G W J Fleet Quick CV, Research Interests, Complete Publication and Patent List

Quick CV: Undergraduate at Magdalene College Cambridge UK, Ph D with Ian Fleming at Cambridge on heterocyclic analogues of benzyne. MRC Post doctoral fellow at Oxford with Jeremy Knowles and Rodney Porter [Nobel prize winner] on the Photoaffinity Labeling of Antibodies by Azides. Post doctoral work with E J Corey [Nobel prize winner] at Harvard on prostaglandin synthesis and chromium(VI) oxidation. At Oxford since.

Research Interests: Our interests are in a wide range of aspects of carbohydrates including hydroxylated alkaloids, nucleosides, green amino acid synthesis, new biopolymers, Peptidomimetics. Bioactive sugar mimics as potential agents for the treatment of HIV, cancer, cystic fibrosis, hepatitis B and C; novel immunostimulatory materials. A green approach to the biotechnological and chemical synthesis of new carbohydrates

Nutraceuticals are likely to benefit the human race as novel chemotherapeutic agents and alternative food stuffs; this is one of our major projects. We are also interested in green environmentally friendly syntheses of nucleosides – the most successful compounds for keeping humans who have cancer AIDS and nasty viral diseases alive with a reasonable life style.

Publications and patents: Some idea of where we are at present is given from the full list below of publications and patents which runs from the most recent backwards. A reliable assessment of published work for chemists is the Hirsch-index. The group h-index is 56; we have an h index of 38 since 1995 and of 26 since 2000.

Further information can also be found at: http://www.chem.ox.ac.uk/researchguide/gwjfleet.html

Anyone interested in working with us should contact me by e.mail  george.fleet@chem.ox.ac.uk

534. G. M. J. Lenagh-Snow, N. Araujo, S. F. Jenkinson,a C. Rutherford, S. Nakagawa, A. Kato, C.-Y. Yu, A. C. Weymouth-Wilson and G. W. J. Fleet, Inhibition of Nonmammalian Glycosidases by Azetidine Iminosugars Derived from Stable 3,5-Di-O-triflates of Pentoses, Org. Lett. 2011, 13, doi.org/10.1021/ol2024482.

533. R. J. Nash, A. Kato, C.-Y. Yu, G. W. J. Fleet, Iminosugars as therapeutic agents: Recent advances and promising trends, Future Med. Chem. 2011, 3, 1513-1521. 

532. W. Zhang, K. Sato, A. Kato, Y.-M. Jia, X.-G. Hu, F. X. Wilson, R. van Well, G. Horne, G. W. J. Fleet, R. J. Nash, and C.-Y. Yu, Synthesis of Fully Substituted Polyhydroxylated Pyrrolizidines via Cope–House Cyclization, Org. Lett. 2011, 13, 4414-4417.

531. S. F. Jenkinson, G. W. J. Fleet, R. J. Nash, Y. Koike, I. Adachi, A. Yoshihara, K. Morimoto, K. Izumori and A. Kato, Looking-glass synergistic pharmacological chaperones: DGJ and L-DGJ from the enantiomers of tagatose, Org. Lett. 2011, 13, 4064-4067.

530. F. P. da Cruz, S. Newberry, S. F. Jenkinson, M. R. Wormald, T. D. Butters, D. S. Alonzi, S. Nakagawa, F. Becq, C. Norez, R. J. Nash, A. Kato and G. W. J. Fleet, 4-C-Methyl-DAB and 4-C-Me-LAB - enantiomeric alkyl branched pyrrolidine iminosugars - are specific and potent a-glucosidase inhibitors; acetone as the sole protecting group, Tetrahedron Lett. 2011, 52, 219-223.

529. M. I. Simone, A. A. Edwards, G. E. Tranter, G. W. J. Fleet, C-3 Branched-3,5-cis- and trans-THF sugar amino acids: synthesis of the first generation of branched homooligomers, Amino Acids, 2011, 41, 643-661.

528. Y.-X. Li, M.-H. Huang, Y. Yamashita, A. Kato, Y.-M. Jia, W.-B. Wang, G. W. J. Fleet, R. J. Nash and C.-Y. Yu, L-DMDP, L-homoDMDP and Their C-3 Fluorinated Derivatives: Synthesis and Glycosidase-Inhibition, Org. Biomol. Chem., 2011, 9, 3405-3414.

527. S. F. Jenkinson, G. W. J. Fleet, Oxetanes from the ring contraction of a-triflates of g-lactones: oxetane nucleosides and oxetane amino acids, Chimia 2011, 65, 71-75.

526. J. S. S. Rountree, T. D. Butters, R. A. Dwek and G. W. J. Fleet, Enantiomeric 2-acetamido-1,4-dideoxy-1,4-iminoribitols as potential pyrrolidine N-acetylhexosaminidase inhibitors, Comptes Rendus Chimie 2011, 14, 126-133.

525. Jenkinson, S. F., Parry, L. L., Wilson, F. X., Fleet, G. W. J., Watkin, D. J., 6-Deoxy-3,4-O-isopropylidene-2-i-methyl-L-galactono-1,5-lactone, Acta Cryst. 2011, E67, o2531-2532.

524. Jenkinson, S. F., Lenagh-Snow, G. M. J., Fleet, G. W. J., Thompson, A. L., N-Benzyl-1,3-dideoxy-1,3-imino-L-xylitol, Acta Cryst. 2011, E67, o2452.

523. Jenkinson, S. F., OÒa, N., Romero, A., Fleet, G. W. J., Thompson, A. L., Pino-Gonz·lez, M. S., N,N-Diethyl-6-azido-3-O-benzyl-6-deoxy-1,2-O-isopropylidene-a-D-gluco-heptofuranuronamide, Acta Cryst. 2011, E67, o38-o39.

522. G. W. J. Fleet and T. D. Butters, Synthesis of 2-acetamido-1,2-dideoxy-D-galacto-nojirimycin from D-glucuronolactone and its use to inhibit -N-a-acetylgalactosaminidases, PCT Int. Appl. (2011), WO 2011095893 A1 20110811,

521. G. W. J. Fleet and R. Storer, Novel iminosugar therapeutics, PCT application WO/2011/0095772 A2 published 11/08/11.

520. G. W. J. Fleet and R. Storer, Pyrrolidine Iminosugars used in the treatment of cystic fibrosis PCT application WO/2011/086347 A1 published 21/07/11.

519. D. Best, S. F. Jenkinson, A. W. Saville, D. S. Alonzi, M. R. Wormald, T. D. Butters, C. Norez, F. Becq, Y. BlÈriot, I. Adachi, A. Kato and G. W. J. Fleet. Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon branched pyrrolidine iminosugars, Tetrahedron Lett. 2010, 51, 4170-4174.

518. X.-G. Hu, B. Bartholomew, R. J. Nash, F. X. Wilson, G. W. J. Fleet, S. Nakagawa, A. Kato, Y.-M. Jia, R. van Well, and C.-Y. Yu, Synthesis and Glycosidase Inhibition of the Enantiomer of (-)-Steviamine, the First Example of a New Class of Indolizidine Alkaloid, Org. Lett. 2010, 12, 2562-2565.

517. A. Kato, J. Hollinshead, Y. Yamashita, S. Nakagawa, Y. Koike, I. Adachi, C.-Y. Yu, G. W. J. Fleet, R. J. Nash, An a-glucoside of 1,4-dideoxy-1,4-imino-D-lyxitol with an eleven carbon side chain Phytochem. Lett. 2010, 3, 230-233

516. A. Michalik, J. Hollinshead, L. Jones, G. W. J. Fleet, C.-Y. Yu, X.-G. Hu, R. van Well, G. Horne, F. X. Wilson, R. J. Nash, Steviamine, a new class of indolizidine alkaloid from Stevia rebaudiana, Phytochem. Lett. 2010, 3, 136-138.

515. L. Jones, J. Hollinshead, G. W. J. Fleet, A. L. Thompson, D. J. Watkin, Z. A. Gal, S. F. Jenkinson, A. Kato, R. J. Nash, Isolation of the pyrrolizidine alkaloid 1-epialexine from Castanospermum australe. Phytochem. Lett. 2010, 3, 133-135.

514. D. Best, P. Chairatana, A. F. G. Glawar, E. Crabtree, T. D. Butters, F. X. Wilson, C.-Y. Yu, W.-B. Wang, Y.-M. Jia, I. Adachi, A. Kato and G. W. J. Fleet, Synthesis of DGJNAc [2-acetamido-1,2-dideoxy-D-galacto-nojirimycin] - the first sub-micromolar inhibitor of a-N-acetylgalactosaminidases - from D-glucuronolactone, Tetrahedron Lett. 2010, 51, 2222-2224.

513. S. D. Boomkamp, J. S. S. Rountree, D. C. A. Neville, R. A. Dwek, G. W. J. Fleet, T. D. Butters, Lysosomal storage of oligosaccharide and glycosphingolipid in imino sugar treated cells, Glycoconj. J. 2010, 27, 297-308.

512. D. Best, C. Wang, A. C. Weymouth-Wilson, R. A. Clarkson, F. X. Wilson, R. J. Nash, S. Miyauchi, A. Kato and G. W. J. Fleet, Looking glass inhibitors: scalable syntheses of DNJ, DMDP and (3R)-3-hydroxy-L-bulgecinine from D-glucuronolactone and of L-DNJ, L-DMDP and (3S)-3-hydroxy-D-bulgecinine from L-glucuronolactone. DMDP inhibits b-glucosidases and b-galactosidases whereas L-DMDP is a potent and specific inhibitor of a-glucosidases Tetrahedron: Asymmetry 2010, 21, 311-319.

511. P. Gullapalli, A. Yoshihara, K. Morimoto, D. Rao, S. F. Jenkinson, M. R. Wormald, G. W. J. Fleet and K. Izumori, Conversion of L-rhamnose into ten of the sixteen 1- and 6-deoxyketohexoses in water with 3 reagents: D-tagatose-3-epimerase equilibrates C3 epimers of deoxyketoses, Tetrahedron Lett. 2010, 51, 895-898.

510. M. I. Simone, A. A. Edwards, A. R. Cowley, G. W. J. Fleet and D. J. Watkin, (3R,4R,5R)-5-(Acetamidomethyl)-N-benzyl-3,4-dihydroxytetrahydrofuran-3-carboxamide, Acta Cryst. 2010, E66, 2750-o2751.

509. M. I. Simone, A. A. Edwards, S. G. Parker, G. E. Tranter, G. W. J. Fleet and D. J. Watkin, Pentafluorophenyl (3R,4R,5S)-5-{[(3R,4R,5S)-5-azidomethyl-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxamido]methyl}-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxylate, Acta Cryst. 2010, E66, o2699-o2700.

508. S. F. Jenkinson, D. Best, K. Izumori, F. X. Wilson, A. C. Weymouth-Wilson, G. W. J. Fleet and A. L. Thompson, 1-Deoxy-1-fluoro-L-galactitol, Acta Cryst. 2010, E66, o1330.

507. S. F. Jenkinson, D. Best, K. Izumori, F. X. Wilson, A. C. Weymouth-Wilson, G. W. J. Fleet and A. L. Thompson, 6-Deoxy-6-fluoro-D-galactose, Acta Cryst. 2010, E66, o1315.

