Giulia Laura Celora

DPhil Candidate in Mathematical Biology

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I am a DPhil Candidate in Mathematical Biology at the Wolfson Centre for Mathematical Biology (WCMB) supervised by Prof Helen B Byrne, Prof Philip Maini and Dr Joe Pitt-Francis. I have joined the department as part of the SABS CDT after completing the first year of training. In my research I am interested in understanding how spatio-temporal heterogeneity in the tumour micro-environment affects tumour growth and response to therapy. In particular I have been focusing on a phenomenon known as cycling hypoxia and how such fluctuations in the oxygen level in the tissue might be driving the selection of more aggressive and resistant cancer cell phenotypes. To do so, I have been using mathematical models, in particular population balance models where population heteregeneity is described via a structure variable which determines cell behaviours. My research project is in collaboration with Prof. Ester Hammond representative of CRUK.


Pre-Prints and Publication

Mathematical Oncology:

"Spatio-temporal modelling of phenotypic heterogeneiry in tumour tissues and its impact on radiotherapy treatment"
G.L. Celora, H. M. Byrne, P. G. Kevrekidis, preprint arXiv (2021)

"A DNA-structured mathematical model of cell-cycle progression in cyclic hypoxia "
G.L. Celora, S. M. Bader, E. M. Hammond, P. K. Maini, J. Pitt-Francis, H. M. Byrne,
Journal of Theoretical Biology (2022)

"Phenotypic variation modulates the growth dynamics and response to radiotherapy of solid tumours under normoxia and hypoxia"
G.L. Celora, H. M. Byrne, C. Zois, P. G. Kevrekidis,
Journal of Theoretical Biology (2021)

Material Science:

"A kinetic model of a polyelectrolyte gel undergoing phase separation"
G. L. Celora, M. G. Hennessy, A. Munch, S. L. Waters and B. Wagner
Journal for the Mechanics and Physics of Solids (2022)

"The dynamics of a collapsing polyelectrolyte gel"
G. L. Celora , M. G. Hennessy, A. Munch, S. L. Waters and B. Wagner (arXiv 2021)

"Asymptotic study of the electric double layer at the interface of polyelectrolyte gel and salt bath"
M. G. Hennessy, G. L. Celora , A. Much, S. L. Waters and B. Wagner (arXiv 2022)

Conferences


Past events:


British Applied Mathematics Colloquium (BAMC22)

Loughborough | 11th-13th April 2022

Contributed talk (Session: Cancer and Cells)
"Modelling spatial and phenotypic heterogeneity in solid tumours in the presence of radiation therapy"


18th European Mechanics of Materials Conference

Oxford | 4th-6th April 2022

Contributed talk (Session S14: Mechanics of soft materials and structures)
"A mathematical model for the dynamics of a polyelectrolyte gel undergoing phase separation"

"Characterising the biological response to cyclic hypoxia: insights from combining mathematical and in vitro modelling"

American Physical Society (APS) March meeting

Chicago | March 2022

Contributed talk (Session S16: Self-Assembled Polymers)
"The breaking of electroneutrality in a phase separating polyelectrolyte gel"

Oxbridge Applied Maths meeting

Cambridge | October 2021

Talk: "A model of cell-cycle progression in cyclic hypoxia: insights from combining mathematical and in vitro modelling."

SIAM Student Chapter National Conference (SIAM-SC)

Online | 2021

Talk: "Modelling spatial and phenotypic heterogeneity in tumour tissues in the presence of radiation theraphy ."

Society for Mathematical Biology Annual Meeting (SMB)

Online | 2020

Research Experience

12-weeks Rotation Project

University of Oxford | 2019

"The Effect of Fluctuations in Oxygen Supply on Avascular Tumour Composition"
supervised by Prof. Helen Byrne, Dr. Joe Pitt-Francis and Prof. Philip Maini
in collaboration with Prof Ester Hammond from CRUK

"A thermodynamically consistent poro-visco-elastic model of the extracellular matrix"
supervised by Prof. Sarah Waters and Prof. Sonia A. Contera

Master Thesis

University of Oxford | 2018

"Bifurcation Analysis with two Parameters"
supervised by Prof. Patrick Farrell

32nd ECMI Modelling Week

University of Novi Sad, Serbia | 2018

"Diffusion and anomalous diffusion models: simulation and application to biology"
supervised by Michal Balcerek