Publications

for Dr Keith Brain PhD, MB/BS(Hons), BSc(Med)(Hons), BSc

• Brain, Keith L. and Nagy, Zsuzsa. (2023). "A modified Angoff B screening method for collusion detection in examinations delivered on the MSCAA and Speedwell platforms". The Clinical Teacher. 20 (S1):e13657 doi:10.1111/tct.13657.
• Saleeb-Mousa, James, Nathanael, Demitris, Coney, Andrew M., Kalla, Manish, Brain, Keith L. and Holmes, Andrew P. (2023). "Mechanisms of atrial fibrillation in obstructive sleep apnoea". Cells. doi:10.3390/cells12121661.
• Appukuttan, Shailesh; Brain, Keith L.; Manchanda, Rohit (2021). "Effect of variations in gap junctional coupling on the frequency of oscillatory action potentials in a smooth muscle syncytium". Frontiers in Physiology. doi:10.3389/fphys.2021.655225. ISSN:1664-042X.
• Cao, L.L., Marshall, J.M., Fabritz, L. and Brain, K.L. (2021). "Resting cardiac sympathetic firing frequencies suppress terminal norepinephrine transporter uptake". Autonomic Neuroscience, 232:102794. doi:10.1016/j.autneu.2021.102794 PMID:33714751
• Abdulaziz A.A, Cao, L.L., Aldossary, H.S., Nathanael, D., Fu, J., Ray, C.J., Brain, K.L., Kumar, P., Coney, A.M. & Holmes, A.P. (2021). "β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia". Pflügers Archiv - European Journal of Physiology, 473:37-51 doi:10.1007/s00424-020-02492-0 PMID:33210151
• Cao, L.; Holmes, A.; Marshall, J.; Fabritz, L.; Brain, Keith L. (2020). "Dynamic monitoring of single-terminal norepinephrine transporter rate in the rodent cardiovascular system: a novel fluorescence imaging method". Autonomic Neuroscience, 223:102611. doi:10.1016/j.autneu.2019.102611. PMID:31901784.
• Padmakumar, M.; Brain, K.L.; Manchanda, R. (2019). "Analysis of spontaneous depolarization-linked hyperpolarizations in mouse detrusor smooth muscle cells". Biomedical Research Journal, 6:49-54. doi:10.4103/BMRJ.BMRJ_9_19.
• Hansen, Thomas; Tarasova, Olga S.; Khammy, Makhala M.; Ferreira, Avelino; Kennard, James A.; Andresen, Jørgen; Staehr, Christian; Brain, Keith L.; Nilsson, Holger; Aalkjær, Christian (2019). "[Ca²⁺] changes in sympathetic varicosities and Schwann cells in rat mesenteric arteries—Relation to noradrenaline release and contraction". Acta Physiologica. 226 (4). doi:10.1111/apha.13279. PMID:30957955.
• Appukuttan, Shailesh; Padmakumar, Mithun; Young, John S.; Brain, Keith L.; Manchanda, Rohit (2018). "Investigation of the Syncytial Nature of Detrusor Smooth Muscle as a Determinant of Action Potential Shape". Frontiers in Physiology. 9. doi:10.3389/fphys.2018.01300. ISSN:1664-042X. PMID:30294280.
• Mahapatra, Chitaranjan; Brain, Keith L.; Manchanda, Rohit; Guerrero-Hernandez, Agustín (2018). "A biophysically constrained computational model of the action potential of mouse urinary bladder smooth muscle". PLOS ONE. 13 (7): e0200712. doi:10.1371/journal.pone.0200712. PMID:30048468.
• Padmakumar, Mithun; Brain, Keith L.; Young, John S.; Manchanda, Rohit; Guerrero-Hernandez, Agustín (2018). "A four-component model of the action potential in mouse detrusor smooth muscle cell". PLOS ONE. 13 (1): e0190016. doi:10.1371/journal.pone.0190016. PMID:29351282.
• Appukuttan, Shailesh; Padmakumar, Mithun; Brain, Keith L.; Manchanda, Rohit (2017). "A Method for the Analysis of AP Foot Convexity: Insights into Smooth Muscle Biophysics". Frontiers in Bioengineering and Biotechnology. 5. doi:10.3389/fbioe.2017.00064.
• Appukuttan, Shailesh; Brain, Keith; Manchanda, Rohit (2017). "Investigation of Action Potential Propagation in a Syncytium". Biomedical Research Journal. 4 (1): 102-115.