506. S. F. Jenkinson, N. Dai, G. W. J. Fleet, D. J. Watkin, 2-Azido-2-deoxy-3,4-O-isopropylidene-2-C-methyl-D-talono-1,5-lactone, Acta Cryst. 2010, E66, o1221-o1222.

505. S. F. Jenkinson, E. V. Crabtree, A. F. G. Glawar, T. D. Butters, G. W. J. Fleet, D. J. Watkin, 2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-xylitol (N-Benzyl-XYLNAc), Acta Cryst. 2010, E66, o1147-o1148.

504. S. F. Jenkinson, D. Best, F. X. Wilson, G. W. J. Fleet, D. J. Watkin, (1R,2R,3S,6aS,7R,8R,9S,12aS)-1,2,3,7,8,9-Hexahydroxyperhydrodipyrido[1,2-a:1',2'-d]pyrazine-6,12-dione, Acta Cryst. 2010, E66, o853-o853.

503. S. F. Jenkinson, G. M. J. Lenagh-Snow, K. Izumori, G. W. J. Fleet, D. J. Watkin and A. L. Thompson, 2-Azido-3,4;6,7-di-O-isopropylidene-a-D-glycero-D-talo-heptopyranose, Acta Cryst. 2010, E66, o525-o526.

502. N. Dai, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin 3 4-O-Isopropylidene-2-C-methyl-D-galactonolactone Acta Cryst. 2010, E66, o406-o407.

501. G. M. J. Lenagh-Snow, S. F. Jenkinson, A. J. Stewart, G. W. J. Fleet and D. J. Watkin 1-(1-Carboxymethyl-1,4-anhydro-2,3-O-isopropylidene-a-D-erythrofuranosyl)thymine, Acta Cryst. 2010, E66, o404.

500. A C Weymouth-Wilson and G W J Fleet, Stereospecific Synthesis Of Iduronic Acid Derivatives, Deoxynojirimycin and Deoxyidonojirimycin PCT application WO/2010/004269 14/01/10.

499. T. B. Mercer, S. F. Jenkinson, R. J. Nash, S. Miyauchi, A. Kato and G. W. J. Fleet, Looking glass inhibitors: both enantiomeric N-benzyl derivatives of 1,4-dideoxy-1,4-imino-D-lyxitol [a potent competitive inhibitor of a-D-galactosidase] and of  1,4-dideoxy-1,4-imino-L-lyxitol [a weak competitive inhibitor of a-D-galactosidase] inhibit naringinase, an a-L-rhamnosidase, competitively, Tetrahedron: Asymmetry 2009, 20, 2368-2373.

498.  S. F. Jenkinson, K. V. Booth, A. M. Estevez Reino, G. Horne, R. J. Estevez and G. W. J. Fleet, Carbon-branched carbohydrate chirons: synthesis of C-3 and C-4 branched sugar lactones derived from D-erythronolactone, Tetrahedron: Asymmetry 2009, 20, 2357-2367.

497. A. C. Weymouth-Wilson, R. Clarkson, D. Best, M.-S. Pino-Gonzalez, F. X. Wilson and G. W. J. Fleet, Large scale synthesis of the acetonides of L-glucuronolactone and of L-glucose: easy access to L-sugar chirons, Tetrahedron Lett. 2009, 50, 6307-6310.

496. K. V. Booth, S. F. Jenkinson, D. Best, F. Fernandez Nieto, R. J. Estevez, M. R. Wormald, A. C. Weymouth-Wilson and G. W. J. Fleet,  Doubly carbon-branched pentoses: synthesis of both enantiomers of 2,4-di-C-methyl arabinose and 2-deoxy-2,4-di-C-methyl arabinose using only acetonide protection, Tetrahedron Lett. 2009, 50, 5088-5093.

495. D. Rao, D. Best, A. Yoshihara, P. Gullapalli, K. Morimoto, M. R. Wormald, F. X. Wilson, K.  Izumori and G. W. J. Fleet, A concise approach to the synthesis of all twelve 5-deoxyhexoses: D-Tagatose-3-epimerase - a reagent that is both specific and general, Tetrahedron Lett. 2009, 50, 3559-3563.

494. A. J. Rawlings, H. Lomas, A. W. Pilling, M. J-R Lee, D. S. Alonzi, J. S. S. Rountree, S. F. Jenkinson, G. W. J. Fleet, R. A. Dwek, J. H. Jones and T. D. Butters, Synthesis and Biological Characterisation of Novel N-Alkyl-DNJ [Deoxynojirimycin] a-Glucosidase Inhibitors, ChemBioChem 2009, 10, 1101-1105.

493. J. S. S. Rountree, T. D. Butters, M. R. Wormald, R. A. Dwek, N. Asano, K. Ikeda, E. L. Evinson, R. J. Nash and G. W. J. Fleet, Design, synthesis and biological evaluation of enantiomeric b-N-acetylhexosaminidase inhibitors; LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff diseases, ChemMedChem 2009, 4, 378-392.

492. A. L. Thompson, A. Michalik, R. J. Nash, F. X. Wilson, R. van Well, P. Johnson, G. W. J. Fleet, C.-Y. Yu, X.-G. Hu, R. I. Cooper and D. J. Watkin, Steviamine, a new class of indolizidine alkaloid [(1R,2S,3R,5R,8aR)-3-(Hydroxymethyl)-5- methyloctahydroindolizine-1,2-diol hydrobromide], Acta Cryst. 2009, E65, o2904.

491. D. Best, S. F. Jenkinson, D. J. Watkin, F. X. Wilson, R.  J. Nash and G. W. J. Fleet, (2S,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidine-2-carboxylic acid [(2S,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-L-proline], Acta Cryst. 2009, E65, o2418-o2419.

490. K. V. Booth, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet, 2,3-O-(S)-Benzylidene-2-C-methyl-D-ribono-1,4-lactone, Acta Cryst. 2009, E65, o2199.

489. S. F. Jenkinson, K. V. Booth, S. Newberry, G. W. J. Fleet, K. Izumori, K. Morimoto, R. J. Nash, L. Jones, D. J. Watkin and A. L. Thompson, 2,6-Dideoxy-2,6-imino-L-glycero-D-ido-heptitol, Acta Cryst. 2009, E65, o1755-o1756

488. F. Punzo, D. J. Watkin and G W. J. Fleet, a-D-Tagatopyranose, Acta Cryst. 2009, E65, o1393-1394.

487. K. V. Booth, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin, 2-Deoxy-2,3-O-isopropylidene-2,4-di-C-methyl-b-L-arabinose, Acta Cryst. 2009, E65, o570.

486. S. F. Jenkinson, J. R. Fenton, K. V. Booth, G. W. J. Fleet and D. J. Watkin, (4S,5R,6R)-Methyl 4-hydroxy-4,5-isopropylidenedioxy-4,5,6,7-tetrahydro-1,2,3-triazolo[1,5-a]pyridine-3-carboxylate, Acta Cryst. 2009, E65, o610-o611

485. S. F. Jenkinson, D. Best, A. C. Weymouth-Wilson, R. A. Clarkson, G. W. J. Fleet and D. J. Watkin, (1S)-1,2-O-Benzylidene-a-D-glucurono-6,3-lactone, Acta Cryst. 2009, E65, o414-o415.

484.S. F. Jenkinson, C. Wang, M.-S. Pino-Gonz∑lez, G. W. J. Fleet and D. J. Watkin, 7-Azido-N,N-diethyl-4,5-O-isopropylidene-4-C-methyl-3,6-anhydro-7-deoxy-D-glycero-D-manno-heptonamide, Acta Cryst. 2009, E65, o263.

483. Izumori, K.; Tokuda, M.; Fleet, G.; Tsujisaka, Y.; Takeshita, K.; Tsusaki, K.; Okuma, K., Preparation of deoxyketohexose isomerase of Pseudomonas cichorii for deoxyhexose epimerization and enzymic production of rare deoxy-sugars by the Izumoring strategy, PCT Int. Appl. 2008, WO 2008062780 A1 20080529.

482. D. Rao, P. Gullapalli, A. Yoshihara, K. Morimoto, G. Takata, S. F. Jenkinson, G. W. J. Fleet and K. Izumori, Direct production of L-tagatose from L-psicose by Enterobacter aerogenes 230S, J. Biosci. Bioengineer. 2008, 106, 473-480.

481. M. I. Simone; A. A. Edwards; G. E. Tranter; G. W. J. Fleet, Carbon-branched d-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds, Tetrahedron: Asymmetry 2008, 19, 2887-2894.

480. J. M Otero, A. M Estevez, R. M Soengas, R. J Nash, J C Estevez, G. W. J. Fleet, R. J Estevez, Studies on the transformation of nitrosugars into branched chain iminosugars. II: Synthesis of (3R,4R,5R,6S)-2,2-bis(hydroxymethyl)azepane-3,4,5,6-tetraol, Tetrahedron: Asymmetry 2008, 19, 2443-2446.

479. K. V. Booth, F. P. da Cruz, D. J. Hotchkiss, S. F. Jenkinson, N. A. Jones, A. C. Weymouth-Wilson, R. Clarkson, T. Heinz and G. W. J. Fleet, Carbon-branched carbohydrate chirons: practical access to both enantiomers of 2-C-methyl-ribono-1,4-lactone and 2-C-methyl-arabinonolactone Tetrahedron: Asymmetry 2008, 19, 2417-2424

478. F. P. da Cruz, G. Horne and G. W. J. Fleet, Hydroxylated C-branched pyrrolidines, C-branched prolines and C-branched piperidines from a 2-C-methyl sugar lactone; efficient azide displacement of a tertiary triflate with inversion of configuration, Tetrahedron Lett. 2008, 49, 6812-6815.

477. A. L. Thompson, D. J. Watkin, Z. A. Gal, L. Jones, J. Hollinshead, S. F. Jenkinson, G. W. J. Fleet and R. J. Nash, The absolute configuration of 1-epialexine hemihydrate, Acta Cryst. 2008, C64, o649-o652.

476. N. A. Jones, D. Rao, A. Yoshihara, P. Gullapalli, K. Morimoto, G. Takata, S. J. Hunter, M. R. Wormald, R. A. Dwek, K. Izumori and G. W. J. Fleet, Green syntheses of new 2-C-methyl aldohexoses and 5-C-methyl ketohexoses: D-Tagatose-3-epimerase (DTE) - a promiscuous enzyme, Tetrahedron: Asymmetry 2008, 19, 1904-1918.

475. A. A. Edwards, B. D. Alexander, G. W. J. Fleet, G. E. Tranter, Spectroscopic studies of oligomers containing 2,5-trans furanoid sugar amino acids, Chirality 2008, 20, 969-972.

474. Y. Minami, C. Kuriyama, K. Ikeda, A. Kato, K. Takebayashi, I. Adachi, G. W. J. Fleet, A. Kettawan, T. Okamoto and N. Asano, Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases, Bioorg. Med. Chem. 2008, 16, 2734-2740.

