt, Enantiomerically Pure Compounds: Meeting the Synthetic Challenge, Chem. in Brit., 1989, 25, 259.

 

88. G. W. J. Fleet, S. A. Daher, S. K. Namgoong and B. Winchester, Changes in Specificity of Glycosidase inhibition by N-Alkylation of aminosugars, Biochem. J., 1989, 258, 613.

 

87. G. W. J. Fleet, S. Petursson, A. Campbell, R. A. Mueller, J. R. Behling, K. A. Babiak, J. S. Ng and M. G. Scaros, Short Efficient Synthesis of the a-L-Fucosidase Inhibitor, Deoxyfuconojirimycin [1,5-Dideoxy-1,5-imino-L-fucitol] from D-Lyxonolactone, J. Chem. Soc., Perkin Trans. 1, 1989, 665.

 

86. G. W. J. Fleet, N. G. Ramsden and D. R. Witty, A Practical Synthesis of Deoxymannojirimycin and of (2S,3R,4R,5R)-3,4,5-Trihydroxypipecolic Acid from D-Glucose, Tetrahedron, 1989, 45, 327.

 

85. G. W. J. Fleet, N. G. Ramsden and D. R. Witty, Practical synthesis of Deoxymannojirimycin and Mannonolactam from L-Gulonolactone. Synthesis of L-Deoxymannojirimycin and L-Mannonolactam from D-Gulonolactone, Tetrahedron, 1989, 45, 319.

 

84. G. W. J. Fleet, G. C. Kite, L. E. Fellows, P. S. Liu, A. M. Scofield and N. G. Smith, a-Homonojirimycin [2,6-Dideoxy-2,6-imino-D-glycero-L-gulo-heptitol] from Omphalea diandra L.: Isolation and Glucosidase Inhibition, Tetrahedron Lett., 1988, 29, 6483.

 

83. G. W. J. Fleet, M. Haraldsson, R. J. Nash and L. E. Fellows, Synthesis from D-Glucose of Alexine [(1R,2R,3R,7S,8S)-3-Hydroxymethyl-1,2,7-trihydroxypyrrolizidine], 3-Epialexine and 7-Epialexine, Tetrahedron Lett., 1988, 29, 5441.

 

82. G. W. J. Fleet, A. Karpas, R. A. Dwek, S. Petursson, S. K. Namgoong, G. S. Jacob and T. W. Rademacher, Aminosugar Derivatives as Potential Anti-HIV Agents, Proc. Natl. Acad. Sci. US, 1988, 85, 9229.

 

81. G. W. J. Fleet, A. Karpas, R. A. Dwek, L. E. Fellows, A. S. Tyms, S. Petursson, S. K. Namgoong, N. G. Ramsden, P. W. Smith, J. C. Son, F. X. Wilson, D. R. Witty, G. S. Jacob and T. W. Rademacher, Inhibition of HIV Replication by Aminosugar Derivatives, FEBS Lett., 1988, 237, 128.

 

80. G. W. J. Fleet, R. J. Nash, L. E. Fellows, A. C. Plant, A. E. Derome, P. D. Baird, M. P. Hegarty and A. M. Scofield, Isolation from Castanospermum australe and X-Ray Crystal Structure of 3,8-Diepialexine, (1R,2R,3S,7S,8R)-3-Hydroxymethyl-1,2,7-trihydroxypyrrolizidine [(2S,3R,4R,5S,6R)-2-Hydroxymethyl-1-azabicyclo[3.3.0]octan-3,4,6-triol], Tetrahedron, 1988, 44, 5959.

 

79. G. W. J. Fleet and L. E. Fellows, Alkaloidal Glycosidase Inhibitors from Plants, Chap. 13 in Natural Product Isolation, (ed. G. H. Wagman and R. Cooper), p.540-560, Elsevier, 1988.

 

78. G. W. J. Fleet, R. G. Compton, R. J. Northing, J. C. Son and B. P. Bashyal, A Modified Electrode for the Electrochemical Reduction of Isoflurane, Clin. Phys. Physiol. Meas., 1988, 9, 133.