• Appukuttan, Shailesh; Brain, Keith L.; Manchanda, Rohit (2017). "Modeling extracellular fields for a three-dimensional network of cells using NEURON". Journal of Neuroscience Methods. 290: 27-38. doi:10.1016/j.jneumeth.2017.07.005. ISSN:0165-0270. PMID:28705695.
• Lu, Zhongmin; Chouhan, Amit K.; Borycz, Jolanta A.; Lu, Zhiyuan; Rossano, Adam J.; Brain, Keith L.; Zhou, You; Meinertzhagen, Ian A.; Macleod, Gregory T. (2016). "High-Probability Neurotransmitter Release Sites Represent an Energy-Efficient Design". Current Biology. 26 (19): 2562-2571. doi:10.1016/j.cub.2016.07.032. ISSN:0960-9822. PMID:27593375.
• Holmes, AP; Yu, TY; Tull, S; Syeda, F; Kuhlmann, SM; O'Brien, SM; Patel, P; Brain, KL; Pavlovic, D; Brown, NA; Fabritz, L; Kirchhof, P (2016). "A Regional Reduction in Ito and IKACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity". PloS one. 11 (5): e0154077. doi:10.1371/journal.pone.0154077. PMID:27149380.
• Appukuttan, Shailesh; Brain, Keith; Manchanda, Rohit (2015). "Syncytial Basis for Diversity in Spike Shapes and their Propagation in Detrusor Smooth Muscle". Procedia Computer Science. 51: 785-794. doi:10.1016/j.procs.2015.05.199.
• Appukuttan, Shailesh; Brain, Keith L.; Manchanda, Rohit (2015). "A computational model of urinary bladder smooth muscle syncytium". Journal of Computational Neuroscience. 38 (1): 167-187. doi:10.1007/s10827-014-0532-6. ISSN:1573-6873.
• Yu, T.Y.; Dehghani, H.; Brain, K.; Syeda, F.; Holmes, A. P.; Kirchhof, P.; Fabritz, L. (2015). "Optical mapping design for murine atrial electrophysiology". Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization. 5 (5): 368-376. doi:10.1080/21681163.2015.1081079.
• Yu, TY; Syeda, F; Holmes, AP; Osborne, B; Dehghani, H; Brain, KL; Kirchhof, P; Fabritz, L (2014). "An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials". Progress in biophysics and molecular biology. 115 (2-3): 340-8. doi:10.1016/j.pbiomolbio.2014.07.012. PMID:25130572.
• Newman, AS; Batis, N; Grafton, G; Caputo, F; Brady, CA; Lambert, JJ; Peters, JA; Gordon, J; Brain, KL; Powell, AD; Barnes, NM (2013). "5-Chloroindole: a potent allosteric modulator of the 5-HT₃ receptor". British journal of pharmacology. 169 (6): 1228-38. doi:10.1111/bph.12213. PMID:23594147.
• Boersma, AJ; Brain, KL; Bayley, H (2012). "Real-time stochastic detection of multiple neurotransmitters with a protein nanopore". ACS nano. 6 (6): 5304-8. doi:10.1021/nn301125y. PMID:22616662.
• Kobayter, S; Young, JS; Brain, KL (2012). "Prostaglandin E2 induces spontaneous rhythmic activity in mouse urinary bladder independently of efferent nerves". British journal of pharmacology. 165 (2): 401-13. doi:10.1111/j.1476-5381.2011.01543.x. PMID:21671904.
• Williams, DJ; Sidaway, P; Cunnane, TC; Brain, KL (2011). "Mechanisms involved in nicotinic acetylcholine receptor-induced neurotransmitter release from sympathetic nerve terminals in the mouse vas deferens". PloS one. 6 (12): e29209. doi:10.1371/journal.pone.0029209. PMID:22216213.
• Brading, A.F.; Brain, K.L. "Ion Channel Modulators". In Andersson, KE; Michel, MC (eds.). Urinary tract. Springer. ISBN 9783642164989.
• Parker, LK; Shanks, JA; Kennard, JA; Brain, KL (2010). "Dynamic monitoring of NET activity in mature murine sympathetic terminals using a fluorescent substrate". British journal of pharmacology. 159 (4): 797-807. doi:10.1111/j.1476-5381.2009.00574.x. PMID:20136837.
