for Dr Keith Brain PhD, MB/BS(Hons), BSc(Med)(Hons), BSc

Holmes, A.P., Yu, T.Y., Tull, S., Syeda, F., Kuhlmann, S.M., O'Brien, S.-M., Patel, P., Brain, K.L., Pavlovic, D., Brown, N.A., Fabritz, L. and Kirchhof, P. (2016) "A regional reduction in Ito and IKACh in the murine posterior left atrial myocardium is associated with action potential prolongation and increased ectopic activity," PLoS One [article].

Yu, T.Y., Dehghani, H., Brain, K.L., Syeda, F., Holmes, A.P., Kirchhof, P. and Fabritz, L. (2015) "Optical mapping design for murine atrial electrophysiology," Computer Methods in Biomechanics and Biomedical Engineering doi:10.1080/21681163.2015.1081079.

Appukuttan, S., Brain, K. and Manchanda, R. (2015) "Syncytial basis for diversity in spike shapes and their propagation in detrusor smooth muscle," Procedia Computer Science 51:785-794. [Paper]

Appukuttan, S., Brain, K.L. and Manchanda, R. (2015) "A computational model of urinary bladder smooth muscle syncytium: validation and investigation of electrical properties," Journal of Computational Neuroscience 38: 167-187. [Paper]

Yu, T., Syeda, F., Holmes, A., Osborne, B., Dehghani, H., Brain, K.L., Kirchhof, P. & Fabritz, L. (2014) "An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials," Progress in Biophysics & Molecular Biology 115: 340-348. [Paper]

Newman, A.S., Batis, N., Grafton, G., Caputo, F., Brady, C.A., Lambert, J., Peters, J.A., Gordon, J., Brain, K.L., Powell, A.D., Barnes, N.M. (2013) "5-Chloroindole: a potent allosteric modulator of the 5-HT3 receptor," British Journal of Pharmacology 169:1228-1238. [Paper]

Boersma, A.J., Brain, K.L. and Bayley, H. (2012) "Real-time stochastic detection of multiple neurotransmitters with a protein nanopore," ACS Nano 6:5304-5308.[Paper]

Kobayter, S. Young, J.S. and Brain, K.L. (2012) "Prostaglandin E2 induces spontaneous rhythmic activity in mouse urinary bladder independently of efferent nerves," British Journal of Pharmacology, 165:401-413.[Paper]

Williams, D.J., Sidaway, P., Cunnane, T.C. and Brain, K.L. (2011) "Mechanisms involved in nicotinic acetylcholine receptor-induced neurotransmitter release from sympathetic nerve terminals in the mouse vas deferens," PLoS One, 6:e29209. [Paper]

Brading, A.F. and Brain, K.L. (2011). "Ion Channel Modulators". In Handbook of Experimental Pharmacology: Urinary Tract, ed. Andersson KE & Michel MC, pp. 375-393, Springer. [World Cat.]

Parker, L.K., Shanks, J.A., Kennard, J.A.G. and Brain, K.L. (2010) "Dynamic monitoring of NET activity in mature murine sympathetic terminals using a fluorescent substrate," British Journal of Pharmacology, 159:797-807. [Paper][Open Access]

Brain, K.L. (2010) "Parasympathetic cholinergic transmission, minus the vesicles," Experimental Physiology, 92:263-4. [Paper]

Valeri, A., Brain, K.L., Young, J.S., Sgaragli, G. and Pessina, F. (2009) "Effects of 17β-estradiol on rat detrusor smooth muscle contractility," Experimental Physiology 94:834-846. [Paper][Open Access]

Young, J.S., Amos, R.J. and Brain, K.L. (2009) "Focal Ca2+ transient detection in smooth muscle," Journal of Visualized Experiments, 28 doi: 10.3791/1247. [Video Article][Open Access]

Rahman, F., Manchanda, R. and Brain, K.L. (2009) "Prejunctional and postjunctional actions of heptanol and 18β-glycyrretinic acid in the rodent vas deferens," Autonomic Neuroscience: Basic and Clinical 148:69-75. [Open Access]

Brain, K.L. (2009) "Neuroeffector Ca2+ transients for the direct measurement of purine release and indirect measurement of co-transmitters," Experimental Physiology, 94:25-30. [Paper] [Open Access].

Young, J.S., Meng, E., Cunnane, T.C. and Brain, K.L. (2008) "Spontaneous purinergic neurotransmission in the mouse urinary bladder," Journal of Physiology, 586:5743-5755. [Paper] [Open Access]

Brain, K.L. and Cunnane, T.C. (2008) "Bretylium abolishes neurotransmitter release without necessarily abolishing the nerve terminal action potential in sympathetic terminals," British Journal of Pharmacology 153:831-839. [Paper] [Open Access]

Zhu, H-L., Brain, K.L., Aishima, M., Shibata, A., Young, J.S., Sueishi, K. and Teramoto, N. (2008) "Actions of two main metabolites of propiverine (M-1 and M-2) on voltage-dependent L-Type Ca2+ currents and Ca2+ transients in murine urinary bladder myocytes," Journal of Pharmacology and Experimental Therapeutics 324:118-127. [Paper] [Open Access Preproof] [UKPubmed Open Access]