 

77. G. W. J. Fleet, N. G. Ramsden, R. J. Molyneux and G. S. Jacob, Synthesis of 6-Epicastanospermine and 1,6-Diepicastanospermine from L-Gulonolactone and Synthesis of L-6-Epicastanospermine and L-1,6-Diepicastanospermine from D-Gulonolactone, Tetrahedron Lett., 1988, 29, 3603.

 

76. G. W. J. Fleet, N. G. Ramsden and D. R. Witty, Short Syntheses of D-Deoxymannojirimycin and D-Mannonolactam from L-Gulonolactone and of L-Deoxymannojirimycin and L-Mannonolactam from D-Gulonolactone, Tetrahedron Lett., 1988, 29, 2871.

 

75. G. W. J. Fleet, L. E. Fellows, R. J. Nash, J. V. Dring, A. E. Derome, T. A. Hamor, A. M. Scofield and D. J. Watkin, Isolation from Alexa Leiopetala and X-Ray Crystal Structure of Alexine, (1R,2R,3R,7S,8S)-3-Hydroxymethyl-1,2,7-trihydroxypyrrolizidine [(2R,3R,4R,5S,6S)-2-Hydroxymethyl-1-azabicyclo[3.3.0]-octan-3,4,6-triol], a Unique Pyrrolizidine Alkaloid, Tetrahedron Lett., 1988, 29, 2487.

 

74. G. W. J. Fleet, R. G. Compton, R. J. Northing, A. M. Waller, J. C. Son and B. P. Bashyal, The Electroreduction of the Anaesthetic Gas Isoflurane, J. Electroanalytical Chem., 1988, 244, 203.

 

73. G. W. J. Fleet, Amino Sugar Derivatives and Related Compounds as Glycosidase Inhibitors, Topics in Medicinal Chemistry, 4th SCI-RSC Med. Chem. Symp., Cambridge, September 1987, (Ed. P. R. Leeming), p.149-162, Royal Society of Chemistry, London, 1988.

 

72. G. W. J. Fleet, J. C. Son, D. St. C. Green, I. C. di Bello and B. Winchester, Synthesis from D-Mannose of 1,4-Dideoxy-1,4-imino-L-ribitol and of the a-Mannosidase Inhibitor 1,4-Dideoxy-1,4-imino-D-talitol, Tetrahedron, 1988, 44, 2649.

 

71. G. W. J. Fleet and J. C. Son, Polyhydroxylated Pyrrolidines from Sugar Lactones: Synthesis of 1,4-Dideoxy-1,4-imino-D-glucitol from D-Galactonolactone and Syntheses of 1,4-Dideoxy-1,4-imino-D-allitol, 1,4-Dideoxy-1,4-imino-D-ribitol and (2S,3R,4S)-3,4-Dihydroxyproline from D-Gulonolactone, Tetrahedron, 1988, 44, 2637.

 

70. G. W. J. Fleet, J. A. Seijas and M. P. V. Tato, Synthesis of cis- and trans-1-Amino-3-hydroxymethyl-cyclobutane-1-carboxylic acids, Tetrahedron, 1988, 44, 2077.

 

69. G. W. J. Fleet, J. C. Son, K. Vogt, J. M. Peach and T. A. Hamor, Reaction of Adenine with an a-Chlorooxetane: an Approach to the Synthesis of Oxetane Nucleosides, Tetrahedron Lett., 1988, 29, 1451.

 

68. G. W. J. Fleet, J. C. Son, J. M. Peach and T. A. Hamor, Synthesis and X-Ray Crystal Structure of a Stable a-Chlorooxetane, Tetrahedron Lett., 1988, 29, 1449.

 

67. G. W. J. Fleet, N. G. Ramsden, R. A. Dwek, T. W. Rademacher, L. E. Fellows, R. J. Nash, D. St. C. Green and B. Winchester, d-Lactams: Synthesis from D-Glucose and Preliminary Evaluation as a Fucosidase Inhibitor of L-Fuconic-d-lactam, J. Chem. Soc., Chem. Commun., 1988, 483.

