Clinical Optical Imaging

FLIM beamline We are developing optical, spectrally-agile devices with clinical applications (surgery). These exploit fluorescence imaging in the Near-Infrared (NIR) optical region (650-1000 nm). Tissues are ‘transparent’ in the NIR band and these devices will ultimately allow us to detect and image tumour tissues at depths up to 10-15 mm. image 2

Further Reading

Laparoscope lens pdf

An electrically-tuneable achromatic laparoscope imaging lens

We present the design, implementation and performance of a novel electrically-tuneable laparoscope imaging lens based on the Optotune EL-10-30-TC lens. The achromatic performance is assessed over the 450-850 nm range to include use with NIR fluorescence. It uses of-the-shelf optical components and a custom small-footprint driver board.

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A prospective pilot study of detection of sentinel lymph nodes in gynaecological cancers using a novel near infrared fluorescence imaging system

A novel, custom-made, optical imaging system was developed to enable detection of multiple fluorescence dyes and allow simultaneous bright-field imaging during open surgery and laparoscopic procedures. We then evaluated the performance of the system in a prospective study of 49 women with early stage vulval, cervical and endometrial cancer who were scheduled to undergo complete lymphadenectomy.

Light Flux pdf

A fast method for estimation of light flux in fluorescence image guided surgery

We present a theoretical method to estimate the light flux in near-infrared fluorescence imaging of tissues. This method is a very good approximation to the more usual Monte-Carlo methods, but runs in a fraction of the time. A Windows executable called FIFAC.exe is available that implements this method in Software Downloads.

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Checking Missed Frames In Digital Imaging

If you are capturing live video and want to be sure no frames are missed, this is the device for you.

Laser Driver pdf

A Medium Power CW Laser Driver

Design, circuits and PCB layouts for a medium power laser diode driver.

Tunable Lens pdf

A simple focus-programmable lens power supply

Here we describe a variable power supply for driving a focus tunable lens such as the Optotune EL-10-30.

Imaging formats pdf

Notes on imaging sensor and display formats.

fibre notes pdf

Notes on optical fibres and fibre bundles

Notes on optical fibres and fibre bundles, including light guidance, numerical aperture, etendue, absorption and losses.

Sony sensors pdf

Sony CCD and CMOS 2D imaging sensors

Information on Sony extensive range of CCD sensors in one place.

Tissue autofluorescence pdf

Tissue autofluorescence: watch out what's on the menu...

A tale of how optical imaging can be disrupted by what was eaten for breakfast.