Tel. +44 (0)1865 2813905
Fax. +44 (0)1865 310447
Microbes really matter. Their importance ranges from causing disease to making ecosystems run smoothly. Our research attempts to address how the environment (both physical and other organisms) shapes how they evolve to do what they do. Rather than inferring evolution in natural populations, we literally follow the evolution of microbes in real time under defined conditions. This is made possible by the very short generation times and massive population sizes of microbes, and the precise experimental control afforded by laboratory conditions.
Our major interest is the evolutionary ecology of pathogenic microbes and their hosts. For example, understanding: the causes and consequences of coevolution between bacteria and their parasitic viruses; the ecological and genetic conditions that results in parasites evolving to cause severe compared with mild infections; and the conditions that favour bacteria to cooperate with each other, or otherwise.
Gabriel Guimond-Perron (DPhil student)
Robert Inglis (DPhil student)
42. Buckling, A., Brockhurst, M., Travisano, M. & Rainey, P. B. 2007. Experimental adaptation to high and low quality environments under different scales of temporal variation. Journal of Evolutionary Biology doi: 10.1111/j.1420-9101.2006.01195.x pdf
41. Fleming, V., Feil, R., Sewell, A. K., Day, N., Buckling, A. and Massey, R. C. 2006. Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence. Journal of Bacteriology 188, 7686-7688. pdf
40. Brockhurst, M. A.,
38. Morgan, A. D. & Buckling, A. 2006. Relative number of generations of hosts and parasites does not influence parasite local adaptation in coevolving populations of bacteria and phage. Journal of Evolutionary Biology 19, 1956-1963. pdf
37. Colegrave, N. & Buckling, A. 2006 Reply to Edwards' response. Bioessays 28, 442-442.
A., Wei, Y., Massey, R.C. Brockhurst, M. A. & Hochberg, M.E. 2006.
Antagonistic coevolution with parasites
increases the cost of host deleterious mutations. Proceedings
of the Royal Society of
35. Brockhurst, M.A., Buckling, A. & Rainey P.B. 2006. Spatial heterogeneity and the stability of host-parasite coexistence. Journal of Evolutionary Biology 19, 374-379.pdf
34. Buckling, A. & Brockhurst, M.A. 2005. RAMP resistance. Nature 438, 170-171. pdf
33. Harrison, E. F. & Buckling, A. 2005. Hypermutability impedes cooperation in a pathogenic bacterium. Current Biology 15, 1968-1971 pdf
32. Rainey, P.
B., Brockhurst, M. A., Buckling, A.,
Hodgson, D. J. & Kassen, R. 2005 The use of model Pseudomonas fluorescens
populations to study the causes and consequences of microbial diversity. In Biological diversity and function in soil
(ed. R. Bardgett, M. Usher & D. Hopkins), pp.
31. Dillon, R.J., Vennard, C., Buckling, A. & Charnley, A.K. 2005. Diversity of locust gut bacteria protects against pathogen invasion. Ecology Letters 8, 1291-1298. pdf
30. Buckling, A. & Colegrave, N. 2005. Microbial experiments on adaptive landscapes. BioEssays 27, 1167-1173. pdf
29. Morgan, A.D., Gandon, S. & Buckling, A. 2005. The effect of migration on local adaptation in a coevolving host-parasite system. Nature 437, 253-256. pdf
28. McCart, C., Buckling, A. & ffrench-Constant. 2005. DDT resistance in flies carries no cost. Current Biology 15, R587-R589. pdf
27. Jenkins, A. T. A, Buckling, A., McGhee, M., ffrench-Constant, R. H. 2005. surface Plasmon Resonance (SPR) shows that type IV pili are important in surface attachment by Pseudomonas aeruginosa. Journal of the Royal Society Interface 2, 255-259. pdf
Brockhurst, M. A., Buckling, A.