Young, J.S., Brain, K.L. and Cunnane, T.C. (2007) "Electrical and optical study of nerve impulse-evoked ATP-induced, P2X-receptor-mediated sympathetic neurotransmission at single smooth muscle cells in mouse isolated vas deferens," Neuroscience 148:82-91. [Open Access]

Williams, D.J., Brain, K.L. and Cunnane, T.C. (2007) "The effect of epibatidine on spontaneous and evoked neurotransmitter release in the mouse and guinea pig isolated vas deferens," British Journal of Pharmacology 150:906-912. [Paper] [Open Access]

Young, J.S., Brain, K.L. and Cunnane, T.C. (2007) "The origin of the skewed amplitude distribution of spontaneous excitatory junction potentials in poorly coupled smooth muscle cells," Neuroscience 145:153-161. [Paper] [UKPubmed Open Access] <

Brain, K.L., Kay, J. and Shine, B. (2006) "Measurement of urinary metanephrines to screen for pheochromocytoma in an unselected hospital referral population," Clinical Chemistry 52:2060-2064. [UKPubmed Open Access]

Webster, R.G., Brain, K.L., Wilson, R.H., Grem, J.L. and Vincent, A. (2005) "Oxaliplatin induces hyperexcitability at motor and autonomic neuromuscular junctions through effects on voltage-gated sodium channels," British Journal of Pharmacology 146:1027-1039. [Paper] [UKPubmed Open Access]

Brain, K.L., Cuprian, A.M., Williams, D.J. and Cunnane, T.C. (2003) "The sources and sequestration of Ca2+ contributing to Neuroeffector Ca2+ transients in the mouse vas deferens," Journal of Physiology 553:627-635. [Paper] [UKPubmed Open Access]

Brain, K.L., Jackson, V.M., Trout, S.J. and Cunnane, T.C. (2002) "Intermittent ATP release from nerve terminals elicits focal smooth muscle Ca2+ transients in mouse vas deferens," Journal of Physiology 541:849-862. [Paper] [UKPubmed Open Access]

Brain, K.L., Trout, S.J., Jackson, V.M., Dass, N. and Cunnane, T.C. (2001) "Nicotine induces calcium spikes in single nerve terminal varicosities: a role for intracellular calcium stores," Neuroscience 106:395-403. [Paper]

Jackson, V.M., Trout, S.J., Brain, K.L. and Cunnane, T.C. (2001) " Characterisation of action potential-evoked calcium transients in postganglionic sympathetic axon bundles," Journal of Physiology 537:3-16. [Paper] [UKPubmed Open Access]

Lengyel, I., Olesen, L.E., Nichol, K.A., Brain, K.L., Wang, X., Robinson, P.J., Bennett, M.R. and Rostas, J.A.P. (1999) " Phosphorylation of proteins in chick ciliary ganglion under conditions that induce long-lasting changes in synaptic transmission: phosphoprotein targets for nitric oxide action," Neuroscience 90:607-619. [Paper]

O'Connor, S.C., Brain, K.L. and Bennett, M.R. (1999) "Individual sympathetic varicosities possess different sensitivities to alpha 2 and P2 receptor agonists and antagonists in mouse vas deferens," British Journal of Pharmacology 128:1739-1753. [Paper][UKPubmed Open Access]

Brain, K.L. and Bennett, M.R. (1998) "Calcium transients evoked by action potentials in the somata of chick ciliary neurons," Journal of the Autonomic Nervous System 71:120-133. [Paper]

Bennett, M.R., Cheung, A. and Brain, K.L. (1998) "Sympathetic neuromuscular transmission at a varicosity in a syncytium," Microscopy Research and Technique 42:433-450. [Paper]

Lin, Y.Q., Brain, K.L, and Bennett, M.R. (1998) "Calcium in sympathetic boutons of rat superior cervical ganglion during facilitation, augmentation and potentiation," Journal of the Autonomic Nervous System 73:26-37. [Paper]

Brain, K.L. and Bennett, M.R. (1997) "Calcium in sympathetic varicosities of mouse vas deferens during facilitation, augmentation and autoinhibition," Journal of Physiology 502:521-536. [Paper]

Brain, K.L., Cottee, L.J. and Bennett, M.R. (1997) "Varicosities of single sympathetic nerve terminals possess different synaptotagmin N-terminus labelling following stimulation," Journal of Neurocytology 26:491-500. [Paper]

Bennett, M.R. and Brain, K. (1997) "Autonomic synaptic transmission at single boutons and calyces," Journal of Neurocytology 26:577-603.[Paper]

Lin, Y.Q., Brain, K.L, Nichol, K.A., Morgan, J.J. and Bennett, M.R. (1996) "Vesicle-associated proteins and calcium in nerve terminals of chick ciliary ganglia during the development of facilitation," Journal of Physiology 497:639-656. [Paper]

Brain, K.L. and Bennett, M.R. (1995) "Calcium in the nerve terminals of chick ciliary ganglia during facilitation, augmentation and potentiation," Journal of Physiology 489:637-648. [Paper]

Sheppard, C.J.R., Gu, M., Brain, K.L. and Zhou, H. (1994) "Influence of spherical aberration on axial imaging of confocal reflection microscopy," Applied Optics 33:616-624. [Paper]

A list of published Abstracts is also available.

Email: Keith Brain