Miriam Klein-Flügge

See also my profiles on Google scholar and ResearchGate.

Preprints/under review

Klein-Flügge MC, Jensen DEA, Verhagen L, Tagaki Y, Smith S, Rushworth, MFS (2020) High anatomical precision in relating specific amygdala connections to selective markers of mental well-being in humans (in revision) Pdf of preprint on BiorXiv link

Accepted/in press

Sel AS, Verhagen L, Angerer K, David R, Klein-Flügge MC, and Rushworth MFS. Entraining Corticocortical Plasticity Changes Oscillatory Activity in Action Control and Inhibition. BioRxiv, 2020 (accepted at PNAS) link

Peer-reviewed

Takagi Y, Hunt L, Woolrich MW, Behrens TEJ†, Klein-Flügge MC† (2021) Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice, ELife 10: e60988. https://doi.org/10.7554/eLife.60988 [† Joint senior authors] pdf link

Bongioanni A, Folloni D, Verhagen L, Sallet J, Klein-Flügge MC†, Rushworth MFS† (2021) Activation and disruption of a neural mechanism for novel choice in monkeys, Nature, 6 January 2021, 1–5, [† Joint senior authors] Europe PMC Link Nature link

Harrison, OK, Guell X†, Klein-Flügge MC†, Barry RL† (2021) Structural and functional connectivity beyond the cortex, Neuroimage 240: 118379 (invited review) († equal contribution) https://doi.org/10.1016/j.neuroimage.2021.118379 pdf link

Wittmann, MK, Trudel N, Trier H, Klein-Flügge MC, Sel A, Verhagen L, and Rushworth MFS (2021) Causal Manipulation of Self-Other-Mergence in Dorsomedial Prefrontal Cortex, Neuron 109, no.14: 2353-2361.e11 https://doi.org/10.1016/j.neuron.2021.05.027 pdf link

Müller T, Klein-Flügge MC, Manohar S, Husain M, Apps MAJ (2021) Neural and computational mechanisms of momentary fatigue and persistence in effort-based choice, Nature Communications 12, no.1:4593 https://doi.org/10.1038/s41467-021-24927-7 pdf link

Jensen DEA, Leoni V, Klein-Flügge MC, Ebmeier KP, Suri S (2021) Associations of Dietary Markers with Brain Volume and Connectivity: A Systematic Review of MRI Studies. Ageing Research Reviews 70 (1 September 2021): 101360. https://doi.org/10.1016/j.arr.2021.101360 pdf link

Lockwood PL*, Klein-Flügge MC*, Abdurahman A, Crockett MJ (2020) Model-Free Decision Making Is Prioritized When Learning to Avoid Harming Others, PNAS, 117,44:27719–30 [* Shared first authors] pdf link

Wittmann MK, Fouragnan E, Folloni D, Klein-Flügge MC, Chau B, Khamassi M, Rushworth, MFS (2020) Global reward state affects learning, the raphe nucleus, and anterior insula in monkeys, Nature Communications, 11, 3771 pdf link

Trudel N, Scholl J, Klein-Flügge MC, Fouragnan E, Tankelevitch L, Wittmann MK, Rushworth MFS (2020) Polarity of subjective uncertainty in ventromedial prefrontal cortex changes with behavioural adaptation, Nature Human Behaviour pdf link

Chau BKH, Law C, Lopez-Persem A, Kolling N, Klein-Flügge MC, Rushworth MFS (2020) Consistent patterns of distractor effects during decision making, eLife, 9: e53850 pdf link

Lockwood PL, Klein-Flügge MC (2020) Computational modelling of social cognition and behaviour – a reinforcement learning primer Social Cognitive and Affective Neuroscience pdf link

Klein-Flügge MC , Wittmann, MK, Shpektor A, Jensen DEA, Rushworth MFS (2019) Multiple associative structures created by reinforcement and incidental statistical learning mechanisms, Nature Communications 10, 4835 pdf link

Fouragnan EF, Chau BKH, Folloni D, Kolling N, Verhagen L, Klein-Flügge MC, Tankelevitch L, Papageorgiou GK, Aubry J, Sallet J, Rushworth MFS (2019) The macaque anterior cingulate cortex translates counterfactual choice value into actual behavioral change, Nature Neuroscience volume 22: 797–808 pdf link

Verhagen L, Gallea C, Folloni D, Constans C, Jensen D, Ahnine H, Roumazeilles L, Santin M, Ahmed B, Lehericy S, Klein-Flügge MC, Krug K, Mars RB, Rushworth MFS, Pouget P, Aubry J, Sallet J (2019) Offline impact of transcranial focused ultrasound on cortical activation in primates. eLife 8: e40541 pdf link

Lockwood PL, Wittmann M, Apps MAJ, Klein-Flügge MC, Crockett MJ, Humphreys GW, Rushworth MFS (2018) Neural mechanisms for learning self and other ownership, Nature Communications 9: 4747 pdf link

Scholl J, Klein-Flügge MC (2018) Understanding psychiatric disease by capturing ecologically relevant features of learning and decision-making, Beh Brain Res 355:56-75 pdf link

Klein-Flügge MC, Kennerley SW, Friston K, Bestmann S (2016) Neural signatures of value comparison in human cingulate cortex during decisions requiring an effort-reward trade-off, J. Neurosci. 36(39):10002-10015 pdf video summary

