for Dr Keith Brain PhD, MB/BS(Hons), BSc(Med)(Hons), BSc

See also the Scopus summary.

Hansen, T., Tarasova, O.S., Khammy, M.M., Ferreira, A., Kennard, J.A., Andresen, J, Staehr C, Brain, K.L., Nilsson, H. and Aalkjaer, C. (2019) "Ca2+ changes in sympathetic varicosities and Schwann cells in rat mesenteric arteries - relation to noradrenaline release and contraction," Acta Physiologica 226(4):e13279, doi:10.1111/apha.13279.

Appukuttan, S. Padmakumar, M., Young, J.S., Brain, K.L. and Manchanda, R. (2018) "Investigation of the syncytial nature of detrusor smooth muscle as a determinant of action potential shape," Frontiers in Physiology, doi:10.3389/fphys.2018.01300.

Mahapatra, C., Brain, K.L. and Manchanda, R. (2018) "A biophysically constrained computational model of the action potential of mouse urinary bladder smooth muscle," PLoS One, doi:10.1371/journal.pone.0200712 [Paper]

Padmakumar, M., Brain, K.L., Young, J.S. and Manchanda, R. (2018) "A four-component model of the action potential in mouse detrusor smooth muscle cell," PLoS One, doi:10.1371/journal.pone.0190016. [Paper]

Appukuttan, S., Padmakumar, M., Brain, K. and Manchanda, R. (2017) "A method for the analysis of AP foot convexity," Frontiers in Bioengineering and Biotechnology 5:64 doi: 10.3389/fbioe.2017.00064. [Paper] [Birmingham erepository version]

Appukuttan, S., Brain, K.L. and Manchanda, R. (2017b) "Investigation of action potential propagation in a syncytium," Biomedical Research Journal 4:102-115. Paper

Appukuttan, S., Brain, K. and Manchanda, R. (2017a) "Modeling extracellular fields for a three-dimensional network of cells using NEURON," Journal of Neuroscience Methods 290:27-38.Paper

Zhongmin, L., Chouhan, A.K., Borycz, J.A., Lu, Z., Rossano, A.J., Brain, K.L., Zhou, Y., Meinertzhagen, I.A., Macleod, G.T. (2016) "High probability neurotransmitter release sites represent an energy efficient design." Current Biology 26:2562-2571, doi:10.1016/j.cub.2016.07.032 Online now.

Holmes, A.P., Yu, T.Y., Tull, S., Syeda, F., Kuhlmann, S.M., O'Brien, S.-M., Patel, P., Brain, K.L., Pavlovic, D., Brown, N.A., Fabritz, L. and Kirchhof, P. (2016) "A regional reduction in Ito and IKACh in the murine posterior left atrial myocardium is associated with action potential prolongation and increased ectopic activity," PLoS One doi:10.1371/journal.pone.0154077.

Appukuttan, S., Brain, K. and Manchanda, R. (2015) "Syncytial basis for diversity in spike shapes and their propagation in detrusor smooth muscle," Procedia Computer Science 51:785-794. [Paper]

Appukuttan, S., Brain, K.L. and Manchanda, R. (2015) "A computational model of urinary bladder smooth muscle syncytium: validation and investigation of electrical properties," Journal of Computational Neuroscience 38: 167-187. [Paper]

Yu, T.Y., Dehghani, H., Brain, K.L., Syeda, F., Holmes, A.P., Kirchhof, P. and Fabritz, L. (2015) "Optical mapping design for murine atrial electrophysiology," Computer Methods in Biomechanics and Biomedical Engineering 5(5):368-376. doi:10.1080/21681163.2015.1081079.

Yu, T., Syeda, F., Holmes, A., Osborne, B., Dehghani, H., Brain, K.L., Kirchhof, P. & Fabritz, L. (2014) "An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials," Progress in Biophysics & Molecular Biology 115: 340-348. [Paper]

Newman, A.S., Batis, N., Grafton, G., Caputo, F., Brady, C.A., Lambert, J., Peters, J.A., Gordon, J., Brain, K.L., Powell, A.D., Barnes, N.M. (2013) "5-Chloroindole: a potent allosteric modulator of the 5-HT3 receptor," British Journal of Pharmacology 169:1228-1238. [Paper]

