DTC - Alice Eddershaw

Alice Eddershaw

Doctoral Student at the

Doctoral Training Centre

Rex Richards Building, South Parks Road, Oxford OX1 3QU

Background

University of Bath - Bsc Biochemistry with Industrial Placement Year

Interests

I am interested in protein structural study and enzyme kinetics. I enjoy running, yoga and baking in my spare time.

Research

12 week final year research project in Prof. Jody Mason laboratory, setting up a cell assay to detect early stage beta-amyloid dimerisation for identification of peptide inhibitors.
Industrial placement year at AstraZeneca, working in the Biochemical Assay Development team. My project was to characterise the kinetic mechanism of a methyltransferase, and involved carrying out pre-steady state kinetics, initial velocity, dead-end and product inhibition experiments, a solvent viscosity study and an isotope exchange study.
3 week summer placement at GSK, performing a literature review and setting up a database of research on the use of antenatal corticosteroids for women in preterm labour.

Conferences

Podium presentation at the ‘Current Trends in Drug Discovery: young scientists and tomorrow’s medicines’conference organised by the British Pharmaceutical Society and Society of Medicines research in June 2018

Publications

Collie, G W., Koh, C M., O’Neill, D J., Stubbs, C J., Khurana, P., Eddershaw, A., Snijder, A., Mauritzson, F., Barlind, L., Dale, I L., Shaw, J., Phillips, C., Hennessy, E J., Cheung, T., Narvaez, A., 2019. Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors. ACS Medical ChemistryLetters, 10, 1322-1327