Ashcroft, S.J.H. (1980) Glucoreceptor mechanisms and the
control of insulin release and biosynthesis. Diabetologia
18, 5-15 PDF file
Grant, A.M., Christie, M.R., Ashcroft, S.J.H. (1980)
Insulin release from human pancreatic islets in vitro.
Diabetologia 19, 114-117 PDF file
Pierluissi, J., Pierluissi, R., Ashcroft, S.J.H. (1980)
Effects of growth hormone on insulin release in the rat.
Diabetologia 19, 391-396 PDf file
Gagliardino, J.J., Harrison, D.E., Christie, M.R.,
Gagliardino, E.E., Ashcroft, S.J.H. (1980) Evidence for the
participation of calmodulin in stimulus-secretion coupling
in the pancreatic ß-cell. Biochem.J. 192, 919-927 PDf file
Ashcroft, S.J.H., Sugden, M.C., Williams, I.H. (1980)
Carbohydrate metabolism and the glucoreceptor mechanism.
Horm.Metab.Res.Suppl. Series No.10, 1-7
Pierluissi, R., Pierluissi, J., Ashcroft, S.J.H. (1981)
Effects of an enkephalin analogue (DAMME) on insulin
release from cultured rat islets of Langerhans.
Diabetologia 20, 642-646 PDF file
Aynsley-Green, A., Polak, J.M., Bloom, S.R., Gough, M.H.,
Keeling, J., Ashcroft, S.J.H., Turner, R.C. ,Baum, J.D.
(1981) Nesidioblastosis of the pancreas: definition of the
syndrome and the management of the severe neonatal
hyperinsulinaemic hypoglycaemia. Arch.Disease Childhood 56,
496-508 PDF file
Sugden, M.C., Ashcroft, S.J.H. (1981) Cyclic nucleotide
phosphodiesterase of rat pancreatic islets. Biochem.J. 197,
459-464 PDf file
Ashcroft, S.J.H. (1981) Metabolic controls of insulin
secretion. In: 'The Islets of Langerhans: Biochemistry,
Physiology and Pathology' Ed. by Cooperstein, S.J.,
Watkins, D. Academic Press. pp 117-148
Harrison, D.E. & Ashcroft, S.J.H. (1982) Effects of
Ca2+, calmodulin and cyclic AMP on the
phosphorylation of endogenous proteins by homogenates of
rat islets of Langerhans. Biochim.Biophys.Acta 714, 313-319 PDf file
Campillo, J.E. & Ashcroft, S.J.H. (1982) Protein
carboxymethylation in rat islets of Langerhans. FEBS Letts.
138, 71-75 PDf file
Pierluissi, J., Pierluissi, R., Ashcroft,S.J.H. (1982)
Effects of hypophysectomy and growth hormone on cultured
islets of Langerhans of the rat. Diabetologia 22, 134-137
PDf file
Tait, S.P.C., Poje, M., Rocic, B., Ashcroft, S.J.H. (1983)
Diabetogenic action of alloxan-like compounds: the effect
of dehydrouramilhydrate hydrochloride on isolated islets of
Langerhans of the rat. Diabetologia 25, 360-364 PDF file
Christie, M.R., Ashcroft, S.J.H. (1984) Cyclic
AMP-dependent protein phosphorylation and insulin secretion
in intact islets of Langerhans. Biochem.J. 218, 87-99
PDF file
Turgeon, J.L., Ashcroft, S.J.H., Waring, D.W., Milewski,
M.A., Walsh, D.A. (1984) Characterisation of the
adenohypophyseal Ca2+-phospholipid-dependent protein
kinase. Mol.Cell Endocrinol. 34 107-112 PDF file
Lord, J.M. & Ashcroft, S.J.H. (1984) Identification and
characterization of Ca2+-phospholipid-dependent
protein kinase in rat islets and hamster B-cells.
Biochem.J. 219, 547-551 PDF file
Dominis ,M., Rocic, S., Ashcroft, S.J.H., Rocic, B., Poje,
M. (1984) Diabetogenic action of alloxan-like compounds:
cytoxic effects of 5-hydroxy-pseudouric acid and
dehydrouramil hydratehydrochloride on rat pancreatic
ß-cells. Diabetologia 27, 403-406 PDF file
Harrison, D.E., Ashcroft, S.J.H., Christie, M.R., Lord,J.M.
(1984) Protein phosphorylation in the pancreatic ß-cell.
Experientia 40, 1057-1084 PDF file
Ashcroft, F.M., Harrison, D.E., Ashcroft, S.J.H. (1984)
Glucose induces closure of single ion channels in isolated
rat pancreatic beta-cells. Nature 312, 446-448 PDF file
Christie, M.R. & Ashcroft, S.J.H. (1985) Substrates for
cyclic AMP-dependent protein kinase in islets of
Langerhans: studies with forskolin and catalytic subunit.
Biochem.J. 227, 727-736 PDF file
Grant, A.M., Harrison, D.E., Moysey, L., Smith, D.,
Ashcroft,S.J.H. (1985) Detection of islet cell surface
antibodies using cloned ß-cells and comparison of their
incidence with that of islet cell cytoplasmic antibodies.
Diabetes Research 2, 225-229
Rocic, B., Harrison, D.E., Ashcroft, S.J.H., Harrison,
D.E., Poje,M. (1985) Diabetogenic action of alloxan-like
compounds: the cytotoxic effect of dehydroisouramil
hydrochloride on the rat pancreatic beta-cells. Diab.
Croat. 14, 143-148
Pierluissi, J., Navas, F.O., Ashcroft, S.J.H. (1986) Effect
of adrenal steroids on insulin release from cultured rat
islets of Langerhans. Diabetologia 29, 119-121 PDF file
Harrison, D.E., Poje, M., Rocic, B., Ashcroft, S.J.H.
