G W J Fleet Quick CV, Complete Publication and Patent List

 

Quick CV: Undergraduate at Magdalene College Cambridge UK, Ph D with Ian Fleming at Cambridge on heterocyclic analogues of benzyne. MRC Post doctoral fellow at Oxford with Jeremy Knowles and Rodney Porter [Nobel prize winner] on the Photoaffinity labeling of antibodies by nitrenes derived from azides. Post doctoral work with E J Corey [Nobel prize winner] at Harvard on prostaglandin synthesis and chromium(VI) oxidation. At Oxford since. Visiting Professor at National Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang. China from 2010. Emeritus research professor St John’s College Oxford 2011. From 2013-2015 Emeritus Leverhulme Research Fellow. Visiting Professor at International Institute of Rare Sugar Research and Education,  University of Kagawa, Kagawa, Japan from 2016

 

Research interests: Synthesis and investigations of rare and expensive sugars with only acetone as protecting groups; adding high value cheaply with industrial scale production. Collaborative power of chemistry and biotechnology. Isolation and synthesis of missed bioactive water-soluble low molecular weight nitrogen compounds from plants which are used as sources of food.  Pharmacological chaperones: iminosugars as small molecules to assist correction of protein mis-folding diseases including cystic fibrosis and lysosomal storage diseases – Tay-Sachs, Sandhoff, Schindler-Kanzaki, Fabry. Synthesis of iminosugars of all stereoisomers from cheap carbohydrates by convergent syntheses for the systematic investigation of their properties as glycosidase inhibitors; novel anti-cancer strategies. Development of general syntheses of highly functionalized azetidines from sugars. Azetidine carboxylic acids as novel peptidomimetics. Sugar amino acids as scaffolds for the study of foldamers. 

 

Publications and patents: A full list of publications and patents, which runs from the most recent backwards, is given below. A reliable assessment of published work for chemists is the Hirsch-index. The group H-index is 70 - H index 27 since 2014; more than 110 papers with 50 citations [Google scholar].

 

Anyone interested should contact me by e.mail  george.fleet@chem.ox.ac.uk

 

594. Kato, A.; Koyama, J.; Shinzawa, K.; Imaeda, S.; Adachi, I.; Nash, R. J.; Fleet, G. W. J.; Shintani, M.; Takeuchi, C.; Ishikawa, F., Ginnalin B induces differentiation markers and modulates the proliferation / differentiation balance via the upregulation of NOTCH1 in human epidermal keratinocytes, Bioorg. Med. Chem. 2019, 27, in press.

 

593. Martínez, R. F.; Jenkinson, S. F.; Nakagawa, S.; Kato, A.; Wormald, M. R.; Fleet, G. W. J.; Hollinshead, J.; Nash, R. J., Isolation from Stevia rebaudiana of DMDP acetic acid a novel iminosugar amino acid: protecting group-free synthesis and glycosidase inhibition profile of glycine and b-alanine pyrrolidine amino acids, Amino Acids, 2019, 51, in press

 

592. Wood, A.; Prichard, K.; Clarke, Z.; Houston, T. A.; Kato, A.; Fleet, G. W. J.; Simone, M. I., Synthetic Pathways to 3, 4, 5-Trihydroxypiperidines from the Chiral Pool, Eur. J. Org. Chem. 2018, 6812-6829.

 

591. Prichard, K.; Campkin, D.; O'Brien, N.; Kato, A.; Fleet, G. W. J.; Simone, M. I., Biological Activities of 3, 4, 5-Trihydroxypiperidines and their N and O Derivatives, Chem. Biol. Drug Design,  2018, 92, 1171-1197.

 

590. Kato, A; Nakagome, I.; Nakagawa, S.; Kinami, K.; Adachi, I.; Jenkinson, S. F; Desire, J.; Bleriot, Y.; Nash, R. J.; Fleet, G. W. J.; Hirono, S., in silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease, Org. Biomol. Chem. 2017, 15, 9297-9304.

 

589.  Thompson, A. L.; Jenkinson, S. F.; Fleet, G. W. J.,  Some experimental aspects of absolute configuration determination using single crystal X-ray diffraction, Tetrahedron: Asymmetry 2017, 228, 1330-1336.

 

588. Miyawaki, S.; Hirokami, Y.; Kinami, K.; Hoshino, M.; Minehira, D.; Miyamoto, D.; Nash, R. J.; Fleet, G. W. J.; Adachi, I.; Toyooka, N.; Kato, A., Strategy for designing selective α-L-rhamnosidase inhibitors: Synthesis and biological evaluation of DMDP cyclic isothioureas,  Bioorg. Med. Chem. 2017, 25, 107-115.

 

587. Glawar, A. F. G.; Martnez,  R. F.; Ayers, B. J.; Hollas, M. A.; Ngo, N.; Nakagawa, S.; Kato, A.; Butters, T. D.; Fleet, G. W. J. ; Jenkinson, S. F., Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids, Org. Biomol. Chem. 2016, 14, 10371–10385.

 

586. Kamori, A.; Kato, A.; Miyawaki, S.; Koyama, J.; Nash, R. J.; Fleet, G. W. J.; Miura, D.; Ishikawa, F.; Adachi, I., Dual action of acertannins as potential regulators of intracellular ceramide levels, Tetrahedron: Asymmetry 2016, 27, 1177-1185.

 

585. Liu, Z.; Yoshihara, A.; Jenkinson, S. F.; Wormald, M. R.; Estevez, R. J.; Fleet, G. W. J.; Izumori, K., Triacetonide of Glucoheptonic Acid in the Scalable Syntheses of D-Gulose, 6-Deoxy-D-gulose, L-Glucose, 6-Deoxy-L-glucose and Related Sugars, Org. Lett. 2016, 18, 4112–4115.

 

584. Liu, Z.; Jenkinson, S. F.; Kato,  A.; Nakagawa, S.; Wormald,  M. R.; Yu,  C.-Y.; Fleet,  G. W. J., Azidoazetidines as the first scaffolds for β-amino azetidine carboxylic acid peptidomimetics: azetidine iminosugars containing an acetamido group do not inhibit β-N-acetylhexosaminidases, Tetrahedron: Asymmetry 2016, 27, 872-881.

 

583.  Liu, Z.; Yoshihara, A.; Kelly, C. L.; Heap, J. T.; Marqvorsen, M. H. S.; Jenkinson, S. F.; Wormald, M. R.; Otero, J.; Estvez, A.; Kato, A.; Fleet, G. W. J; Estvez, R. J.; Izumori, K.; 6-Deoxyhexoses from L-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology, Chem. Eur. J. 2016, 22, 12557–12565.

 

582. Kelly, C. L.; Liu, Z.; Yoshihara, A.; Jenkinson, S. F.; Wormald, M. R.; Otero, J.; Estvez, A.; Kato, A.; Marqvorsen, M. H. S.; Fleet, G. W. J; Estvez, R. J.; Izumori, K.; Heap, J. T., Synthetic chemical inducers and genetic decoupling enable orthogonal control of the rhaBAD promoter, ACS Synth. Biol. 2016, 5, 1136–1145.

 

581. Song, Y. -Y.; Kinami, K.; Kato, A.; Li, Y.-X.; Fleet, G. W. J.; Yu, C.-Y.,  First Total Synthesis of (+)-Broussonetine W: Glycosidase Inhibition of Natural Product & Analogs, Org. Biomol. Chem. 2016, 14, 5157-5174.

 

580. Wang, H.-Y.;  Kato, A.; Kinami, K.; Li, Y.-X.; Fleet, G. W. J.; Yu, C.-Y.,  Concise Synthesis of Calystegine B2 and B3 via Intramolecular Nozaki–Hiyama–Kishi Reaction, Org. Biomol. Chem. 2016, 14,  4885-4896.

 

579. Qian,  B.-C.; Kamori,  A.; Kinami, K.; Kato, A.; Li, Y.-X.; Fleet, G. W. J.; Yu, C.-Y.,  Epimerization of C5 of an N-Hydroxypyrrolidine in the Synthesis of Swainsonine Related Iminosugars, Org. Biomol. Chem. 2016, 14, 4488-4499.

 

578. Li, Y.-X.; Kinami, K.; Hirokami, Y.; Kato, A.; Su, J.-K.; Jia, Y.-M.; Fleet, G. W. J.; Yu, C.-Y., Gem-difluoromethylated and Trifluoromethylated Derivatives of DMDP related Iminosugars:  Synthesis and Glycosidase Inhibition, Org. Biomol. Chem. 2016, 14, 2249-2263.

 

577.  Li, Y.-X.; Iwaki, R.; Kato, A.; Jia, Y.-M.; Fleet, G. W. J.; Zhao, X.; Xiao, M.; Yu, C.-Y., Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition, Eur. J. Org. Chem.  2016, 1429–1438.

 

576. Kato, A.; Nakagome, I.; Sato, K.; Yamamoto, A.; Adachi, I.; Nash, R. J.; Fleet,   G. W. J.; Natori, Y.; Watanabe, Y.; Imahori, T.; Yoshimura, Y.; Takahata, H.; Hirono, S., Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease, Org. Biomol. Chem. 2016,  14, 1039-1048.

 

575. Li, Y.-X.; Shimada, Y.; Adachi, I.; Kato, A.; Jia, Y.-M.; Fleet, G. W. J.; Xiao, M.; Yu, C.-Y., Fluorinated and Conformationally-fixed Derivatives of L-homoDMDP: Synthesis and Glycosidase Inhibition, J. Org. Chem. 2015, 80, 5151–5158.

 

574. Liu, Z.; Jenkinson, S. F.; Vermaas, T.; Adachi, I.; Wormald, M. R.; Hata, Y.; Kurashima, Y.; Kaji, A.; Yu, C.-Y.; Kato, A.; Fleet, G. W. J., 3-Fluoro-azetidine Carboxylic Acids and trans,trans-3,4-Difluoroproline as Peptide Scaffolds: Inhibition of Pancreatic Cancer Cell Growth by a Fluoroazetidine Iminosugar, J. Org. Chem. 2015, 80, 4244–4258.

 

573. Kato, A.; Zhang, Z.-L.; Wang, H.-Y.; Jia, Y.-M.; Yu, C.-Y.; Kinami, K.; Hirokami, Y.; Tuji, Y.; Adachi, I.; Nash, R. J.; Fleet, G. W. J.; Koseki, J.; Nakagome, I.; Hirono, S., Design and Synthesis of Labystegines, Hybrid Iminosugars from LAB and Calystegine, as Inhibitors of Intestinal a-Glucosidases: Binding Conformation and Interaction for ntSI, J. Org. Chem. 2015, 80, 4501–4515.

 

572. Gonzlez-Castro, M. A.; Poole, D. L.; Estvez, J. C.; Fleet, G. W. J.; Estvez. R. J. A stereoselective transformation of (-)-shikimic acid into (3R,4S,5R,7R)-7-(hydroxymethyl)azepane-3,4,5-triol,  a potential glycosidase inhibitor,  Tetrahedron: Asymmetry 2015, 26, 320-323.

 

571. Li, Y.-X.: Shimada, Y.; Sato, K.; Kato, A.; Zhang, W.; Jia, Y.-M.; Fleet, G. W. J.; Xiao, M.; Yu, C.-Y., Synthesis and Glycosidase Inhibition of Australine and Its Fluorinated Derivatives, Org. Lett. 2015, 17, 716-719.

 

570. Kato, A.; Hirokami, Y.; Kinami, K.; Tsuji, Y.; Miyawaki, S.; Adachi, I.; Hollinshead, J.; Nash, R. J.; Kiappes, J. L.; Zitzmann, N.; Cha, J. K.; Molyneux, R. J.; Fleet, G. W. J.; Asano, N., Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors, Phytochemistry 2015, 111, 124-131.

 

569. Fleet, G., Raphael, F., Izumori,, K., Manufacture of L-glucose or D-gulose involves extending carbon-1 side of D-glucose using Kiliani reaction, removing hydroxy methyl group, and producing hexose product L-glucose or D-gulose having skeleton of newly enriched carbon, Patent Number: WO2015068724-A1 Patents Published: May 14 2015.