473. T. D. W. Claridge, B. Lopez-Ortega, S. F. Jenkinson and G. W. J. Fleet, Secondary structural investigations into homooligomers of delta-2,4-cis oxetane amino acids, Tetrahedron: Asymmetry 2008, 19, 984-988.

472. B. Lopez-Ortega, S. F. Jenkinson, T. D. W. Claridge and G. W. J. Fleet, Oxetane amino acids: synthesis of tetrameric and hexameric carbopeptoids derived from L-ribo 4-(aminomethyl)-oxetan-2-carboxylic acid, Tetrahedron: Asymmetry 2008, 19, 976-983.

471. D. Rao, A. Yoshihara, P. Gullapalli, K. Morimoto, G. Takata, F P. da Cruz, S. F. Jenkinson, M. R. Wormald, R. A. Dwek, G. W. J. Fleet and K. Izumori, Towards the biotechnological isomerization of branched sugars: D-Tagatose-3-epimerase equilibrates both enantiomers of 4-C-methyl-ribulose with both enantiomers of 4-C-methyl-xylulose, Tetrahedron Lett. 2008, 49, 3316-3121.

470. A. Yoshihara, S. Haraguchi, P. Gullapalli, D. Rao, K. Morimoto, G. Takata, N. A. Jones, S. F. Jenkinson, M. R. Wormald, R. A. Dwek, G. W. J. Fleet and K. Izumori, Isomerization of deoxyhexoses: bioproduction of 1-deoxy-D-tagatose from L-fucose and of 6-deoxy-D-tagatose from D-fucose using Enterobacter agglomerans strain 221e, Tetrahedron: Asymmetry 2008, 19, 739-745.

469. D. Best, S. F. Jenkinson, S. D. Rule, R. Higham, T. B. Mercer, R. J. Newell, A. C. Weymouth-Wilson, G. W. J. Fleet, and S. Petursson, High yield protection of alcohols, including tertiary and base sensitive alcohols, as benzhydryl ethers by heating with diphenyldiazomethane in the absence of any other reagent, Tetrahedron Lett. 2008, 49, 2196-2199.

468. A. E. Hakansson, J. van Ameijde, G. Horne, R. J. Nash, M. R. Wormald, A. Kato, G. S. Besra, S. Gurcha and G. W. J. Fleet, Synthesis of the naringinase inhibitors L-swainsonine and related 6-C-methyl-L-swainsonine analogues: (6R)-C-methyl-L-swainsonine is a more potent inhibitor of L-rhamnosidase by an order of magnitude than L-swainsonine, Tetrahedron Lett. 2008, 49, 179-184.

467. S. F. Jenkinson, D. Best, F. X. Wilson, G. W. J. Fleet and D. J. Watkin, (4R)-4-(2-Allyl-2H-1,2,3-triazol-4-yl)-1,2-O-isopropylidene-L-threose, Acta Cryst. 2008, E64, o2361-2362.

466. S. F. Jenkinson, K. V. Booth, D. Best, G. W. J. Fleet and D. J. Watkin, tert-Butyl 2-deoxy-4,5-O-isopropylidene-D-gluconate, Acta Cryst. 2008, E64, o2011-o2012.

465. F. P. da Cruz, K. V. Booth, G. W. J. Fleet and D. J. Watkin 3-O-Benzhydryl-2,5-dideoxy-2,5-imino-2-C-methyl-L-lyxono-1,4-lactone, Acta Cryst. 2008, E64, o1902-o1903.

464. S. F. Jenkinson, K. V. Booth, P. Gullapalli, K. Morimoto, K. Izumori, G. W. J. Fleet and D. J. Watkin 1-Deoxy-L-mannitol (6-deoxy-L-mannitol or L-rhamnitol), Acta Cryst. 2008, E64, o1705-o1706.

463. K. V. Booth, S. F. Jenkinson, D. Rao, T. Simonisi, G. W. J. Fleet, K. Izumori and D. J. Watkin 6-Azido-6-deoxy-a-L-galactose (6-Azidofucose), Acta Cryst. 2008, E64, o1568-o1569.

462. S. F. Jenkinson, K. V. Booth, A. Yoshihara, K. Morimoto, G. W. J. Fleet, K. Izumori and D. J. Watkin, 1-Deoxy-D-galactitol (L-fucitol), Acta Cryst. 2008, E64, o1429.

461. K. V. Booth, S. F. Jenkinson, G. W. J. Fleet, P. Gullapalli, A. Yoshihara, K. Izumori and D. J. Watkin 6-Deoxy-a-L-talopyranose, Acta Cryst. 2008, E64, o1385.

460. S. F. Jenkinson, S. D. Rule, K. V. Booth, G. W. J. Fleet, D. J. Watkin and S. Petursson, 2-O-Benzhydryl-3,4-(S)-O-benzylidene-D-xylono-1,4-lactone, Acta Cryst. 2008, E64, o1012 .

459. S. F. Jenkinson, F. P. Cruz, K. V. Booth, G. W. J. Fleet, K. Izumori, C.-Y. Yu and D. J. Watkin, 1-Deoxy-D-arabinitol, Acta Cryst. 2008, E64, o1010-o1011.

458. S. F. Jenkinson, D. J. Hotchkiss, A. R. Cowley, G. W. J. Fleet and D. J. Watkin, (S)-3-Dimethylamino-2-{(4S,5R)-5-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-1,3-dioxolan-4-yl}-2-hydroxypropanoic acid Acta Cryst. 2008, E64, o294-o295.

457. S. F. Jenkinson, S. D. Rule, K. V. Booth, G. W. J. Fleet, D. J. Watkin and S. Petursson, 2-O-Benzhydryl-3,4-(S)-O-benzylidene-D-lyxono-1,4-lactone, Acta Cryst. 2008, E64, o26-o26.

456. S. F. Jenkinson, N. A. Jones, A. Moussa, A. J. Stewart, T. Heinz and G. W. J. Fleet Anomeric stereospecific synthesis of 2-C-methyl-b-nucleosides; the Holy reaction of cyanamide with 2-C-methyl-D-arabinose, Tetrahedron Lett. 2007, 48, 4441-4445.

455. J. S. S. Rountree, T. D. Butters, M. R. Wormald, R. A. Dwek, N. Asano, K. Ikeda, E. L. Evinson, R. J. Nash and G. W. J. Fleet, Efficient Synthesis from D-lyxonolactone of 2-acetamido-1,4-imino-1,2,4-trideoxy-L-arabinitol LABNAc, a potent pyrrolidine inhibitor of hexosaminidases, Tetrahedron Lett. 2007, 48, 4287-4291.

454. P. Gullapalli, T. Shiji, D. Rao, A. Yoshihara, K. Morimoto, G. Takata , G. W. J. Fleet and K. Izumori, Bioproduction of a novel sugar 1-deoxy-L-fructose by Enterobacter aerogenes IK7; isomerization of a 6-deoxyhexose to a 1-deoxyhexose, Tetrahedron: Asymmetry 2007, 18, 1995-2000.

453. M. D. P. Risseeuw, M. Overhand, G. W. J. Fleet, M. I. Simone, A compendium of sugar amino acids (SAA): scaffolds, peptide- and glyco-mimetics, Tetrahedron: Asymmetry 2007, 18, 2001-2010.

452. D. A. Mitchell, N. A. Jones, S. J. Hunter, J. M. D. Cook, S. F. Jenkinson, M. R. Wormald, R. A. Dwek and G. W. J. Fleet, Synthesis 2-C-branched derivatives of D-mannose: 2-C-aminomethyl-D-mannose binds to the human C-type lectin DC-SIGN with affinity greater than an order of magnitude compared to that of D-mannose, Tetrahedron: Asymmetry 2007, 18, 1502-1510.

451. D. J. Hotchkiss, R. Soengas, K. V. Booth, A. C. Weymouth-Wilson, V. Eastwick-Field and G. W. J. Fleet, Green aldose isomerisation: 2-C-Methyl-1,4-lactones from the reaction of Amadori ketoses with calcium hydroxide, Tetrahedron Lett. 2007, 48, 517-520.

450. N. A. Jones, S. F. Jenkinson, R. Soengas, M. Fanefjord, M. R. Wormald, R. A. Dwek, G. P. Kiran, R. Devendar, G. Takata, K. Morimoto, K. Izumori and G. W. J. Fleet, Synthesis of and NMR studies on the four diastereomeric 1-deoxy-ketohexoses, Tetrahedron: Asymmetry 2007, 18, 774-786.

449. D. J. Hotchkiss, A. Kato, B. Odell, T. D. W. Claridge and G. W. J. Fleet, Homochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer - removal of glycosidase inhibition, Tetrahedron: Asymmetry 2007, 18, 500-512.

448. A. E. HÂkansson, J. van Ameijde, L. Guglielmini, G. Horne, R. J. Nash, E. L. Evinson, A. Kato and G. W. J. Fleet^, Looking glass inhibitors: Synthesis of a potent naringinase inhibitor L-DIM [1,4-dideoxy-1,4-imino-L-mannitol], the enantiomer of DIM [1,4-dideoxy-1,4-imino-D-mannitol] a potent α-D-mannosidase inhibitor, Tetrahedron: Asymmetry 2007, 18, 282-289.

447. Kato, A.; Kato, N.; Adachi. I.; Hollinshead, J.; Fleet, G. W. J.; Kuriyama, C.; Ikeda, K.; Asano, N.; Nash, R. J. Isolation of glycosidase-inhibiting hyacanthines and related alkaloids from Scilla socialis, J. Nat. Prod. 2007, 70, 993-997.

446. J. M. Otero, R. G. Soengas, J. C. EstÈvez, R. J. EstÈvez, D. J. Watkin, E. L. Evinson, R. J. Nash, G. W. J. Fleet, Preliminary studies on the transformation of nitrosugars into branched aza-sugars: Synthesis of 1,4-dideoxy-4-C-hydroxymethyl-1,4-imino-pentanols, Org. Lett., 2007, 9, 623-626.

445. I. Streeter; S. F. Jenkinson; G. W. J. Fleet; R. G. Compton, Chemical instability promotes apparent electrochemical irreversibility: Studies on the electrode kinetics of the one electron reduction of the 2,6-diphenylpyrylium cation in acetonitrile solution, J. Electroanalytical Chem. 2007, 600, 285-293.

444. D. D. Le Pevelen, A. A. Edwards, G. E. Tranter, D. J. Watkin and G. W.J. Fleet, Isopropyl 6-amino-2,5-anhydro-3,6-dideoxy-6- N-(2,5-anhydro-6-azido-3,6-dideoxy-L-lyxo-hexonyl)–L-lyxo-hexonate, Acta Cryst. 2007, E63, o4719-o4720.

443. S. Petursson, S. F. Jenkinson, K. V. Booth, A. C. Weymouth-Wilson, D. J. Watkin, G. W. J. Fleet and D. Best, 2-O-(4,4'-Dimethylbenzhydryl)-L-erythronolactone, Acta Cryst. 2007, E63, o4121-o4121.