 

66. G. W. J. Fleet, J. C. Son and A. E. Derome, Methyl 5-O-tert-Butyldiphenylsilyl-2-deoxy- a-D-threo-pentofuranoside as a Divergent Intermediate for the Synthesis of 3'-Substituted-2',3'-dideoxynucleosides: Synthesis of 3'-Azido-3'-deoxythymidine, 3'-Deoxy-3'-fluorothymidine and 3'-Cyano-3'-deoxythymidine, Tetrahedron, 1988, 44, 625.

 

65. G. W. J. Fleet, Oxidation and Reduction, Chap. 5 in Organic Reaction Mechanisms, 1986, ed. A. C. Knipe and W. E. Watts, John Wiley, 1988.

 

64. G. W. J. Fleet, G. N. Austin, J. M. Peach, K. Prout, and J. C. Son, Chiral Oxetanes from Sugar Lactones: Synthesis of Derivatives of 3,5-Anhydro-1,2-O-isopropylidene- a-D-glucuronic Acid and of 3,5-Anhydro-1,2-O-isopropylidene--L-iduronic Acid, Tetrahedron Lett., 1987, 28, 4741.

 

63. G. W. J. Fleet, R. T. Aplin and R. R. Dixon, Application of FAB and Thermospray to Structure Determination of w-Carboxy-a-amino Acids, Proc. 35 ASMS Conf. on Mass Spec. and Allied Topics, p. 479, Denver, Colorado, May 1987.

 

62. G. W. J. Fleet, J. C. Dho, J. M. Peach, K. Prout and P. W. Smith, Synthesis of 2R,3S,4S-Dihydroxyproline from D-Ribonolactone; an Approach to the Synthesis of Polyfunctionalised D-Amino Acids from Sugar Lactones. X-Ray Crystal Structures of 2-Azido-3,4-O-(R)-benzylidene-2-deoxy-D-ribono-1,5-lactone, 2-Azido-2-deoxy-D-ribono-1,4-lactone, and 2R,3S,4R-3,4-Dihydroxyproline, J. Chem. Soc., Perkin Trans. 1, 1987, 1785.

 

61. G. W. J. Fleet and J. C. Son, Methyl 5-O-tert-Butyldiphenylsilyl-2-deoxy-a-D-threo-pentofuranoside; an Approach to the Synthesis of 3'-Substituted-2',3'-dideoxynucleosides including 3'-Azido-3'-deoxythymidine and of 3'-Substituted-2',3'-dideoxy-C-nucleosides, Tetrahedron Lett., 1987, 28, 3615.

 

60. G. W. J. Fleet, G. N. Austin, P. D. Baird, J. M. Peach, P. W. Smith and D. J. Watkin, 3,6-Dideoxy-3,6-imino-1,2-O-isopropylidene-a-D-glucofuranose as a Divergent Intermediate for the Synthesis of Hydroxylated Pyrrolidines: Synthesis of 1,4-Dideoxy-1,4-imino-L-gulitol, 1,4-Dideoxy-1,4-imino-D-lyxitol, 2S,3S,4R-3,4-Dihydroxyproline and (1S,2R,8S,8aR)-1,2,8-Trihydroxyoctahydroindolizine [8-epi-Swainsonine]. X-Ray Crystal Structure of (1S,2R,8S,8aR)-1,2,8-Trihydroxy-5-oxo-octahydroindolizine, Tetrahedron, 1987, 43, 3095.

 

59. G. W. J. Fleet, B. P. Bashyal, M. J. Gough and P. W. Smith, Synthesis of the a-Mannosidase Inhibitors Swainsonine [(1S, 2R, 8R, 8aR)-1,2,8-Trihydroxyoctahydroindolizine] and 1,4-Dideoxy-1,4-imino-D-mannitol from Mannose, Tetrahedron, 1987, 43, 3083.

 

58. G. W. J. Fleet and L. C. Seymour, Synthesis of Intermediates for Stereospecific Synthesis of a- and -C-Nucleosides: Ring Contraction of Protected 2-O-Trifluoromethanesulphonates of Galacto- and Altro-Pyranosides, Tetrahedron Lett., 1987, 28, 3015.