 

568. Zitzmann, N.; Butters, T. D.; Platt, F. M.; Jacob, G. S.; Picker, D. H.; Carrouee, S.; Fleet, G. W. J., Dwek, R. A.;  Durantel, D.; Mehta, M.; Block, T. M., Long chain N-alkyl compounds and oxa-derivatives thereof, Patent Number: US 09089515, Official Gazette of the United States Patent and Trademark Office Patents Published: July 28 2015.

 567. Butters, T. D.; Dwek, R. A.; Fleet, G. W. J., Deoxynojirimycin and D-arabinitol analogs and methods of using, Patent Number: US 08975280, Official Gazette of the United States Patent and Trademark Office Patents Published: March 10 2015.

 

566. Liu, Z.; Yoshihara, A.; Wormald, M. R.; Jenkinson, S. F.; Gibson, V.; Izumori, K.; Fleet, G. W. J., L-Fucose From Vitamin C With Only Acetonide Protection, Org. Lett. 2014, 16, 5663–5665.

 

565. Dsir, J.; Mondon, M.; Fontelle, N.; Nakagawa, S.; Hirokami, Y.; Adachi, I.; Iwaki, R.; Fleet, G. W. J.; Alonzi, D. S.; Twigg, G.; Butters, T. D.; Bertrand, J.; Cendret, V.; Becq, F.; Norez, C.; Marrot, J.;         , A.; Blriot, Y., N- and C-Functionalisation of seven-membered iminosugars with long alkyl chains generate potent glycosidase inhibitors and F508del-CFTR correctors, Org. Biomol. Chem. 2014, 12, 8977-8996.

 

564. Crabtree, E. V.; Martnez, R. F.; Nakagawa, S.; Adachi, I.; Butters, T. D.; Kato, A.; Fleet, G. W. J.; Glawar, A. F. G, Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of b-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols, Org. Biomol. Chem. 2014, 12, 3932-3943.

 

563.  Ayers, B. J.; Glawar, A. F. G.; Martnez, R. F.; Ngo, N.; Liu, Z.; Fleet, G. W. J.; Butters, T. D.; Nash, R. J.; Yu, C.-Y.; Wormald, M. R.; Nakagawa, S.; Adachi, I.; Kato, A.; Jenkinson, S. F., 9 of 16 Stereoisomeric Polyhydroxylated Proline Amides are Potent _-N-Acetylhexosaminidase Inhibitors, J. Org. Chem. 2014, 79, 3398-3409.

 

562. Martnez, R. F.; Liu, Z.; Glawar, A. F. G; Yoshihara, A.; Izumori, K.; Fleet, G. W. J.; Jenkinson, S. F., Short and Sweet: D-Glucose to L-Glucose and L-Glucuronic Acid, Angew. Chem. Int. Edit. 2014, 53, 1160-1162; Kurz und Knapp: L-Glucose und L-Gluconsaure von D-Glucose, Angew. Chem. 2014, 126, 1179-1182.

 

561. Ayers, B. J.; Fleet, G. W. J., One-pot tandem Strecker reaction and iminocyclisations – syntheses of trihydroxy piperidine _-iminonitriles, Eur. J. Org. Chem. 2014, 2053–2069.

 

560. Ayers, B. J.; Hollinshead, J.; Saville, A. W.; Nakagawa, S.; Adachi, I.; Kato, A.; Izumori, K.; Bartholomew, B.; Fleet, G. W. J.; Nash. R. J., Iteamine, the first alkaloid isolated from Itea virginica L. inflorescence, Phytochemistry 2014, 100, 126-131. 

 

559. Martnez, R. F.; Fleet, G. W. J., Carbohydrate derived bicyclic azetidin-3-ones as scaffolds for highly functionalized azetidines, Tetrahedron: Asymmetry 2014, 25, 373-380.

 

558. Butters, T. D.; Dwek, R. A.; Fleet, G. W. J.; Orchard, M. G.; Platt, F. M., Pharmaceutically active piperidine derivatives, Patent Number: US 08729099, Official Gazette of the United States Patent and Trademark Office Patents Published: May 20 2014.

 

557. Zhu, J.-S.; Nakagawa, S.; Chen, W.; Adachi, I.; Jia, Y.-M.; Hu, X.-G.; Fleet, G. W. J.; Wilson, F. X.; Nitoda, T.; Horne, G.; van Well, R.; Kato, A.; Yu, C.-Y. Synthesis of Eight Stereoisomers of Pochonicine: Nanomolar Inhibition of b-N-Acetylhexosaminidases,  J. Org. Chem. 201378, 10298-10309.

 

556. Glawar, A. F. G.; Jenkinson, S. F.; Newberry, S. J.; Thompson, A. L.; Nakagawa, S.; Yoshihara, A.; Akimitsu, K.; Izumori, K.; Butters, T. D.; Kato, A.; Fleet, G. W. J., An approach to 8 stereoisomers of homonojirimycin from D-glucose via kinetic & thermodynamic azido-g-lactones, Org. Biomol. Chem. 2013, 11, 6886-6899.

 

555. Bertrand, J; Boinot, C.; Mouzannar, K.; Fleet, G.; Meyer, P.; Becq, F.; Norez, C. Inhibition of HSP90/f508DEL-CFTR interaction by isolab leads to the restoration of the mutated protein to the plasma membrane in cystic fibrosis epithelial cells, Pediatric Pulmonology 2013, 48, 219-220.

 

554. Zhao, H.; Wang, W.-B.; Nakagawa, S.; Jia, Y.-M.; Hu, X.-G.; Fleet, G. W. J.; Wilson, F. X.; Nash, R. J.; Kato,  A.; Yu, C.-Y., Novel 2-aryl-3,4,5-trihydroxypiperidines: Synthesis and glycosidase inhibition, Chin. Chem. Lett. 2013, 24, 1059-1063.

 

553. Jenkinson, S. F.; Best, D.; Saville, A. W.; Mui, J.; Martinez, R. F.; Nakagawa, S.; Kunimatsu, T.; Alonzi, D. S.; Butters, T. D.; Norez, C.; Becq, F.; Bleriot, Y.; Wilson, F. X.; Weymouth-Wilson, A. C.; Kato, A.; Fleet, G. W. J., C_Branched Iminosugars: __Glucosidase Inhibition by Enantiomers of isoDMDP, isoDGDP, and isoDAB_L_isoDMDP Compared to Miglitol and Miglustat, J. Org. Chem. 2013, 78, 7380-7397.

 

552. Risseeuw, M. D. P.; Overhand, M.; Fleet, G. W. J.; Simone, M. I., A compendium of cyclic sugar amino acids and their carbocyclic and heterocyclic nitrogen analogues, Amino Acids, 2013, 45, 613-689.

 

551. Zhao, W.-B.; Nakagawa, S.; Kato, A.; Adachi, I.; Jia, Y.-M.; Hu, X.-G.; Fleet, G. W. J.; Wilson, F. X.; Horne, G.; Yoshihara, A.; Izumori, K.; Yu, C.-Y., General Synthesis of Sugar-Derived Azepane Nitrones: Precursors of Azepane Iminosugars, J. Org. Chem. 2013, 78, 3208-3221.

 

550. Martnez, R. F.; Arajoa, N.; Jenkinson, S. F.; Nakagawa, S.; Kato, A.; Fleet, G. W. J., (3R,4S,5R,6R,7S)-3,4,5,7-Tetrahydroxyconidine, an azetidine analogue of 6,7-diepicastanospermine and a conformationally constrained D-deoxyaltronojirimycin, from L-arabinose, Bioorg. Med. Chem. 2013, 21, 4813-4819.

 

549. Glawar, A. F. G.; Jenkinson, S. F.; Thompson, L.; Nakagawa, S.; Kato, A.; Butters, T. D.; Fleet, G. W. J., 3-Hydroxyazetidine Carboxylic Acids: Novel Non-proteinogenic Amino Acids for Medicinal Chemists, ChemMedChem 2013, 8, 658-666.

 

548. Ayers, B. J.; Jenkinson, S. F.; Fleet, G. W. J.; Thompson, A. L., 2-N-Benzyl-2,6-dideoxy-2,6-O-isopropylidene-D-allononitrile, Acta Cryst. 2013, E69, o1772.

 

547. Izumori, K.; Tokuda, M.; Fleet, G. W. .J.; Tsujisaka, Y.; Takeshita, K.; Tsusaki, K.; Okuma, K., Deoxyketohexose isomerase and method for producing deoxyhexose and derivative thereof using same, Official Gazette of the United States Patent and Trademark Office Patents  Published: MAR 5 2013

 

546. Clark, N. E.; Metcalf, M. C.; Best, D.; Fleet, G. W. J.; Garman, S. C., Pharmacological Chaperones for Human a-N-Acetylgalactosaminidase, Proc. Natl. Acad. Sci. U. S. A.  2012, 109, 17000-17005.

 

545. Ayers, B. J.; Ngo, N.; Jenkinson, S. F.; Martnez, R. F.; Shimada, Y.; Adachi, I.; Weymouth-Wilson, A. C.; Kato, A.; Fleet, G. W. J., Glycosidase inhibition by all ten stereoisomeric 2,5-dideoxy-2,5-iminohexitols prepared from the enantiomers of glucuronolactone,  J. Org. Chem. 2012, 77, 7777-7792.

 

544. Arajo, N.; Jenkinson, S. F.; Martnez, F. R.; Glawar, A. F. G.; Wormald, M. R.; Butters, T. D.; Nakagawa, S.; Adachi, I.; Kato, A.; Yoshihara, A.; Akimitsu, K.; Izumori, K.; Fleet, G. W. J., Synthesis from D-Altrose of (5R,6R,7R,8S)-5,7-Dihydroxy-8-hydroxymethylconidine and 2,4-Dideoxy-2,4-imino-D-glucitol, Azetidine Analogues of Swainsonine and 1,4-Dideoxy-1,4-imino-D-mannitol, Org. Lett. 2012, 14, 4174-4177.

 

543. Glawar, A. F. G.; Best, D.; Ayers, B.; Miyauchi, S.; Nakagawa, S.; Aguilar-Moncayo, M.; Garca Fernndez, J. M.; Mellet, C.O.; Crabtree, E. V.; Butters, T. D.; Wilson, F. X.; Kato, A.; Fleet, G. W. J., Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone; effect of N-alkylation on hexosaminidase inhibition, Chem. Eur. J. 2012, 18, 9341-9359.

 

542. Soengas, R. G.; Fontanella, M.; Santos, J. I.; Fleet, G. W. J.; Jimnez-Barbero, J., Synthesis and Conformational Analysis of Heterogeneous Cyclic Oligomers of 6-Amino-6-deoxygalactonic Acid and Phenylalanine, Eur. J. Org. Chem. 2012, 5701-5711.

 

541. Lenagh-Snow, G. M. J.; Araujo, N.; Jenkinson, S. F.; Martinez, R. F.; Shimada, Y.; Yu, C.-Y.; Kato, A.; Fleet, G. W. J. Azetidine iminosugars from the cyclization of 3,5-di-O-triflates of _-furanosides and of 2,4-di-O-triflates of b-pyranosides derived from glucose, Org. Lett. 2012, 14, 2142-2145.

 

540. Lenagh-Snow, G. M. J.; Jenkinson, S. F.; Newberry, S. J.; Kato, A.; Nakagawa, S.; Adachi, I.; Wormald, M. R.; Yoshihara, A.; Morimoto, K.; Akimitsu, K.; Izumori, K.; Fleet, G. W. J., Eight stereoisomers of homonojirimycin from D-mannose, Org. Lett. 2012, 14, 2050-2053.

 

539. Simone, M. I.; Soengas, R. G.; Jenkinson, S. F.; Evinson, E. L.; Nash; R. J.; Fleet .G. W. J. Synthesis of three branched iminosugars [(3S,4R,5S)-3-(hydroxymethyl)piperidine-3,4,5-triol, (3R,4R,5R)-3-(hydroxymethyl)piperidine-3,4,5-triol and (3S,4R,5R)-3-(hydroxymethyl)piperidine-3,4,5-triol] and a branched trihydroxynipecotic acid [(3R,4R,5R)-3,4,5-trihydroxypiperidine-3-carboxylic acid] from sugar lactones with a carbon substituent at C-2, Tetrahedron: Asymmetry 2012, 23, 401-408.