442. K. V. Booth, S. F. Jenkinson, D. J. Watkin, H. Sharp, P. W. Jones, R. J. Nash and G. W. J. Fleet, (2S,3R,4R,5S)-3,4,5-Trihydroxypipecolic acid dihydrate [(2S,3R,4R,5S)-3,4,5-Trihydroxypiperidine-2-carboxylic acid dihydrate], Acta Cryst. 2007, E63, o3783-o3784.

441. K. V. Booth, S. F. Jenkinson A. Cowley, A. Kato, N. Kato, J. Hollinshead, R. J. Nash and G. W. J. Fleet, (2R,3S)3-Hydroxy-N,N-dimethylproline hydrate, Acta Cryst. 2007, E63, o3717-o3717.

440. K. V. Booth, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet, 2,4-Di-C-methyl-a-L-arabinose monohydrate, Acta Cryst. 2007, E63, o3592-o3593.

439. L. A. Curran, N. A. Jones, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet, 5,6-O-Isopropylidene-3-C-methyl-D-mannono-1,4-lactone, Acta Cryst. 2007, E63, o3416-o3416.

438. N. A. Jones, S. F. Jenkinson, L. A. Curran, D. J. Watkin and G. W. J. Fleet, 2,3-Di-C-methyl-D-allono-1,4-lactone, Acta Cryst. 2007, E63, o3415-o3415.

437. L. A. Curran, S. F. Jenkinson, N. A. Jones, D. J. Watkin and G. W. J. Fleet, 2,6-Anhydro-1-deoxy-3,4-O-isopropylidene-3-C-methyl-b-D-ribo-hex-2-ulofuranose, Acta Cryst. 2007, E63, o3388- o3388.

436. L. A. Curran, S. F. Jenkinson, N. A. Jones, D. J. Watkin and G. W. J. Fleet, 2,3-C-Dimethyl-3,4-O-isopropylidene-D-allono-1,5-lactone, Acta Cryst. 2007, E63, o3387- o3387.

435. K. V. Booth, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet, 2-C-Hydroxymethyl-2,3-O-isopropylidene-3-C-methyl- b-L-erythrose, Acta Cryst. 2007, E63, o3386- o3386.

434. K. V. Booth, S. F. Jenkinson, G. J. W. Fleet and D. J. Watkin, 3,5-Di-C-methyl-5,6-O-isopropylidene-L-mannono-1,4-lactone, Acta Cryst. 2007, E63, o2427-o2429.

433. K. V. Booth, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin, 3,5-Di-C-methyl-5,6-O-isopropylidene-L-glucono-1,4-lactone, Acta Cryst. 2007, E63, o2424-o2426.

432. K. V. Booth, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin, 2,3:5,6-Di-O-isopropylidene-3,5-di-C-methyl-L-mannono-1,4-lactone, Acta Cryst. 2007, E63, o2204-o2206.

431. S. F. Jenkinson, N. A. Jones, A. Moussa, A. J. Stewart, T. Heinz, G. W. J. Fleet and D. J. Watkin, 2,2'-Anhydro-2'-C-methyl-1-(D-arabinofuranosyl)uracil (2,2'-anhydro-2'-C-methyluridine), Acta Cryst. 2007, E63, o2171-o2173.

430. D. J. Hotchkiss, S. F. Jenkinson, K. V. Booth, G. W. J. Fleet and D. J. Watkin, 2-Azido-(R)-3,5-O-benzylidene-2-deoxy-2-C-methyl-D-xylono-1,4-lactone [(2S,4aR,7R,7aR)-7-azido-7-methyl-2-phenyldihydro-4H-furo[3,2-d][1,3]dioxin-6(4aH)-one], Acta Cryst. 2007, E63, o2168-o2170.

429. D. Best, S. F. Jenkinson, K. V. Booth, G. W. J. Fleet and D. J. Watkin, 1-Deoxy-4-C-hydroxymethyl-3,4-O-isopropylidene-L-ribulofuranose [(2R,3S,4S)-4-(hydroxymethyl)-3,4-O-isopropylidene-2-methyltetrahydrofuran-2,3,4-triol], Acta Cryst. 2007, E63, o2165-o2167.

428. K. Izumori, S. F. Jenkinson, D. J. Watkin and G. W. J. Fleet 1-Deoxy-b-fructopyranose monohydrate, Acta Cryst. 2007, E63, o1882-o1884.

427. K. V. Booth, D. J. Watkin, S. F. Jenkinson and G. W. J. Fleet, 2-Azido-2-deoxy-2,4-C-dimethyl-3,4-O-isopropylidene-L-ribono-1,5-lactone, Acta Cryst. 2007, E63, o1759-o1760.

426. M. Simone, G W. J. Fleet, R. Bream and D. J. Watkin, 5-Amino-5-deoxy-2-C-hydroxymethyl-2,3-O-isopropylidene-L-lyxono-1,5-lactam, Acta Cryst. 2007, E63, o1409-o1411.

425. K. V. Booth, D. J. Watkin, S. F. Jenkinson and G. W. J. Fleet, 2,4-Dimethyl-3,4-O-isopropylidene-L-arabinono-1,5-lactone, Acta Cryst. 2007, E63, o1128-o1130

424. M. Simone, G. W. J. Fleet and D. J. Watkin, 5-O-tert-Butyldiphenylsilyl-2-C-hydroxymethyl-2,3-O-isopropylidene-2'-O-trifluoromethanesulfonyl-D-ribono-1,4-lactone, Acta Cryst. 2007, E63, o1088-o1090.

423. D. Best, S. F. Jenkinson, D. J. Watkin, K. V. Booth and G. W. J. Fleet, 2,3-O-Isopropylidene-L-apiono-1,4-lactone [(3S,4S)-3,4-dihydroxy-4-(hydroxymethyl)-3,4-di-O-isopropylidene-dihydrofuran-2(3H)-one], Acta Cryst. 2007, E63, o1056-o1057.

422. N. A. Jones, D. J. Watkin, L. A. Curran, S. F. Jenkinson and G. W. J. Fleet, 3-C-Methyl-D-allono-1,5-lactone, Acta Cryst. 2007, E63, o992-o994.

421. M. Simone, G. W. J. Fleet and D. J. Watkin, 1,5-Anhydro-2,3-O-isopropylidene-L-lyxofuranose [(1S,4S,5S,6R)-5,6-O-isopropylidene-2,7-dioxabicyclo[2.2.1]heptane-5,6-diol], Acta Cryst. 2007, E63, o896-o897.

420. R. Bream, D. J. Watkin, A. R. Cowley, M. I Simone and G. W. J. Fleet, 3,3¢:5,6-Di-O-isopropylidene-3-C-hydroxymethyl-D-allono-1,4-lactone: An organic lattice structure containing a large unoccupied void, Acta Cryst. 2007, E63, o799-o801.

419. R. Bream, S. J. Hunter, G. W. J. Fleet and D. J. Watkin, 2-C-Hydroxymethyl-2,3-O-isopropylidene-D-mannono-1,5-lactam, Acta Cryst. 2007, E63, o621-o623.

418. Cox, D. J.; Hakansson, A.E.; Fleet, G. W. J.; Watkin, D. J., 2,5-Anhydro-N-benzyl-2-C-methyl-D-arabinonamide [(2S,3R,4R)-N-benzyl-3,4-dihydroxy-2-methyltetrahydrofuran-2-carboxamide], Acta Cryst. 2007, E63, o574-o576.

417. Jones, N. A., Jenkinson, S. F., Soengas, R., Izumori, K., Fleet, G. W. J., Watkin, D. J., The concomitant crystallization of two polymorphs of 1-deoxy-a-D-tagatose, Acta Cryst. 2007, C63, o7-o10.

416. Hakansson, A.E., Horne, G., Fleet, G.W.J. Watkin, D.J., (6S)-Methyl-L-swainsonine [(1R,2S,6S,8S,8aS)-6-methyloctahydroindolizine-1,2,8-triol] Acta Cryst. 2007, E63, o210-o212.

415. R. H. Furneaux; P. C. Tyler;S. P. H.; Mee; G. B. Evans; V. L. Schramm,.; G. Fleet,. Preparation of deazapurine analogs of 4'-aza-l-nucleosides as prodrugs treating cancer, bacterial and parasitic infection, and T-cell mediated diseases. PCT Int. Appl. (2007), 59pp. CODEN: PIXXD2 WO 2007069924

414. R. J. Nash; M. W. Carroll; A. A. Watson; G. W. J. Fleet; G. Horne Pyrrolidine derivatives as immunomodulators and antiviral agents. PCT Int. Appl. (2007), 72pp. CODEN: PIXXD2 WO 2007010266

413. D. Hotchkiss; G. Fleet; T. Heinz; R. Storer Process for preparing saccharinic acids and lactones. PCT Int. Appl. (2007), 53pp. CODEN: PIXXD2 WO 2007025304.

412. R. A. Jockusch, F. O. Talbot, M. I. Simone, P. S. Rogers, G. W. J. Fleet and J. P. Simons, Carbohydrate amino acids: the intrinsic conformational preference for a b-turn type structure in a carbopeptoid building block, J. Am. Chem. Soc., 2006, 128, 16771-16777.

411. J. Van Ameijde, G. Horne, M. R. Wormald, R. A. Dwek, R. J. Nash, P. W. Jones, E. L. Evinson and G. W. J. Fleet, Isolation synthesis and glycosidase inhibition profile of 3-epi-casuarine, Tetrahedron: Asymmetry 2006, 17, 2702-2713.

410. N. A. Jones, M. Fanefjord, S. F. Jenkinson, G. W. J. Fleet and D. J. Watkin, 1-Deoxy-a-D-sorbopyranose, Acta Cryst. 2006, E62, o4663-o4665.

409. R. Bream, D. J. Watkin, N. A. Jones, S. F. Jenkinson and G. W. J. Fleet, 2-C-Methyl-3,4-O-methylidene-D-arabinono-1,5-lactone, Acta Cryst. 2006, E62, o4356-o4358.

408. S. Parker, D. J. Watkin, M. I Simone and G. W. J. Fleet, 3,4:5,6-Di-O-isopropylidene-3-C-hydroxymethyl-D-altrono-1,3π-lactone, Acta Cryst. 2006, E62, o3961-o3963.

407. Y. Bleriot, M. I. Simone, M. R. Wormald, R. A. Dwek, D. J. Watkin and G. W. J. Fleet, Sugar amino acids at the anomeric position of carbohydrates: synthesis of spirocyclic amino acids of 6-deoxy-L-lyxofuranose, Tetrahedron: Asymmetry 2006, 17, 2276-2286.

406. Hakansson, A.E., van Ameijde, J., Horne, G., Guglielmini, L., Nash, R.J., Fleet, G.W.J. Watkin, D.J., 2,3:6,7-Di-O-diethylidene-D-glycero-L-talo-heptono-1,4-lactone, Acta Cryst. 2006, E62, o3890-o3892.

405. A. A. Edwards, G. J. Sanjayan, S. Hachisu, G. E. Tranter and G. W. J. Fleet, A novel series of oligomers from 4-aminomethyl-tetrahydrofuran-2-carboxylates with 2,4-cis and 2,4-trans stereochemistry, Tetrahedron 2006, 62, 7718-7725.