• Brain, KL (2010). "Parasympathetic cholinergic transmission, minus the vesicles". Experimental physiology. 95 (2): 263-4. doi:10.1113/expphysiol.2009.050559. PMID:20150402.
• Valeri, A; Brain, KL; Young, JS; Sgaragli, G; Pessina, F (2009). "Effects of 17beta-oestradiol on rat detrusor smooth muscle contractility". Experimental physiology. 94 (7): 834-46. doi:10.1113/expphysiol.2009.047118. PMID:19395661.
• Young, JS; Amos, RJ; Brain, KL (2009). "Focal Ca²⁺ transient detection in smooth muscle". Journal of visualized experiments : JoVE (28). doi:10.3791/1247. PMID:19564842.
• Rahman, F; Manchanda, R; Brain, KL (2009). "Prejunctional and postjunctional actions of heptanol and 18 beta-glycyrretinic acid in the rodent vas deferens". Autonomic neuroscience : basic & clinical. 148 (1-2): 69-75. doi:10.1016/j.autneu.2009.03.006. PMID:19375392.
• Brain, KL (2009). "Neuroeffector Ca²⁺ transients for the direct measurement of purine release and indirect measurement of cotransmitters in rodents". Experimental physiology. 94 (1): 25-30. doi:10.1113/expphysiol.2008.043679. PMID:18805863.
• Young, JS; Meng, E; Cunnane, TC; Brain, KL (2008). "Spontaneous purinergic neurotransmission in the mouse urinary bladder". The Journal of physiology. 586 (23): 5743-55. doi:10.1113/jphysiol.2008.162040. PMID:18936079.
• Brain, KL; Cunnane, TC (2008). "Bretylium abolishes neurotransmitter release without necessarily abolishing the nerve terminal action potential in sympathetic terminals". British journal of pharmacology. 153 (4): 831-9. doi:10.1038/sj.bjp.0707623. PMID:18071295.
• Zhu, HL; Brain, KL; Aishima, M; Shibata, A; Young, JS; Sueishi, K; Teramoto, N (2008). "Actions of two main metabolites of propiverine (M-1 and M-2) on voltage-dependent L-type Ca²⁺ currents and Ca²⁺ transients in murine urinary bladder myocytes". The Journal of pharmacology and experimental therapeutics. 324 (1): 118-27. doi:10.1124/jpet.107.130021. PMID:17928569.
• Young, JS; Brain, KL; Cunnane, TC (2007). "Electrical and optical study of nerve impulse-evoked ATP-induced, P2X-receptor-mediated sympathetic neurotransmission at single smooth muscle cells in mouse isolated VAS deferens". Neuroscience. 148 (1): 82-91. doi:10.1016/j.neuroscience.2007.05.044. PMID:17629625.
• Williams, DJ; Brain, KL; Cunnane, TC (2007). "The effect of epibatidine on spontaneous and evoked neurotransmitter release in the mouse and guinea pig isolated vas deferens". British journal of pharmacology. 150 (7): 906-12. doi:10.1038/sj.bjp.0707183. PMID:17325648.
• Young, JS; Brain, KL; Cunnane, TC (2007). "The origin of the skewed amplitude distribution of spontaneous excitatory junction potentials in poorly coupled smooth muscle cells". Neuroscience. 145 (1): 153-61. doi:10.1016/j.neuroscience.2006.11.054. PMID:17208381.
• Brain, KL; Kay, J; Shine, B (2006). "Measurement of urinary metanephrines to screen for pheochromocytoma in an unselected hospital referral population". Clinical chemistry. 52 (11): 2060-4. doi:10.1373/clinchem.2006.070805. PMID:16990424.
• Webster, RG; Brain, KL; Wilson, RH; Grem, JL; Vincent, A (2005). "Oxaliplatin induces hyperexcitability at motor and autonomic neuromuscular junctions through effects on voltage-gated sodium channels". British journal of pharmacology. 146 (7): 1027-39. doi:10.1038/sj.bjp.0706407. PMID:16231011.
• Brain, KL; Cuprian, AM; Williams, DJ; Cunnane, TC (2003). "The sources and sequestration of Ca²⁺ contributing to neuroeffector Ca²⁺ transients in the mouse vas deferens". The Journal of physiology. 553 (Pt 2): 627-35. doi:10.1113/jphysiol.2003.049734. PMID:14500773.
