Tutorials in Neuroscience

 

 

Essay Week 4

What can we learn about cerebellar structure and function from genetic disorders causing, or animal models of, cerebellar dysfunction?

 

References

1.       Voogd, J. and M. Glickstein, The anatomy of the cerebellum. Trends Neurosci, 1998, 21, 370-5 http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0V-3TVXF8B-2&_coverDate=09%2F01%2F1998&_alid=62880903&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=4872&_sort=d&wchp=dGLbVzb-lSztb&_acct=C000010360&_version=1&_urlVersion=0&_userid=126524&md5=57cefedf16a79645c2f442c7abd8c920

2.       Middleton, F.A. and P.L. Strick, The cerebellum: an overview. Trends Neurosci, 1998, 21, 367-9 http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0V-3TVXF8B-1&_user=126524&_coverDate=09%2F01%2F1998&_rdoc=1&_fmt=full&_orig=browse&_srch=%23toc%234872%231998%23999789990%2320194!&_cdi=4872&_sort=d&_docanchor=&wchp=dGLbVzb-lSztb&_acct=C000010360&_version=1&_urlVersion=0&_userid=126524&md5=0ea81edb641f549c8d0f6297088236e1

3.       Klockgether, T. and B. Evert, Genes involved in hereditary ataxias. Trends Neurosci, 1998, 21, 413-8 http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0V-3TVXF8B-8&_user=126524&_coverDate=09%2F01%2F1998&_rdoc=8&_fmt=full&_orig=browse&_srch=%23toc%234872%231998%23999789990%2320194!&_cdi=4872&_sort=d&_docanchor=&wchp=dGLbVzb-lSztb&_acct=C000010360&_version=1&_urlVersion=0&_userid=126524&md5=840650d23ea81d5e8bb49d4d85d7cf1c

4.       Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, Shigemoto R, Katsuki M, Aiba A. mGluR1 in cerebellar Purkinje cells are essential for long-term depression, synapse elimination, and motor coordination. Science. 2000: 288:1832-5 http://www.sciencemag.org/cgi/content/full/288/5472/1832

5.       Lin X, Antalffy B, Kang D, Orr HT, Zoghbi HY. Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1. Nat Neurosci. 2000: 3:157-63 http://www.nature.com/cgi-taf/DynaPage.taf?file=/neuro/journal/v3/n2/abs/nn0200_157.html&dynoptions=doi1036595239

6.       Maricich SM, Soha J, Trenkner E, Herrup K. Failed cell migration and death of purkinje cells and deep nuclear neurons in the weaver cerebellum. J Neurosci. 1997: 17:3675-83 http://www.jneurosci.org/cgi/content/full/17/10/3675

7.       Ito M (2002) The molecular organisation of cerebellar long-term depression Nature Reviews Neuroscience 3, 896-902 http://www.nature.com/cgi-taf/DynaPage.taf?file=/nrn/journal/v3/n11/full/nrn962_fs.html

8.       Genetic regulation of cerebellar development (2001) Nature Reviews Neuroscience 2, 484-491 http://www.nature.com/cgi-taf/DynaPage.taf?file=/nrn/journal/v2/n7/full/nrn0701_484a_fs.html

 

Web Resources

Trends in Neurosciences special issue on the cerebellum at http://www.sciencedirect.com/science?_ob=IssueURL&_tockey=%23TOC%234872%231998%23999789990%2320194%23FLA%23display%23Volume_21,_Issue_9,_Pages_367-419_(1_September_1998)%23tagged%23Volume%23first%3D21%23Issue%23first%3D9%23Pages%23first%3D367%23last%3D419%23date%23(1_September_1998)%23&_auth=y&wchp=dGLbVzb-lSztb&_acct=C000010360&_version=1&_urlVersion=0&_userid=126524&md5=46624cede32817a5cdbcc4d781eff44b

Cerebellum at MIT http://cognet.mit.edu/MITECS/Entry/ito

 

 

 

 

 

mjaw

21.x.04