404. S. W. Johnson, G. W. J. Fleet and J. H. Jones, Cyclic oligomers of oxetane-based dipeptide isosteres derived from L-Rhamnose, J. Peptide Sci., 2006, 12, 559-561.

403. Nash, R. J., Fleet, G. W. J., Van Ameijde, J., and Horne, G., Synthesis of Polyhydroxylated Alkaloids PCT Int. Appl. Publication date 26 Jan 2006, publication no WO 2006/008493 A1

402. A. A. Edwards, G. J. Sanjayan, S. Haschisu, R. Soengas, A. Stewart, G. E. Tranter and G. W. J. Fleet, Synthesis of 4-aminomethyl-tetrahydrofuran-2-carboxylates with 2,4-cis and 2,4-trans relationships, Tetrahedron 2006, 62, 4110-4119.

401. K. Clinch, G. B. Evans, G. W. J. Fleet, R. H. Furneaux, S. W. Johnson, D. Lenz, S. Mee, P. R. Rands, V. L. Schramm, E. A. T. Ringia and P. C. Tyler, Syntheses and activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases, Org. Biomol. Chem., 2006, 4, 1131-1139.

400. Edwards, A.A.; Fleet, G.W.J.; Tranter, G.E., Classification of Conformation for Sugar Amino Acid Systems using Chiroptical Spectroscopy, Chirality 2006, 18, 265-272.

399. D. J. Hotchkiss, S. F. Jenkinson, R. Storer, T. Heinz and G. W. J. Fleet, Amadori ketoses with calcium hydroxide and the Kiliani reaction on 1-deoxy ketoses: two approaches to the synthesis of saccharinic acids, Tetrahedron Lett. 2006, 47, 315-318.

398. Chesterton A.K.S., Jenkinson S.F., Jones N.A., Fleet G.W.J., Watkin D.J., (2S,4S)-4-Azido-1-benzyl-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl] pyrrolidine Acta Cryst. 2006, E62, o2983-o2985.

397. R. Bream, D. Watkin, R. Soengas, G. W. J. Fleet, Alison A. Edwards, S. J. Hunter and G. E. Tranter, cyclo[(6-Amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonic acid)-(D-Phe)]₂), Acta Cryst. 2006, E62, o1851-o1853.

396. F. Punzo, D. J. Watkin, D. Hotchkiss and G. W. J. Fleet, 3-Deoxy-D-galactono-1,4-lactone (3-deoxy-D-xylo-hexono-1,4-lactone), Acta Cryst. 2006, E62, o1344-o1346

395. S. Parker, D. J. Watkin, B. Mayes, R. Storer, S. Jenkinson and G. Fleet, 2-Deoxy-2-fluoro-2-C-methyl-D-ribono-1,4-lactone (fluoromethylrib), Acta Cryst. 2006, E62, o1208-o1210.

394. R. Bream, D. J. Watkin, R. Soengas, V. Eastwick-Field and G. W. J. Fleet, 2,5-Di-O-acetyl-3-C-methyl-D-lyxono-1,4-lactone, Acta Cryst. 2006, E62, o977-o979.

393. F. Punzo, D. J. Watkin, J. van Ameijde, G. Horne and G. W. J. Fleet, 3,7,7a-Tri-epi-casuarine pentaacetate, Acta Cryst. 2006, E62, o928-o930.

392. F. Punzo, A. R. Cowley, D. J. Watkin, M. I. Simone, A. A. Edwards, G. E. Tranter and G. W. J. Fleet, Pentafluorophenyl (3R,4R,5R)-5-{[(3R,4R,5R)-5-Azidomethyl-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carbonylamino]methyl}-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxylate, Acta Cryst. 2006, E62, o473-o475.

391. D. J. Watkin, M. Watterson, G. E. Tranter, A. A. Edwards and G. W. J. Fleet Isopropyl 2,5-anhydro-6-azido-3,6-dideoxy-D-xylo-hexonate, Acta Cryst. 2006, E62, o363-o365.

390. F. Punzo, D. J. Watkin, S. F. Jenkinson, F. P. da Cruz and G. W. J. Fleet, 2-C-Azidomethyl-2-deoxy-3,4-O-isopropylidene-D-ribono-1,5-lactone, Acta Cryst. 2006, E62, o321-o323.

389. F. Punzo, D. J. Watkin, D. Hotchkiss and G. W. J. Fleet, 2-C-Methyl-D-lyxono-1,4-lactone, Acta Cryst. 2006, E62, o98-o100.

388. Nash, R. J., Wolferstan, P., Fleet, G. W. J., Van Ameijde, J., and Horne, G., Antibacterial Compounds PCT Int. Appl. Publication date 26 May 2005, publication no WO 2005/046674 A2

387. K. A. Watson, E. D. Chrysina, K. E. Tsitsanou, S. E. Zographos, G. Archontis, D. D. Leonidas, N. G. Oikonomakos, G. W. J. Fleet, Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogues inhibitors of glycogen phosphorylase. Proteins: Structure, Function, and Bioinformatics, 2005, 61, 966-983.

386. Y. BlÈriot, D. Gretzke, T. M. Kr¸lle, T. D. Butters, R. A. Dwek, R. J. Nash, N. Asano, G. W. J. Fleet, Looking glass inhibitors: efficient synthesis and biological evaluation of D-deoxyfuconojirimycin, Carbohydr. Res., 2005, 340, 2713-2718.

385. D. J. Watkin, L. L. Parry, D. J. Hotchkiss, V. Eastwick-Field and G. W. J. Fleet, 3,5-O-Isopropylidene-2-C-methyl-D-xylonolactone, Acta Cryst. 2005, E61, o3302-o3303.

384. D. J. Watkin, A. F. G. Glawar, R. Soengas, K. Izumori, M. R. Wormald, R. A. Dwek and G. W. J. Fleet, 1,2:3,4-Di-O-isopropylidene-b-D-psicofuranose, Acta Cryst. 2005, E61, o2949-o2951.

383. D. J. Watkin, L. L. Parry, R. Soengas, K. Izumori and G. W. J. Fleet, 2-C-Benzyloxymethyl-2,3:5,6-di-O-isopropylidene-D-allono-1,4-lactone, Acta Cryst. 2005, E61, o2955-o2957.

382. S. W. Johnson, S. F. Jenkinson (nÈe Barker), D. Angus, I. Perez-Victoria, A. A. Edwards, T. D. W. Claridge, G. E. Tranter, G. W. J. Fleet, J. H. Jones. Conformational Studies of Oligomeric Oxetane-Based Dipeptide Isosteres derived from L-Rhamnose or D-Xylose, J. Peptide Sci., 2005, 11, 517-524.

381. M. I. Simone, R. Soengas, C. R. Newton, D. J. Watkin and G. W. J. Fleet, Branched tetrahydrofuran a,a-disubstituted d-sugar amino acid scaffolds from branched sugar lactones: a new family of foldamers?, Tetrahedron Lett. 2005, 46, 5761-5765.

380. R. Soengas, K, Izumori, M. I. Simone, D. J. Watkin, U. P. Skytte, W. Soetaert and G. W. J. Fleet^, Kiliani reaction on ketoses: branched carbohydrate building blocks from D-tagatose and D-psicose, Tetrahedron Lett. 2005, 46, 5755-5759.

379. S. W. Johnson, S. F. Jenkinson (nÈe Barker), D. Angus, I. Perez-Victoria, T. D. W. Claridge, G. W. J. Fleet, J. H. Jones. The Synthesis of Oligomers of Oxetane-Based Dipeptide Isosteres derived from L-Rhamnose or D-Xylose, J. Peptide Sci., 2005, 11, 303-318.

378. Edwards, A.A.; Fleet, G.W.J.; Mayes, B.A.; Hunter, S.J.; Tranter, G.E., Spectroscopic studies of carbopeptoid-cyclodextrins, Chirality 2005, 17, S114-S117.

377. T. D. W. Claridge, D. D. Long, C. M. Baker, B. Odell, G. H. Grant, A. A. Edwards, G. E. Tranter, G. W. J. Fleet and M. D. Smith, Helix-forming carbohydrate amino acids, J. Org. Chem., 2005, 70, 2082-2090.

376. D. J. Watkin, A. F. G. Glawar, R. Soengas, U. P. Skytte, M. R. Wormald, R. A. Dwek and G. W. J. Fleet, 1,2:3,4-Di-O-isopropylidene-a-D-tagatofuranose, Acta Cryst. 2005, E61, o2891-o2893.

375. D. J. Watkin, L. L. Parry, R. Soengas and G. W. J. Fleet, 1,4-Anhydro-2-C-benzyloxymethyl-2,3:5,6-di-O-isopropylidene-D-tallitol, Acta Cryst. 2005, E61, o2865-o2867.

374. A. Glawar, B. A. Mayes, D. J. Watkin and G. W. J. Fleet, (2R,3S,4S,5R)-Methyl 5-cyano-2,3:4,5-di-O-isopropylidene-2,3,4,5-tetrahydroxypentanoate, Acta Cryst. 2005, E61, o2727-o2729.

373. A. F. G. Glawar, D. J. Watkin, G. J. Sanjayan, G. E. Tranter, A. A. Edwrads and G. W. J. Fleet, Isopropyl 2,5-anhydro-3,4-di-O-tert-butyldiphenylsilyl-L-ribonate, Acta Cryst. 2005, E61, o2724-o2726.

372. F. Punzo, D. J. Watkin, J.M.D. Cook, D. Hotchkiss and G. W. J. Fleet, N-(p-Tolyl)-b-L-rhamnopyranosylamine 1.5 hydrate, Acta Cryst. 2005, E61, o2155-o2157.

371. M. R. Probert, D. J. Watkin, A. J. Stewart, R. Storer and G. W. J. Fleet, The crystal and molecular structure of (2R,3R,4R)-Methyl 2-bromo-3,4-dihydroxy-3,4-di-O-isopropylidene-tetrahydrofuran-2-carboxylate, Acta Cryst. 2005, E61, o1718-o1720.

370. C. C. Harding, J. S. S. Rountree, D. J. Watkin, A. R. Cowley, T. D. Butters, M. R. Wormald, R. A. Dwek and G W. J. Fleet, 2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-arabinitol hydrate, Acta Cryst., 2005, E61, o1683-o1685.

369. C. C. Harding, A. R. Cowley, D. J. Watkin, F. Punzo, D. J. Hotchkiss and G. W. J. Fleet, 1-Amino-1-deoxy-N,N-dibenzyl-a-D-tagatopyranose methanol solvate, Acta Cryst. 2005, E61, o1475-o1477.

368. C. C. Harding, D. J. Watkin, N. K. Sawyer, S. F. Jenkinson and G. W. J. Fleet, 2-C-Methyl-D-allono-1,4-lactone, Acta Cryst. 2005, E61, o1472-o1474.

367.C. C. Harding, D. J. Watkin, D. J. Hotchkiss, J. M. D. Cook and G. W. J. Fleet,1-Amino-N,N-dibenzyl-1,6-dideoxy-b-L-fructofuranose, Acta Cryst. 2005, E61, o995-o997

366. C. C. Harding, D. J. Watkin, J. S. S. Rountree, T. D. Butters, M. R. Wormald, R. A. Dwek and G W. J. Fleet, 2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-ribitol, Acta Cryst., 2005, E61, o930-932

365. S. Humphreys, D. J. Watkin, G. J. Sanjayan, G. E. Tranter, A. A. Edwards and G. W. J. Fleet, Isopropyl 2,5-anhydro-4-(2,5-anhydro-4-azido-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonylamino)-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonate, Acta Cryst., 2005, E61, o918-o919.

