Angus Buckling

Royal Society University Research Fellow

Department of Zoology, University of Oxford

Oxford OX1 3PS, UK

Tel. +44 (0)1865 2813905

Fax. +44 (0)1865 310447





Current Group




Microbes really matter.  Their importance ranges from causing disease to making ecosystems run smoothly.  Our research attempts to address how the environment (both physical and other organisms) shapes how they evolve to do what they do.  Rather than inferring evolution in natural populations, we literally follow the evolution of microbes in real time under defined conditions.  This is made possible by the very short generation times and massive population sizes of microbes, and the precise experimental control afforded by laboratory conditions.


Our major interest is the evolutionary ecology of pathogenic microbes and their hosts.  For example, understanding: the causes and consequences of coevolution between bacteria and their parasitic viruses; the ecological and genetic conditions that results in parasites evolving to cause severe compared with mild infections; and the conditions that favour bacteria to cooperate with each other, or otherwise.





Rebecca Benmayor (Leverhulme Postdoc)

Gabriel Guimond-Perron (DPhil student)

Freya Harrison (DPhil student)

Robert Inglis (DPhil student)

Csaba Pal (EMBO Fellow)

Laura Lopez Pascua (DPhil student)






Michael Bonsall

Mike Brockhurst

Sylvain Gandon

Andy Gardner

Ashleigh Griffin

Michael Hochberg

Dave Hodgson

Stu west





42.  Buckling, A., Brockhurst, M., Travisano, M. & Rainey, P. B.  2007. Experimental adaptation to high and low quality environments under different scales of temporal variation.  Journal of Evolutionary Biology doi: 10.1111/j.1420-9101.2006.01195.x pdf

41.  Fleming, V., Feil, R., Sewell, A. K., Day, N., Buckling, A. and Massey, R. C. 2006. Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence. Journal of Bacteriology 188, 7686-7688. pdf

40.  Brockhurst, M. A., Bell, T., Hochberg, M. E. & Buckling, A. 2006. Character displacement and cooperation in bacterial biofilms. Current Biology 16, 1-5. pdf

39.  Harrison, E. F., Browning, L., Vos, M. & Buckling, A. 2006.  Cooperation and virulence in acute Pseudomonas aeruginosa infections.  BMC Biology 4, 21 pdf

38.  Morgan, A. D. & Buckling, A.  2006. Relative number of generations of hosts and parasites does not influence parasite local adaptation in coevolving populations of bacteria and phage.  Journal of Evolutionary Biology 19, 1956-1963. pdf

37.  Colegrave, N. & Buckling, A. 2006 Reply to Edwards' response. Bioessays 28, 442-442.

36.  Buckling, A., Wei, Y., Massey, R.C. Brockhurst, M. A. & Hochberg, M.E.  2006.  Antagonistic coevolution with parasites increases the cost of host deleterious mutations.  Proceedings of the Royal Society of London Series B 273, 45-49.pdf

35.  Brockhurst, M.A., Buckling, A. & Rainey P.B. 2006. Spatial heterogeneity and the stability of host-parasite coexistence.  Journal of Evolutionary Biology 19, 374-379.pdf

34.  Buckling, A. & Brockhurst, M.A.  2005. RAMP resistance. Nature 438, 170-171. pdf

33.  Harrison, E. F. & Buckling, A.  2005. Hypermutability impedes cooperation in a pathogenic bacterium.  Current Biology 15, 1968-1971 pdf

32.  Rainey, P. B., Brockhurst, M. A., Buckling, A., Hodgson, D. J. & Kassen, R. 2005 The use of model Pseudomonas fluorescens populations to study the causes and consequences of microbial diversity. In Biological diversity and function in soil (ed. R. Bardgett, M. Usher & D. Hopkins), pp. 83-99. Cambridge: Cambridge University Press.

31. Dillon, R.J., Vennard, C., Buckling, A. & Charnley, A.K.  2005. Diversity of locust gut bacteria protects against pathogen invasion.  Ecology Letters 8, 1291-1298. pdf

30.  Buckling, A. & Colegrave, N.  2005. Microbial experiments on adaptive landscapes.  BioEssays 27, 1167-1173. pdf

29. Morgan, A.D., Gandon, S. & Buckling, A. 2005. The effect of migration on local adaptation in a coevolving host-parasite system.  Nature 437, 253-256. pdf

28.  McCart, C., Buckling, A. & ffrench-Constant.  2005. DDT resistance in flies carries no cost.  Current   Biology 15, R587-R589. pdf

27. Jenkins, A. T. A, Buckling, A., McGhee, M., ffrench-Constant, R. H. 2005. surface Plasmon Resonance (SPR) shows that type IV pili are important in surface attachment by Pseudomonas aeruginosa.  Journal of the Royal Society Interface 2, 255-259. pdf

26. Brockhurst, M. A., Buckling, A. & Rainey, P. B.  2005. The effect of a bacteriophage on the diversification of the opportunistic pathogen Pseudomonas aeruginosa.  Proceedings of the Royal Society of London Series B  272, 1385-1391. pdf