Boersma, A.J., Brain, K.L. and Bayley, H. (2012) "Real-time stochastic detection of multiple neurotransmitters with a protein nanopore," ACS Nano 6:5304-5308.[Paper]

Kobayter, S. Young, J.S. and Brain, K.L. (2012) "Prostaglandin E2 induces spontaneous rhythmic activity in mouse urinary bladder independently of efferent nerves," British Journal of Pharmacology, 165:401-413.[Paper]

Williams, D.J., Sidaway, P., Cunnane, T.C. and Brain, K.L. (2011) "Mechanisms involved in nicotinic acetylcholine receptor-induced neurotransmitter release from sympathetic nerve terminals in the mouse vas deferens," PLoS One, 6:e29209. [Paper]

Brading, A.F. and Brain, K.L. (2011). "Ion Channel Modulators". In Handbook of Experimental Pharmacology: Urinary Tract, ed. Andersson KE & Michel MC, pp. 375-393, Springer. [World Cat.]

Parker, L.K., Shanks, J.A., Kennard, J.A.G. and Brain, K.L. (2010) "Dynamic monitoring of NET activity in mature murine sympathetic terminals using a fluorescent substrate," British Journal of Pharmacology, 159:797-807. [Paper][Open Access]

Brain, K.L. (2010) "Parasympathetic cholinergic transmission, minus the vesicles," Experimental Physiology, 92:263-4. [Paper]

Valeri, A., Brain, K.L., Young, J.S., Sgaragli, G. and Pessina, F. (2009) "Effects of 17β-estradiol on rat detrusor smooth muscle contractility," Experimental Physiology 94:834-846. [Paper][Open Access]

Young, J.S., Amos, R.J. and Brain, K.L. (2009) "Focal Ca2+ transient detection in smooth muscle," Journal of Visualized Experiments, 28 doi: 10.3791/1247. [Video Article][Open Access]

Rahman, F., Manchanda, R. and Brain, K.L. (2009) "Prejunctional and postjunctional actions of heptanol and 18β-glycyrretinic acid in the rodent vas deferens," Autonomic Neuroscience: Basic and Clinical 148:69-75. [Open Access]

Brain, K.L. (2009) "Neuroeffector Ca2+ transients for the direct measurement of purine release and indirect measurement of co-transmitters," Experimental Physiology, 94:25-30. [Paper] [Open Access].

Young, J.S., Meng, E., Cunnane, T.C. and Brain, K.L. (2008) "Spontaneous purinergic neurotransmission in the mouse urinary bladder," Journal of Physiology, 586:5743-5755. [Paper] [Open Access]

Brain, K.L. and Cunnane, T.C. (2008) "Bretylium abolishes neurotransmitter release without necessarily abolishing the nerve terminal action potential in sympathetic terminals," British Journal of Pharmacology 153:831-839. [Paper] [Open Access]

Zhu, H-L., Brain, K.L., Aishima, M., Shibata, A., Young, J.S., Sueishi, K. and Teramoto, N. (2008) "Actions of two main metabolites of propiverine (M-1 and M-2) on voltage-dependent L-Type Ca2+ currents and Ca2+ transients in murine urinary bladder myocytes," Journal of Pharmacology and Experimental Therapeutics 324:118-127. [Paper] [Open Access Preproof] [UKPubmed Open Access]

Young, J.S., Brain, K.L. and Cunnane, T.C. (2007) "Electrical and optical study of nerve impulse-evoked ATP-induced, P2X-receptor-mediated sympathetic neurotransmission at single smooth muscle cells in mouse isolated vas deferens," Neuroscience 148:82-91. [Open Access]

Williams, D.J., Brain, K.L. and Cunnane, T.C. (2007) "The effect of epibatidine on spontaneous and evoked neurotransmitter release in the mouse and guinea pig isolated vas deferens," British Journal of Pharmacology 150:906-912. [Paper] [Open Access]

Young, J.S., Brain, K.L. and Cunnane, T.C. (2007) "The origin of the skewed amplitude distribution of spontaneous excitatory junction potentials in poorly coupled smooth muscle cells," Neuroscience 145:153-161. [Paper] [UKPubmed Open Access] <

Brain, K.L., Kay, J. and Shine, B. (2006) "Measurement of urinary metanephrines to screen for pheochromocytoma in an unselected hospital referral population," Clinical Chemistry 52:2060-2064. [UKPubmed Open Access]