 

538. Soengas, R. G.; Simone, M. I.; Hunter, S.; Nash; R. J.; Evinson, E. L.; Fleet, G. W. J. Hydroxymethyl-Branched Piperidines from Hydroxymethyl-Branched Lactones: Synthesis and Biological Evaluation of 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-D-mannitol, 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-L-gulitol and 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-D-talitol, Eur. J. Org. Chem. 2012, 2394-2402.

 

537. Edgeley, D. S.; Martinez, R. F.; Jenkinson, S. F.; Nash, R. J.; Fleet G. W. J.; Thompson, A. L. N-(2-Carboxyethyl)-2,5-dideoxy-2,5-imino-D-mannonic acid [(2S,3R,4R,5R)-1-(2-carboxyethyl)-3,4-dihydroxy-5-(hydroxymethyl)proline], Acta Cryst. 2012, E68, o2865- o2866.

 

536. Edgeley, D. S; Jenkinson, S. F.; Lenagh-Snow, G.; Rutherford, C.; Fleet, G. W. J.; Thompson, A. L. N-Benzyl-3,5-dideoxy-3,5-imino-1,2-O-isopropylidene-b-L-lyxofuranose Acta Cryst. 2012, E68, o2410.

 

535. Ayers, B. J.; Jenkinson, S. F.; Fleet, G. W. J.; Thompson, A. L. 2-N-Benzyl-2,6-dideoxy-2,6-imino-3,4-O-isopropylidene-3-C-methyl-D-allononitrile, Acta Cryst. 2012E68, o1474.

 

534. G. M. J. Lenagh-Snow, N. Araujo, S. F. Jenkinson, C. Rutherford, S. Nakagawa, A. Kato, C.-Y. Yu, A. C. Weymouth-Wilson and G. W. J. Fleet, Inhibition of Nonmammalian Glycosidases by Azetidine Iminosugars Derived from Stable 3,5-Di-O-triflates of Pentoses, Org. Lett. 2011, 13, 5834-5837.

 

533. R. J. Nash, A. Kato, C.-Y. Yu, G. W. J. Fleet, Iminosugars as therapeutic agents: Recent advances and promising trends, Future Med. Chem. 2011, 3, 1513-1521. 

 

532. W. Zhang, K. Sato, A. Kato, Y.-M. Jia, X.-G. Hu, F. X. Wilson, R. van Well, G. Horne, G. W. J. Fleet, R. J. Nash, and C.-Y. Yu, Synthesis of Fully Substituted Polyhydroxylated Pyrrolizidines via Cope–House Cyclization, Org. Lett. 2011, 13, 4414-4417.

 

531. S. F. Jenkinson, G. W. J. Fleet, R. J. Nash, Y. Koike, I. Adachi, A. Yoshihara, K. Morimoto, K. Izumori and A. Kato, Looking-glass synergistic pharmacological chaperones: DGJ and L-DGJ from the enantiomers of tagatose, Org. Lett. 2011, 13, 4064-4067.

 

530. F. P. da Cruz, S. Newberry, S. F. Jenkinson, M. R. Wormald, T. D. Butters, D. S. Alonzi, S. Nakagawa, F. Becq, C. Norez, R. J. Nash, A. Kato and G. W. J. Fleet, 4-C-Methyl-DAB and 4-C-Me-LAB - enantiomeric alkyl branched pyrrolidine iminosugars - are specific and potent a-glucosidase inhibitors; acetone as the sole protecting group, Tetrahedron Lett. 2011, 52, 219-223.

 

529. M. I. Simone, A. A. Edwards, G. E. Tranter, G. W. J. Fleet, C-3 Branched-3,5-cis- and trans-THF sugar amino acids: synthesis of the first generation of branched homooligomers, Amino Acids, 2011, 41, 643-661.

 

528. Y.-X. Li, M.-H. Huang, Y. Yamashita, A. Kato, Y.-M. Jia, W.-B. Wang, G. W. J. Fleet, R. J. Nash and C.-Y. Yu, L-DMDP, L-homoDMDP and Their C-3 Fluorinated Derivatives: Synthesis and Glycosidase-Inhibition, Org. Biomol. Chem. 2011, 9, 3405-3414.

 

527. S. F. Jenkinson, G. W. J. Fleet, Oxetanes from the ring contraction of a-triflates of g-lactones: oxetane nucleosides and oxetane amino acids, Chimia 2011, 65, 71-75.

 

526. J. S. S. Rountree, T. D. Butters, R. A. Dwek and G. W. J. Fleet, Enantiomeric 2-acetamido-1,4-dideoxy-1,4-iminoribitols as potential pyrrolidine N-acetylhexosaminidase inhibitors, Comptes Rendus Chimie 2011, 14, 126-133.

 

525. Jenkinson, S. F., Parry, L. L., Wilson, F. X., Fleet, G. W. J., Watkin, D. J., 6-Deoxy-3,4-O-isopropylidene-2-i-methyl-L-galactono-1,5-lactone, Acta Cryst. 2011, E67, o2531-2532. 

 

524. Jenkinson, S. F., Lenagh-Snow, G. M. J., Fleet, G. W. J., Thompson, A. L., N-Benzyl-1,3-dideoxy-1,3-imino-L-xylitol, Acta Cryst. 2011, E67, o2452. 

 

523. Jenkinson, S. F., O񡬠N., Romero, A., Fleet, G. W. J., Thompson, A. L., Pino-Gonzᬥz, M. S., N,N-Diethyl-6-azido-3-O-benzyl-6-deoxy-1,2-O-isopropylidene-a-D-gluco-heptofuranuronamide, Acta Cryst. 2011, E67, o38-o39.

 

522. G. W. J. Fleet and T. D. Butters, Synthesis of 2-acetamido-1,2-dideoxy-D-galacto-nojirimycin from D-glucuronolactone and its use to inhibit -N-a-acetylgalactosaminidases, PCT Int. Appl. (2011), WO 2011095893 A1 20110811; G. W. J. Fleet and T. D. Butters, Forming 2-acetamido-1,2-dideoxy-D-galacto-nojirimycin/its derivative involves introducing nitrogen at position 5 of D-glucuronolactone, inversion of configuration of hydroxyl at position 3, and introducing nitrogen between position 6 and 2 WO2011095893-A1 CA2788983-A1 EP2531201-A1 KR2013009751-A US2013040990-A1 JP2013518814-W CN102985092-A IN201206974-P1

 

521. G. W. J. Fleet and R. Storer, Novel iminosugar therapeutics, PCT application WO/2011/0095772 A2 published 11/08/11; G. W. J. Fleet and R. Storer, Pyrrolidine Iminosugars used in the treatment of cystic fibrosis PCT application WO/2011/086347 A1 published 21/07/11. New carbon-branched pyrrolidine iminosugar compound used in pharmaceutical composition and in inhalation device such as metered dose inhaler and nebulizer for treating cystic fibrosis Patent Number: WO2011086347-A1

 

520.  G. W. J. Fleet and R. Storer, New pyrrolidine or azetidine iminosugars useful for treating or preventing infection selected from viral, bacterial, fungal or protozoal, immune disorder, neoplasia, insulin resistance, obesity, polycystic ovarian syndrome, hemochromatosis  WO2011095772-A2 WO2011095772-A3 Patent Assignee: SUMMIT CORP PLC

 

519. D. Best, S. F. Jenkinson, A. W. Saville, D. S. Alonzi, M. R. Wormald, T. D. Butters, C. Norez, F. Becq, Y. Blot, I. Adachi, A. Kato and G. W. J. Fleet. Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon branched pyrrolidine iminosugars, Tetrahedron Lett. 2010, 51, 4170-4174.

                                                                                                                    

518. X.-G. Hu, B. Bartholomew, R. J. Nash, F. X. Wilson, G. W. J. Fleet, S. Nakagawa, A. Kato, Y.-M. Jia, R. van Well, and C.-Y. Yu, Synthesis and Glycosidase Inhibition of the Enantiomer of (-)-Steviamine, the First Example of a New Class of Indolizidine Alkaloid, Org. Lett. 2010, 12, 2562-2565.

                                                                                                                    

517. A. Kato, J. Hollinshead, Y. Yamashita, S. Nakagawa, Y. Koike, I. Adachi, C.-Y. Yu, G. W. J. Fleet, R. J. Nash, An a-glucoside of 1,4-dideoxy-1,4-imino-D-lyxitol with an eleven carbon side chain Phytochem. Lett. 2010, 3, 230-233

 

516. A. Michalik, J. Hollinshead, L. Jones, G. W. J. Fleet, C.-Y. Yu, X.-G. Hu, R. van Well, G. Horne, F. X. Wilson, R. J. Nash, Steviamine, a new class of indolizidine alkaloid from Stevia rebaudiana, Phytochem. Lett. 2010, 3, 136-138.

                                                                                                                    

515. L. Jones, J. Hollinshead, G. W. J. Fleet, A. L. Thompson, D. J. Watkin, Z. A. Gal, S. F. Jenkinson, A. Kato, R. J. Nash, Isolation of the pyrrolizidine alkaloid 1-epialexine from Castanospermum australe. Phytochem. Lett. 2010, 3, 133-135.

 

514. D. Best, P. Chairatana, A. F. G. Glawar, E. Crabtree, T. D. Butters, F. X. Wilson, C.-Y. Yu, W.-B. Wang, Y.-M. Jia, I. Adachi, A. Kato and G. W. J. Fleet, Synthesis of DGJNAc [2-acetamido-1,2-dideoxy-D-galacto-nojirimycin] - the first sub-micromolar inhibitor of a-N-acetylgalactosaminidases - from D-glucuronolactone, Tetrahedron Lett. 2010, 51, 2222-2224.

 

513. S. D. Boomkamp, J. S. S. Rountree, D. C. A. Neville, R. A. Dwek, G. W. J. Fleet, T. D. Butters, Lysosomal storage of oligosaccharide and glycosphingolipid in imino sugar treated cells, Glycoconj. J. 2010, 27, 297-308.

 

512. D. Best, C. Wang, A. C. Weymouth-Wilson, R. A. Clarkson, F. X. Wilson, R. J. Nash, S. Miyauchi, A. Kato and G. W. J. Fleet, Looking glass inhibitors: scalable syntheses of DNJ, DMDP and (3R)-3-hydroxy-L-bulgecinine from D-glucuronolactone and of L-DNJ, L-DMDP and (3S)-3-hydroxy-D-bulgecinine from L-glucuronolactone. DMDP inhibits b-glucosidases and b-galactosidases whereas L-DMDP is a potent and specific inhibitor of a-glucosidases Tetrahedron: Asymmetry 2010, 21, 311-319.

 

511. P. Gullapalli, A. Yoshihara, K. Morimoto, D. Rao, S. F. Jenkinson, M. R. Wormald, G. W. J. Fleet and K. Izumori, Conversion of L-rhamnose into ten of the sixteen 1- and 6-deoxyketohexoses in water with 3 reagents: D-tagatose-3-epimerase equilibrates C3 epimers of deoxyketoses, Tetrahedron Lett. 2010, 51, 895-898.

 

510. M. I. Simone, A. A. Edwards, A. R. Cowley, G. W. J. Fleet and D. J. Watkin, (3R,4R,5R)-5-(Acetamidomethyl)-N-benzyl-3,4-dihydroxytetrahydrofuran-3-carboxamide, Acta Cryst. 2010, E66, 2750-o2751. 

 

509. M. I. Simone, A. A. Edwards, S. G. Parker, G. E. Tranter, G. W. J. Fleet and D. J. Watkin, Pentafluorophenyl (3R,4R,5S)-5-{[(3R,4R,5S)-5-azidomethyl-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxamido]methyl}-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxylate, Acta Cryst. 2010, E66, o2699-o2700. 

 

508. S. F. Jenkinson, D. Best, K. Izumori, F. X. Wilson, A. C. Weymouth-Wilson, G. W. J. Fleet and A. L. Thompson, 1-Deoxy-1-fluoro-L-galactitol, Acta Cryst. 2010E66, o1330.

 

507. S. F. Jenkinson, D. Best, K. Izumori, F. X. Wilson, A. C. Weymouth-Wilson, G. W. J. Fleet and A. L. Thompson, 6-Deoxy-6-fluoro-D-galactose, Acta Cryst. 2010E66, o1315.

