Books
Insulin:Molecular Biology to Pathology. (Editors, FM
Ashcroft & SJH Ashcroft). IRL Press, 1992
Papers
Váradi A, Lebel L, Hashim Y, Mehta Z, Ashcroft SJH, Turner
RC (1999) Sequence variants of the sarco(endo)plasmic
reticulum Ca2+-transport ATPase 3 gene (SERCA3)
in Caucasian Type II diabetic patients. Diabetologia 42:
1240-1243 PDF file
Ashfield R, Gribble F, Ashcroft SJH, Ashcroft FM (1999)
Identification of the high-affinity tolbutamide site on the
SUR1 subunit of the KATP channel. Diabetes 48: 1341-1347
PDF file
Southam L, Ashfield R, Cox R, Lathrop M, Ashcroft SJH.
(1999) Human islets of Langerhans express the dc isoform of
calcium/calmodulin-dependent protein kinase II.
Diabetes/Metabolism Research and Reviews 15: 292-294
PDF file
Tian Y-M, Johnson G, Ashcroft SJH (1998) Sulfonylureas
enhance exocytosis from pancreatic ß-cells by a mechanism
that does not involve direct activation of protein kinase
C. Diabetes 47: 1722-1726 PDF file
Salt IP, Johnson G, Ashcroft SJH, Hardie G (1998)
AMP-activated protein kinase is activated by low glucose in
cell lines derived from pancreatic ß-cells and may regulate
insulin release. Biochem J 335: 533-539 PDF file
Ashfield R, Ashcroft SJH (1998). Cloning of the promoters
for the beta-cell ATP-sensitive K-channel subunits Kir6.2
and SUR1. Diabetes 47: 1274-1280 PDF file
Noor H, Ashcroft SJH (1998) Insulinotropic activity of
Tinospora crispa extract: Effect on beta- cell
Ca2+ handling. Phytotherapy Research 12: 98-102
PDF file
Noor H, Ashcroft SJH (1998) Pharmacological
characterisation of the antihyperglycaemic properties of
Tinospora crispa extract. Journal of Ethnopharmacology 62:
7-13 PDF file
Sakura H, Ashcroft SJH, Terauchi Y, Kadowaki T, Ashcroft FM
(1998) Glucose modulation of ATP-sensitive K-currents in
wild-type, homozygous and heterozygous glucokinase
knock-out mice. Diabetologia 41: 654-659 PDF file
Mikhailov MV, Proks P, Ashcroft FM, Ashcroft SJH (1998)
Expression of functionally active ATP-sensitive K-channels
in insect cells using baculovirus. FEBS Lett 429: 390-394
PDF file
Goodison S, Ashcroft SJH (1997) Trans-acting factor(s)
confer glucose-responsive transcriptional regulation in the
insulin gene. Adv Exp Med Biol 426: 97-100
Urquid, V, Ashcroft SJH (1997) Molecular cloning of the
cDNA encoding beta-cell calcium/calmodulin- dependent
protein kinase II. Adv Exp Med Biol 426: 73-80
Niki I, Coles B, Ashcroft FM, Ashcroft SJH (1997) Effects
of protein phosphorylation on the sulphonylurea receptor of
the pancreatic beta-cell. Adv Exp Med Biol 426: 59-69
Vucic M, Rocic B, Bozikov V, Ashcroft SJH (1997) Plasma
uric acid and total antioxidant status in patients with
diabetes meelitus. Horm Metab Res 29: 355-357
Breen M A, Ashcroft SJH (1997) A truncated isoform of
Ca2+/calmodulin-dependent protein kinase II
expressed in human islets of Langerhans may result from
trans-splicing. FEBS Lett 409: 375-379 PDF file
Vucic M, Gavella M, Bozikov V, Ashcroft SJH, Rocic B (1997)
Superoxide dismutase activity in lymphocytes and
polymorphonuclear cells of diabetic patients. Eur J Clin
Chem Clin Biochem 35: 517-521
Breen M A, Ashcroft SJH (1997) Human islets of Langerhans
express multiple isoforms of calcium/calmodulin-dependent
protein kinase II. Biochem Biophys Res Commun 236: 473-478
PDF file
Váradi A, Molnár E, Östenson C-G, Ashcroft SJH (1996)
Isoforms of endoplasmic reticulum Ca2+-ATPase
are differentially expressed in normal and diabetic islets
of Langerhans. Biochem J 319: 521-527 PDF file
Tian Y-M, Urquidi V, Ashcroft SJH (1996) Protein kinase C
in beta cells: expression of multiple isoforms and
involvement in cholinergic stimulation of insulin
secretion. Mol Cell Endocrinol 119: 185-193 PDF file
Ämmälä C, Moorhouse A, Proks P, Gribble F, Smith PA, Sakura
H, Coles B, Ashcroft SJH, Ashfield R, Ashcroft FM (1996)
The sulphonylurea receptor couples promiscuously to Kir
channels. Nature 379: 545-548 PDF file
Váradi A, Molnár E, Ashcroft SJH (1996) A unique
combination of plasma membrane Ca2+-ATPase
isoforms is expressed in islets of Langerhans and
pancreatic ß-cell lines. Biochem J 314: 663-669 PDF file
Molnár E, Váradi A, McIlhinney RAJ, Ashcroft SJH (1995)
Identification of functional ionotropic glutamate receptor
proteins in pancreatic ß-cells and in islets of Langerhans.
FEBS Lett 371: 253-257 PDF file
German M, Ashcroft SJH, Docherty K, Edlund H, Edlund T,
Goodison S, Imura H, Kennedy G, Madsen O, Melloul D, Moss
L, Olson K, Permutt M A, Philippe J, Robertson BP, Rutter
WJ, Serup P, Stein R, Steiner D, Tsai MJ, Walker MD (1995)
The insulin gene promoter. A simplified nomenclature.