Haemmerer D*, Bonaiuto J*, Klein-Flügge MC*, Bikson M, Bestmann S (2016) Selective alteration of human value decisions with medial frontal tDCS is predicted by changes in attractor dynamics [* These authors contributed equally to the work] Scientific Reports 6, Article number: 25160 pdf

Klein-Flügge MC, Kennerley SW, Saraiva AC, Penny WD, Bestmann S (2015) Behavioral Modeling of Human Choices Reveals Dissociable Effects of Physical Effort and Temporal Delay on Reward Devaluation, PLoS Comput Biol.11(3):e1004116 pdf

Klein-Flügge MC, Nobbs D, Pitcher JB, Bestmann S (2013) Variability of human cortico-spinal excitability tracks the state of action preparation, J. Neurosci. 33(13), 5564 –5572 pdf

Klein-Flügge MC*, Barron H*, Brodersen KH, Dolan RJ, Behrens TEJ (2013) Segregated encoding of reward-identity and stimulus-reward associations in human orbitofrontal cortex, J. Neurosci. 33(7), 3202–3211 [* These authors contributed equally to the work] pdf

Nicolle A, Klein-Flügge MC, Hunt LT, Vlaev I, Dolan RJ, Behrens TEJ (2012) An agent independent axis for executed and modeled choice in medial prefrontal cortex, Neuron 75(6), 1114-21 pdf

Hall CN, Klein-Flügge MC, Howarth C, Attwell D (2012) Oxidative phosphorylation, not glycolysis, powers pre- and postsynaptic mechanisms underlying brain information processing, J. Neurosci. 32(26), 8940-51 pdf

Klein-Flügge MC, Bestmann S (2012) Time-dependent changes in human cortico-spinal excitability reveal value-based competition for action during decision processing, J. Neurosci. 32(24), 8373-82. pdf

Klein-Flügge MC, Hunt LT, Bach DR, Dolan RJ, Behrens TEJ (2011) Dissociable Reward and Timing Signals in Human Midbrain and Ventral Striatum. Neuron 72(4), 654-664 pdf

Neubert F, Klein MC (2010). What is Driving Inhibition-Related Activity in the Frontal Lobe? J. Neurosci. 30(14), 4830–4832 pdf

Scholz J, Klein MC, Behrens TE, Johansen-Berg H (2009). Training induces changes in white-matter architecture, Nature Neuroscience, 12(11), 1370-1371 pdf
*** identified by Thomson Reuters as featured article: one of the most-cited papers from the last 2 years

Mars RB, Klein MC, Neubert F, Olivier E, Buch ER, Boorman ED, Rushworth MFS (2009). Short-Latency Influence of Medial Frontal Cortex on Primary Motor Cortex during Action Selection under Conflict. J. Neurosci., 29(21), 6926-6931. pdf

Public engagement articles & news coverage

Coverage of our recent Nature paper (2021) on novel decision-making Oxford University Science Blog Cherwell News Sky-News

Coverage of our Nat Comms 2019 article on multiple mechanisms of knowledge acquisition on Oxford News Oxford University News Tech Explorist Neuroscience News

Press release on JNS paper in 2016 on effort-reward trade-offs: link

Scholz J, Klein MC (2010) Lernen verbindet, Gehirn & Geist, 2010
[Learning connects: Brain&Mind –magazine; published in German] link

Invited talks

Cognitive Computational Neuroscience (CCN) Generative Adversarial Collaborations (2020, online) recording

Neuroeconomics Seminar, Department of Economics (2020), University of Zurich (online)

In Translation Meeting, Department of Psychiatry (2020), University of Oxford

4th Quadrennial Meeting on Orbitofrontal Cortex Function (2019) Paris, France

Research Centre for Cognitive Neuroscience at Brunel University London (2019), London UK

Eigth International Symposium on Biology of Decision-Making (SBDM, Oxford 2019)

Beh & Cog Neuroscience seminar, Department of Experimental Psychology, Oxford (2019)

Max Planck Centre for Computational Psychiatry (2018), UCL, UK

Oxford Autumn School in Cognitive Neuroscience (2017), Oxford, UK

Royal Society Fatigue Meeting (2017), Kavli Centre, Buckinghamshire

Paris (2015) Fifth International Symposium on Biology of Decision-Making

Wellcome Trust Centre for Neuroimaging, University College London (2015) Brain meeting lecture

Copenhagen (2015), FENS workshop on Bridging Neural Mechanisms and Cognition

University of Tohoku (2015), Japan, Symposium on prefrontal cortex, learning and memory

Wellcome Trust Centre for Neuroimaging, University College London (2014) Behavioural and neural signatures of choice computation for human effort-based decision making

Department of Economics, University of Zurich (2013) The impact of physical effort on behavioural and neural computations guiding value-based choice

Joint University College London - Johns Hopkins University workshop, London: “Unresolved questions in motor control” (2012) Variability of cortico-spinal excitability tracks the preparatory state of human motor cortex.

Centre for Data Analysis and Modeling, Freiburg (2012) Causal and correlative approaches for understanding interactions between decision and action systems of the human brain

HBM annual meeting, Quebec City (2011) Intra-parietal sulcus links decisions to actions and receives value-modulated inputs from vmPFC. Presentation #2156

Einstein Fellowship Symposium on Decision Making, Berlin (2011) Learning in time and reward: Human ventral tegmental area encodes a temporal difference reward prediction error whereas ventral striatum encodes task-specific learning signals.

HBM annual meeting, Barcelona (2010) Characterization of Prediction Error Signals in the Ventral Tegmental Area under Variable Timings. Presentation #638