& Rainey, P. B. 2005. The
effect of a bacteriophage on the diversification of
the opportunistic pathogen Pseudomonas aeruginosa. Proceedings of the Royal Society of
25. Buckling, A., Neilson, J., Lindsay, J., ffrench-Constant, R., Enright, M., Day, N. & Massey, R. C. 2005. Clonal distribution and phase variable expression of a MHC-analogue protein in Staphylococcus aureus. Journal of Bacteriology 187, 2917-2919. pdf
24. Morgan, A. D. & Buckling, A. 2004. Parasites modulate the relationship between host diversity and disturbance frequency. Ecology Letters 7, 1029-1034. pdf
22. Jenkins, A. T. A., ffrench-Constant, R, Buckling, A., Clarke, D. J., Jarvis, K. 2004. A study of the attachment of Pseudomonas aeruginosa on gold and modified gold surfaces using Surface Plasmon Resonance. Biotechnology Progress 20, 1233-1236. pdf
20. Jessup, C.M., Kassen, R., Forde, S.E., Kerr, B., Buckling, A., Rainey, P.B., Bohannan, B.J.M. 2004. Big questions, small worlds: microbial model systems in ecology. Trends in Ecology and Evolution 19, 189-197 pdf
19. Massey, R.C., Buckling, A. & ffrench-Constant, R.H. 2004. Interference competition and virulence, Proceedings of the Royal Society of London Series B 271, 785-788. pdf
18. Brockhurst, M.A, Rainey, P. B. & Buckling, A. 2004. The
interaction between exploiters and spatial heterogeneity on host
diversification. Proceedings of
the Royal Society of
17. Buckling, A., Wills, M.A. & Colegrave, N. 2003. Adaptation constrains diversification in experimental bacterial populations. Science 302, 2107-2109. pdf
16. Brockhurst, M.A, Morgan, A. D., Rainey, P. B. & Buckling, A. 2003. Population mixing accelerates coevolution. Ecology Letters 6, 975-979. pdf
15. West, S. A. & Buckling, A. 2003. Cooperation, virulence and siderophore production in bacterial parasites. Proceedings
of the Royal Society of
13. Massey, R. C. & Buckling, A. 2002. Environmental regulation of mutation rates at
specific sites. Trends in Micro
12. Hodgson, D.J., Rainey, P.B. & Buckling, A. 2002 Mechanisms linking diversity, productivity and invasibility in experimental bacterial communities. Proceedings of the Royal Society Series B. 269, 2277-2283. pdf
A. & Rainey, P.B. 2002. Antagonistic coevolution between a bacterium and bacteriophage.
Proceedings of the Royal Society of
10. Buckling, A.
& Read, A. F. 2001. The effect of partial host immunity
on the transmission of malaria parasites. Proceedings of the Royal
9. Massey, R. C., Buckling,
A. & Peacock, S. J. 2001. Phenotypic switching of anti
8. Buckling, A., Kassen, R.,
7. Rainey, P. B., Buckling, A., Kassen, R. M. & Travisano, M. 2000. The evolution of diversity: insights from experimental microbial populations. Trends in Ecology and Evolution 15, 243-247. pdf
6. Kassen, R., Buckling, A.,
5. Spiers, A. J., Buckling, A. & Rainey, P. B. 2000. The causes of Pseudomonas diversity. Microbiology 146, 2345-2350. pdf
4. Buckling, A., Ranford-Cartwright, L. C., Miles, A. & Read, A. F. 1999. Chloroquine increases Plasmodium falciparum gametocytogenesis in vitro. Parasitology 118, 339-346. pdf
3. Buckling, A. & Read, A. F. 1999. The effect of chloroquine treatment on the infectivity of Plasmodium chabaudi gametocytes. International Journal of Parasitology 29, 619-625.
2. Buckling, A., Crooks, L. & Read, A. F. 1999. The effect of chemotherapy on the gametocytogenesis of Plasmodium chabaudi. Experimental Parasitology 93, 45-54. pdf
1. Buckling, A.,