 

506. S. F. Jenkinson, N. Dai, G. W. J. Fleet, D. J. Watkin, 2-Azido-2-deoxy-3,4-O-isopropylidene-2-C-methyl-D-talono-1,5-lactone, Acta Cryst. 2010E66, o1221-o1222.

 

505. S. F. Jenkinson, E. V. Crabtree, A. F. G. Glawar, T. D. Butters, G. W. J. Fleet, D. J. Watkin, 2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-xylitol (N-Benzyl-XYLNAc), Acta Cryst. 2010, E66, o1147-o1148.

 

504. S. F. Jenkinson, D. Best, F. X. Wilson, G. W. J. Fleet, D. J. Watkin, (1R,2R,3S,6aS,7R,8R,9S,12aS)-1,2,3,7,8,9-Hexahydroxyperhydrodipyrido[1,2-a:1',2'-d]pyrazine-6,12-dione, Acta Cryst. 2010, E66, o853-o853.

 

503. S. F. Jenkinson, G. M. J. Lenagh-Snow, K. Izumori, G. W. J. Fleet, D. J. Watkin and A. L. Thompson, 2-Azido-3,4;6,7-di-O-isopropylidene-a-D-glycero-D-talo-heptopyranose, Acta Cryst. 2010, E66, o525-o526.

 

502. N. Dai, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin 3 4-O-Isopropylidene-2-C-methyl-D-galactonolactone Acta Cryst. 2010, E66, o406-o407.

 

501. G. M. J. Lenagh-Snow, S. F. Jenkinson, A. J. Stewart, G. W. J. Fleet and D. J. Watkin 1-(1-Carboxymethyl-1,4-anhydro-2,3-O-isopropylidene-a-D-erythrofuranosyl)thymine, Acta Cryst. 2010, E66, o404.

 

500. A C Weymouth-Wilson and G W J Fleet, Stereospecific Synthesis Of Iduronic Acid Derivatives, Deoxynojirimycin and Deoxyidonojirimycin PCT application WO/2010/004269 14 January 2010; G W J Fleet  and A C Weymouth-Wilson Synthesizing substituted hydroxy-tetrahydro-furo-dioxolone compounds, useful as intermediates in the synthesis of e.g. 1-deoxynojirimycin, comprises reacting glucuronolactone with ketone compounds and introducing leaving group  WO2010004269-A2 WO2010004269-A3

 

499. T. B. Mercer, S. F. Jenkinson, R. J. Nash, S. Miyauchi, A. Kato and G. W. J. Fleet, Looking glass inhibitors: both enantiomeric N-benzyl derivatives of 1,4-dideoxy-1,4-imino-D-lyxitol [a potent competitive inhibitor of a-D-galactosidase] and of  1,4-dideoxy-1,4-imino-L-lyxitol [a weak competitive inhibitor of a-D-galactosidase] inhibit naringinase, an a-L-rhamnosidase, competitively, Tetrahedron: Asymmetry 2009, 20, 2368-2373.

 

498.  S. F. Jenkinson, K. V. Booth, A. M. Estevez Reino, G. Horne, R. J. Estevez and G. W. J. Fleet, Carbon-branched carbohydrate chirons: synthesis of C-3 and C-4 branched sugar lactones derived from D-erythronolactone, Tetrahedron: Asymmetry 2009, 20, 2357-2367.

 

497. A. C. Weymouth-Wilson, R. Clarkson, D. Best, M.-S. Pino-Gonzalez, F. X. Wilson and G. W. J. Fleet, Large scale synthesis of the acetonides of L-glucuronolactone and of L-glucose: easy access to L-sugar chirons, Tetrahedron Lett. 2009, 50, 6307-6310.

 

496. K. V. Booth, S. F. Jenkinson, D. Best, F. Fernandez Nieto, R. J. Estevez, M. R. Wormald, A. C. Weymouth-Wilson and G. W. J. Fleet,  Doubly carbon-branched pentoses: synthesis of both enantiomers of 2,4-di-C-methyl arabinose and 2-deoxy-2,4-di-C-methyl arabinose using only acetonide protection, Tetrahedron Lett. 2009, 50, 5088-5093.

 

495. D. Rao, D. Best, A. Yoshihara, P. Gullapalli, K. Morimoto, M. R. Wormald, F. X. Wilson, K.  Izumori and G. W. J. Fleet, A concise approach to the synthesis of all twelve 5-deoxyhexoses: D-Tagatose-3-epimerase - a reagent that is both specific and general, Tetrahedron Lett. 2009, 50, 3559-3563.

 

494. A. J. Rawlings, H. Lomas, A. W. Pilling, M. J-R Lee, D. S. Alonzi, J. S. S. Rountree, S. F. Jenkinson, G. W. J. Fleet, R. A. Dwek, J. H. Jones and T. D. Butters, Synthesis and Biological Characterisation of Novel N-Alkyl-DNJ [Deoxynojirimycin] a-Glucosidase Inhibitors, ChemBioChem  2009, 10, 1101-1105.

 

493. J. S. S. Rountree, T. D. Butters, M. R. Wormald, R. A. Dwek, N. Asano, K. Ikeda, E. L. Evinson, R. J. Nash and G. W. J. Fleet, Design, synthesis and biological evaluation of enantiomeric b-N-acetylhexosaminidase inhibitors; LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff diseases, ChemMedChem 2009, 4, 378-392.

 

492. A. L. Thompson, A. Michalik, R. J. Nash, F. X. Wilson, R. van Well, P. Johnson, G. W. J. Fleet, C.-Y. Yu, X.-G. Hu, R. I. Cooper and D. J. Watkin, Steviamine, a new class of indolizidine alkaloid [(1R,2S,3R,5R,8aR)-3-(Hydroxymethyl)-5- methyloctahydroindolizine-1,2-diol hydrobromide], Acta Cryst. 2009, E65, o2904.

 

491. D. Best, S. F. Jenkinson, D. J. Watkin, F. X. Wilson, R.  J. Nash and G. W. J. Fleet, (2S,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidine-2-carboxylic acid [(2S,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-L-proline], Acta Cryst. 2009, E65, o2418-o2419.

 

490. K. V. Booth, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet, 2,3-O-(S)-Benzylidene-2-C-methyl-D-ribono-1,4-lactone, Acta Cryst. 2009, E65, o2199.

 

489. S. F. Jenkinson, K. V. Booth, S. Newberry, G. W. J. Fleet, K. Izumori, K. Morimoto, R. J. Nash, L. Jones, D. J. Watkin and A. L. Thompson, 2,6-Dideoxy-2,6-imino-L-glycero-D-ido-heptitol, Acta Cryst. 2009, E65, o1755-o1756

 

488. F. Punzo, D. J. Watkin and G W. J. Fleet, a-D-Tagatopyranose, Acta Cryst. 2009, E65, o1393-1394.     

 

487. K. V. Booth, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin, 2-Deoxy-2,3-O-isopropylidene-2,4-di-C-methyl-b-L-arabinose, Acta Cryst. 2009, E65, o570.

 

486. S. F. Jenkinson, J. R. Fenton, K. V. Booth, G. W. J. Fleet and D. J. Watkin, (4S,5R,6R)-Methyl 4-hydroxy-4,5-isopropylidenedioxy-4,5,6,7-tetrahydro-1,2,3-triazolo[1,5-a]pyridine-3-carboxylate, Acta Cryst. 2009, E65, o610-o611

 

485. S. F. Jenkinson, D. Best, A. C. Weymouth-Wilson, R. A. Clarkson, G. W. J. Fleet and D. J. Watkin, (1S)-1,2-O-Benzylidene-a-D-glucurono-6,3-lactone, Acta Cryst. 2009, E65, o414-o415.

 

484.S. F. Jenkinson, C. Wang, M.-S. Pino-Gonzlez, G. W. J. Fleet and D. J. Watkin, 7-Azido-N,N-diethyl-4,5-O-isopropylidene-4-C-methyl-3,6-anhydro-7-deoxy-D-glycero-D-manno-heptonamide, Acta Cryst. 2009, E65, o263.

 

483. Izumori, K.; Tokuda, M.; Fleet, G.; Tsujisaka, Y.; Takeshita, K.; Tsusaki, K.; Okuma, K., Preparation of deoxyketohexose isomerase of Pseudomonas cichorii for deoxyhexose epimerization and enzymic production of rare deoxy-sugars by the Izumoring strategy, PCT Int. Appl. 2008, WO 2008062780 A1 20080529.

 

482. D. Rao, P. Gullapalli, A. Yoshihara, K. Morimoto, G. Takata, S. F. Jenkinson, G. W. J. Fleet and K. Izumori, Direct production of L-tagatose from L-psicose by Enterobacter aerogenes 230S, J. Biosci. Bioengineer. 2008, 106, 473-480.

 

481. M. I. Simone; A. A. Edwards; G. E. Tranter; G. W. J. Fleet, Carbon-branched d-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds, Tetrahedron: Asymmetry 2008, 19, 2887-2894.

 

480. J. M Otero, A. M Estevez, R. M Soengas, R. J Nash, J C Estevez, G. W. J. Fleet, R. J Estevez, Studies on the transformation of nitrosugars into branched chain iminosugars. II: Synthesis of (3R,4R,5R,6S)-2,2-bis(hydroxymethyl)azepane-3,4,5,6-tetraol, Tetrahedron: Asymmetry 2008, 19, 2443-2446.

 

479. K. V. Booth, F. P. da Cruz, D. J. Hotchkiss, S. F. Jenkinson, N. A. Jones, A. C. Weymouth-Wilson, R. Clarkson, T. Heinz and G. W. J. Fleet, Carbon-branched carbohydrate chirons: practical access to both enantiomers of 2-C-methyl-ribono-1,4-lactone and 2-C-methyl-arabinonolactone Tetrahedron: Asymmetry 2008, 19, 2417-2424

 

478. F. P. da Cruz, G. Horne and G. W. J. Fleet, Hydroxylated C-branched pyrrolidines, C-branched prolines and C-branched piperidines from a 2-C-methyl sugar lactone; efficient azide displacement of a tertiary triflate with inversion of configuration, Tetrahedron Lett. 2008, 49, 6812-6815.

 

477. A. L. Thompson, D. J. Watkin, Z. A. Gal, L. Jones, J. Hollinshead, S. F. Jenkinson, G. W. J. Fleet and R. J. Nash, The absolute configuration of 1-epialexine hemihydrate, Acta Cryst. 2008, C64, o649-o652.

 

476. N. A. Jones, D. Rao, A. Yoshihara, P. Gullapalli, K. Morimoto, G. Takata, S. J. Hunter, M. R. Wormald, R. A. Dwek, K. Izumori and G. W. J. Fleet, Green syntheses of new 2-C-methyl aldohexoses and 5-C-methyl ketohexoses: D-Tagatose-3-epimerase (DTE) - a promiscuous enzyme, Tetrahedron: Asymmetry 2008, 19, 1904-1918.

 

475. A. A. Edwards, B. D. Alexander, G. W. J. Fleet, G. E. Tranter, Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids, Chirality 2008, 20, 969-972.

 

474. Y. Minami, C. Kuriyama, K. Ikeda, A. Kato, K. Takebayashi, I. Adachi, G. W. J. Fleet, A. Kettawan, T. Okamoto and N. Asano, Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases, Bioorg. Med. Chem. 2008, 16, 2734-2740.

 

473. T. D. W. Claridge, B. Lopez-Ortega, S. F. Jenkinson and G. W. J. Fleet, Secondary structural investigations into homooligomers of delta-2,4-cis oxetane amino acids, Tetrahedron: Asymmetry 2008, 19, 984-988.

 

472. B. Lopez-Ortega, S. F. Jenkinson, T. D. W. Claridge and G. W. J. Fleet, Oxetane amino acids: synthesis of tetrameric and hexameric carbopeptoids derived from L-ribo 4-(aminomethyl)-oxetan-2-carboxylic acid, Tetrahedron: Asymmetry 2008, 19, 976-983.

 

471. D. Rao, A. Yoshihara, P. Gullapalli, K. Morimoto, G. Takata, F P. da Cruz, S. F. Jenkinson, M. R. Wormald, R. A. Dwek, G. W. J. Fleet and K. Izumori, Towards the biotechnological isomerization of branched sugars: D-Tagatose-3-epimerase equilibrates both enantiomers of 4-C-methyl-ribulose with both enantiomers of 4-C-methyl-xylulose, Tetrahedron Lett. 2008, 49, 3316-3121.

