Genetic factors control the development and patterning of the central nervous system. Discuss this statement critically with particular reference to the spinal cord and hindbrain.
1. Developmental Biology, 6th Edition: Scott F Gilbert
2. Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb. Cell. 2000, 102:161-73. (Jessell TM)
3. Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification. Nature. 2000, 403, 734-40 (Jessell TM) http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v403/n6771/full/403734a0_fs.html
4. Closing in on rhombomere boundaries. Nat Cell Biol. 1999 Aug;1, E83-5 (Lumsden A) http://www.nature.com/cgi-taf/DynaPage.taf?file=/ncb/journal/v1/n4/full/ncb0899_E83.html
5. Homeotic transformation of rhombomere identity after localized Hoxb1 misexpression. Science. 1999, 284, 2168-71 (Lumsden A) http://www.sciencemag.org/cgi/content/full/284/5423/2168
Nature focus on neural development: http://www.nature.com/nrn/focus/neurodev/
Nature Reviews in Neuroscience November 2001: http://www.nature.com/cgi-taf/DynaPage.taf?file=/nrn/journal/v2/n11/index.html
Nature supplement – molecular approaches to neural development: http://www.nature.com/cgi-taf/dynapage.taf?file=/neuro/journal/v4/n11s/index.html
mjaw
12.x.04