• Brain, KL; Jackson, VM; Trout, SJ; Cunnane, TC (2002). "Intermittent ATP release from nerve terminals elicits focal smooth muscle Ca²⁺ transients in mouse vas deferens". The Journal of physiology. 541 (Pt 3): 849-62. doi:10.1113/jphysiol.2002.019612. PMID:12068045.
• Brain, KL; Trout, SJ; Jackson, VM; Dass, N; Cunnane, TC (2001). "Nicotine induces calcium spikes in single nerve terminal varicosities: a role for intracellular calcium stores". Neuroscience. 106 (2): 395-403. doi:10.1016/s0306-4522(01)00280-9. PMID:11566509.
• Jackson, VM; Trout, SJ; Brain, KL; Cunnane, TC (2001). "Characterization of action potential-evoked calcium transients in mouse postganglionic sympathetic axon bundles". The Journal of physiology. 537 (Pt 1): 3-16. doi:10.1111/j.1469-7793.2001.0003k.x. PMID:11711556.
• Lengyel, I; Olesen, LE; Nichol, KA; Brain, KL; Wang, X; Robinson, PJ; Bennett, MR; Rostas, JA (1999). "Phosphorylation of proteins in chick ciliary ganglion under conditions that induce long-lasting changes in synaptic transmission: phosphoprotein targets for nitric oxide action". Neuroscience. 90 (2): 607-19. doi:10.1016/s0306-4522(98)00452-7. PMID:10215163.
• O'Connor, SC; Brain, KL; Bennett, MR (1999). "Individual sympathetic varicosities possess different sensitivities to alpha 2 and P2 receptor agonists and antagonists in mouse vas deferens". British journal of pharmacology. 128 (8): 1739-53. doi:10.1038/sj.bjp.0702984. PMID:10588930.
• Brain, KL; Bennett, MR (1998). "Calcium transients evoked by action potentials in the somata of chick ciliary neurons". Journal of the autonomic nervous system. 71 (2-3): 120-33. doi:10.1016/s0165-1838(98)00066-6. PMID:9760048.
• Bennett, MR; Cheung, A; Brain, KL (1998). "Sympathetic neuromuscular transmission at a varicosity in a syncytium". Microscopy research and technique. 42 (6): 433-50. doi:10.1002/(SICI)1097-0029(19980915)42:6<433::AID-JEMT6>3.0.CO;2-N. PMID:9817550.
• Lin, YQ; Brain, KL; Bennett, MR (1998). "Calcium in sympathetic boutons of rat superior cervical ganglion during facilitation, augmentation and potentiation". Journal of the autonomic nervous system. 73 (1): 26-37. doi:10.1016/s0165-1838(98)00108-8. PMID:9808368.
• Brain, KL; Bennett, MR (1997). "Calcium in sympathetic varicosities of mouse vas deferens during facilitation, augmentation and autoinhibition". The Journal of physiology. 502 ( Pt 3): 521-36. doi:10.1111/j.1469-7793.1997.521bj.x. PMID:9279805.
• Brain, KL; Cottee, LJ; Bennett, MR (1997). "Varicosities of single sympathetic nerve terminals possess syntaxin zones and different synaptotagmin N-terminus labelling following stimulation". Journal of neurocytology. 26 (7): 491-500. doi:10.1023/a:1018533524643. PMID:9306247.
• Bennett, MR; Brain, K (1997). "Autonomic synaptic transmission at single boutons and calyces". Journal of neurocytology. 26 (9): 577-603. doi:10.1023/a:1018537625551. PMID:9352445.
• Lin, YQ; Brain, KL; Nichol, KA; Morgan, JJ; Bennett, MR (1996). "Vesicle-associated proteins and calcium in nerve terminals of chick ciliary ganglia during development of facilitation". The Journal of physiology. 497 ( Pt 3): 639-56. doi:10.1113/jphysiol.1996.sp021796. PMID:9003550.
• Brain, KL; Bennett, MR (1995). "Calcium in the nerve terminals of chick ciliary ganglia during facilitation, augmentation and potentiation". The Journal of physiology. 489 ( Pt 3): 637-48. doi:10.1113/jphysiol.1995.sp021079. PMID:8788930.
• Sheppard, Colin J. R.; Gu, Min; Brain, Keith; Zhou, Hao (1994). "Influence of spherical aberration on axial imaging of confocal reflection microscopy". Applied Optics. 33 (4): 616. doi:10.1364/AO.33.000616.

Email: Keith Brain