Matt Raybould

DPhil Candidate on the Systems Approaches to Biomedical Sciences CDT

Hi, and welcome to my small portion of the internet! I am currently a DPhil candidate on the SABS Centre for Doctoral Training. Here you'll find out more about my research and my academic interests. I'm passionate about computational modelling - using the power of modern-day computing to solve the mysteries of the biomolecular world, contributing to the design of the next era of pharmaceuticals. It would be great to keep in touch via email or LinkedIn. Thanks for visiting!

Education

DPhil Research

Therapeutic Monoclonal Antibody Design

The global market for therapeutic monoclonal antibodies (mAbs), targeting a remarkably wide range of diseases, is exploding, with ~10 new mAbs approved each year and a positive outlook for the years ahead. There is high demand for a reliable in silico protocol that can aid in designing an efficacious antibody lead against any specific protein epitope. I will aim to improve our ability to do this during my DPhil, by first looking at already-approved antibody therapeutics and deriving key design principles from them. This will lead into developing a computational pipeline that generates, from a diverse human-based starting library, a subset of specific, non-immunogenic, antigen-binders.

This work is an open-IP collaboration between the University of Oxford and four industry-leading biopharmaceutical companies.

SABS Rotation Projects

In addition to 6 months of academic courses, the SABS programme offers students the opportunity to experience working in two different research labs before committing to one for the three year DPhil. I worked in the following areas between April and October 2017.

Antibody Informatics (April-July)

Supervised by Prof. Charlotte Deane in the Department of Statistics, in collaboration with GSK, Roche, MedImmune and UCB.

Molecular Dynamics of the hERG Ion Channel (July-October)

Jointly supervised by Dr. Phillip Stansfeld and Prof. Mark Sansom in the Department of Biochemistry, in collaboration with UCB.

Master's Research

A summary of the research experience I gained during my Master's degree.

Mechanistic Insights into the Horner-Wadsworth-Emmons and Still-Gennari Olefinations (Sept 2015-June 2016)

A DFT computational study into the intra- and inter-molecular interactions governing diastereoselectivity in these two closely related organic systems. Master's project conducted in Prof. Robert Paton's group.

Designing a Synthesis of the [18F]-Labelled SSAO/VAP-1 Inhibitor, PXS-4681A (Summer, 2014)

Working towards a new [18F]-labelled synthesis of a potential anti-inflammatory drug desired by oncology departments. Vacation project conducted in Prof. Véronique Gouverneur's group.

Publications

  1. Kovaltsuk, A.; Raybould, M.I.J.; Wong, W.K.; Marks, C.; Kelm, S.; Snowden, J.; Trück, J. & Deane, C.M. Structural Diversity of B-cell Receptor Repertoires along the B-cell Differentiation Axis in Humans and Mice (2019) BioRxiv. doi: 10.1101/762880

    [Link to Preprint]

  2. Raybould, M.I.J.; Marks, C.; Lewis, A.P.; Shi, J.; Bujotzek, A.; Taddese, B. & Deane, C.M. Thera-SAbDab: the Therapeutic Structural Antibody Database (2019) Nucleic Acids Res. 48(1):gkz827.

    [Links to Paper; Database]

  3. Raybould, M.I.J. & Deane, C.M. Structural Information to Aid in silico Therapeutic Antibody Design from Next Generation Sequencing Repertoires (2019) Am. Pharm. Rev. 22(5):28-33.

    [Link to Article]

  4. Krawczyk, K.; Raybould, M.I.J.; Kovaltsuk, A. & Deane, C.M. Looking for Therapeutic Antibodies in Next Generation Sequencing Repositories (2019) mAbs. 11(7):1197-1205.

    [Link to Paper]

  5. Raybould, M.I.J.; Wong, W. & Deane, C.M. Antibody-Antigen Complex Modelling in the Era of Immunoglobulin Repertoire Sequencing (2019) Mol. Syst. Des. Eng. 4:679-688.

    [Link to Paper]

  6. Raybould, M.I.J.; Marks, C.; Krawczyk, K.; Taddese, B.; Nowak, J.; Lewis, A.P.; Bujotzek, A.; Shi, J. & Deane, C.M. Five Computational Developability Guidelines for Therapeutic Antibody Profiling (2019) Proc. Natl. Acad. Sci. USA. 116(10):4025-4030.

    [Links to Paper; Web Application]

Joint authorship

Conferences

Upcoming

  • CASSS Higher Order Structure
    Gaithersburg MD, USA
    20th-22nd April 2020
    Invited Talk and Poster Presentation.

  • PEGS Summit
    Boston MA, USA
    3rd-8th May 2020
    Short Course and Poster Presentation.

Past

  • Intelligent Systems for Molecular Biology (ISMB)
    Chicago IL, USA
    6th-10th July 2018

    Poster Presentation.

Teaching

Since October 2017, I have tutored the first year Merton biochemists in organic chemistry. I have also mentored students through the first (Prelims) and third (Finals, Part IB) year chemistry courses at Merton. I am always eager for new teaching opportunities, so please contact me if you require a tutor in chemistry. All tutorial problem sets are available via WebLearn.

Contact

Email and LinkedIn are the best ways to contact me. Feel free to ask me about anything on the website!

Address

24-29 St Giles'
Department of Statistics
University of Oxford
Oxford
OX1 3LB

Email

matthew.raybould[at]stats.ox.ac.uk