364. N. Asano, K. Ikeda, L. Yu, A. Kato, K. Takebayashi, I. Adachi, I. Kato, H. Ouchi, H. Takahata and G. W. J. Fleet, The L-enantiomers of D-sugar-mimicking iminosugars are non-competitive inhibitors of D-glycohydrolase?, Tetrahedron: Asymmetry, 2005, 16, 223-229.

363. G. W. J. Fleet Carbohydrate Science Tetrahedron: Asymmetry, 2005, 16, 1-2.

362. F. Punzo, D. J. Watkin, M. Iezzi Simone and G. W. J. Fleet, (3R,4R,5S)-5-(Acetamidomethyl)-N-benzyl-3,4-dihydroxytetrahydrofuran-3-carboxamide, Acta Cryst., 2005, E61, o513-o515.

361. F. Punzo, D. J. Watkin, S. F. Jenkinson, F. P. Cruz and G. W. J. Fleet, 2-Azido-2-deoxy-3,4-O-isopropylidene-2-C-methyl-D-ribono-1,5-lactone, Acta Cryst., 2005, E61, o511-o512.

360. F. Punzo, D. J. Watkin, S. F. Jenkinson and G. W. J. Fleet, 2C-Methyl-D-arabinono-1,4-lactone monohydrate, Acta Cryst., 2005, E61, o326-o327.

359. C. C. Harding, D. J. Watkin, A. R. Cowley, R. Soengas, U. P. Skytte and G. W. J. Fleet, 2,2º:5,6-Di-O-isopropylidene-2-C-hydroxymethyl-D-talono-1,4-lactone, Acta Cryst., 2005, E61, o250-o252.

358. F. Punzo, D. J. Watkin, S. F. Jenkinson and G. W. J. Fleet, 3,4-O-Isopropylidene-2C-methyl-D-arabinono-1,5-lactone, Acta Cryst., 2005, E61, o127-129.

357. R.A. Jockusch, F.O. Talbot, N. Asano, G.W.J. Fleet and J.P. Simons, Gas phase structure and conformation of the glycosidase and ceramide glucosyltransferase inhibitor N-benzyl-deoxynojirimycin, Phys. Chem. Chem. Phys. 2004, 6, 5283-5287.

356. D. Hotchkiss, R. Soengas, M. I. Simone, J. van Ameijde, S. Hunter, A. R. Cowley and G. W. J. Fleet, Kiliani on ketoses: branched carbohydrate building blocks from D-fructose and L-sorbose, Tetrahedron Lett. 2004, 45, 9461-9464.

355. C. C. Harding, H. Shallard-Brown, D. J. Watkin, R. Soengas and George W. J. Fleet, 3-Azido-3-deoxy-2,2':5,6-di-O-isopropylidene-2-C-hydroxmethyl-D-gulono-1,4-lactone, Acta Cryst., 2004, E60, o2334-o2336.

354. F. Punzo, D. J. Watkin, M. I. Simone and G. W. J. Fleet , (1R,5S,8R)-1,8-Dihydroxy-6-oxa-3-azabicyclo[3.2.1]octan-2-one, Acta Cryst., 2004, E60, o2315-2317.

353. H. A. Shallard-Brown, C. C. Harding, D. J. Watkin, R. Soengas, U. P. Skytte and G. W. J. Fleet, 2,3:5,6-Di-O-isopropylidene-2-C-hydroxymethyl-D-talono-1,4-lactone, Acta Cryst. 2004 E60, o2163-o2164.

352. A. R. Cowley, G. W. J. Fleet, M. I. Simone and R. Soengas, 3-O-tert-Butyldimethylsilyl-2,2':5,6-di-O-isopropylidene-2-C-hydroxymethyl-D-1,4-gluconolactone, Acta Cryst. 2004 E60, o2142-o2143.

351. J. van Ameijde, A. R. Cowley, G. W. J. Fleet, R. J. Nash, M. I. Simone and R. Soengas, 5-Amino-5-deoxy-2-C-hydroxymethyl-2,3-O-isopropylidene-D-talono-1,5-lactam, Acta Cryst. 2004 E60, o2140-o2141.

350. D. J. Watkin, M. Muller, Y. Bleriot, M.I. Simone and G. W. J. Fleet, (2S,3R,4R,5S)-3,4-O-isopropylidene-2-methyl-6,9-diazo-1-oxaspiro-[4.5]-decane-7,10-dione, Acta Cryst. 2004 E60, o1820-o1822.

349. S. W. Johnson, S. F. Jenkinson (n»e Barker), J. H. Jones, D. J. Watkin and G. W. J. Fleet, Pseudoenantiomeric oxetane d-amino acid scaffolds derived from L-rhamnose and D-xylose; D/L-Alanine-D-Serine and Glycine-L-Serine dipeptide isosteres, Tetrahedron: Asymmetry 2004, 15, 3263-3273.

348. D. J. Watkin, S. W. Johnson, J. H. Jones, G. W. J. Fleet, Methyl 2,4-anhydro-5-azido-5,6-dideoxy-L-altronate, Acta Cryst. 2004 E60, o1609-o1610.

347. S. W. Johnson, S. F. Jenkinson (n»e Barker), D. Angus, C. Taillefumier, J. H. Jones and G. W. J. Fleet Oxetane cis- and trans b-amino-acid scaffolds from L-rhamnose by efficient S_N2 reactions in oxetane rings; pseudoenantiomeric analogues of the antibiotic oxetin, Tetrahedron: Asymmetry, 2004, 15, 2681-2686.

346. S. F. Jenkinson (n»e Barker), T. Harris and G. W. J. Fleet Oxetane cis- and trans b-amino-acid scaffolds from D-xylose by efficient S_N2 reactions in oxetane rings: methyl and hydroxymethyl analogues of the antibiotic oxetin, an oxetane b-amino-acid, Tetrahedron: Asymmetry, 2004, 15, 2667-2679.

345. Chu-Yi Yu, Naoki Asano, Kyoko Ikeda, Mei-Xiang Wang, Terry D. Butters, Mark R. Wormald, Raymond A. Dwek, Ana L. Winters, Robert J. Nash and George W. J. Fleet, L-DMDP, a More Potent and Specific Inhibitor of a-Glucosidases than the Enantiomeric Natural Product DMDP, Chem. Commun., 2004, 1936-1937.

344. Newton, C.R.; van Ameijde, J.; Fleet, G.W.J.; Nash, R.J.; Watkin, D.J. 3-epi-Casuarine monohydrate, Acta Cryst. 2004 E60, o1463-o1464.

343. Newton, C.R.; Simone, M.I.; Fleet, G.W.J.; Bleriot, Y.; Watkin, D.J. 2-C-Hydroxymethyl-2,3-O-isopropylidene-D-ribono-1,5-lactam, Acta Cryst. 2004 E60, o909-o910.

342. Newton, C. R.; Horne, G.; Fleet, G. W. J.; Nash, R. J.; Watkin, D.J. Methyl 3,6-anhydro-4-azido-5,7-O-(S)-benzylidene-2,4-dideoxy-D-talo-heptonate, Acta Cryst. 2004 E60, o839-o840

341. Zhao, M.X., Wang M.X., Yu, C.Y., Huang, Z.T., Fleet, G.W.J., Ring-chain tautomerism in organic synthesis: Synthesis of heterocyclic enamines from a novel and practical formal ring transformation reaction of lactones, J. Org. Chem., 2004, 69, 997-1000

340. B. A. Mayes, R.J.E. Stetz, M. P. Watterson, A. A. Edwards, C. W.G. Ansell, G. E. Tranter and G. W.J. Fleet, Towards hydroxylated nylon 6: linear and cyclic oligomers from a protected 6-amino-6-deoxy-D-galactonate – a novel class of carbopeptoid-cyclodextrin (CPCD), Tetrahedron: Asymmetry, 2004, 15, 627-638.

339. Y.-K. Chung, T.D.W. Claridge, G.W.J. Fleet, S.W. Johnson, J.H. Jones, K.W. Lumbard, A.V. Stachulski, An Unsaturated peptidomimetic assembly derived from a carbohydrate, J. Peptide. Sci., 2004, 10, 1-7.

338. A. A. Edwards,^, O. Ichihara, S. Murfin, R. Wilkes, D. J. Watkin, and G. W. J. Fleet, Tetrahydrofuran based amino acids as novel library scaffolds, J. Combinatorial Chem., 2004, 6, 230-238.

337. B. A. Mayes, A.R. Cowley, C.W.G. Ansell and G. W.J. Fleet, Mixed sugar-nylon 14-, 28- and 42-membered ring macrocyclic lactams, Tetrahedron Lett., 2004, 45, 163-166.

336. B. A. Mayes, L. Simon, D. J. Watkin, C.W.G. Ansell and G. W.J. Fleet, Huge (14-, 21-, 28-, 35-, 56- and 70-membered ring) macrocyclic lactams – a novel family of carbopeptoid-cyclodextrins Tetrahedron Lett., 2004, 45, 157-162.

335. B. A. Mayes, R.J.E. Stetz, C.W.G. Ansell and G. W.J. Fleet, Cyclo[(6-amino-6-deoxy-D-galactonic acid)₄]: a new class of carbopeptoid-cyclodextrin (CPCD), Tetrahedron Lett., 2004, 45, 153-156.

334. S. Mons and G. W.J. Fleet, An approach to the generation of simple analogues of the antitumor agent spicamycin, Org. Biomol. Chem., 2003, 1, 3685-3691.

333. M. D. Smith, T. D. W. Claridge, M. P. Sansom and G. W. J. Fleet, Bend ribbon-forming Tetrahydrofuran amino acids, Org. Biomol. Chem., 2003, 1, 3647-3655.

332. D.F.W. Hunter and G.W. J. Fleet, Towards hydroxylated nylon 6: oligomers from a protected 6-amino-6-deoxy-D-allonate, Tetrahedron: Asymmetry, 2003, 14, 3831-3839.

331. R. I. Cooper, A. Edwards, G. W. J. Fleet and D. J.Watkin, Isopropyl 6-amino-2,5-anhydro-3,6-dideoxy-6-N-(2,5-anhydro-6-azido-3,6-dideoxy-L- arabino-hexonyl)-L-arabino-hexonate,

Acta Cryst. 2003 E59, 1712-1714

330. M.P. Watterson, A.A. Edwards, J.A. Leach, M.D. Smith, O. Ichihara, G. W. J. Fleet, Synthesis of all diastereomeric methyl 2,5-anhydro-3-deoxy-hexonates: precursors to C-2- deoxynucleosides and THF-templated g- and d-amino acids, Tetrahedron Lett., 2003, 44, 5853-5857.