Diabetes 44: 1002-1004 PDf file
Urquidi V, Ashcroft SJH (1995) A novel pancreatic ß-cell
isoform of calcium/calmodulin-dependent protein kinase II
(ß3 isoform) contains a proline-rich tandem repeat in the
association domain. FEBS Lett 358: 23-26 PDF file
Váradi A, Molnár E, Ashcroft SJH (1995) Characterisation of
endoplasmic reticulum and plasma membrane
Ca2+-ATPases in pancreatic ß-cells and in islets
of Langerhans. Biochim Biophys Acta 1236: 119-127 PDF file
Ashcroft SJH (1994) The cell biology of insulin secretion.
In: The Diabetes Annual. Eds: Marshall S.M., Home, P.D. pp
1-19. Elsevier,Amsterdam, London, New York
Goodison S, Miyazaki JI, Ashcroft SJH (1994) Response to
glucose of transcription factor binding to the rat
insulin-1 gene promoter. Biochem Biophys Res Commun 30:
702-710 PDf file
Ashcroft SJH (1994) Protein phosphorylation and beta-cell
function. Diabetologia 37 [Suppl 2]: S21-S29 PDF file
Ashcroft SJH (1994) The ß-cell sulfonylurea receptor. Diab
Nutr Metab 7: 149-163
Kenna S, Röper J, Ho K, Hebert S, Ashcroft S H, Ashcroft FM
(1994) Differential expression of the inwardly-rectifying
K-channel ROMK1 in rat brain. Mol Brain Res. 24: 353-356 PDF file
Skeer JM, Dégano P, Coles B, Potier M, Ashcroft FM,
Ashcroft SJH (1994) Determination of the molecular mass of
the native ß-cell sulfonylurea receptor. FEBS Lett 338:
98-102 PDF file
Ashcroft SJH, Niki I, Kenna S, Weng L, Skeer J, Coles B,
Ashcroft F M (1993) The beta-cell sulfonylurea receptor.
Adv Exp Med Biol 334: 47-61.
Weng L, Davies M, Ashcroft SJH (1993) Effects of
cholinergic agonists on diacylglycerol and intracellular
calcium levels in pancreatic ß-cells. Cellular Signalling
5: 777-786 PDF file
Niki I, Ashcroft SJH (1993) Characterization and
solubilization of the sulphonylurea receptor in rat brain.
Neuropharmacol 32: 951-957 PDF file
Hughes SJ, Smith H, Ashcroft SJH (1993) Characterization of
Ca2+/calmodulin-dependent protein kinase in rat
pancreatic islets. Biochem J 289: 795-800 PDF file
Ashcroft SJH, Ashcroft FM (1992) The sulfonylurea receptor.
Biochim Biophys Acta 1175: 45-59 PDF file
Modríc N, Derome AE, Ashcroft SJH, Poje M (1992) Tracing
and identification of uricase reaction intermediates. A
direct 13C-NMR/isotope-labelling evidence. Tetrahedron
Letters 33: 6691-6694
Oosawa Y, Ashcroft SJH, Ashcroft FM (1992)
Ca2+-activated K+-channels from an
insulin-secreting cell line incorporated into planar lipid
bilayers. Diabetologia 35: 619-623 PDf file
Goodison S, Kenna S, Ashcroft SJH (1992) Control of insulin
gene expression by glucose. Biochem J 285: 563-568 PDF file
Ashcroft SJH, Ashcroft FM (1992) Mechanism of insulin
secretion. In: Insulin. Molecular Biology to Pathology
(eds. Ashcroft FM & Ashcroft SJH). IRL Press :37-63
Hughes SJ, Carpinelli A, Niki I, Nicks JL, Ashcroft SJH
(1992) Stimulation of insulin release by vasopressin in the
clonal ß-cell line, HIT-T15: the role of protein kinase C.
J Mol Endocrinol 8: 145-153 PDF file
Niki I, Ashcroft SJH (1992) Possible involvement of protein
phosphorylation in the regulation of the sulphonylurea
receptor of a pancreatic ß-cell line, HIT T15. Biochim
Biophys Acta 1133: 95-101 PDF file
Niki I, Welsh M, Berggren P-O, Hubbard P, Ashcroft SJH
(1991) Characterization of the solubilized glibenclamide
receptor in a hamster pancreatic ß-cell line, HIT T15.
Biochem J 277: 619-624 PDF file
Hughes SJ, Ashcroft SJH (1991) Cyclic AMP, protein
phosphorylation and insulin release. In "Nutrient
Regulation of Insulin Secretion" Ed. Flatt, P.R. Portland
Press.pp 271-288
Ashcroft SJH, Ashcroft FM (1990) Properties and functions
of ATP-sensitive K-channels. Cellular Signalling 2: 197-214 PDF file
Niki I, Nicks JL, Ashcroft SJH (1990) The ß-cell
glibenclamide receptor is an ADP-binding protein. Biochem J
268: 713-718 PDF file
Betsholtz C, Baumann A, Kenna S, Ashcroft FM, Ashcroft SJH,
Berggren P-O, Grupe A, Rorsman P, Sandblom J, Welsh M
(1990) Expression of voltage-gated K+-channels
in insulin-producing cells. Analysis by polymerase chain
reaction. FEBS Lett 263: 121-126 PDF file
Hughes SJ, Chalk JG, Ashcroft SJH (1990) The role of
cytosolic free Ca2+ and protein kinase C in
acetylcholine-induced insulin release in the clonal ß-cell
line, HIT-T15. Biochem J 267: 227-232 PDF file