 

470. A. Yoshihara, S. Haraguchi, P. Gullapalli, D. Rao, K. Morimoto, G. Takata, N. A. Jones, S. F. Jenkinson, M. R. Wormald, R. A. Dwek, G. W. J. Fleet and K. Izumori, Isomerization of deoxyhexoses: bioproduction of 1-deoxy-D-tagatose from L-fucose and of 6-deoxy-D-tagatose from D-fucose using Enterobacter agglomerans strain 221e, Tetrahedron: Asymmetry 2008, 19, 739-745.

 

469. D. Best, S. F. Jenkinson, S. D. Rule, R. Higham, T. B. Mercer, R. J. Newell, A. C. Weymouth-Wilson, G. W. J. Fleet, and S. Petursson, High yield protection of alcohols, including tertiary and base sensitive alcohols, as benzhydryl ethers by heating with diphenyldiazomethane in the absence of any other reagent, Tetrahedron Lett. 2008, 49, 2196-2199.

 

468. A. E. Hakansson, J. van Ameijde, G. Horne, R. J. Nash, M. R. Wormald, A. Kato, G. S. Besra, S. Gurcha and G. W. J. Fleet, Synthesis of the naringinase inhibitors L-swainsonine and related 6-C-methyl-L-swainsonine analogues: (6R)-C-methyl-L-swainsonine is a more potent inhibitor of L-rhamnosidase by an order of magnitude than L-swainsonine, Tetrahedron Lett. 2008, 49, 179-184.

 

467. S. F. Jenkinson, D. Best, F. X. Wilson, G. W. J. Fleet and D. J. Watkin, (4R)-4-(2-Allyl-2H-1,2,3-triazol-4-yl)-1,2-O-isopropylidene-L-threose, Acta Cryst. 2008, E64, o2361-2362.

 

466. S. F. Jenkinson, K. V. Booth, D. Best, G. W. J. Fleet and D. J. Watkin, tert-Butyl 2-deoxy-4,5-O-isopropylidene-D-gluconate, Acta Cryst. 2008, E64, o2011-o2012.

                                                            

465. F. P. da Cruz, K. V. Booth, G. W. J. Fleet and D. J. Watkin 3-O-Benzhydryl-2,5-dideoxy-2,5-imino-2-C-methyl-L-lyxono-1,4-lactone, Acta Cryst. 2008, E64, o1902-o1903.

 

464. S. F. Jenkinson, K. V. Booth, P. Gullapalli, K. Morimoto, K. Izumori, G. W. J. Fleet and D. J. Watkin 1-Deoxy-L-mannitol (6-deoxy-L-mannitol or L-rhamnitol), Acta Cryst. 2008, E64, o1705-o1706.

 

463. K. V. Booth, S. F. Jenkinson, D. Rao, T. Simonisi, G. W. J. Fleet, K. Izumori and D. J. Watkin 6-Azido-6-deoxy-a-L-galactose (6-Azidofucose), Acta Cryst. 2008, E64, o1568-o1569.

 

462. S. F. Jenkinson, K. V. Booth, A. Yoshihara, K. Morimoto, G. W. J. Fleet, K. Izumori and D. J. Watkin, 1-Deoxy-D-galactitol (L-fucitol), Acta Cryst. 2008, E64, o1429.

 

461. K. V. Booth, S. F. Jenkinson, G. W. J. Fleet, P. Gullapalli, A. Yoshihara, K. Izumori and D. J. Watkin 6-Deoxy-a-L-talopyranose, Acta Cryst. 2008, E64, o1385.

 

460. S. F. Jenkinson, S. D. Rule, K. V. Booth, G. W. J. Fleet, D. J. Watkin and S. Petursson, 2-O-Benzhydryl-3,4-(S)-O-benzylidene-D-xylono-1,4-lactone, Acta Cryst. 2008, E64, o1012 .

 

459. S. F. Jenkinson, F. P. Cruz, K. V. Booth, G. W. J. Fleet, K. Izumori, C.-Y. Yu and D. J. Watkin, 1-Deoxy-D-arabinitol, Acta Cryst. 2008, E64, o1010-o1011.

 

458. S. F. Jenkinson, D. J. Hotchkiss, A. R. Cowley, G. W. J. Fleet and D. J. Watkin, (S)-3-Dimethylamino-2-{(4S,5R)-5-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hydroxypropanoic acid Acta Cryst. 2008, E64, o294-o295.

 

457. S. F. Jenkinson, S. D. Rule, K. V. Booth, G. W. J. Fleet, D. J. Watkin and S. Petursson, 2-O-Benzhydryl-3,4-(S)-O-benzylidene-D-lyxono-1,4-lactone, Acta Cryst. 2008, E64, o26-o26.

 

456. S. F. Jenkinson, N. A. Jones, A. Moussa, A. J. Stewart, T. Heinz and G. W. J. Fleet Anomeric stereospecific synthesis of 2-C-methyl-b-nucleosides; the Holy reaction of cyanamide with 2-C-methyl-D-arabinose, Tetrahedron Lett. 2007, 48, 4441-4445.

 

455. J. S. S. Rountree, T. D. Butters, M. R. Wormald, R. A. Dwek, N. Asano, K. Ikeda, E. L. Evinson, R. J. Nash and G. W. J. Fleet, Efficient Synthesis from D-lyxonolactone of 2-acetamido-1,4-imino-1,2,4-trideoxy-L-arabinitol LABNAc, a potent pyrrolidine inhibitor of hexosaminidases, Tetrahedron Lett. 2007, 48, 4287-4291.

 

454. P. Gullapalli, T. Shiji, D. Rao, A. Yoshihara, K. Morimoto, G. Takata , G. W. J. Fleet and K. Izumori, Bioproduction of a novel sugar 1-deoxy-L-fructose by Enterobacter aerogenes IK7; isomerization of a 6-deoxyhexose to a 1-deoxyhexose, Tetrahedron: Asymmetry 2007, 18, 1995-2000.

 

453. M. D. P. Risseeuw, M. Overhand, G. W. J. Fleet, M. I. Simone, A compendium of sugar amino acids (SAA): scaffolds, peptide- and glyco-mimetics, Tetrahedron: Asymmetry 2007, 18, 2001-2010.

 

452. D. A. Mitchell, N. A. Jones, S. J. Hunter, J. M. D. Cook, S. F. Jenkinson, M. R. Wormald, R. A. Dwek and G. W. J. Fleet, Synthesis 2-C-branched derivatives of D-mannose: 2-C-aminomethyl-D-mannose binds to the human C-type lectin DC-SIGN with affinity greater than an order of magnitude compared to that of D-mannose, Tetrahedron: Asymmetry 2007, 18, 1502-1510.

 

451. D. J. Hotchkiss, R. Soengas, K. V. Booth, A. C. Weymouth-Wilson, V. Eastwick-Field and G. W. J. Fleet, Green aldose isomerisation: 2-C-Methyl-1,4-lactones from the reaction of Amadori ketoses with calcium hydroxide, Tetrahedron Lett. 2007, 48, 517-520. 

 

450. N. A. Jones, S. F. Jenkinson, R. Soengas, M. Fanefjord, M. R. Wormald, R. A. Dwek, G. P. Kiran, R. Devendar, G. Takata, K. Morimoto, K. Izumori and G. W. J. Fleet, Synthesis of and NMR studies on the four diastereomeric 1-deoxy-ketohexoses, Tetrahedron: Asymmetry 2007, 18, 774-786.

 

449. D. J. Hotchkiss, A. Kato, B. Odell, T. D. W. Claridge and G. W. J. Fleet, Homochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer - removal of glycosidase inhibition, Tetrahedron: Asymmetry 2007, 18, 500-512.

 

448. A. E. Hnsson, J. van Ameijde, L. Guglielmini, G. Horne, R. J. Nash, E. L. Evinson, A. Kato and G. W. J. Fleet, Looking glass inhibitors: Synthesis of a potent naringinase inhibitor L-DIM [1,4-dideoxy-1,4-imino-L-mannitol], the enantiomer of DIM [1,4-dideoxy-1,4-imino-D-mannitol] a potent _-D-mannosidase inhibitor, Tetrahedron: Asymmetry 2007, 18, 282-289.

 

447. Kato, A.; Kato, N.; Adachi. I.; Hollinshead, J.; Fleet, G. W. J.; Kuriyama, C.; Ikeda, K.; Asano, N.; Nash, R. J. Isolation of glycosidase-inhibiting hyacanthines and related alkaloids from Scilla socialis, J. Nat. Prod. 2007, 70, 993-997.

 

446. J. M. Otero, R. G. Soengas, J. C. Estz, R. J. Estz, D. J. Watkin, E. L. Evinson, R. J. Nash, G. W. J. Fleet, Preliminary studies on the transformation of nitrosugars into branched aza-sugars: Synthesis of 1,4-dideoxy-4-C-hydroxymethyl-1,4-imino-pentanols, Org. Lett., 2007, 9, 623-626.

 

445. I. Streeter; S. F. Jenkinson; G. W. J. Fleet; R. G. Compton, Chemical instability promotes apparent electrochemical irreversibility: Studies on the electrode kinetics of the one electron reduction of the 2,6-diphenylpyrylium cation in acetonitrile solution, J. Electroanalytical Chem. 2007, 600, 285-293.

 

444. D. D. Le Pevelen, A. A. Edwards, G. E. Tranter, D. J. Watkin and G. W.J. Fleet, Isopropyl 6-amino-2,5-anhydro-3,6-dideoxy-6- N-(2,5-anhydro-6-azido-3,6-dideoxy-L-lyxo-hexonyl)–L-lyxo-hexonate, Acta Cryst. 2007, E63, o4719-o4720.

 

443. S. Petursson, S. F. Jenkinson, K. V. Booth, A. C. Weymouth-Wilson, D. J. Watkin, G. W. J. Fleet and D. Best, 2-O-(4,4'-Dimethylbenzhydryl)-L-erythronolactone, Acta Cryst. 2007, E63, o4121-o4121.

 

442. K. V. Booth, S. F. Jenkinson, D. J. Watkin, H. Sharp, P. W. Jones, R. J. Nash and G. W. J. Fleet, (2S,3R,4R,5S)-3,4,5-Trihydroxypipecolic acid dihydrate [(2S,3R,4R,5S)-3,4,5-Trihydroxypiperidine-2-carboxylic acid dihydrate], Acta Cryst. 2007, E63, o3783-o3784.

 

441. K. V. Booth, S. F. Jenkinson A. Cowley, A. Kato, N. Kato, J. Hollinshead, R. J. Nash and G. W. J. Fleet, (2R,3S)3-Hydroxy-N,N-dimethylproline hydrate, Acta Cryst. 2007, E63, o3717-o3717.

 

440. K. V. Booth, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet, 2,4-Di-C-methyl-a-L-arabinose monohydrate, Acta Cryst. 2007, E63, o3592-o3593.

 

439. L. A. Curran, N. A. Jones, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet, 5,6-O-Isopropylidene-3-C-methyl-D-mannono-1,4-lactone, Acta Cryst. 2007, E63, o3416-o3416.

 

438. N. A. Jones, S. F. Jenkinson, L. A. Curran, D. J. Watkin and G. W. J. Fleet, 2,3-Di-C-methyl-D-allono-1,4-lactone, Acta Cryst. 2007, E63, o3415-o3415.

 

437. L. A. Curran, S. F. Jenkinson, N. A. Jones, D. J. Watkin and G. W. J. Fleet, 2,6-Anhydro-1-deoxy-3,4-O-isopropylidene-3-C-methyl-b-D-ribo-hex-2-ulofuranose, Acta Cryst. 2007, E63, o3388- o3388.

 

436. L. A. Curran, S. F. Jenkinson, N. A. Jones, D. J. Watkin and G. W. J. Fleet, 2,3-C-Dimethyl-3,4-O-isopropylidene-D-allono-1,5-lactone, Acta Cryst. 2007, E63, o3387- o3387. 

 

435. K. V. Booth, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet, 2-C-Hydroxymethyl-2,3-O-isopropylidene-3-C-methyl- b-L-erythrose, Acta Cryst. 2007, E63, o3386- o3386.

