Welcome to the Uphoff lab
Department of Biochemistry | University of Oxford
Our group investigates DNA repair and mutagenesis in bacteria. We seek to understand the mechanisms of DNA repair pathways and how mutation rates are regulated through DNA damage responses. Our goal is to directly measure these fundamental processes inside individual living cells. To this end, we develop single-molecule/super-resolution microscopy, single-cell manipulation, microfluidics, flow cytometry, and whole genome sequencing techniques. We also advance data analysis and computational modeling for quantitative descriptions of DNA repair and mutagenesis. We are currently very interested in the consequences of gene expression noise and stochastic processes on the fidelity of genome maintenance. This work also informs about the origins of mutations that lead to antibiotic resistance.
Stephan has won a Wellcome-Beit Prize. A very welcome boost of funding for the new lab!
Join our group
We have a postdoc position opening in my group. Students interested in joining our lab for their PhD can apply to different graduate programs at Oxford University. Find out more and contact me directly.
Scc2/Nipbl Hops Between Chromosomal Cohesin Rings After Loading
Live-cell single-molecule tracking of the cohesin loader protein. This article from our collaboration with James Rhodes and Kim Nasmyth is now published in eLife.
Sir Henry Dale Fellowship
Stephan has been awarded a Sir Henry Dale Fellowship by the Wellcome Trust to set up a research group at the Department of Biochemistry, University of Oxford.
Annual Reviews of Biophysics
Our article Single-molecule analysis of bacterial DNA repair and mutagenesis is now published in the Annual Reviews of Biophysics.
Frequent exchange of the DNA polymerase during bacterial chromosome replication
New publication in Elife from our collaboration with Rodrigo Reyes-Lamothe's lab.