Tutorials in Neuroscience

 

MICHAELMAS 2005

Essays please to be in my pigeonhole in the Anatomy and Genetics Department by 9am on the day of the tutorial.

 

GENERAL READING for the course

Grays Anatomy

The Human Brain; an Introduction to Functional Anatomy, Nolte

Clinical Neuroanatomy, Snell

Principles of Neural Science, Kandel et al

Fundamental Neuroscience, Zigmund, Bloom et al

Human Molecular Genetics, Strachan and Read

Developmental Biology, Gilbert

The Extended Phenotype, Dawkins

Mindwaves, Editors Blakemore and Greenfield

The Fabric of Reality, Deutsch

 

ESSAY WEEK 1

How, when and where are neurons generated? What features distinguish the neuronal identity?

 

REFERENCES

1.       McKay R (1997) Stem cells in the central nervous system. Science, 276, 66-71 http://www.sciencemag.org/cgi/content/full/276/5309/66

2.       Gage, F. H. (2000). Mammalian neural stem cells. Science 287, 1433-8 http://www.sciencemag.org/cgi/content/full/287/5457/1433

3.       Identification of a neural stem cell in the adult mammalian central nervous system. (1999) Cell, 96, 25-34

4.       Lee, S. H., Lumelsky, N., Studer, L., Auerbach, J. M., and McKay, R. D. (2000). Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nature Biotechnology 18, 675-9 http://www.nature.com/cgi-taf/DynaPage.taf?file=/nbt/journal/v18/n6/full/nbt0600_675.html

5.       Hynes, M., and Rosenthal, A. (2000). Embryonic stem cells go dopaminergic. Neuron 28, 11-4.

6.       Kim, JH et al. (2002) Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 418: 50-6 http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v418/n6893/full/nature00900_fs.html

 

WEB RESOURCES

Nature focus on stem cells: http://www.nature.com/reviews/focusarticles/stem_cell/

Science special on stem cells:  http://www.sciencemag.org/content/vol287/issue5457/index.shtml

Nature focus on neural development: http://www.nature.com/nrn/focus/neurodev/

Nature Reviews in Neuroscience November 2001: http://www.nature.com/cgi-taf/DynaPage.taf?file=/nrn/journal/v2/n11/index.html

 

 

mjaw

4.x.2005