329. G. J. Sanjayan, A.J. Stewart, S. Hachisu, R. Gonzalez, M. P. Watterson and G. W. J. Fleet, Templated scaffolds of cis- and trans-tetrahydrofuran g-amino acids: g-azido-b-hydroxy-tetrahydrofuran-2-carboxylates from pentono-d-lactones, Tetrahedron Lett., 2003, 44, 5847-5852.

328. Wang M.X., Liu Y,, Gao, H.Y., Zhang, Y., Yu, C.Y., Huang, Z.T., Fleet, G.W.J., Ring-chain tautomerism in organic synthesis: Synthesis of heterocyclic enamines from a novel and practical formal ring transformation reaction of lactones, J. Org. Chem., 2003, 68, 3281-3286.

327. Kato A, Kano E, Adachi I, Molyneux RJ, Watson AA, Nash RJ, Fleet GWJ, Wormald MR, Kizu H, Ikeda K, Asano N Australine and related alkaloids: easy structural confirmation by C-13 NMR spectral data and biological activities,, Tetrahedron: Asymmetry, 2003 14, 325-331.

326. Butters, Terence D.; Dwek, Raymond A.; Fleet, George; Orchard, Michael Glen; Platt, Frances Mary. Preparation of pharmaceutically active aza-sugar piperidine derivatives as inhibitors of galactosidase and glucosylceramide synthase. PCT Int. Appl. (2002), 38 pp. CODEN: PIXXD2 WO 2002055498 A1 20020718 CAN 137:93950 AN 2002:539660 CAPLUS

325 Yamashita T, Yasuda K, Kizu H, Kameda Y, Watson AA, Nash RJ, Fleet GWJ , Asano N, New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica, J. Nat. Prod., 2002, 65, 1875-1881.

324. A.J. Stewart, R.M. Evans, A.C. Weymouth-Wilson, A.R. Cowley, D.J. Watkin, and G.W.J. Fleet, 2-Deoxy-L-ribose from an L-arabinono-1,5-lactone, Tetrahedron: Asymmetry, 2002, 13, 2667-2672.

323. Long DD, Smith MD, Martin A, Wheatley JR, Watkin DG, Muller M, Fleet GWJ Complex tetrahydrofurans from carbohydrate lactones: THF amino acids as building blocks for unnatural biopolymers, J. Chem. Soc., Perkin Trans. 1, 2002, 1982-1998.

322. Mellor HR, Nolan J, Pickering L, Wormald MR, Platt FM, Dwek RA, Fleet GWJ, Butters TD Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins, Biochem. J., 2002, 366, 225-233.

321. K. Yasuda, H. Kizu, T. Yamashita, Y. Kameda, A. Kato, R.J. Nash, G.W.J.Fleet N. Asano, New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii, J. Nat. Prod., 2002, 65, 198-202

320. T. D. W. Claridge, J. M. Goodman, A. Moreno, D. Angus, S. F. Barker, C. Taillefumier, M. P. Watterson, and G. W. J. Fleet, 10-Helical conformations in oxetane b-amino acid hexamers, Tetrahedron Lett., 2001, 42, 4251-4255.

318. S. F. Barker, D. Angus, C. Taillefumier, M.R. Probert, D.J. Watkin, M. P. Watterson, T.D.W. Claridge and G. W. J. Fleet, cis- and trans-3-Azido-oxetane-2-carboylate scaffolds: Hexamers of oxetane cis-b-amino acids, Tetrahedron Lett., 2001, 42, 4247-4250.

317. Watson, A.A., Fleet, G.W.J., Asano, N., Molyneux, R.J., Nash, R.J., Polyhydroxylated alkaloids – natural occurrence and therapeutic applications, Phytochemistry, 2001, 56, 265-295

316. Long, D.D.;Tennant-Eyles, R.J; Estevez, J.C.; Wormald, M.R.; Dwek, R.A.; Smith, M.D.; Fleet, G.W.J. Carbopeptoids: Peptides and diketopiperazines incorporating the anomeric centre of mannopyranose, J. Chem. Soc., Perkin Trans. 1, 2001, 807-813.

315. Asano N, Yasuda K, Kizu H, Kato A, Fan JQ, Nash RJ, Fleet GWJ, Molyneux RJ, Novel alpha-L-fucosidase inhibitors from the bark of Angylocalyx pynaertii (Leguminosae), Eur. J. Biochem., 2001, 268, 35-41.

314. Zitzmann, Nicole; Butters, Terry D.; Platt, Frances M.; Carrouee, Sandra; Jacob, Gary S.; Picker, Donald H.; Fleet, George W. J.; Dwek, Raymond A. Preparation of long chain N-alkyl amino and imino alditols and oxa-derivatives as antiviral agents. PCT Int. Appl. (2001), 47 pp. CODEN: PIXXD2 WO 2001010429 A2 20010215 CAN 134:163282 AN 2001:114972 CAPLUS

313. Fleet, George; Scott, David; Finn, Malcolm; Krulle, Thomas. Bis(1,3-dihydroxy-prop-2-yl)amine and derivatives thereof in manufacture of polymers. PCT Int. Appl. (2000), 77 pp. CODEN: PIXXD2 WO 2000055111 A2 20000921 CAN 133:252855 AN 2000:666687 CAPLUS

312. S. W. Johnson, D. Angus, C. Taillefumier, J. H. Jones, D. J. Watkin, E. Floyd, J. G. Buchanan and G. W. J. Fleet, Two Epimerisations in the formation of oxetanes from L-rhamnose: towards oxetane-containing peptidomimetics, Tetrahedron Asymm., 2000, 11, 4113-4125.

311. N. L. Hungerford and G. W. J. Fleet, Tetrahydrofuran Amino Acids: b- and g-Azido-tetrahydrofuran carboxylic acid monomers derived from D-glucoheptonolactone as building blocks for b- and g-oligopeptides, J. Chem. Soc., Perkin Trans. 1, 2000, 3680-3685.

310. N. L. Hungerford, T. D. W. Claridge, M. P. Watterson, R. T. Aplin, A. Moreno and G. W. J. Fleet, Tetrahydrofuran Amino Acids: Secondary Structure in Tetrameric and Octameric Carbopeptoids Derived from a D-allo 5-Aminomethyl Tetrahydrofuran-2-Carboxylic Acid, J. Chem. Soc., Perkin Trans. 1, 2000, 3666-3679.

309. D. E. A. Brittain, M. P. Watterson, T. D. W. Claridge, M. D. Smith and G. W. J. Fleet, Tetrahydrofuran Amino Acids - Versatile Building blocks for Unnatural Biopolymers: Lack of Secondary Structure in Oligomeric Carbopeptoids Derived from a D-galacto-5-Aminomethyl Tetrahydrofuran-2-Carboxylic Acid, J. Chem. Soc., Perkin Trans. 1, 2000, 3655-3665.

308. D. A. Scott, T. M. Krulle, M. Finn and G. W.J. Fleet, Bis(1,3-dihydroxy-isopropyl)amine (BDI) as an AB₄ Dendritic Building Block: Rapid Synthesis of a Second Generation Dendrimer, Tetrahedron Lett., 2000, 41, 3955-3958.

307. N. Asano, R. J. Nash, R. J. Molyneux and G. W.J. Fleet, Nitrogen-in-the-Ring Sugar Mimetics: Natural Occurrence, Biological Activity and Prospects for Therapeutic Application, in Tetrahedron Asymm., 2000, 11, 1645-1680.

306. N. Asano, M. Nishida, M. Miyauchi, K. Ikeda, M. Yamamoto, H. Kizu, Y. Kameda, A. A. Watson, R. J. Nash, G. W. J. Fleet, Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae), Phytochemistry, 2000, 53, 379-382.

305. N. Asano, H. Kuroi, K. Ikeda, H. Kizu, Y. Kameda, A. Kato, I. Adachi, A. A Watson, R. J. Nash, and G. W.J. Fleet, New polyhydroxylated pyrrolizidine alkaloids from Muscari armeniacum: structural determination and biological activity, Tetrahedron Asymm., 2000, 11, 1-8.

304. T.D. Butters, L.A.G.M. van den Broek, G.W.J.Fleet, T. M. Krulle, M. R. Wormald, R. A. Dwek, and F. M. Platt, Molecular Requirements of Imino Sugars for the Selective Control of N-linked Glycosylation and Glycosphingolipid Biosynthesis, Tetrahedron Asymm., 2000, 11, 113-125.

303. B. Winchester, G. W. J. Fleet, Modification Of Glycosylation As A Therapeutic Strategy, J. Carbohydr. Chem., 2000, 19, 471-483.

302. K. Ikeda, M. Takahashi , M. Nishida, M. Miyauchi, H. Kizu, Y. Kameda, M. Arisawa, A. A Watson, R. J. Nash, G. W.J. Fleet, N. Asano, Homonojirimycin analogues and their glucosides from Lobelia sessilifolia and Adenophora spp. (Campanulaceae), Carbohydr. Res., 2000, 323, 73-80.

301. D. A. Scott, T. M. Kr∏lle, M. Finn, R. J. Nash, A. L. Winters, N. Asano, T. D. Butters and G. W. J. Fleet Synthesis of bis(1,3-Dihydroxy-isopropyl)amine by Reductive Amination of Dihydroxyacetone: Open Chain Equivalent of DMDP and a Potential AB₄ Dendritic Monomer, Tetrahedron Lett., 1999, 40, 7581-7584.

300. M. D. Smith and G. W. J. Fleet, Carbohydrate-Derived Dipeptide Isosteres, J. Peptide Sci., 1999, 5 , 425-441.

299. R. E. Lee, M. D. Smith, L. Pickering and G. W. J. Fleet, An Approach to Combinatorial Library Generation of Galactofuranose Mimics in the Search for Inhibition of Mycobacterial Cell Wall Biosynthesis: Synthesis of a Peptidomimetic of Uridine 5º-Diphosphogalactofuranose (UDP-Galf), Tetrahedron Lett., 1999, 40, 8689-8692.

298. Kato, A, Adachi_I, Miyauchi, M, Ikeda, K, Komae, T, Kizu, H, Kameda, Y, Watson, AA, Nash, R. J., Wormald, M. R., Fleet, G. W. J., Asano, N Polyhydroxylated pyrrolidine and pyrrolizidine alkaloids from Hyacinthoides non-scripta and Scilla campanulata, Carbohydr. Res.,1999, 316, 95-103.

297. J. P. Shilvock, R. J. Nash, A. A. Watson, A. L. Winters, T. D. Butters, R. A. Dwek, D. A. Winkler, and G. W.J. Fleet, Piperidine analogues of D-galactose as potent inhibitors of a-galactosidase: Synthesis by stannane mediated hydroxymethylation of 5-azido-1,4-lactones. Structural relationships between D-galactosidase and L-rhamnosidase inhibitors, J. Chem. Soc., Perkin Trans. 1, 1999, 2747-2754.

296. J. P. Shilvock, J. R. Wheatley, R. J. Nash, A. A. Watson, R. C. Griffiths, T. D. Butters, M. M∏ller, D. J. Watkin, D. A. Winkler, and G. W.J. Fleet, Synthesisis of Homorhamnojirimycins and Related Trihydroxypipecolic Acid Derivatives via Divergent Bicyclic Aminolactone Intermediates: Inhibition of Naringinase (L-Rhamnosidase) and dTDP-rhamnose Biosynthesis, J. Chem. Soc., Perkin Trans. 1, 1999, 2735-2745.

