Miriam Klein-Flügge

Peer-reviewed journal publications

My profiles on Google scholar and ResearchGate.

Scholl J, Klein-Flügge MC (2017) Understanding psychiatric disease by capturing ecologically relevant features of learning and decision-making, Beh Brain Res (in press)

Klein-Flügge MC, Kennerley SW, Friston K, Bestmann S (2016) Neural signatures of value comparison in human cingulate cortex during decisions requiring an effort-reward trade-off, J. Neurosci. 36(39):10002-10015 pdf video summary

Haemmerer D*, Bonaiuto J*, Klein-Flügge MC*, Bikson M, Bestmann S (2016) Selective alteration of human value decisions with medial frontal tDCS is predicted by changes in attractor dynamics [* These authors contributed equally to the work] Scientific Reports 6, Article number: 25160 pdf

Klein-Flügge MC, Kennerley SW, Saraiva AC, Penny WD, Bestmann S (2015) Behavioral Modeling of Human Choices Reveals Dissociable Effects of Physical Effort and Temporal Delay on Reward Devaluation, PLoS Comput Biol.11(3):e1004116 pdf

Klein-Flügge MC, Nobbs D, Pitcher JB, Bestmann S (2013) Variability of human cortico-spinal excitability tracks the state of action preparation, J. Neurosci. 33(13), 5564 –5572 pdf

Klein-Flügge MC*, Barron H*, Brodersen KH, Dolan RJ, Behrens TEJ (2013) Segregated encoding of reward-identity and stimulus-reward associations in human orbitofrontal cortex, J. Neurosci. 33(7), 3202–3211 [* These authors contributed equally to the work] pdf

Nicolle A, Klein-Flügge MC, Hunt LT, Vlaev I, Dolan RJ, Behrens TEJ (2012) An agent independent axis for executed and modeled choice in medial prefrontal cortex, Neuron 75(6), 1114-21 pdf

Hall CN, Klein-Flügge MC, Howarth C, Attwell D (2012) Oxidative phosphorylation, not glycolysis, powers pre- and postsynaptic mechanisms underlying brain information processing, J. Neurosci. 32(26), 8940-51 pdf

Klein-Flügge MC, Bestmann S (2012) Time-dependent changes in human cortico-spinal excitability reveal value-based competition for action during decision processing, J. Neurosci. 32(24), 8373-82. pdf

Klein-Flügge MC, Hunt LT, Bach DR, Dolan RJ, Behrens TEJ (2011) Dissociable Reward and Timing Signals in Human Midbrain and Ventral Striatum. Neuron 72(4), 654-664 pdf

Neubert F, Klein MC (2010). What is Driving Inhibition-Related Activity in the Frontal Lobe? J. Neurosci. 30(14), 4830–4832 pdf

Scholz J, Klein MC, Behrens TE, Johansen-Berg H (2009). Training induces changes in white-matter architecture, Nature Neuroscience, 12(11), 1370-1371 pdf
*** identified by Thomson Reuters as featured article: one of the most-cited papers from the last 2 years

Mars RB, Klein MC, Neubert F, Olivier E, Buch ER, Boorman ED, Rushworth MFS (2009). Short-Latency Influence of Medial Frontal Cortex on Primary Motor Cortex during Action Selection under Conflict. J. Neurosci., 29(21), 6926-6931. pdf

Public engagement articles & news coverage

Scholz J, Klein MC (2010) Lernen verbindet, Gehirn & Geist, 2010
[Learning connects: Brain&Mind –magazine; published in German] link

Press release on JNS paper in 2016 on effort-reward trade-offs: link

Conference abstracts

Klein-Flügge MC, Kennerley SW, Bestmann, S (2014) Behavioral and neural signatures of choice computation for human effort-based decision making, SfN, Poster #743.08/SS2

Klein-Flügge MC, Barnes, GR, Woolrich MW, Behrens TEJ (2014) Non-invasive measurement of population dynamics during computation of choice, SfN, Poster #624.16/DD27

Haemmerer D*, Klein-Flügge MC*, Bonaiuto J*, Bikson M, Bestmann S (2014), Transcranial direct current stimulation over ventro-medial prefrontal cortex changes human value-based decision making: A computational neurostimulation study, SfN, Poster #84.02/NN3