 

57. G. W. J. Fleet, G. N. Austin, P. D. Baird, H.-F. Chow, L. E. Fellows, R. J. Nash, J. M. Peach, R. J. Pryce and C. H. Stirton, Isolation from Atelia Herbert-smithii (Sophorae, Leguminosae) and X-Ray Structure of cis-1-Amino-3-hydroxymethyl-cyclobutane-1-carboxylic acid, an Achiral Non-protein Amino Acid, Tetrahedron, 1987, 43, 1857.

 

56. G. W. J. Fleet, L. E. Fellows and P. W. Smith, Synthesis of Deoxymannojirimycin, Fagomine, Deoxynojirimycin, 2-Acetamido-1,5-imino-1,2,5-trideoxy-D-mannitol, 2-Acetamido-1,5-imino-1,2,5-trideoxy-D-glucitol, 2S,3R,4R,5R-Trihydroxypipecolic Acid and 2S,3R,4R,5S-Trihydroxypipecolic Acid from Methyl 3-O-Benzyl-2,6-dideoxy-2,6-imino-a-D-mannofuranoside, Tetrahedron, 1987, 43, 979.

 

55. G. W. J. Fleet and P. W. Smith, Methyl 2-Azido-3-O-benzyl-2-deoxy-a-D-mannofuranoside as a Divergent Intermediate for the Synthesis of Polyhydroxylated Piperidines and Pyrrolidines: Synthesis of 2,5-Dideoxy-2,5-imino-D-mannitol [2R,5R-Dihydroxymethyl-3R,4R-dihydroxypyrrolidine], Tetrahedron, 1987, 43, 971.

 

54. G. W. J. Fleet, B. P. Bashyal and H.- F. Chow, Synthesis of 2S,4S,5S-Dihydroxypipecolic Acid and Bulgecinine [2S,4S,5R-4-Hydroxy-5-(hydroxymethyl)proline]; a Strategy for the Synthesis of 2S,4S-4-Hydroxy-a-amino Acids, Tetrahedron, 1987, 43, 423.

 

53. G. W. J. Fleet, B. P. Bashyal, H.- F. Chow and L. E. Fellows, The Synthesis of Polyhydroxylated Amino Acids from Glucuronolactone: Enantiospecific Syntheses of 2S,3R,4R,5S-Trihydroxypipecolic Acid, 2R,3R,4R,5S-Trihydroxypipecolic Acid and 2R,3R,4R-Dihydroxyproline, Tetrahedron, 1987, 43, 415.

 

52. G. W. J. Fleet, Oxidation and Reduction, Chap. 5 in Organic Reaction Mechanisms, 1985, ed. A. C. Knipe and W. E. Watts, John Wiley, 1987.

 

51. G. W. J. Fleet and P. W. Smith, The Synthesis from D-Xylose of the Potent and Specific Enantiomeric Glucosidase Inhibitors, 1,4-Dideoxy-1,4-imino-D-Arabinitol and 1,4-Dideoxy-1,4-imino-L-Arabinitol, Tetrahedron, 1986, 42, 5685.

 

50. G. W. J. Fleet, A. M. Scofield, L. E. Fellows and R. J. Nash, Inhibition of Mammalian Digestive Disaccharidases by Polyhydroxy Alkaloids, Life Sci., 1986, 39, 645.

 

49. G. W. J. Fleet, B. P. Bashyal, and H.-F. Chow, Enantiospecific Syntheses of 2S,3R,4R,5S-Trihydroxypipecolic Acid, 2R,3R,4R,5S-Trihydroxypipecolic Acid, 2S,4S,5S-Dihydroxypipecolic Acid, and Bulgecinine from D-Glucuronolactone, Tetrahedron Lett., 1986, 27, 3205.

 

48. G. W. J. Fleet, J. C. Dho, J. M. Peach, K. Prout and P. W. Smith, Synthesis of 2R,3S,4R-Dihydroxyproline from D-Ribonolactone, Tetrahedron Lett., 1986, 27, 3203.

 

47. G. W. J. Fleet, K. James, R. J. Lunn and C. J. Mathews, An Enantiospecific Synthesis of S-Quinuclidinol from D-Glucose, Tetrahedron Lett., 1986, 27, 3057.

 

46. G. W. J. Fleet, K. James and R. J. Lunn, Enantiospecific Synthesis of S-Quinuclidinol from D-Glucose: a Strategy for the Synthesis of Chiral Quinuclidines, Tetrahedron Lett., 1986, 27, 3053.