(1986) Effects of dehydrouramil on protein phosphorylation
and insulin secretion in rat islets of Langerhans.
Biochem.J. 237, 191-196 PDF file
Ashcroft, F.M., Ashcroft, S.J.H., Harrison, D.E. (1986) A
potassium channel modulated by glucose metabolism in rat
pancreatic beta-cells. In 'Biophysics of the pancreatic
beta-cell'. Ed. Atwater, I. & Rojas, E
Ashcroft, S.J.H, Harrison, D.E., Poje, M., Rocic,B. (1986)
Structure-activity relationships of alloxan-like compounds
derived from uric acid. Br.J.Pharmac. 89, 469-72 PDf file
Kakei, M., Kelly, R.P., Ashcroft, S.J.H., Ashcroft,F.M.
(1986) The ATP-sensitivity of K+ channels in rat
pancreatic B-cells is modulated by ADP. FEBS Lett 208,
63-66 PDf file
Ashcroft, S.J.H., Hammonds, P., Harrison,D.E. (1986)
Insulin secretory responses of a clonal cell line of simian
virus 40-transformed B cells. Diabetologia 29, 727-33
PDF file
Hammonds, P., Schofield, P.N., Ashcroft, S.J.H. (1987)
Glucose regulates preproinsulin messenger RNA levels in a
clonal cell line of simian virus 50-transformed ß-cells.
FEBS Lett. 213, 149-154 PDf file
Hughes, S.J., Christie, M.R., Ashcroft, S.J.H. (1987)
Potentiators of insulin secretion modulate Ca2+
sensitivity in rat pancreatic islets. Mol.Cell Endocrinol.
50, 231-236 PDF file
Ashcroft, F.M., Ashcroft, S.J.H., Harrison, D.E. (1987)
Effects of 2-ketoisocaproate on insulin release and single
potassium channel activity in dispersed rat pancreatic
ß-cells. J.Physiol. 385. 517-529 PDF file
Ashcroft, S.J.H. & Stubbs, M. (1987) The glucose sensor
in HIT cells is the glucose transporter. FEBS Lett. 219,
311-315 PDF file
Hammonds, P., Schofield , P.N., Ashcroft, S.J.H., Sutton,
R., Gray, D.W.R. (1987) Regulation and specificity of
glucose-stimulated insulin gene expression in human islets
of Langerhans. FEBS Lett. 223, 131-137 PDF file
Ashcroft, F.M., Ashcroft, S.J.H., Harrison, D.E. (1988)
Properties of single potassium channels modulated by
glucose in rat pancreatic B-cells. J.Physiol. 400, 501-527
PDF file
Hughes, S.J. & Ashcroft, S.J.H. (1988) Effect of
secretagogues on cytosolic free Ca2+ and insulin
release in the hamster clonal ß-cell line HIT-T15.
J.Mol.Endocr. 1, 13-17 PDF file
Lewis, C.E., Clark, A., Ashcroft, S.J.H., Cooper, G.J.S.,
Morris,J.F. (1988) Calcitonin gene-related peptide and
somatostatin inhibit insulin release from individual rat
B-cells. Mol.Cell Endocrin. 57, 41-49 PDF file
Ashcroft, F.M., Ashcroft, S.J.H., Berggren, P.-O.,
Betzholz, C., Rorsman, P., Trübe, G., Welsh, M. (1988)
Expression of K channels in Xenopus laevis oocytes injected
with poly(A+) mRNA from the insulin-secreting ß-cell line,
HIT T15. FEBS Lett 239, 185-189 PDf file
Hughes, S.J. & Ashcroft, S.J.H. (1988) Effects of a
phorbol ester and clomiphene on protein phosphorylation and
insulin secretion in rat pancreatic islets Biochem J 249,
825-830 PDF file
Hughes, S.J., Chalk, J.G., Ashcroft, S.J.H. (1989) Effects
of secretagogues on cytosolic free Ca2+ and insulin release
at different extracellular Ca2+ concentrations
in the hamster clonal ß-cell line HIT-T15. Mol. Cell
Endocrinol. 65, 35-41 PDF file
Noor, H., Hammonds, P., Sutton, R., Ashcroft, S.J.H. (1989)
The hypoglycaemic and insulinotropic activity of Tinospora
crispa: studies with human and rat islets and HIT T15 B
cells. Diabetologia 32, 354-359 PDF file
Ashcroft, S.J.H. & Ashcroft, F.M. (1989) The role of
the ATP-sensitive K-channel in stimulus-response coupling
in the pancreatic ß-cell. Hormones and Cell Regulation
No.14, Eds J.Nunez, J.E.Dumont. Colloque INSERM/J.Libbey
Eurotext Ltd. Vol. 198. pp. 99-103
Niki, I., Kelly, R.P., Ashcroft, S.J.H. & Ashcroft,
F.M. (1989) ATP-sensitive K-channels in HIT T15 ß-cells
studies by patch-clamp methods, 86Rb efflux and
glibenclamide binding. Pflügers Arch. 415, 47-55 PDf file
Niki, I., Ashcroft, F.M. & Ashcroft, S.J.H. (1989) The
dependence on intracellular ATP concentration of
ATP-sensitive K-channels and of Na-K-ATPase in intact
HIT-T15 ß-cells. FEBS Lett. 257, 361-364 PDf file
Noor, H. & Ashcroft, S.J.H. (1989) Antidiabetic effects
of Tinospora crispa. J. Ethnopharmacol. 27, 149-161 PDf file
Ashcroft, S.J.H. & Hughes, S.J. (1989) Protein
phosphorylation in the regulation of insulin secretion and
biosynthesis. Biochem. Soc. Trans. 18, 116-118