Klein-Flügge MC, Kennerley SW, Penny WD, Bestmann S (2013) Behavioural modelling of effort and delay discounting. British Neuroscience Association, Annual Meeting 2013

Attwell D, Jolivet R, Harris J, Klein-Flügge MC, Howarth C, Hall CN (2013) Energy use and supply in CNS grey and white matter. ISN annual meeting

Klein-Flügge MC, Nobbs D, Pitcher JB, Bestmann S (2012) Variability of cortico-spinal excitability tracks the preparatory state of human motor cortex. SfN, Poster 890.15/MM3

Klein-Flügge MC, Nobbs D, Pitcher JB, Bestmann S (2012) Variability of cortico-spinal excitability tracks the preparatory state of human motor cortex. Magstim Neuroscience conference, Oxford

Klein-Flügge MC, Bestmann S (2011) Biased competition for action in human primary motor cortex during value-based decision making. SfN, Poster 403.17/YY21

Klein-Flügge MC, Behrens TE, Friston KJ, Bestmann S (2011) Intra-parietal sulcus links decisions to actions and receives value-modulated inputs from vmPFC. HBM, Poster #368WTh

Klein-Flügge MC, Behrens TE, Friston KJ, Bestmann S (2010) Dissociating action-linked decisions from abstract value-based decisions in intra-parietal cortex. SfN, Poster 401.12/LLL33

Klein-Flügge MC, Hunt LT, Bach DR, Dolan RJ, Behrens TEJ (2010) Characterization of Prediction Error Signals in the Ventral Tegmental Area under Variable Timings. HBM, Poster 638 MT-PM

Scholz J, Klein-Flügge MC, Johansen-Berg H (2010) Functional changes associated with learning to juggle. HBM, Poster 902 MT-PM

Scholz J, Klein MC, Behrens TEJ, Johansen-Berg H (2009) White Matter Microstructure Changes In Response to Training. HBM, Poster 362 F-PM

Mars, RB, Klein MC, Neubert FX, Olivier E, Buch ER, Boorman ED, Rushworth MF (2009) Pre-SMA exerts top-down control over primary motor cortex during response switching: A paired-pulse transcranial magnetic stimulation and diffusion-weighted imaging study. HBM, Poster 7 M-AM

Klein MC, Mars RB, Buch ER, Rushworth MFS (2008) Changes in Functional Connectivity between Pre-SMA and M1 during Reprogramming of Actions: A Paired-Pulse Transcranial Magnetic Stimulation. Study, Magstim TMS summer school

Invited talks

Royal Society Fatigue Meeting (2017), Kavli Centre, Buckinghamshire

Paris (2015) Fifth International Symposium on Biology of Decision-Making

Wellcome Trust Centre for Neuroimaging, University College London (2015) Brain meeting lecture

Copenhagen (2015), FENS workshop on Bridging Neural Mechanisms and Cognition

University of Tohoku (2015), Japan, Symposium on prefrontal cortex, learning and memory

Wellcome Trust Centre for Neuroimaging, University College London (2014) Behavioural and neural signatures of choice computation for human effort-based decision making

Department of Economics, University of Zurich (2013) The impact of physical effort on behavioural and neural computations guiding value-based choice

Joint University College London - Johns Hopkins University workshop, London: “Unresolved questions in motor control” (2012) Variability of cortico-spinal excitability tracks the preparatory state of human motor cortex.

Centre for Data Analysis and Modeling, Freiburg (2012) Causal and correlative approaches for understanding interactions between decision and action systems of the human brain

HBM annual meeting, Quebec City (2011) Intra-parietal sulcus links decisions to actions and receives value-modulated inputs from vmPFC. Presentation #2156

Einstein Fellowship Symposium on Decision Making, Berlin (2011) Learning in time and reward: Human ventral tegmental area encodes a temporal difference reward prediction error whereas ventral striatum encodes task-specific learning signals.

HBM annual meeting, Barcelona (2010) Characterization of Prediction Error Signals in the Ventral Tegmental Area under Variable Timings. Presentation #638