 

45. G. W. J. Fleet, P. W. Smith, R. J. Nash, L. E. Fellows, R. B. Parekh and T. W. Rademacher, Synthesis of 2-Acetamido-1,5-imino-1,2,5-trideoxy-D-mannitol and of 2-Acetamido-1,5-imino-1,2,5-trideoxy-D-glucitol, a Potent and Specific Inhibitor of a Number of -N-Acetylglucosaminidases, Chem. Lett., 1986, 1051.

 

44. G. W. J. Fleet, Oxidation and Reduction, Chap. 5 in Organic Reaction Mechanisms, 1984, p. 179, ed. A. C. Knipe and W. E. Watts, John Wiley & Son, 1986

 

43. G. W. J. Fleet, G. Palamartczky, M. Mitchell, P. W. Smith and A. D. Elbein, 1,4-Dideoxy-1,4-imino-D-mannitol Inhibits Glycoprotein Processing and Mannosidase I, Arch. Biochem. Biophys., 1985, 242, 35.

 

42. G. W. J. Fleet, S. V. Evans, T. K. M. Shing, R. T. Aplin and L. E. Fellows, Novel Sulphate Ester of trans-4-Hydroxypipecolic Acid, Phytochemistry, 1985, 24, 2593.

 

41. G. W. J. Fleet, S. V. Evans, L. E. Fellows and T. K. M. Shing, Glycosidase Inhibition by Plant Alkaloids which are Structural Analogues of Monosaccharides, Phytochemistry, 1985, 24, 1953.

 

40. G. W. J. Fleet, An Alternative Proposal for the Mode of Inhibition of Glycosidase Activity by Polyhydroxylated Piperidines, Pyrrolidines and Indolizidines, Tetrahedron Lett., 1985, 26, 5073

 

39. G. W. J. Fleet, S. J. Nicholas, P. W. Smith, S. V. Evans, L. E. Fellows and R. J. Nash, Potent Competitive Inhibition of a-Galactosidase and -Glucosidase Activity by 1,4-Dideoxy-1,4-iminopentitols: Syntheses of 1,4-Dideoxy-1,4-imino-D-lyxitol and of both Enantiomers of 1,4-Dideoxy-1,4-iminoarabinitol, Tetrahedron Lett., 1985, 26, 3127.

 

38. G. W. J. Fleet, A. N. Shaw, S. V. Evans and L. E. Fellows, Synthesis from D-Glucose of 1,5-Dideoxy-1,5-imino-L-fucitol, a Potent a-L-Fucosidase Inhibitor, J. Chem. Soc., Chem. Commun., 1985, 841.

 

37. G. W. J. Fleet, R. J. Nash, E. A. Bell, R. H. Jones and J. M. Williams, The Identification of a Hydroxylated Pyrrolidine Derivative from Castanospernum Australe, J. Chem. Soc., Chem. Commun., 1985, 738.

 

36. G. W. J. Fleet and P. W. Smith, Enantiospecific Syntheses of Deoxymannojirimycin, Fagomine and 2R,5R-Dihydroxymethyl-3R,4R-dihydroxypyrrolidine from D-Glucose, Tetrahedron Lett., 1985, 26, 1469.

 

35. G. W. J. Fleet,, S. V. Evans, A. R. Hayman, L. E. Fellows, T. K. M. Shing and A. E. Derome, Lack of Glycosidase Inhibition by, and Isolation from Xanthocercis Zambesiaca (Leguminosae) of 4-O-(-D-Glucopyranosyl)fagomine [1,2,5-Trideoxy-4-O-(-D-glucopyranosyl)-1,5-imino-D-arabino-hexitol], a Novel Glucoside of a Polyhydroxylated Piperidine Alkaloid, Tetrahedron Lett., 1985, 26, 1465.

 

34. G. W. J. Fleet, Oxidation and Reduction, Chap. 4 in Organic Reaction Mechanisms, 1983, ed. A. C. Knipe and W. E. Watts, John Wiley & Son, 1985.