295. A. MartÃn, T. D. Butters and G. W.J. Fleet, Synthesis and Biological Evaluation of Enantiomeric Rhamnose Analogues of the Antitumour Agent Spicamycin - Is the Mode of Action by Modification of N-linked Glycoproteins?, Tetrahedron Asymm., 1999, 10, 2343-2360.

294. M. P Watterson, L. Pickering, M. D. Smith, S. H. Hudson, P. R. Marsh, J. E. Mordaunt, D. J. Watkin, C. J. Newman and G. W. J. Fleet, 3-Azidotetrahydrofuran-2-Carboxylates: A Family of Five-ring Templated b-Aminoacid Foldamers?, Tetrahedron Asymm., 1999, 10, 1855-1859.

293. M. D. Smith, D. D. Long, A. MartÃn, N. Campbell, Y. Bl»riot, G. W. J. Fleet, Tetrahydrofuran a-Azido Esters: Precursors of Anomeric a-Amino Acid Monomers via Radical Bromination, Synlett, 1999, 1151-1153.

292. Tsitsanou, K.E., Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Gregoriou, M., Watson, K.A., Johnson, L.N., Fleet, G.W.J. Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure, Protein Sci., 1999, 8, 741-749.

291. K. H. Smelt, A. J. Harrison, K. Biggadike, M. Muller, C. K. Prout, D. J. Watkin, G. W. J. Fleet, Components for a Combinatorial Library of Rigid Azabicyclic a-L-Fucose Mimics: First X-Ray Crystal Structure of a Stable Monoalkylated Triazene formed by Hydrogenation of an Azide, Tetrahedron Lett., 1999, 40, 3259-3262.

290. K. H. Smelt, Y. Bl»riot, K. Biggadike, S. Lynn, A. L. Lane, D. J. Watkin, G. W. J. Fleet, Photobromination of a Bicyclic Mimic of a-L-Fucose; Components for a Combinatorial Library of Rigid Fucose Analogues, Tetrahedron Lett., 1999, 40, 3255-3258.

289. D. D. Long, R. J. E. Stetz, R. J. Nash, D. G. Marquess, J. D. Lloyd, A. L. Winters, N. Asano, G. W.J. Fleet, Open Chain Acetonides of 1,4-D-Galactonolactone as Starting Materials for Pyrrolidines, Azepines and 5-Azidomethyltetrahydrofuran-2-carboxylates: Monomers for Polyhydroxylated Nylon and for Tetrahydrofuran Carbopeptoids, J. Chem. Soc., Perkin Trans. 1, 1999, 901-908.

288. T.D.W. Claridge, D.D. Long, N.L. Hungerford, M.D. Smith, R.T. Aplin, D.G. Marquess, G.W.J. Fleet, An Octameric Carbopeptoid; Secondary Structure in Octameric and Tetrameric 5-Aminomethyl-Tetrahydrofuran-2-carboxylates, Tetrahedron Lett., 1999, 40, 2199-2203.

287. D.D. Long, N.L. Hungerford, M.D. Smith, D.E.A. Brittain, D.G. Marquess, T.D.W. Claridge, G.W.J Fleet, From Sequencamers to foldamers? Tetrameric Furanose Carbopeptoids from cis- and trans-5-Aminomethyl-Tetrahydrofuran-2-carboxylates, Tetrahedron Lett., 1999, 40, 2195-2198.

286. M. D. Smith, D. D. Long, A. MartÃn, D. G. Marquess, T. D. W. Claridge, G. W. J. Fleet, Absence of Secondary Structure in a Carbopeptoid Tetramer of a trans-5-Aminomethyl-Tetrahydrofuran-2-carboxylate, Tetrahedron Lett., 1999, 40, 2191-2194.

285. B. G. Davis, R. J. Nash, A. A. Watson, C. Smith, G. W. J. Fleet, Tetrazoles of Manno- and Rhamno- Furanoses, Tetrahedron, 1999, 55, 4489-4500

284. B. G. Davis, T. W. Brandstetter, L. Hackett, B. G. Winchester, R. J. Nash, A. A. Watson, R. C. Griffiths, C. Smith, G. W. J. Fleet, Tetrazoles of Manno- and Rhamno-Pyranoses: Contrasting Inhibition of Mannosidases by [4.3.0] but of Rhamnosidase by [3.3.0] Bicyclic Tetrazoles, Tetrahedron, 1999, 55, 4501-4520.

283. A. MartÃn, M. P. Watterson, A. R. Brown, F. Imtiaz, B.G. Winchester, D J. Watkin, G. W. J. Fleet 6R-, and 6S, -6C-Methylmannose from D-Mannuronolactone: Inhibition of Phosphoglucomutase and Phosphomannomutase: Agents for the Study of the Primary Metabolism of Mannose, Tetrahedron Asymm., 1999, 10, 355-366.

282. J. P. Shilvock, K. Y. Hsia, R. J. Nash, J. D. Lloyd, A. L. Winters, N. Asano, G. W. J. Fleet, Synthesis of an Eight carbon Homologue of a-Homomannojirimycin via a Bicyclic Aminolactone, Tetrahedron Asymm., 1998, 9, 4157-4164.

281. J. P. Shilvock, R. J. Nash, J. D. Lloyd, A. L. Winters, N. Asano, G. W. J. Fleet, Intermediates for incorporation of tetrahydroxypipecolic acid analogues of a- and b-D-mannopyranose into combinatorial Libraries: Unexpected Nanomolar-range Hexosaminidase Inhibitors. Synthesis of a- and b-Homomannojirimycin, Tetrahedron Asymm., 1998, 9, 3505-3516.

280. D. D. Long, M. D. Smith, D. G. Marquess, T. D. W. Claridge, G. W. J. Fleet, A Solid Phase Approach to Oligomers of Carbohydrate Amino-Acids: Secondary Structure in a Trimeric Furanose Carbopeptoid, Tetrahedron Lett., 1998, 39, 9293-9296.

279. B. G. Davis, A. Hull, C. Smith, R. J. Nash, A. A. Watson, D. A. Winkler, R. C. Griffiths, G. W. J. Fleet, 5-epi-Deoxyrhamnojirimycin is a Potent Inhibitor of an a-L-Rhamnosidase: 5-epi-Deoxymannojirimycin is not a Potent Inhibitor of an a-D-Mannosidase, Tetrahedron Asymm., 1998, 9, 2947-2960.

278. A. MartÃn, T. D. Butters, G. W. J. Fleet, A Highly Cytotoxic L-Rhamnose Analogue of the Antitumour Agent Spicamycin, J. Chem. Soc., Chem. Commun., 1998, 2119-2220.

277. M. D. Smith, D. D. Long, T. D. W. Claridge, D. G. Marquess, G. W. J. Fleet, Synthesis of Oligomers of Tetrahydrofuran Amino-Acids: Furanose Carbopeptoids, J. Chem. Soc., Chem. Commun., 1998, 2039-2040.

276. M. D. Smith, T. D. W. Claridge, G. E. Tranter, M. S. P. Sansom, G. W. J. Fleet, Secondary Structure in Oligomers of Carbohydrate Amino-Acids, J. Chem. Soc., Chem. Commun., 1998, 2041-2042.

275. J. C. Estevez, A. J. Fairbanks, G. W. J. Fleet, Synthesis of Tetrahydropyrans from Sugar Lactones, Tetrahedron, 1998, 54, 13591-13620.

274. M. R. Wormald, R. J. Nash, P. Hrnicar, J. D. White, R. J. Molyneux and G. W. J. Fleet, Configurational and Conformational Analysis of Highly Oxygenated Pyrrolizidines: Definitive Identification of Some Naturally Occurring 7a-epi-Alexines, Tetrahedron Asymm., 1998, 9, 2549-2558.

273. D. D. Long, S. M. Frederiksen, D. G. Marquess, A. L. Lane, D. J. Watkin, D. A. Winkler, G. W. J. Fleet, Potential intermediates for incorporation of polyhydroxylated prolines into combinatorial libraries, Tetrahedron Lett., 1998, 39, 6091-6094.

272. N Asano, A. Kato, M. Miyauchi, H. Kizu, A. A. Watson, R. J. Nash, G. W. J. Fleet, Nitrogen-in-the-Ring Furanose and Pyranose Analogues form Hyacinthus orientalis, J. Nat. Prod., 1998, 61, 625-628.

271. N. Asano, M. Nishida, A. Kato, H. Kizu, K. Matsui, Y. Shimada, T. Itoh, M. Baba, A. A. Watson, R. J. Nash, P. M. de Q. Lilley, D. J. Watkin, G. W. J. Fleet, Homonojirimycin Isomers and N-Alkylated Homonojirimycins: Structural and Conformational Basis of Inhibition of Glycosidases, J. Med. Chem., 1998, 41, 2565-2571.

270. J. C. Estevez, J. W. Burton, R. J. Estevez, H. Ardron, M. R. Wormald, R. A. Dwek, D. Brown, G. W. J Fleet, Spirodiketopiperazines of Mannofuranose: Carbopeptoid a-Amino Acid esters at the anomeric position of mannofuranose, Tetrahedron Asymm., 1998, 9, 2137-2154.

269. M. Gregoriou, M. E. M. Noble, K. A. Watson, E. F. Garman, T. M. Kr∏lle, C. de la Fuente, G. W. J. Fleet, N. G. Oikonomakos, L. N. Johnson, The Structure of a Glycogen Phosphorylase Glucopyranose Spirohydantoin Complex at 1.8A resolution and 100 K: the Role of the Water Structure and its Contribution to Binding, Protein Sci., 1998, 7, 915-927.

268. J. P. Shilvock and G. W. J. Fleet, The Synthesis of Deoxygalactostatin and 2,6-Imino-heptitol Derivatives via Stannane Mediated Hydroxymethylation of 5-Azido-1,4-lactones Synlett, 1998, 554-556.

267. G. W. J. Fleet, J. C. Estevez, M. D. Smith, Y. Bl»riot, C. de la Fuente, T. M. Kr∏lle, G. S. Besra, P. J. Brennan, R.J. Nash, L. N. Johnson, N. G. Oikonomakos and W. Stalmans, Sugar Mimics from Sugar Lactones, Pure Appl. Chem., 1998, 70, 279-284.

266. Y. Wang, G. W J Fleet, L. Zhao, 1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl (TIPS) Migration Facilitates One-pot formation of Enantiomerically Pure Methyl 2,3-Epoxy-D-xylonate, Carbohydr. Res., 1998, 307, 159-162

265. Nash, R.J., Watson, A.A., Winters, A.L., Fleet, G.W.J., Wormald, M.R., Dealler, S., Lees, E., Asano, N., and Molyneux, R.J.Glycosidase Inhibitors in British Plants as Causes of Livestock Disorders. Chapter 56, pp. 276-284 In: Toxic Plants and Other Natural Toxicants. (Ed. Garland, T., Barr, A. C.), , CAB International, Wallingford, U, K, 1998

264.