Webster, R.G., Brain, K.L., Wilson, R.H., Grem, J.L. and Vincent, A. (2005) "Oxaliplatin induces hyperexcitability at motor and autonomic neuromuscular junctions through effects on voltage-gated sodium channels," British Journal of Pharmacology 146:1027-1039. [Paper] [UKPubmed Open Access]

Brain, K.L., Cuprian, A.M., Williams, D.J. and Cunnane, T.C. (2003) "The sources and sequestration of Ca2+ contributing to Neuroeffector Ca2+ transients in the mouse vas deferens," Journal of Physiology 553:627-635. [Paper] [UKPubmed Open Access]

Brain, K.L., Jackson, V.M., Trout, S.J. and Cunnane, T.C. (2002) "Intermittent ATP release from nerve terminals elicits focal smooth muscle Ca2+ transients in mouse vas deferens," Journal of Physiology 541:849-862. [Paper] [UKPubmed Open Access]

Brain, K.L., Trout, S.J., Jackson, V.M., Dass, N. and Cunnane, T.C. (2001) "Nicotine induces calcium spikes in single nerve terminal varicosities: a role for intracellular calcium stores," Neuroscience 106:395-403. [Paper]

Jackson, V.M., Trout, S.J., Brain, K.L. and Cunnane, T.C. (2001) " Characterisation of action potential-evoked calcium transients in postganglionic sympathetic axon bundles," Journal of Physiology 537:3-16. [Paper] [UKPubmed Open Access]

Lengyel, I., Olesen, L.E., Nichol, K.A., Brain, K.L., Wang, X., Robinson, P.J., Bennett, M.R. and Rostas, J.A.P. (1999) " Phosphorylation of proteins in chick ciliary ganglion under conditions that induce long-lasting changes in synaptic transmission: phosphoprotein targets for nitric oxide action," Neuroscience 90:607-619. [Paper]

O'Connor, S.C., Brain, K.L. and Bennett, M.R. (1999) "Individual sympathetic varicosities possess different sensitivities to alpha 2 and P2 receptor agonists and antagonists in mouse vas deferens," British Journal of Pharmacology 128:1739-1753. [Paper][UKPubmed Open Access]

Brain, K.L. and Bennett, M.R. (1998) "Calcium transients evoked by action potentials in the somata of chick ciliary neurons," Journal of the Autonomic Nervous System 71:120-133. [Paper]

Bennett, M.R., Cheung, A. and Brain, K.L. (1998) "Sympathetic neuromuscular transmission at a varicosity in a syncytium," Microscopy Research and Technique 42:433-450. [Paper]

Lin, Y.Q., Brain, K.L, and Bennett, M.R. (1998) "Calcium in sympathetic boutons of rat superior cervical ganglion during facilitation, augmentation and potentiation," Journal of the Autonomic Nervous System 73:26-37. [Paper]

Brain, K.L. and Bennett, M.R. (1997) "Calcium in sympathetic varicosities of mouse vas deferens during facilitation, augmentation and autoinhibition," Journal of Physiology 502:521-536. [Paper]

Brain, K.L., Cottee, L.J. and Bennett, M.R. (1997) "Varicosities of single sympathetic nerve terminals possess different synaptotagmin N-terminus labelling following stimulation," Journal of Neurocytology 26:491-500. [Paper]

Bennett, M.R. and Brain, K. (1997) "Autonomic synaptic transmission at single boutons and calyces," Journal of Neurocytology 26:577-603.[Paper]

Lin, Y.Q., Brain, K.L, Nichol, K.A., Morgan, J.J. and Bennett, M.R. (1996) "Vesicle-associated proteins and calcium in nerve terminals of chick ciliary ganglia during the development of facilitation," Journal of Physiology 497:639-656. [Paper]

Brain, K.L. and Bennett, M.R. (1995) "Calcium in the nerve terminals of chick ciliary ganglia during facilitation, augmentation and potentiation," Journal of Physiology 489:637-648. [Paper]

Sheppard, C.J.R., Gu, M., Brain, K.L. and Zhou, H. (1994) "Influence of spherical aberration on axial imaging of confocal reflection microscopy," Applied Optics 33:616-624. [Paper]

A list of published Abstracts is also available.

Email: Keith Brain