 

33. G. W. J. Fleet, P. W. Smith, S. V. Evans and L. E. Fellows, Design Synthesis and Preliminary Evaluation of a Potent a-Mannosidase Inhibitor: 1,4-Dideoxy-1,4-imino-D-mannitol, J. Chem. Soc., Chem. Commun., 1984, 1240.

 

32. G. W. J. Fleet, M. J. Gough and T. K. M. Shing, Synthesis of 1,5-Dideoxy-1,5-imino-D-mannitol from D-Mannose and D-Glucose, Tetrahedron Lett., 1984, 25, 4029.

 

31. G. W. J. Fleet and T. K. M. Shing, An Approach to the Enantiospecific Synthesis of Sesbanimide and Its Enantiomer from D-Glucose, J. Chem. Soc., Chem. Commun., 1984, 835.

 

30. G. W. J. Fleet, T. K. M. Shing and S. M. Warr, Enantiospecific Synthesis of Shikimic Acid from D-Mannose: Formation of a Chiral Cyclohexene by Intramolecular Olefination of a Carbohydrate-derived Intermediate, J. Chem. Soc., Perkin Trans. 1, 1984, 905.

 

29. G. W. J. Fleet, M. J. Gough and P. W. Smith, Enantiospecific Synthesis of Swainsonine from D-Mannose, Tetrahedron Lett., 1984, 25, 1853.

 

28. G. W. J. Fleet, Oxidation and Reduction, Chap. 4 in Organic Reaction Mechanisms, 1982, ed. A. C. Knipe and W. E. Watts, John Wiley & Son, 1984.

 

27. G. W. J. Fleet, M. J. Gough and T. K. M. Shing, Enantiospecific Total Synthesis of Pseudomonic Acids from Arabinose, Tetrahedron Lett., 1983, 24, 3661.

 

26. G. W. J. Fleet and T. K. M. Shing, Enantiospecific Synthesis of (3S-Hydroxy-2S-methyl)butyltriphenylphosphonium Iodide, a Precursor for the Chiral Side Chain of Pseudomonic Acid, Tetrahedron Lett., 1983, 24, 3657.

 

25. G. W. J. Fleet and T. K. M. Shing, An Entry to Chiral Cyclohexenes from Carbohydrates: a Short Efficient and Enantiospecific Synthesis of (-)-Shikimic Acid from D-Mannose, J. Chem. Soc., Chem. Commun., 1983, 849.

 

24. G. W. J. Fleet and M. J. Gough, Enantiospecific Syntheses of Intermediates in the Total Synthesis of Pseudomonic Acids, Tetrahedron Lett., 1982, 23, 4509.

 

23. G. W. J. Fleet and C. R. C. Spensley, Model Studies on the Synthesis of Pseudomonic Acids, Tetrahedron Lett., 1982, 23, 109.

 

22. G. W. J. Fleet, Oxidation and Reduction, Chap. 4 in Organic Reaction Mechanisms, 1981, ed. A. C. Knipe and W. E. Watts, John Wiley & Son, 1982.

 

21. G. W. J. Fleet and P. J. C. Harding, Bis(triphenylphosphine)copper (I) Tetrahydroborate as a Reducing Agent, Ventron Alembic, 1981, 24.

 

20. G. W. J. Fleet, P. N. Davey and P. J. C. Harding, Preparations of, and a Comparison of the Reduction of Acid Chlorides and Carbonyl Compounds by, Bis(triphenylphosphine)copper (I) Tetrahydroborate, (o-Phenanthroline)(triphenylphosphine)copper (I) Tetrahydroborate and 1,2-Bis(diphenylphosphino)ethanecopper(I) Tetrahydroborate, J. Chem. Res., (S), 1981, 336.

 

19. G. W. J. Fleet, S. J. Clark and E. M. Irving, Reduction of Aromatic Azides by Bis(triphenylphosphine)copper (I) Tetrahydroborate, J. Chem. Res., (S), 1981, 17.

 

18. G. W. J. Fleet and P. J. C. Harding, Selectivity in the Acid Catalysed Reduction of Carbonyl Compounds to Alcohols by Bis(triphenylphosphine)copper (I) Tetrahydroborate: Reduction of Aldehydes in the Presence of Ketones, Tetrahedron Lett., 1981, 22, 675.