25. Buckling, A., Neilson, J., Lindsay, J., ffrench-Constant, R., Enright, M., Day, N. & Massey, R. C.  2005. Clonal distribution and phase variable expression of a MHC-analogue protein in Staphylococcus aureus.  Journal of Bacteriology 187, 2917-2919. pdf

24. Morgan, A. D. & Buckling, A. 2004. Parasites modulate the relationship between host diversity and disturbance frequency.  Ecology Letters 7, 1029-1034. pdf

23. Griffin, A. S., West, S. A. & Buckling, A. 2004. Cooperation and competition in a pathogenic bacterium.  Nature 430, 1024-1027. pdf

22. Jenkins, A. T. A., ffrench-Constant, R, Buckling, A., Clarke, D. J., Jarvis, K. 2004. A study of the attachment of Pseudomonas aeruginosa on gold and modified gold surfaces using Surface Plasmon Resonance. Biotechnology Progress 20, 1233-1236. pdf

21.Gardner. A., West, S. A & Buckling, A.  2004. Bacteriocins, spite & virulence.  Proceedings of the Royal Society of London Series B 271, 1529-1535. pdf

20. Jessup, C.M., Kassen, R., Forde, S.E., Kerr, B., Buckling, A., Rainey, P.B., Bohannan, B.J.M.  2004. Big questions, small worlds: microbial model systems in ecology. Trends in Ecology and Evolution 19, 189-197 pdf

19. Massey, R.C., Buckling, A. & ffrench-Constant, R.H.  2004. Interference competition and virulence, Proceedings of the Royal Society of London Series B 271, 785-788. pdf

18. Brockhurst, M.A, Rainey, P. B. & Buckling, A. 2004. The interaction between exploiters and spatial heterogeneity on host diversification. Proceedings of the Royal Society of London B 271, 107-111. pdf

17. Buckling, A., Wills, M.A. & Colegrave, N. 2003. Adaptation constrains diversification in experimental bacterial populations. Science 302, 2107-2109. pdf

16. Brockhurst, M.A, Morgan, A. D., Rainey, P. B. & Buckling, A. 2003. Population mixing accelerates coevolution. Ecology Letters 6, 975-979. pdf

15. West, S. A. & Buckling, A. 2003. Cooperation, virulence and siderophore production in bacterial parasites. Proceedings of the Royal Society of London Series B 270, 37-44. pdf

14. Buckling, A. & Rainey, P. B. 2002. The role of parasites in sympatric and allopatric host diversification. Nature 420, 496-499. pdf pdf

13. Massey, R. C. & Buckling, A. 2002. Environmental regulation of mutation rates at specific sites.  Trends in Microbiology 12, 580-584. pdf

12. Hodgson, D.J., Rainey, P.B. & Buckling, A. 2002 Mechanisms linking diversity, productivity and invasibility in experimental bacterial communities. Proceedings of the Royal Society Series B. 269, 2277-2283. pdf

11. Buckling, A. & Rainey, P.B. 2002. Antagonistic coevolution between a bacterium and bacteriophage. Proceedings of the Royal Society of London Series B 269, 931-936. pdf

10. Buckling, A. & Read, A. F. 2001. The effect of partial host immunity on the transmission of malaria parasites. Proceedings of the Royal Society of London Series B 268, 2325-2330. pdf

9. Massey, R. C., Buckling, A. & Peacock, S. J. 2001. Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus. Current Biology 11, 1810-1814. pdf

8. Buckling, A., Kassen, R., Bell, G. & Rainey, P. B.  2000.  Disturbance and diversity in experimental microcosms.  Nature 408, 961-964. pdf

7. Rainey, P. B., Buckling, A., Kassen, R. M. & Travisano, M.  2000.  The evolution of diversity: insights from experimental microbial populations. Trends in Ecology and Evolution 15, 243-247. pdf

6. Kassen, R., Buckling, A., Bell, G. & Rainey, P. B.  2000.  Diversity peaks at intermediate productivity in a laboratory microcosm. Nature 406, 508-512.

5. Spiers, A. J., Buckling, A. & Rainey, P. B.  2000.  The causes of Pseudomonas diversity.  Microbiology 146, 2345-2350. pdf

4. Buckling, A., Ranford-Cartwright, L. C., Miles, A. & Read, A. F.  1999.  Chloroquine increases Plasmodium falciparum gametocytogenesis in vitro.  Parasitology 118, 339-346. pdf

3. Buckling, A. & Read, A. F.  1999.  The effect of chloroquine treatment on the infectivity of Plasmodium chabaudi gametocytes.  International  Journal of  Parasitology  29, 619-625.

2. Buckling, A., Crooks, L. & Read, A. F.  1999.  The effect of chemotherapy on the  gametocytogenesis of Plasmodium chabaudi.  Experimental Parasitology  93, 45-54. pdf

1. Buckling, A., Taylor, L. H., Carlton, J. M.-R. & Read, A. F.  1997.  Adaptive changes in Plasmodium transmission strategies following chloroquine chemotherapy.  Proceedings of the Royal Society of London Series B 264, 553-559. pdf