 

434. K. V. Booth, S. F. Jenkinson, G. J. W. Fleet and D. J. Watkin, 3,5-Di-C-methyl-5,6-O-isopropylidene-L-mannono-1,4-lactone, Acta Cryst. 2007, E63, o2427-o2429.

 

433. K. V. Booth, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin, 3,5-Di-C-methyl-5,6-O-isopropylidene-L-glucono-1,4-lactone, Acta Cryst. 2007, E63, o2424-o2426.

 

432. K. V. Booth, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin, 2,3:5,6-Di-O-isopropylidene-3,5-di-C-methyl-L-mannono-1,4-lactone, Acta Cryst. 2007, E63, o2204-o2206.

 

431. S. F. Jenkinson, N. A. Jones, A. Moussa, A. J. Stewart, T. Heinz, G. W. J. Fleet and D. J. Watkin, 2,2'-Anhydro-2'-C-methyl-1-(D-arabinofuranosyl)uracil (2,2'-anhydro-2'-C-methyluridine), Acta Cryst. 2007, E63, o2171-o2173.

 

430. D. J. Hotchkiss, S. F. Jenkinson, K. V. Booth, G. W. J. Fleet and D. J. Watkin, 2-Azido-(R)-3,5-O-benzylidene-2-deoxy-2-C-methyl-D-xylono-1,4-lactone [(2S,4aR,7R,7aR)-7-azido-7-methyl-2-phenyldihydro-4H-furo[3,2-d][1,3]dioxin-6(4aH)-one], Acta Cryst. 2007, E63, o2168-o2170.

 

429. D. Best, S. F. Jenkinson, K. V. Booth, G. W. J. Fleet and D. J. Watkin, 1-Deoxy-4-C-hydroxymethyl-3,4-O-isopropylidene-L-ribulofuranose [(2R,3S,4S)-4-(hydroxymethyl)-3,4-O-isopropylidene-2-methyltetrahydrofuran-2,3,4-triol], Acta Cryst. 2007, E63, o2165-o2167.

 

428. K. Izumori, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet 1-Deoxy-b-fructopyranose monohydrate, Acta Cryst. 2007, E63, o1882-o1884.

 

427. K. V. Booth, D. J. Watkin, S. F. Jenkinson and G. W. J. Fleet, 2-Azido-2-deoxy-2,4-C-dimethyl-3,4-O-isopropylidene-L-ribono-1,5-lactone, Acta Cryst. 2007, E63, o1759-o1760.

 

426. M. Simone, G W. J. Fleet, R. Bream and D. J. Watkin, 5-Amino-5-deoxy-2-C-hydroxymethyl-2,3-O-isopropylidene-L-lyxono-1,5-lactam, Acta Cryst. 2007, E63, o1409-o1411.

 

 

425. K. V. Booth, D. J. Watkin, S. F. Jenkinson and G. W. J. Fleet, 2,4-Dimethyl-3,4-O-isopropylidene-L-arabinono-1,5-lactone, Acta Cryst. 2007, E63, o1128-o1130

 

424. M. Simone, G. W. J. Fleet and D. J. Watkin, 5-O-tert-Butyldiphenylsilyl-2-C-hydroxymethyl-2,3-O-isopropylidene-2'-O-trifluoromethanesulfonyl-D-ribono-1,4-lactone, Acta Cryst. 2007, E63, o1088-o1090.

 

423. D. Best, S. F. Jenkinson, D. J. Watkin, K. V. Booth and G. W. J. Fleet, 2,3-O-Isopropylidene-L-apiono-1,4-lactone [(3S,4S)-3,4-dihydroxy-4-(hydroxymethyl)-3,4-di-O-isopropylidene-dihydrofuran-2(3H)-one], Acta Cryst. 2007, E63, o1056-o1057.

 

422. N. A. Jones, D. J. Watkin, L. A. Curran, S. F. Jenkinson and G. W. J. Fleet, 3-C-Methyl-D-allono-1,5-lactone, Acta Cryst. 2007, E63, o992-o994.

 

421. M. Simone, G. W. J. Fleet and D. J. Watkin, 1,5-Anhydro-2,3-O-isopropylidene-L-lyxofuranose [(1S,4S,5S,6R)-5,6-O-isopropylidene-2,7-dioxabicyclo[2.2.1]heptane-5,6-diol], Acta Cryst. 2007, E63, o896-o897.

 

420. R. Bream, D. J. Watkin, A. R. Cowley, M. I Simone and G. W. J. Fleet, 3,3:5,6-Di-O-isopropylidene-3-C-hydroxymethyl-D-allono-1,4-lactone: An organic lattice structure containing a large unoccupied void, Acta Cryst. 2007, E63, o799-o801.

 

419. R. Bream, S. J. Hunter, G. W. J. Fleet and D. J. Watkin, 2-C-Hydroxymethyl-2,3-O-isopropylidene-D-mannono-1,5-lactam, Acta Cryst. 2007, E63, o621-o623.

 

418. Cox, D. J.; Hakansson, A.E.; Fleet, G. W. J.; Watkin, D. J., 2,5-Anhydro-N-benzyl-2-C-methyl-D-arabinonamide [(2S,3R,4R)-N-benzyl-3,4-dihydroxy-2-methyltetrahydrofuran-2-carboxamide], Acta Cryst. 2007, E63, o574-o576.

 

417. Jones, N. A., Jenkinson, S. F., Soengas, R., Izumori, K., Fleet, G. W. J., Watkin, D. J., The concomitant crystallization of two polymorphs of 1-deoxy-a-D-tagatose, Acta Cryst. 2007, C63, o7-o10.

 

416. Hakansson, A.E., Horne, G., Fleet, G.W.J. Watkin, D.J., (6S)-Methyl-L-swainsonine [(1R,2S,6S,8S,8aS)-6-methyloctahydroindolizine-1,2,8-triol] Acta Cryst. 2007, E63, o210-o212.

 

415. R. H. Furneaux; P. C. Tyler;S. P. H.; Mee; G. B. Evans; V. L. Schramm,.; G. Fleet,. Preparation of deazapurine analogs of 4'-aza-l-nucleosides as prodrugs treating cancer, bacterial and parasitic infection, and T-cell mediated diseases. PCT Int. Appl. (2007), 59pp. CODEN: PIXXD2 WO 2007069924

 

414. R. J. Nash; M. W. Carroll; A. A. Watson; G. W. J. Fleet; G. Horne Pyrrolidine derivatives as immunomodulators and antiviral agents. PCT Int. Appl. (2007), 72pp. CODEN: PIXXD2 WO 2007010266

 

413. D. Hotchkiss; G. Fleet; T. Heinz; R. Storer Process for preparing saccharinic acids and lactones. PCT Int. Appl. (2007), 53pp. CODEN: PIXXD2 WO 2007025304.

 

412. R. A. Jockusch, F. O. Talbot, M. I. Simone, P. S. Rogers, G. W. J. Fleet and J. P. Simons, Carbohydrate amino acids: the intrinsic conformational preference for a b-turn type structure in a carbopeptoid building block, J. Am. Chem. Soc., 2006, 128, 16771-16777.

 

411. J. Van Ameijde, G. Horne, M. R. Wormald, R. A. Dwek, R. J. Nash, P. W. Jones, E. L. Evinson and G. W. J. Fleet, Isolation synthesis and glycosidase inhibition profile of 3-epi-casuarine, Tetrahedron: Asymmetry 2006, 17, 2702-2713.

 

410. N. A. Jones, M. Fanefjord, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin, 1-Deoxy-a-D-sorbopyranose, Acta Cryst. 2006, E62, o4663-o4665.

 

409. R. Bream, D. J. Watkin, N. A. Jones, S. F. Jenkinson and G. W. J. Fleet, 2-C-Methyl-3,4-O-methylidene-D-arabinono-1,5-lactone, Acta Cryst. 2006, E62, o4356-o4358.

 

408. S. Parker, D. J. Watkin, M. I Simone and G. W. J. Fleet, 3,4:5,6-Di-O-isopropylidene-3-C-hydroxymethyl-D-altrono-1,3-lactone, Acta Cryst. 2006, E62, o3961-o3963.

 

407. Y. Bleriot, M. I. Simone, M. R. Wormald, R. A. Dwek, D. J. Watkin and G. W. J. Fleet, Sugar amino acids at the anomeric position of carbohydrates: synthesis of spirocyclic amino acids of 6-deoxy-L-lyxofuranose, Tetrahedron: Asymmetry 2006, 17, 2276-2286.

 

406. Hakansson, A.E., van Ameijde, J., Horne, G., Guglielmini, L., Nash, R.J., Fleet, G.W.J. Watkin, D.J., 2,3:6,7-Di-O-diethylidene-D-glycero-L-talo-heptono-1,4-lactone, Acta Cryst. 2006, E62, o3890-o3892.

 

405. A. A. Edwards, G. J. Sanjayan, S. Hachisu, G. E. Tranter and G. W. J. Fleet, A novel series of oligomers from 4-aminomethyl-tetrahydrofuran-2-carboxylates with 2,4-cis and 2,4-trans stereochemistry, Tetrahedron 2006, 62, 7718-7725.

 

404. S. W. Johnson, G. W. J. Fleet and J. H. Jones, Cyclic oligomers of oxetane-based dipeptide isosteres derived from L-Rhamnose, J. Peptide Sci., 2006, 12, 559-561.

 

403. Nash, R. J., Fleet, G. W. J., Van Ameijde, J., and Horne, G., Synthesis of Polyhydroxylated Alkaloids PCT Int. Appl. Publication date 26 Jan 2006, publication no WO 2006/008493 A1

 

402. A. A. Edwards, G. J. Sanjayan, S. Haschisu, R. Soengas, A. Stewart, G. E. Tranter and G. W. J. Fleet, Synthesis of 4-aminomethyl-tetrahydrofuran-2-carboxylates with 2,4-cis and 2,4-trans relationships, Tetrahedron 2006, 62, 4110-4119.

 

401. K. Clinch, G. B. Evans, G. W. J. Fleet, R. H. Furneaux, S. W. Johnson, D. Lenz, S. Mee, P. R. Rands, V. L. Schramm, E. A. T. Ringia and P. C. Tyler, Syntheses and activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases, Org. Biomol. Chem., 2006, 4, 1131-1139.

 

400. Edwards, A.A.; Fleet, G.W.J.; Tranter, G.E., Classification of Conformation for Sugar Amino Acid Systems using Chiroptical Spectroscopy, Chirality 2006, 18, 265-272.

 

399. D. J. Hotchkiss, S. F. Jenkinson, R. Storer, T. Heinz and G. W. J. Fleet, Amadori ketoses with calcium hydroxide and the Kiliani reaction on 1-deoxy ketoses: two approaches to the synthesis of saccharinic acids, Tetrahedron Lett. 2006, 47, 315-318.

 

398. Chesterton A.K.S., Jenkinson S.F., Jones N.A., Fleet G.W.J., Watkin D.J., (2S,4S)-4-Azido-1-benzyl-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl] pyrrolidine Acta Cryst. 2006, E62, o2983-o2985.

 

397. R. Bream, D. Watkin, R. Soengas, G. W. J. Fleet, Alison A. Edwards, S. J. Hunter and G. E. Tranter, cyclo[(6-Amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonic acid)-(D-Phe)]2), Acta Cryst. 2006, E62, o1851-o1853.

 

396. F. Punzo, D. J. Watkin, D. Hotchkiss and G. W. J. Fleet, 3-Deoxy-D-galactono-1,4-lactone (3-deoxy-D-xylo-hexono-1,4-lactone), Acta Cryst. 2006, E62, o1344-o1346

 

395. S. Parker, D. J. Watkin, B. Mayes, R. Storer, S. Jenkinson and G. Fleet, 2-Deoxy-2-fluoro-2-C-methyl-D-ribono-1,4-lactone (fluoromethylrib), Acta Cryst. 2006, E62, o1208-o1210.

 

394. R. Bream, D. J. Watkin, R. Soengas, V. Eastwick-Field and G. W. J. Fleet, 2,5-Di-O-acetyl-3-C-methyl-D-lyxono-1,4-lactone, Acta Cryst. 2006, E62, o977-o979.

 

393. F. Punzo, D. J. Watkin, J. van Ameijde, G. Horne and G. W. J. Fleet, 3,7,7a-Tri-epi-casuarine pentaacetate, Acta Cryst. 2006, E62, o928-o930.

