Books

Insulin:Molecular Biology to Pathology. (Editors, FM Ashcroft & SJH Ashcroft). IRL Press, 1992

Papers

Váradi A, Lebel L, Hashim Y, Mehta Z, Ashcroft SJH, Turner RC (1999) Sequence variants of the sarco(endo)plasmic reticulum Ca2+-transport ATPase 3 gene (SERCA3) in Caucasian Type II diabetic patients. Diabetologia 42: 1240-1243 PDF file

Ashfield R, Gribble F, Ashcroft SJH, Ashcroft FM (1999) Identification of the high-affinity tolbutamide site on the SUR1 subunit of the KATP channel. Diabetes 48: 1341-1347 PDF file

Southam L, Ashfield R, Cox R, Lathrop M, Ashcroft SJH. (1999) Human islets of Langerhans express the dc isoform of calcium/calmodulin-dependent protein kinase II. Diabetes/Metabolism Research and Reviews 15: 292-294 PDF file

Tian Y-M, Johnson G, Ashcroft SJH (1998) Sulfonylureas enhance exocytosis from pancreatic ß-cells by a mechanism that does not involve direct activation of protein kinase C. Diabetes 47: 1722-1726 PDF file

Salt IP, Johnson G, Ashcroft SJH, Hardie G (1998) AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic ß-cells and may regulate insulin release. Biochem J 335: 533-539 PDF file

Ashfield R, Ashcroft SJH (1998). Cloning of the promoters for the beta-cell ATP-sensitive K-channel subunits Kir6.2 and SUR1. Diabetes 47: 1274-1280 PDF file

Noor H, Ashcroft SJH (1998) Insulinotropic activity of Tinospora crispa extract: Effect on beta- cell Ca2+ handling. Phytotherapy Research 12: 98-102 PDF file

Noor H, Ashcroft SJH (1998) Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract. Journal of Ethnopharmacology 62: 7-13 PDF file

Sakura H, Ashcroft SJH, Terauchi Y, Kadowaki T, Ashcroft FM (1998) Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice. Diabetologia 41: 654-659 PDF file

Mikhailov MV, Proks P, Ashcroft FM, Ashcroft SJH (1998) Expression of functionally active ATP-sensitive K-channels in insect cells using baculovirus. FEBS Lett 429: 390-394 PDF file

Goodison S, Ashcroft SJH (1997) Trans-acting factor(s) confer glucose-responsive transcriptional regulation in the insulin gene. Adv Exp Med Biol 426: 97-100

Urquid, V, Ashcroft SJH (1997) Molecular cloning of the cDNA encoding beta-cell calcium/calmodulin- dependent protein kinase II. Adv Exp Med Biol 426: 73-80

Niki I, Coles B, Ashcroft FM, Ashcroft SJH (1997) Effects of protein phosphorylation on the sulphonylurea receptor of the pancreatic beta-cell. Adv Exp Med Biol 426: 59-69

Vucic M, Rocic B, Bozikov V, Ashcroft SJH (1997) Plasma uric acid and total antioxidant status in patients with diabetes meelitus. Horm Metab Res 29: 355-357

Breen M A, Ashcroft SJH (1997) A truncated isoform of Ca2+/calmodulin-dependent protein kinase II expressed in human islets of Langerhans may result from trans-splicing. FEBS Lett 409: 375-379 PDF file

Vucic M, Gavella M, Bozikov V, Ashcroft SJH, Rocic B (1997) Superoxide dismutase activity in lymphocytes and polymorphonuclear cells of diabetic patients. Eur J Clin Chem Clin Biochem 35: 517-521

Breen M A, Ashcroft SJH (1997) Human islets of Langerhans express multiple isoforms of calcium/calmodulin-dependent protein kinase II. Biochem Biophys Res Commun 236: 473-478 PDF file

Váradi A, Molnár E, Östenson C-G, Ashcroft SJH (1996) Isoforms of endoplasmic reticulum Ca2+-ATPase are differentially expressed in normal and diabetic islets of Langerhans. Biochem J 319: 521-527 PDF file

Tian Y-M, Urquidi V, Ashcroft SJH (1996) Protein kinase C in beta cells: expression of multiple isoforms and involvement in cholinergic stimulation of insulin secretion. Mol Cell Endocrinol 119: 185-193 PDF file

Ämmälä C, Moorhouse A, Proks P, Gribble F, Smith PA, Sakura H, Coles B, Ashcroft SJH, Ashfield R, Ashcroft FM (1996) The sulphonylurea receptor couples promiscuously to Kir channels. Nature 379: 545-548 PDF file

Váradi A, Molnár E, Ashcroft SJH (1996) A unique combination of plasma membrane Ca2+-ATPase isoforms is expressed in islets of Langerhans and pancreatic ß-cell lines. Biochem J 314: 663-669 PDF file

Molnár E, Váradi A, McIlhinney RAJ, Ashcroft SJH (1995) Identification of functional ionotropic glutamate receptor proteins in pancreatic ß-cells and in islets of Langerhans. FEBS Lett 371: 253-257 PDF file

German M, Ashcroft SJH, Docherty K, Edlund H, Edlund T, Goodison S, Imura H, Kennedy G, Madsen O, Melloul D, Moss L, Olson K, Permutt M A, Philippe J, Robertson BP, Rutter WJ, Serup P, Stein R, Steiner D, Tsai MJ, Walker MD (1995) The insulin gene promoter. A simplified nomenclature. Diabetes 44: 1002-1004 PDf file

