Our recent studies involve the investigation of the function of human coronary resistance arteries obtained from patients with atherosclerosis, diabetes mellitus and hypertension. In addition, arteries from the heart and skeletal muscle are being investigated in animal models of diseases. With these preparations we can make detailed quantitative analysis in a well-defined and physiologic system. We want to develop a greater understanding of how microvessels are controlled in health and disease and discover new targets for therapeutic intervention.

2013 March: Congratulations to Attila Feher, mathced at Cornell.

2013 Jan: The Lab welcomes Zuzana Broskova Postdoctoral Fellow.

Feher et al. Increased tissue angiotensin converting enzyme activity impairs bradykinin-induced dilation of coronary arterioles in obesity. 2013. In press, Circulation J.

Bagi et al. Increased availability of AT1 receptors leads to sustained arterial constriction to angiotensin II in diabetes – role for Rho-kinase activation. British J Pharmacology. 2011. 2011 Jul;163(5):1059-68.

Beleznai et al. Arginase 1 Contributes to Diminished Coronary Arteriolar Dilation in Patients with Diabetes.  Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H777-83.

Prospective postdoctoral fellows please send CV and research interest to Dr. Zsolt Bagi.