 

17. G. W. J. Fleet, Oxidation and Reduction, Chap. 4 in Organic Reaction Mechanisms, 1980, ed. A. C. Knipe and W. E. Watts, John Wiley & Son, 1981.

 

16. G. W. J. Fleet, P. J. C. Harding and M. J. Whitcombe, Bis(triphenylphosphine)copper (I) Tetrahydroborate in the Reduction of p-Toluenesulphonylhydrazones and 2,4,6-Triisopropylbenzenesulphonylhydrazones to Alkanes, Tetrahedron Lett., 1980, 21, 4031.

 

15. G. W. J. Fleet, Oxidation and Reduction, Chap. 4 in Organic Reaction Mechanisms, 1979, ed. A. C. Knipe and W. E. Watts, John Wiley & Son, 1980.

 

14. G. W. J. Fleet, S. J. Flatt and B. J. Taylor, Diethyl Ether - Chromium Trioxide in the Oxidation of Alcohols to Carbonyl Compounds, Synthesis, 1979, 815.

 

13. G. W. J. Fleet, Oxidation and Reduction, Chap. 4 in Organic Reaction Mechanisms, 1978, ed. A. C. Knipe and W. E. Watts, John Wiley & Son, 1979.

 

12. G. W. J. Fleet and P. J. C. Harding, Convenient Synthesis of Bis(triphenylphosphine)copper (I) Tetrahydroborate and Reduction of Acid Chlorides to Aldehydes, Tetrahedron Lett., 1979, 975.

 

11. G. W. J. Fleet, C. J. Fuller and P. J. C. Harding, Bis(triphenylphosphine)copper (I) Tetrahydroborate in the Reduction of Acid Chlorides to Aldehydes, Tetrahedron Lett., 1978, 1437.

 

10. G. W. J. Fleet, Nucleophilic Aliphatic Substitution, Chap. 9 in Organic Reaction Mechanisms, 1977, p. 373, ed. A. C. Knipe and W. E. Watts, John Wiley & Son, 1978.

 

9. G. W. J. Fleet and W. Little, Oxidation of Alcohols by Heterocyclic Complexes of Oxodiperoxychromium (VI), CrO₅, Tetrahedron Lett., 1977, 3749.

 

8. G. W. J. Fleet, Nucleophilic Aliphatic Substitution, Chap. 9 in Organic Reaction Mechanisms, 1976, p. 363, ed. A. Perkins, John Wiley & Son, 1976.

 

7. G. W. J. Fleet and E. J. Corey, Oxidation of Alcohols with Chromium Trioxide - 3,5-Dimethylpyrazole Complex, Tetrahedron Lett., 1973, 4499.

 

6. G. W. J. Fleet, E. J. Corey and M. Kato, A Biogenetic Approach to the Synthesis of a Prostanoid Precursor, Tetrahedron Lett., 1973, 3963.

 

5. G. W. J. Fleet, J. R. Knowles and R. R. Porter, The Antibody Binding Site: Labelling of a Specific Antibody against the Photo-precursor of an Aryl Nitrene, Biochem. J., 1972, 128, 499.

 

4. G. W. J. Fleet, I. Fleming and D. Philippides, The Addition of Acetic Acid to Pyridynes and Quinolynes, J. Chem. Soc. (C), 1971, 3948.

 

3. G. W. J. Fleet, E. M. Press and C. E. Fisher, Affinity Labelling of Rabbit Antibodies with e-4-Azido-2-nitrophenyl-Lysine, Progress In Immunology, 1971, 235 (Ed. A. Bernard Amos), Academic Press, New York.

 

2. G. W. J. Fleet and I. Fleming, Preparation of Some N-Aminotriazolopyridines and -quinolines, their Oxidation with Lead Tetraacetate, and the Trapping of the Resulting Pyridynes and Quinolynes with Tetraphenylcyclopentadienone (Tetracyclone), J. Chem. Soc. (C), 1969, 1758.

 

1. G. W. J. Fleet, R. R. Porter and J. R. Knowles, Affinity Labelling of Antibodies with Aryl Nitrene as Reactive Group, Nature, 1969, 224, 511.