Urquidi V, Ashcroft SJH (1995) A novel pancreatic ß-cell isoform of calcium/calmodulin-dependent protein kinase II (ß3 isoform) contains a proline-rich tandem repeat in the association domain. FEBS Lett 358: 23-26 PDF file

Váradi A, Molnár E, Ashcroft SJH (1995) Characterisation of endoplasmic reticulum and plasma membrane Ca2+-ATPases in pancreatic ß-cells and in islets of Langerhans. Biochim Biophys Acta 1236: 119-127 PDF file

Ashcroft SJH (1994) The cell biology of insulin secretion. In: The Diabetes Annual. Eds: Marshall S.M., Home, P.D. pp 1-19. Elsevier,Amsterdam, London, New York

Goodison S, Miyazaki JI, Ashcroft SJH (1994) Response to glucose of transcription factor binding to the rat insulin-1 gene promoter. Biochem Biophys Res Commun 30: 702-710 PDf file

Ashcroft SJH (1994) Protein phosphorylation and beta-cell function. Diabetologia 37 [Suppl 2]: S21-S29 PDF file

Ashcroft SJH (1994) The ß-cell sulfonylurea receptor. Diab Nutr Metab 7: 149-163

Kenna S, Röper J, Ho K, Hebert S, Ashcroft S H, Ashcroft FM (1994) Differential expression of the inwardly-rectifying K-channel ROMK1 in rat brain. Mol Brain Res. 24: 353-356 PDF file

Skeer JM, Dégano P, Coles B, Potier M, Ashcroft FM, Ashcroft SJH (1994) Determination of the molecular mass of the native ß-cell sulfonylurea receptor. FEBS Lett 338: 98-102 PDF file

Ashcroft SJH, Niki I, Kenna S, Weng L, Skeer J, Coles B, Ashcroft F M (1993) The beta-cell sulfonylurea receptor. Adv Exp Med Biol 334: 47-61.

Weng L, Davies M, Ashcroft SJH (1993) Effects of cholinergic agonists on diacylglycerol and intracellular calcium levels in pancreatic ß-cells. Cellular Signalling 5: 777-786 PDF file

Niki I, Ashcroft SJH (1993) Characterization and solubilization of the sulphonylurea receptor in rat brain. Neuropharmacol 32: 951-957 PDF file

Hughes SJ, Smith H, Ashcroft SJH (1993) Characterization of Ca2+/calmodulin-dependent protein kinase in rat pancreatic islets. Biochem J 289: 795-800 PDF file

Ashcroft SJH, Ashcroft FM (1992) The sulfonylurea receptor. Biochim Biophys Acta 1175: 45-59 PDF file

Modríc N, Derome AE, Ashcroft SJH, Poje M (1992) Tracing and identification of uricase reaction intermediates. A direct 13C-NMR/isotope-labelling evidence. Tetrahedron Letters 33: 6691-6694

Oosawa Y, Ashcroft SJH, Ashcroft FM (1992) Ca2+-activated K+-channels from an insulin-secreting cell line incorporated into planar lipid bilayers. Diabetologia 35: 619-623 PDf file

Goodison S, Kenna S, Ashcroft SJH (1992) Control of insulin gene expression by glucose. Biochem J 285: 563-568 PDF file

Ashcroft SJH, Ashcroft FM (1992) Mechanism of insulin secretion. In: Insulin. Molecular Biology to Pathology (eds. Ashcroft FM & Ashcroft SJH). IRL Press :37-63

Hughes SJ, Carpinelli A, Niki I, Nicks JL, Ashcroft SJH (1992) Stimulation of insulin release by vasopressin in the clonal ß-cell line, HIT-T15: the role of protein kinase C. J Mol Endocrinol 8: 145-153

Niki I, Ashcroft SJH (1992) Possible involvement of protein phosphorylation in the regulation of the sulphonylurea receptor of a pancreatic ß-cell line, HIT T15. Biochim Biophys Acta 1133: 95-101 PDF file

Niki I, Welsh M, Berggren P-O, Hubbard P, Ashcroft SJH (1991) Characterization of the solubilized glibenclamide receptor in a hamster pancreatic ß-cell line, HIT T15. Biochem J 277: 619-624 PDF file

Hughes SJ, Ashcroft SJH (1991) Cyclic AMP, protein phosphorylation and insulin release. In "Nutrient Regulation of Insulin Secretion" Ed. Flatt, P.R. Portland Press.pp 271-288

Ashcroft SJH, Ashcroft FM (1990) Properties and functions of ATP-sensitive K-channels. Cellular Signalling 2: 197-214 PDF file

Niki I, Nicks JL, Ashcroft SJH (1990) The ß-cell glibenclamide receptor is an ADP-binding protein. Biochem J 268: 713-718 PDF file

Betsholtz C, Baumann A, Kenna S, Ashcroft FM, Ashcroft SJH, Berggren P-O, Grupe A, Rorsman P, Sandblom J, Welsh M (1990) Expression of voltage-gated K+-channels in insulin-producing cells. Analysis by polymerase chain reaction. FEBS Lett 263: 121-126 PDF file

Hughes SJ, Chalk JG, Ashcroft SJH (1990) The role of cytosolic free Ca2+ and protein kinase C in acetylcholine-induced insulin release in the clonal ß-cell line, HIT-T15. Biochem J 267: 227-232 PDF file