 

392. F. Punzo, A. R. Cowley, D. J. Watkin, M. I. Simone, A. A. Edwards, G. E. Tranter and G. W. J. Fleet, Pentafluorophenyl (3R,4R,5R)-5-{[(3R,4R,5R)-5-Azidomethyl-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carbonylamino]methyl}-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxylate, Acta Cryst. 2006, E62, o473-o475.

 

391. D. J. Watkin, M. Watterson, G. E. Tranter, A. A. Edwards and G. W. J. Fleet Isopropyl 2,5-anhydro-6-azido-3,6-dideoxy-D-xylo-hexonate, Acta Cryst. 2006, E62, o363-o365.

 

390. F. Punzo, D. J. Watkin, S. F. Jenkinson, F. P. da Cruz and G. W. J. Fleet, 2-C-Azidomethyl-2-deoxy-3,4-O-isopropylidene-D-ribono-1,5-lactone, Acta Cryst. 2006, E62, o321-o323.

 

389. F. Punzo, D. J. Watkin, D. Hotchkiss and G. W. J. Fleet, 2-C-Methyl-D-lyxono-1,4-lactone, Acta Cryst. 2006, E62, o98-o100.

 

388. Nash, R. J., Wolferstan, P., Fleet, G. W. J., Van Ameijde, J., and Horne, G., Antibacterial Compounds PCT Int. Appl. Publication date 26 May 2005, publication no WO 2005/046674 A2

 

387. K. A. Watson, E. D. Chrysina, K. E. Tsitsanou, S. E. Zographos, G. Archontis, D. D. Leonidas, N. G. Oikonomakos, G. W. J. Fleet, Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogues inhibitors of glycogen phosphorylase. Proteins: Structure, Function, and Bioinformatics, 2005, 61, 966-983.

 

386. Y. Blot, D. Gretzke, T. M. Krlle, T. D. Butters, R. A. Dwek, R. J. Nash, N. Asano, G. W. J. Fleet, Looking glass inhibitors: efficient synthesis and biological evaluation of D-deoxyfuconojirimycin, Carbohydr. Res., 2005, 340, 2713-2718.

 

385. D. J. Watkin, L. L. Parry, D. J. Hotchkiss, V. Eastwick-Field and G. W. J. Fleet, 3,5-O-Isopropylidene-2-C-methyl-D-xylonolactone, Acta Cryst. 2005, E61, o3302-o3303.

 

384. D. J. Watkin, A. F. G. Glawar, R. Soengas, K. Izumori, M. R. Wormald, R. A. Dwek and G. W. J. Fleet, 1,2:3,4-Di-O-isopropylidene-b-D-psicofuranose, Acta Cryst. 2005, E61, o2949-o2951.

 

383. D. J. Watkin, L. L. Parry, R. Soengas, K. Izumori and G. W. J. Fleet, 2-C-Benzyloxymethyl-2,3:5,6-di-O-isopropylidene-D-allono-1,4-lactone, Acta Cryst. 2005, E61, o2955-o2957.

 

382. S. W. Johnson, S. F. Jenkinson (nBarker), D. Angus, I. Perez-Victoria, A. A. Edwards, T. D. W. Claridge, G. E. Tranter, G. W. J. Fleet, J. H. Jones. Conformational Studies of Oligomeric Oxetane-Based Dipeptide Isosteres derived from L-Rhamnose or D-Xylose, J. Peptide Sci., 2005, 11, 517-524.

 

381. M. I. Simone, R. Soengas, C. R. Newton, D. J. Watkin and G. W. J. Fleet, Branched tetrahydrofuran a,a-disubstituted d-sugar amino acid scaffolds from branched sugar lactones: a new family of foldamers?, Tetrahedron Lett. 2005, 46, 5761-5765.

 

380. R. Soengas, K, Izumori, M. I. Simone, D. J. Watkin, U. P. Skytte, W. Soetaert and G. W. J. Fleet, Kiliani reaction on ketoses: branched carbohydrate building blocks from D-tagatose and D-psicose, Tetrahedron Lett. 2005, 46, 5755-5759.

 

379. S. W. Johnson, S. F. Jenkinson (nBarker), D. Angus, I. Perez-Victoria, T. D. W. Claridge, G. W. J. Fleet, J. H. Jones. The Synthesis of Oligomers of Oxetane-Based Dipeptide Isosteres derived from L-Rhamnose or D-Xylose, J. Peptide Sci., 2005, 11, 303-318.

 

378. Edwards, A.A.; Fleet, G.W.J.; Mayes, B.A.; Hunter, S.J.; Tranter, G.E., Spectroscopic studies of carbopeptoid-cyclodextrins, Chirality 2005, 17, S114-S117.

 

377. T. D. W. Claridge, D. D. Long, C. M. Baker, B. Odell, G. H. Grant, A. A. Edwards, G. E. Tranter, G. W. J. Fleet and M. D. Smith, Helix-forming carbohydrate amino acids, J. Org. Chem., 2005, 70, 2082-2090.

 

376. D. J. Watkin, A. F. G. Glawar, R. Soengas, U. P. Skytte, M. R. Wormald, R. A. Dwek and G. W. J. Fleet, 1,2:3,4-Di-O-isopropylidene-a-D-tagatofuranose, Acta Cryst. 2005, E61, o2891-o2893.

 

375. D. J. Watkin, L. L. Parry, R. Soengas and G. W. J. Fleet, 1,4-Anhydro-2-C-benzyloxymethyl-2,3:5,6-di-O-isopropylidene-D-tallitol, Acta Cryst. 2005, E61, o2865-o2867.

 

374. A. Glawar, B. A. Mayes, D. J. Watkin and G. W. J. Fleet, (2R,3S,4S,5R)-Methyl 5-cyano-2,3:4,5-di-O-isopropylidene-2,3,4,5-tetrahydroxypentanoate, Acta Cryst. 2005, E61, o2727-o2729.

 

373. A. F. G. Glawar, D. J. Watkin, G. J. Sanjayan, G. E. Tranter, A. A. Edwards and G. W. J. Fleet, Isopropyl 2,5-anhydro-3,4-di-O-tert-butyldiphenylsilyl-L-ribonate, Acta Cryst. 2005, E61, o2724-o2726.

 

372. F. Punzo, D. J. Watkin, J.M.D. Cook, D. Hotchkiss and G. W. J. Fleet, N-(p-Tolyl)-b-L-rhamnopyranosylamine 1.5 hydrate, Acta Cryst. 2005, E61, o2155-o2157.

 

371. M. R. Probert, D. J. Watkin, A. J. Stewart, R. Storer and G. W. J. Fleet, The crystal and molecular structure of (2R,3R,4R)-Methyl 2-bromo-3,4-dihydroxy-3,4-di-O-isopropylidene-tetrahydrofuran-2-carboxylate, Acta Cryst. 2005, E61, o1718-o1720.

 

370. C. C. Harding, J. S. S. Rountree, D. J. Watkin, A. R. Cowley, T. D. Butters, M. R. Wormald, R. A. Dwek and G W. J. Fleet, 2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-arabinitol hydrate, Acta Cryst., 2005, E61, o1683-o1685.

 

369. C. C. Harding, A. R. Cowley, D. J. Watkin, F. Punzo, D. J. Hotchkiss and G. W. J. Fleet, 1-Amino-1-deoxy-N,N-dibenzyl-a-D-tagatopyranose methanol solvate, Acta Cryst. 2005, E61, o1475-o1477.

 

368. C. C. Harding, D. J. Watkin, N. K. Sawyer, S. F. Jenkinson and G. W. J. Fleet, 2-C-Methyl-D-allono-1,4-lactone, Acta Cryst. 2005, E61, o1472-o1474.

 

367.C. C. Harding, D. J. Watkin, D. J. Hotchkiss, J. M. D. Cook and G. W. J. Fleet,1-Amino-N,N-dibenzyl-1,6-dideoxy-b-L-fructofuranose, Acta Cryst. 2005, E61, o995-o997

 

366. C. C. Harding, D. J. Watkin, J. S. S. Rountree, T. D. Butters, M. R. Wormald, R. A. Dwek and G W. J. Fleet, 2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-ribitol, Acta Cryst., 2005, E61, o930-932

 

365. S. Humphreys, D. J. Watkin, G. J. Sanjayan, G. E. Tranter, A. A. Edwards and G. W. J. Fleet, Isopropyl 2,5-anhydro-4-(2,5-anhydro-4-azido-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonylamino)-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonate, Acta Cryst., 2005, E61, o918-o919.

 

364. N. Asano, K. Ikeda, L. Yu, A. Kato, K. Takebayashi, I. Adachi, I. Kato, H. Ouchi, H. Takahata and G. W. J. Fleet, The L-enantiomers of D-sugar-mimicking iminosugars are non-competitive inhibitors of D-glycohydrolase?, Tetrahedron: Asymmetry, 2005, 16, 223-229.

 

363. G. W. J. Fleet Carbohydrate Science Tetrahedron: Asymmetry, 2005, 16, 1-2.

 

362. F. Punzo, D. J. Watkin, M. Iezzi Simone and G. W. J. Fleet, (3R,4R,5S)-5-(Acetamidomethyl)-N-benzyl-3,4-dihydroxytetrahydrofuran-3-carboxamide, Acta Cryst., 2005, E61, o513-o515.

 

361. F. Punzo, D. J. Watkin, S. F. Jenkinson, F. P. Cruz and G. W. J. Fleet, 2-Azido-2-deoxy-3,4-O-isopropylidene-2-C-methyl-D-ribono-1,5-lactone, Acta Cryst., 2005, E61, o511-o512.

 

360. F. Punzo, D. J. Watkin, S. F. Jenkinson and G. W. J. Fleet, 2C-Methyl-D-arabinono-1,4-lactone monohydrate, Acta Cryst., 2005, E61, o326-o327.

 

359. C. C. Harding, D. J. Watkin, A. R. Cowley, R. Soengas, U. P. Skytte and G. W. J. Fleet, 2,2:5,6-Di-O-isopropylidene-2-C-hydroxymethyl-D-talono-1,4-lactone, Acta Cryst., 2005, E61, o250-o252.

 

358. F. Punzo, D. J. Watkin, S. F. Jenkinson and G. W. J. Fleet, 3,4-O-Isopropylidene-2C-methyl-D-arabinono-1,5-lactone, Acta Cryst., 2005, E61, o127-129.

 

357. R.A. Jockusch, F.O. Talbot, N. Asano, G.W.J. Fleet and J.P. Simons, Gas phase structure and conformation of the glycosidase and ceramide glucosyltransferase inhibitor N-benzyl-deoxynojirimycin, Phys. Chem. Chem. Phys. 2004, 6, 5283-5287.

 

356. D. Hotchkiss, R. Soengas, M. I. Simone, J. van Ameijde, S. Hunter, A. R. Cowley and G. W. J. Fleet, Kiliani on ketoses: branched carbohydrate building blocks from D-fructose and L-sorbose, Tetrahedron Lett. 2004, 45, 9461-9464.

 

355. C. C. Harding, H. Shallard-Brown, D. J. Watkin, R. Soengas and George W. J. Fleet, 3-Azido-3-deoxy-2,2':5,6-di-O-isopropylidene-2-C-hydroxmethyl-D-gulono-1,4-lactone, Acta Cryst., 2004, E60, o2334-o2336.

 

354. F. Punzo, D. J. Watkin, M. I. Simone and G. W. J. Fleet , (1R,5S,8R)-1,8-Dihydroxy-6-oxa-3-azabicyclo[3.2.1]octan-2-one, Acta Cryst., 2004, E60, o2315-2317.

 

353. H. A. Shallard-Brown, C. C. Harding, D. J. Watkin, R. Soengas, U. P. Skytte and G. W. J. Fleet, 2,3:5,6-Di-O-isopropylidene-2-C-hydroxymethyl-D-talono-1,4-lactone, Acta Cryst. 2004 E60, o2163-o2164.

 

352. A. R. Cowley, G. W. J. Fleet, M. I. Simone and R. Soengas, 3-O-tert-Butyldimethylsilyl-2,2':5,6-di-O-isopropylidene-2-C-hydroxymethyl-D-1,4-gluconolactone, Acta Cryst. 2004 E60, o2142-o2143.

