Bad luck and mutations
Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation.
Single-molecule DNA repair in live bacteria
Using photoactivated single-molecule tracking to directly follow individual DNA repair proteins in living E. coli cells.
Methods for single-molecule imaging
Custom single-molecule fluorescence microscopes, imaging methods, and software.
How to run a single-molecule tracking experiment.
Tracking the action of proteins that shape and segregate bacterial chromosomes.
Protein-DNA interactions in vitro
Single-molecule FRET measures nanometre distances within protein-DNA complexes.
Welcome to Stephan Uphoff's research site
I am a postdoctoral researcher studying bacterial chromosome biology using single-molecule and single-cell microscopy. Explore this website to find out more about me, my research topics, and publications.