 

351. J. van Ameijde, A. R. Cowley, G. W. J. Fleet, R. J. Nash, M. I. Simone and R. Soengas, 5-Amino-5-deoxy-2-C-hydroxymethyl-2,3-O-isopropylidene-D-talono-1,5-lactam, Acta Cryst. 2004 E60, o2140-o2141.

              

350. D. J. Watkin, M. Muller, Y. Bleriot, M.I. Simone and G. W. J. Fleet, (2S,3R,4R,5S)-3,4-O-isopropylidene-2-methyl-6,9-diazo-1-oxaspiro-[4.5]-decane-7,10-dione, Acta Cryst. 2004 E60, o1820-o1822.

 

349. S. W. Johnson, S. F. Jenkinson (nȥ Barker), J. H. Jones, D. J. Watkin and G. W. J. Fleet, Pseudoenantiomeric oxetane d-amino acid scaffolds derived from L-rhamnose and D-xylose; D/L-Alanine-D-Serine and Glycine-L-Serine dipeptide isosteres, Tetrahedron: Asymmetry 2004, 15, 3263-3273.

 

348. D. J. Watkin, S. W. Johnson, J. H. Jones, G. W. J. Fleet, Methyl 2,4-anhydro-5-azido-5,6-dideoxy-L-altronate, Acta Cryst. 2004 E60, o1609-o1610.

 

347. S. W. Johnson, S. F. Jenkinson (nȥ Barker), D. Angus, C. Taillefumier, J. H. Jones and G. W. J. Fleet Oxetane cis- and trans b-amino-acid scaffolds from L-rhamnose by efficient SN2 reactions in oxetane rings; pseudoenantiomeric analogues of the antibiotic oxetin, Tetrahedron: Asymmetry, 2004, 15, 2681-2686.

 

346. S. F. Jenkinson (nȥ Barker), T. Harris and G. W. J. Fleet Oxetane cis- and trans b-amino-acid scaffolds from D-xylose by efficient SN2 reactions in oxetane rings: methyl and hydroxymethyl analogues of the antibiotic oxetin, an oxetane b-amino-acid, Tetrahedron: Asymmetry, 2004, 15, 2667-2679.

 

345. Chu-Yi Yu, Naoki Asano, Kyoko Ikeda, Mei-Xiang Wang, Terry D. Butters, Mark R. Wormald, Raymond A. Dwek, Ana L. Winters, Robert J. Nash and George W. J. Fleet, L-DMDP, a More Potent and Specific Inhibitor of a-Glucosidases than the Enantiomeric Natural Product DMDP, Chem. Commun., 2004, 1936-1937.

 

344. Newton, C.R.; van Ameijde, J.; Fleet, G.W.J.; Nash, R.J.; Watkin, D.J. 3-epi-Casuarine monohydrate, Acta Cryst. 2004 E60, o1463-o1464.

 

343. Newton, C.R.; Simone, M.I.; Fleet, G.W.J.; Bleriot, Y.; Watkin, D.J. 2-C-Hydroxymethyl-2,3-O-isopropylidene-D-ribono-1,5-lactam, Acta Cryst. 2004 E60, o909-o910.

 

342. Newton, C. R.; Horne, G.; Fleet, G. W. J.; Nash, R. J.; Watkin, D.J. Methyl 3,6-anhydro-4-azido-5,7-O-(S)-benzylidene-2,4-dideoxy-D-talo-heptonate, Acta Cryst. 2004 E60, o839-o840

 

341. Zhao, M.X., Wang M.X., Yu, C.Y., Huang, Z.T., Fleet, G.W.J., Ring-chain tautomerism in organic synthesis: Synthesis of heterocyclic enamines from a novel and practical formal ring transformation reaction of lactones, J. Org. Chem., 2004, 69, 997-1000

 

340. B. A. Mayes, R.J.E. Stetz, M. P. Watterson, A. A. Edwards, C. W.G. Ansell, G. E. Tranter and G. W.J. Fleet, Towards hydroxylated nylon 6: linear and cyclic oligomers from a protected 6-amino-6-deoxy-D-galactonate – a novel class of carbopeptoid-cyclodextrin (CPCD), Tetrahedron: Asymmetry, 2004, 15, 627-638.

 

339. Y.-K. Chung, T.D.W. Claridge, G.W.J. Fleet, S.W. Johnson, J.H. Jones, K.W. Lumbard, A.V. Stachulski, An Unsaturated peptidomimetic assembly derived from a carbohydrate, J. Peptide. Sci., 2004, 10, 1-7.

 

338. A. A. Edwards,, O. Ichihara, S. Murfin, R. Wilkes, D. J. Watkin, and G. W. J. Fleet, Tetrahydrofuran based amino acids as novel library scaffolds, J. Combinatorial Chem., 2004, 6, 230-238.

 

337. B. A. Mayes, A.R. Cowley, C.W.G. Ansell and G. W.J. Fleet, Mixed sugar-nylon 14-, 28- and 42-membered ring macrocyclic lactams, Tetrahedron Lett., 2004, 45, 163-166.

 

336. B. A. Mayes, L. Simon, D. J. Watkin, C.W.G. Ansell and G. W.J. Fleet, Huge (14-, 21-, 28-, 35-, 56- and 70-membered ring) macrocyclic lactams – a novel family of carbopeptoid-cyclodextrins Tetrahedron Lett., 2004, 45, 157-162.

 

335. B. A. Mayes, R.J.E. Stetz, C.W.G. Ansell and G. W.J. Fleet, Cyclo[(6-amino-6-deoxy-D-galactonic acid)4]: a new class of carbopeptoid-cyclodextrin (CPCD), Tetrahedron Lett., 2004, 45, 153-156.

 

334. S. Mons and G. W.J. Fleet, An approach to the generation of simple analogues of the antitumor agent spicamycin, Org. Biomol. Chem., 2003, 1, 3685-3691.

 

333. M. D. Smith, T. D. W. Claridge, M. P. Sansom and G. W. J. Fleet, Bend ribbon-forming Tetrahydrofuran amino acids, Org. Biomol. Chem., 2003, 1, 3647-3655.

 

332. D.F.W. Hunter and G.W. J. Fleet, Towards hydroxylated nylon 6: oligomers from a protected 6-amino-6-deoxy-D-allonate, Tetrahedron: Asymmetry, 2003, 14, 3831-3839.

 

331. R. I. Cooper, A. Edwards, G. W. J. Fleet and D. J.Watkin, Isopropyl 6-amino-2,5-anhydro-3,6-dideoxy-6-N-(2,5-anhydro-6-azido-3,6-dideoxy-L- arabino-hexonyl)-L-arabino-hexonate,

Acta Cryst. 2003 E59, 1712-1714

 

330. M.P. Watterson, A.A. Edwards, J.A. Leach, M.D. Smith, O. Ichihara, G. W. J. Fleet, Synthesis of all diastereomeric methyl 2,5-anhydro-3-deoxy-hexonates: precursors to C-2- deoxynucleosides and THF-templated g- and d-amino acids, Tetrahedron Lett., 2003, 44, 5853-5857.

 

329. G. J. Sanjayan, A.J. Stewart, S. Hachisu, R. Gonzalez, M. P. Watterson and G. W. J. Fleet, Templated scaffolds of cis- and trans-tetrahydrofuran g-amino acids: g-azido-b-hydroxy-tetrahydrofuran-2-carboxylates from pentono-d-lactones, Tetrahedron Lett., 2003, 44, 5847-5852.

 

328. Wang M.X., Liu Y,, Gao, H.Y., Zhang, Y., Yu, C.Y., Huang, Z.T., Fleet, G.W.J., Ring-chain tautomerism in organic synthesis: Synthesis of heterocyclic enamines from a novel and practical formal ring transformation reaction of lactones, J. Org. Chem., 2003, 68, 3281-3286.

 

327. Kato A, Kano E, Adachi I, Molyneux RJ, Watson AA, Nash RJ, Fleet GWJ, Wormald MR, Kizu H, Ikeda K, Asano N Australine and related alkaloids: easy structural confirmation by C-13 NMR spectral data and biological activities,, Tetrahedron: Asymmetry, 2003 14, 325-331.

 

326. Butters, Terence D.; Dwek, Raymond A.; Fleet, George; Orchard, Michael Glen; Platt, Frances Mary. Preparation of pharmaceutically active aza-sugar piperidine derivatives as inhibitors of galactosidase and glucosylceramide synthase. PCT Int. Appl. (2002), 38 pp. CODEN: PIXXD2 WO 2002055498 A1 20020718 CAN 137:93950 AN 2002:539660 CAPLUS

 

325 Yamashita T, Yasuda K, Kizu H, Kameda Y, Watson AA, Nash RJ, Fleet GWJ , Asano N, New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica, J. Nat. Prod., 2002, 65, 1875-1881.

 

324. A.J. Stewart, R.M. Evans, A.C. Weymouth-Wilson, A.R. Cowley, D.J. Watkin, and G.W.J. Fleet, 2-Deoxy-L-ribose from an L-arabinono-1,5-lactone, Tetrahedron: Asymmetry, 2002, 13, 2667-2672.

 

323. Long DD, Smith MD, Martin A, Wheatley JR, Watkin DG, Muller M, Fleet GWJ Complex tetrahydrofurans from carbohydrate lactones: THF amino acids as building blocks for unnatural biopolymers, J. Chem. Soc., Perkin Trans. 1, 2002, 1982-1998.

 

322. Mellor HR, Nolan J, Pickering L, Wormald MR, Platt FM, Dwek RA, Fleet GWJ, Butters TD Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins, Biochem. J., 2002, 366, 225-233.

 

321. K. Yasuda, H. Kizu, T. Yamashita, Y. Kameda, A. Kato, R.J. Nash, G.W.J.Fleet N. Asano, New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii, J. Nat. Prod., 2002, 65, 198-202

 

320. T. D. W. Claridge, J. M. Goodman, A. Moreno, D. Angus, S. F. Barker, C. Taillefumier, M. P. Watterson, and G. W. J. Fleet, 10-Helical conformations in oxetane b-amino acid hexamers, Tetrahedron Lett., 2001, 42, 4251-4255.

 

318. S. F. Barker, D. Angus, C. Taillefumier, M.R. Probert, D.J. Watkin, M. P. Watterson, T.D.W. Claridge and G. W. J. Fleet, cis- and trans-3-Azido-oxetane-2-carboylate scaffolds: Hexamers of oxetane cis-b-amino acids, Tetrahedron Lett., 2001, 42, 4247-4250.

 

317. Watson, A.A., Fleet, G.W.J., Asano, N., Molyneux, R.J., Nash, R.J., Polyhydroxylated alkaloids – natural occurrence and therapeutic applications, Phytochemistry, 2001, 56, 265-295

 

316. Long, D.D.; Tennant-Eyles, R.J; Estevez, J.C.; Wormald, M.R.; Dwek, R.A.; Smith, M.D.; Fleet, G.W.J. Carbopeptoids: Peptides and diketopiperazines incorporating the anomeric centre of mannopyranose, J. Chem. Soc., Perkin Trans. 1, 2001, 807-813.

 

315. Asano N, Yasuda K, Kizu H, Kato A, Fan JQ, Nash RJ, Fleet GWJ, Molyneux RJ, Novel alpha-L-fucosidase inhibitors from the bark of Angylocalyx pynaertii (Leguminosae), Eur. J. Biochem., 2001, 268, 35-41.

 

314. Zitzmann, Nicole; Butters, Terry D.; Platt, Frances M.; Carrouee, Sandra; Jacob, Gary S.; Picker, Donald H.; Fleet, George W. J.; Dwek, Raymond A. Preparation of long chain N-alkyl amino and imino alditols and oxa-derivatives as antiviral agents. PCT Int. Appl. (2001), 47 pp. CODEN: PIXXD2 WO 2001010429 A2 20010215 CAN 134:163282 AN 2001:114972 CAPLUS

 

313. Fleet, George; Scott, David; Finn, Malcolm; Krulle, Thomas. Bis(1,3-dihydroxy-prop-2-yl)amine and derivatives thereof in manufacture of polymers. PCT Int. Appl. (2000), 77 pp. CODEN: PIXXD2 WO 2000055111 A2 20000921 CAN 133:252855 AN 2000:666687 CAPLUS